Containing carrier for fluorescent microsphere carrier and detection device

Abstract

The utility model discloses a fluorescent microsphere carrier containing carrier and a detection device, the fluorescent microsphere carrier containing carrier comprises a bottom plate and a limiting plate, the limiting plate is provided with a limiting groove and can be arranged on the bottom plate in a translation mode, a bearing plate is provided with a containing groove used for flatly laying a plurality of fluorescent microspheres, the bearing plate is clamped in the limiting groove, and the limiting groove is arranged on the bearing plate. The vertical projection of the containing groove is located in the vertical projection of the limiting groove. According to the utility model, the accuracy of limiting the position of the fluorescent microsphere and shifting the fluorescent microsphere and the convenience of detection are improved by utilizing the containing carrier, and the fluorescent microsphere in the containing carrier is amplified and detected through the fluorescence microscope, so that the detection efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of microsphere processing equipment technology, and in particular to a container and detection device for fluorescent microsphere carriers. Background Technology

[0002] There are many types of fluorescent microspheres, and those with different colors and properties have different applications. Fluorescent microspheres exhibit high brightness, good stability, high resolution, and high sensitivity when excited. By conjugating antibodies to form immunofluorescent microsphere carriers, they have wide applications in the biomedical and medical diagnostic fields.

[0003] The detection of the morphology and fluorescence intensity of fluorescent microsphere carriers is difficult and demanding due to their small particle size. Existing detection equipment, such as the micro-steel ball appearance inspection tool with a diameter of less than 3 mm (application number 202221784219.1) and the small steel ball magnifying glass appearance inspection device (application number 201821888303.1), is not suitable for the batch packaging and detection of fluorescent microspheres. Utility Model Content

[0004] The purpose of this invention is to provide a container and detection device for fluorescent microsphere carriers. The container improves the accuracy of limiting the position and displacement of fluorescent microspheres, as well as the convenience of detection. Furthermore, the fluorescent microspheres inside the container are magnified and detected using a fluorescence microscope, thereby improving the detection efficiency.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is: a container for fluorescent microsphere carriers, comprising:

[0006] Base plate,

[0007] A limiting plate, which has a limiting groove, is movably mounted on the base plate.

[0008] A support plate is provided with a receiving groove for laying multiple fluorescent microspheres. The support plate is clamped in the limiting groove, and the vertical projection of the receiving groove is located within the vertical projection of the limiting groove.

[0009] As a further optimization, the support plate includes an integrally formed horizontal plate and a vertical plate, with a pair of vertical plates disposed on opposite sides of the horizontal plate; the limiting plate is provided with a retaining plate extending into the limiting groove above the limiting groove, and the vertical plate is located below the retaining plate. Through the arrangement of the vertical plate and its cooperation with the retaining plate, the support plate can be stably positioned in the limiting groove.

[0010] As a further optimization, the side wall of the vertical plate near the receiving groove protrudes beyond the side wall of the card plate near the limiting groove, so as to prevent the vertical projection of the card plate from being located inside the receiving groove and affecting the observation or detection of the fluorescent microspheres.

[0011] As a further optimization, both ends of the carrier plate are equipped with sealing plates to prevent the fluorescent microspheres from spilling out from the sides of the receiving groove.

[0012] As a further optimization, the base plate is provided with a sliding groove, and the limiting plate is horizontally slidably disposed in the sliding groove. The sliding groove can be used to define the moving direction of the limiting plate, thus avoiding positional deviation in multiple directions in the horizontal plane when the limiting plate is moved.

[0013] As a further optimization, the limiting plate is provided with anti-slip texture, which can be easily pulled and moved horizontally.

[0014] As a further optimization, the support plate is made of a shape-retaining material; and the inner wall of the receiving groove is provided with an anti-stick coating.

[0015] This utility model also provides a detection device for detecting fluorescent microsphere carriers, including a base, a fluorescence microscope, a computer host, a fluorescence detection pen, and the aforementioned container for fluorescent microsphere carriers. The fluorescence microscope is mounted on the base, the computer host is connected to the fluorescence microscope via signal, and the container for fluorescent microsphere carriers is mounted on the base.

[0016] As a further optimization, the lower end of the base plate and the upper end of the base are provided with matching positioning components, which can ensure that the base plate is stably set on the base and prevent the base plate from moving when the limiting plate is moved.

[0017] As a further optimization, the base plate is provided with a groove, and the fluorescent detection pen is placed in the groove.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] 1. Multiple fluorescent microspheres are confined within a receiving groove. The supporting plate and its receiving groove are positioned by the limiting groove of the limiting plate. The movement of the limiting plate on the base plate drives the fluorescent microspheres to translate. This allows for the individual detection of indicators such as the morphology and fluorescence intensity of multiple fluorescent microspheres. The use of a container improves the accuracy of limiting the position and moving of the fluorescent microspheres, as well as the convenience of detection.

[0020] 2. The detection efficiency was improved by magnifying and detecting the fluorescent microspheres inside the container using a fluorescence microscope. Attached Figure Description

[0021] Figure 1This is a structural diagram of the container used to hold the fluorescent microsphere carrier in this utility model.

[0022] Figure 2 This is an assembly structure diagram of the limiting plate and the supporting plate of the container for the fluorescent microsphere carrier in this utility model.

[0023] Figure 3 for Figure 2 Enlarged view of point A in the middle.

[0024] Figure 4 This is a structural diagram of another embodiment of the carrier plate of the container for the fluorescent microsphere carrier in this utility model.

[0025] Figure 5 This is a structural diagram of another embodiment of the container for fluorescent microsphere carriers in this utility model.

[0026] Figure 6 This is a structural diagram of the detection device for detecting fluorescent microsphere carriers according to this invention. Detailed Implementation

[0027] The following are specific embodiments of the present invention, which are described in conjunction with the accompanying drawings. However, the present invention is not limited to these embodiments.

[0028] like Figures 1 to 3 As shown, the container for the fluorescent microsphere carrier includes a base plate 1, a limiting plate 2, and a support plate 3. The limiting plate 2 is provided with a limiting groove 20, and the limiting plate 2 is movably mounted on the base plate 1. The support plate 3 is provided with a receiving groove 30 for laying multiple fluorescent microspheres 100. The support plate 3 is clamped in the limiting groove 20, and the vertical projection of the receiving groove 30 is located within the vertical projection of the limiting groove 20.

[0029] In this invention, to facilitate fluorescence intensity detection of fluorescent microspheres 100, especially given their small particle size and large quantity, multiple fluorescent microspheres 100 are first laid flat in the receiving groove 30. The supporting plate 3 with the receiving groove 30 is then embedded in the limiting groove 20 of the limiting plate 2 for positioning and fixing. Therefore, the multiple fluorescent microspheres 100 in a flat state can be moved relatively horizontally on the base plate 1 by (manually) moving the limiting plate 2. The sidewall of the receiving groove 30 is vertical, and its width is less than the width of the limiting groove 20. Therefore, the limiting groove 20 will not cover the receiving groove 30. The multiple fluorescent microspheres slowly moving below can then be detected one by one by a fluorescence microscope located above the base plate 1, facilitating rapid detection of multiple fluorescent microspheres 100.

[0030] More specifically, the support plate 3 includes an integrally formed horizontal plate 31 and a vertical plate 32. A pair of vertical plates 32 are disposed on opposite sides of the horizontal plate 31. The limiting plate 2 has a retaining plate 21 extending towards the limiting groove 20 above it, and the vertical plates 32 are located below the retaining plate 21. In this invention, the vertical plates 32, together with the horizontal plate 31, limit the dispersion of the fluorescent microspheres 100 and prevent the fluorescent microspheres from contacting the sidewall of the limiting groove 20. Furthermore, the vertical plates 32 abut against the sidewall of the limiting groove 20 and the retaining plate 21, ensuring the stability of the support plate 3 within the limiting groove 20. That is, moving the limiting plate 2 can drive the support plate 3 to move stably.

[0031] Furthermore, the sidewall of the vertical plate 32 near the receiving groove 30 protrudes from the sidewall of the card plate 21 near the limiting groove 20, thereby preventing the card plate 21 from blocking the space inside the receiving groove 30, and thus preventing the inability to accurately detect the fluorescent microspheres near the sidewall of the receiving groove 30.

[0032] like Figure 4 As shown, sealing plates 33 can be provided at both ends of the carrier plate 3, so as to realize that the receiving groove 30 is closed on all sides, and prevent the fluorescent microspheres 100 from spilling out on both sides.

[0033] like Figure 5 As shown, in another embodiment of this utility model, a groove 11 can be provided on the base plate 1, and the limiting plate 2 can be horizontally slidably disposed in the groove 11. The visual inspection device is disposed above the groove 11, and the limiting plate 2 moves horizontally within the groove 11. Only the limiting plate 2 needs to be moved in one horizontal direction, and the stability of the translation of the limiting plate 2 can be guaranteed. In addition, multiple adjusting bolts 12 can be provided at the lower end of the base plate 1 to adjust the horizontal state of the base plate 1 (upper end face), so that the limiting plate 2 and the bearing plate 3 located on it are horizontal and prevent the fluorescent microspheres from rolling in the receiving groove 30.

[0034] One end of the limiting plate 2 is provided with anti-slip texture 2a. When the limiting plate 2 is moved manually, the anti-slip texture 2a can be pinched with fingers to ensure friction and pull the limiting plate 2 to move.

[0035] The support plate 3 is made of a molded material, which can have a certain deformation to be snapped into the limiting groove 20; the inner wall of the receiving groove 30 is provided with an anti-stick coating, and the relatively smooth contact surface can prevent the fluorescent microspheres 100 from adhering to the side wall of the receiving groove 30, and can also prevent dust from adhering and causing it to stick back to the fluorescent microspheres 100.

[0036] like Figure 6As shown, this utility model also provides a detection device for microsphere detection, including a fluorescent detection pen 4, a base 5, a fluorescence microscope 6, a computer host 7, and the aforementioned container for fluorescent microsphere carriers. The fluorescence microscope 6 is mounted on the base 5 and its height is adjustable. The computer host 7 is connected to the fluorescence microscope 6 via a signal connection. The container for fluorescent microsphere carriers is mounted on the base 5. The specific working process is as follows: the base plate 1 is placed on the base 5, and the carrier plate 3 and the fluorescent microspheres 100 located therein are moved horizontally below the fluorescence microscope 6 by moving the limiting plate 2. The fluorescence microscope 6 can display the morphology and fluorescence intensity of the fluorescent microspheres at a certain magnification at the eyepiece end of the fluorescence microscope or on the display screen of the computer host 7, so that the detection personnel can accurately observe the state of the fluorescent microspheres by looking at the display screen of the computer host 7. The fluorescence microscope 6 can also facilitate the detection personnel to operate the fluorescent detection pen 4 to act on the target fluorescent microspheres (such as marking the target fluorescent microspheres with the fluorescent detection pen).

[0037] The lower end of the base plate 1 and the upper end of the base 5 are provided with matching positioning components, such as the cooperation of positioning pins and positioning holes, or the cooperation of magnetic components, which can position the base plate 1 on the base 5.

[0038] In addition, a groove 10 is provided on the base plate 1, and the fluorescent detection pen 4 is placed in the groove 10.

[0039] The specific embodiments described herein are merely illustrative examples illustrating the spirit of this utility model. Those skilled in the art to which this utility model pertains may make various modifications or additions to the described specific embodiments or use similar methods to substitute them, without departing from the spirit of this utility model or exceeding the scope defined by the appended claims.

Claims

1. A container for fluorescent microsphere carriers, characterized in that, include: Base plate, A limiting plate, which has a limiting groove, is movably mounted on the base plate. A support plate is provided with a receiving groove for laying multiple fluorescent microspheres. The support plate is clamped in the limiting groove, and the vertical projection of the receiving groove is located within the vertical projection of the limiting groove.

2. The container for fluorescent microsphere carriers according to claim 1, characterized in that, The support plate includes an integrally formed horizontal plate and a vertical plate, with a pair of vertical plates disposed on opposite sides of the horizontal plate; the limiting plate is provided with a retaining plate extending into the limiting groove above the limiting groove, and the vertical plate is located below the retaining plate.

3. The container for fluorescent microsphere carriers according to claim 2, characterized in that, The side wall of the vertical plate near the receiving groove protrudes from the side wall of the card plate near the limiting groove.

4. The container for fluorescent microsphere carriers according to any one of claims 1 to 3, characterized in that, Both ends of the bearing plate are equipped with sealing plates.

5. The container for fluorescent microsphere carriers according to claim 1, characterized in that, The base plate is provided with a sliding groove, and the limiting plate is horizontally slidably disposed in the sliding groove.

6. The container for fluorescent microsphere carriers according to claim 1 or 5, characterized in that, The limiting plate is provided with anti-slip texture.

7. The container for fluorescent microsphere carriers according to claim 1, characterized in that, The support plate is made of a shape-retaining material; the inner wall of the receiving groove is provided with an anti-stick coating.

8. A detection device for detecting fluorescent microsphere carriers, characterized in that, The device includes a base, a fluorescence microscope, a computer host, a fluorescence detection pen, and a container for fluorescent microsphere carriers as described in any one of claims 1 to 7. The fluorescence microscope is mounted on the base, the computer host is connected to the fluorescence microscope via signal, and the container for fluorescent microsphere carriers is mounted on the base.

9. The detection device for detecting fluorescent microsphere carriers according to claim 8, characterized in that, The lower end of the base plate and the upper end of the base are provided with matching positioning components.

10. The detection device for detecting fluorescent microsphere carriers according to claim 8, characterized in that, The base plate has a groove, and the fluorescent detection pen is placed in the groove.

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