Liquid collecting device of liquid chromatograph

Abstract

The utility model discloses a liquid collecting device of a liquid chromatograph, which comprises a liquid inlet, a three-way electromagnetic valve, a waste liquid pool and a collecting component, the collecting component comprises a collecting pipe and a collecting pipe frame, and the three-way electromagnetic valve is respectively communicated with the liquid inlet, the waste liquid pool and the collecting component; an elastic liquid collecting device and a two-way electromagnetic valve are sequentially arranged between the three-way electromagnetic valve and the collecting assembly, when the collecting pipes are switched, the two-way electromagnetic valve is closed, and when switching of the collecting pipes is completed, the two-way electromagnetic valve is opened. The liquid collecting device is suitable for lossless liquid collection under the conditions of low liquid flow rate, small flow or slow switching of collecting pipes; the liquid is stored and discharged only by utilizing the elasticity characteristic of the device, and other mechanisms are not required to be added; the liquid collecting efficiency can be improved, and the structure is simple.

Description

Technical Field

[0001] This utility model relates to liquid processing equipment, specifically a liquid collection device for a liquid chromatograph. Background Technology

[0002] Liquid chromatography (LC) is used in pharmaceuticals, food, chemicals, testing, and environmental analysis. Protein purification LC can separate and purify proteins using LC technology. When collecting the separated or purified liquid, the flow of liquid from the outlet pipe to the waste tank or collection assembly is controlled by switching a three-way solenoid valve. When the collected liquid volume exceeds the volume of a single collection tube, the collection tube needs to be switched to continue collecting. To prevent liquid from spilling into the gaps between collection tubes, the solenoid valve is usually switched to allow the liquid to flow to the waste tank, resulting in liquid loss and reduced liquid yield. Chinese patent CN117959770A discloses a lossless LC fraction collection device suitable for situations with high liquid flow rates and large volumes. However, this device requires an additional gas supply mechanism to blow the distillate temporarily stored in a buffer tank to the collection device, making the overall structure complex. Utility Model Content

[0003] Purpose of the invention: The purpose of this utility model is to provide a liquid collection device for liquid chromatographs that collects liquid without loss.

[0004] Technical solution: The liquid collection device for liquid chromatographs described in this utility model includes an inlet, a three-way solenoid valve, a waste liquid tank, and a collection assembly. The collection assembly includes a collection tube and a collection tube rack. The three-way solenoid valve is connected to the inlet, the waste liquid tank, and the collection assembly. An elastic collection device and a two-way solenoid valve are sequentially arranged between the three-way solenoid valve and the collection assembly. When the collection tube is switched, the two-way solenoid valve is closed; when the collection tube is switched, the two-way solenoid valve is opened.

[0005] Furthermore, the elastic liquid collection device is a rubber hose, a constrictible bladder tube, or a spring tube. It utilizes the elasticity of the elastic liquid collection device itself to complete the storage and discharge of liquid retained in the elastic liquid collection device.

[0006] Furthermore, the collection component includes a moving device for moving the collection tube rack, thereby enabling automatic switching of the collection tubes;

[0007] Furthermore, the collection assembly includes a robotic arm for switching collection tubes, avoiding operational errors and contamination of the collected liquid when manually switching collection tubes;

[0008] Furthermore, the collection component is an automatic partial collector. The automatic partial collector can be set with tube number, switching time, and liquid collection time, and can automatically switch collection tubes to complete the liquid collection work.

[0009] Beneficial effects: Compared with the prior art, this utility model has the following advantages: it is suitable for lossless collection of liquids when the liquid flow rate is low, the flow rate is small, or the collection tube switching is slow; it only utilizes the elastic characteristics of the device itself to complete the liquid storage and discharge without adding other mechanisms; it can improve the liquid collection rate and has a simple structure. Attached Figure Description

[0010] Figure 1 This is a schematic diagram of the structure of this utility model. Detailed Implementation

[0011] The technical solution of this utility model will be further described below with reference to the accompanying drawings.

[0012] like Figure 1 As shown, the three-way solenoid valve 2 is connected to the inlet 1, the waste liquid tank 3, and the collection assembly 4. An elastic liquid collection device 5 and a two-way solenoid valve 6 are sequentially arranged between the three-way solenoid valve 2 and the collection assembly 4. The collection assembly 4 includes a collection pipe 7 and a collection pipe rack 8. Liquid flows into the collection device through the inlet 1. The three-way solenoid valve 2 controls the liquid flow direction. When collecting liquid, the liquid flows sequentially through the elastic liquid collection device 5 and the two-way solenoid valve 6 via the three-way solenoid valve 2, and is finally collected by the collection pipe 7 on the collection pipe rack 8 of the collection assembly 4. Multiple collection pipes 7 are placed on the collection pipe rack 8 of the collection assembly 4 for switching liquid collection. When liquid collection is needed, the three-way solenoid valve 2 is controlled, closing the liquid path in the waste liquid tank 3 and opening the liquid path in the collection component 4, while the two-way solenoid valve 6 remains open. When the volume of liquid to be collected exceeds the collection volume of a single collection pipe 7, and it is necessary to switch collection pipe 7 to continue collecting liquid, the two-way solenoid valve 6 is closed, and the liquid remains in the elastic collection device 5, which expands, causing the hydraulic pressure inside the device to rise. When the replacement of collection pipe 7 is completed, the two-way solenoid valve 6 is opened, the elastic collection device 5 contracts, and the liquid remaining in the device is squeezed out. When liquid collection is no longer needed, the three-way solenoid valve 2 is switched, closing the liquid path in the collection component 4 and opening the liquid path in the waste liquid tank 3, allowing the liquid to drain into the waste liquid tank 3.

[0013] The elastic collection device 5 is preferably a rubber hose. Considering the time and extent of expansion due to blockage in the rubber hose, the rubber hose has good elasticity and can be reused. When switching collection tubes, the two-way solenoid valve 6 is closed, and the liquid remains in the rubber hose, expanding the hose's cavity. When the collection tube switching is complete, the two-way solenoid valve 6 opens, squeezing out the liquid from the rubber hose, and the rubber hose regains its elasticity. Taking into account the rubber hose's elastic recovery capacity, elastic expansion capacity, and the limitation of the liquid pipeline length, the embedded rubber hose length is 8-10 cm.

[0014] The elastic collection device 5 is preferably a contractile capsule. When switching collection tubes, the two-way solenoid valve 6 is closed, the liquid remains in the capsule, and the cavity of the capsule is expanded. When the collection tube switching is completed, the two-way solenoid valve 6 is opened, the capsule contracts, the liquid inside is squeezed out, and the capsule elastically recovers.

[0015] The elastic collection device 5 is preferably a spring tube. When switching the collection tube, the two-way solenoid valve 6 is closed, and the liquid remaining in the spring tube compresses the spring tube spring, increasing the volume of the liquid in the tube. When the collection tube switching is completed, the two-way solenoid valve 6 is opened, and the spring tube spring pushes the liquid in the tube to be discharged.

[0016] The collection component 4 preferably includes a moving device for moving the collection tube rack. Through the smooth movement of the collection tube rack moving device, the collection tubes 7 in the collection tube rack 8 can be automatically switched, avoiding liquid loss and liquid contamination caused by improper operation when manually switching collection tubes, and improving experimental safety.

[0017] The collection component 4 preferably includes a robotic arm for switching collection tubes. The robotic arm completes the replacement of the collection tubes quickly, thus avoiding errors caused by manual operation. The collection component 4 is an automatic partial collector that can be set with tube number, switching time, and liquid collection time, and can automatically switch collection tubes to complete the liquid collection work.

Claims

1. A liquid collection device for a liquid chromatograph, comprising an inlet (1), a three-way solenoid valve (2), a waste liquid tank (3), and a collection assembly (4), wherein the collection assembly (4) comprises a collection tube (7) and a collection tube rack (8), wherein the three-way solenoid valve (2) is connected to the inlet (1), the waste liquid tank (3), and the collection assembly (4) respectively; characterized in that: An elastic liquid collection device (5) and a two-way solenoid valve (6) are sequentially arranged between the three-way solenoid valve (2) and the collection assembly (4). When the collection pipe (7) is switched, the two-way solenoid valve (6) is closed, and when the switching of the collection pipe (7) is completed, the two-way solenoid valve (6) is opened.

2. The liquid collection device for a liquid chromatograph according to claim 1, characterized in that: The elastic liquid collection device (5) is a rubber hose, a constrictible bladder tube, or a spring tube.

3. The liquid collection device for a liquid chromatograph according to claim 1, characterized in that: The collection assembly (4) includes a moving device for moving the collection tube rack (8).

4. The liquid collection device for a liquid chromatograph according to claim 1, characterized in that: The collection assembly (4) includes a robotic arm for switching the collection tube (7).

5. The liquid collection device for a liquid chromatograph according to claim 1, characterized in that: The collection component (4) is an automatic partial collector.

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