Water bath heat preservation device of CTC enrichment dyeing equipment
By designing a water bath insulation device for CTC enrichment staining equipment, and using a fixed frame and warm water contact method, the problem of uneven temperature control in CTC cell enrichment staining experiments was solved, achieving stable fixation of the filter and uniform heating, thus improving experimental efficiency.
Patent Information
- Application Number
- CN202422256056.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-14
- Publication Date
- 2025-11-14
- Estimated Expiration
- 2034-09-14
AI Technical Summary
In CTC cell enrichment staining experiments, the existing technology lacks an effective heating and temperature control device, resulting in uneven temperature control and affecting the reagent reactivity.
A water bath insulation device for CTC enrichment staining equipment was designed. The device uses a hollow heating tank with a fixing frame and water pipes inside. Combined with an outer insulation layer and an inner heating device, it ensures that the filter is stably fixed and achieves uniform heating through direct contact with warm water.
The stability and heating uniformity of the filter were improved, ensuring that the reagents reacted at the optimal temperature of around 37 degrees Celsius, thus enhancing the experimental results.
Smart Images
Figure CN223543023U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of biomedical technology, specifically a water bath insulation device for CTC enrichment staining equipment. Background Technology
[0002] In recent years, several emerging tumor diagnostic and detection technologies have emerged in the field of biomedical engineering, such as circulating tumor DNA (CTC) detection methods, known as liquid biopsy. Studies have shown that CTCs can be detected in peripheral blood before solid tumors form, making CTC detection highly suitable for early screening and diagnosis of malignant tumors. Furthermore, CTC detection demonstrates excellent efficacy in predicting the prognosis, disease progression, recurrence prediction, monitoring of small lesions after surgery, and designing and monitoring the efficacy of targeted drug therapy for malignant tumors. It is currently an advanced method for early screening and diagnosis of malignant tumors. This method avoids trauma to patients, and the test samples are readily available, allowing for wide application in immunological research, gene research, and microbial detection. It can even be applied to biochip and organoid research and development. Currently, the mainstream approach for detecting circulating tumor cells is to enrich them before detection.
[0003] Throughout the CTC cell enrichment staining experiment, multiple reagents need to be added to the filter. These reagents have the highest reactivity at around 37 degrees Celsius, so it is necessary to add a heating and temperature control device during the experiment. Utility Model Content
[0004] To address the problems of the prior art, this invention provides a water bath insulation device for CTC enrichment staining equipment, thereby resolving the issues raised in the background art.
[0005] To achieve the above objectives, this utility model provides the following technical solution: a water bath insulation device for CTC enrichment staining equipment, comprising a heating tank, a fixing frame placed inside the heating tank, several through holes for fixing filters being equidistantly opened at the upper end of the fixing frame, a drain pipe at the tail of the filter passing through the through holes and extending out from the gap between the fixing frame and the heating tank, a water pipe extending into the heating tank, and a water pump connected to the other end of the water pipe to inject hot water into the heating tank.
[0006] With the above structural design, the fixing frame is placed inside the heating tank during the experiment. This allows the filter to be inserted into the through holes on the fixing frame for support and fixation when heated, increasing the stability of the filter and preventing it from tipping over. Warm water directly contacts the filter's sleeve; due to water's high specific heat capacity, heat conduction is better, resulting in more uniform heating.
[0007] Preferably, the heating tank has a hollow structure, and a heating device and an insulation layer are provided inside the hollow structure.
[0008] By adopting the above structural design, the hollow structure effectively slows down the rate at which the temperature inside the heating tank is transferred to the outside, thereby achieving the effect of heat preservation.
[0009] Preferably, the heating tank is divided into an outer water bath and an inner water bath, and an extension plate is fixedly connected to the upper end of the inner water bath, with the extension plate overlapping the outer water bath.
[0010] The above structural design allows the heating tank to be configured as a detachable outer water bath and an inner water bath. This facilitates the installation of heating devices and insulation layers, and also makes it easy to empty the water from the heating tank after the experiment.
[0011] Preferably, the heating device is installed on the outer wall of the inner water bath, and the insulation layer is installed on the inner wall of the outer water bath.
[0012] The above structural design, with an insulation layer inside the outer water bath, helps to slow down heat conduction and reduce the impact of external temperature on the internal liquid. The inner water bath is equipped with a heating device to improve heating efficiency and ensure more uniform heating.
[0013] Preferably, a temperature sensor is installed on the inner wall of the inner water bath, and a display panel that receives the electrical signal from the temperature sensor is provided on the outside of the heating tank.
[0014] With the above structural design, the temperature sensor can monitor the temperature inside the heating tank and display it on the display panel to remind the experimenters.
[0015] Compared with the prior art, the beneficial effects of this utility model are:
[0016] 1. During the experiment, the fixing frame is placed inside the heating tank. This allows the filter to be inserted into the through holes on the fixing frame for support and fixation when heated, increasing the stability of the filter and preventing it from tipping over. Warm water directly contacts the filter's sleeve; due to water's high specific heat capacity, heat conduction is better, resulting in more uniform heating.
[0017] 2. An insulation layer is installed inside the outer water bath to help slow down heat conduction and reduce the impact of external temperature on the internal liquid. A heating device is installed in the inner water bath to improve heating efficiency and ensure more uniform heating. Attached Figure Description
[0018] Figure 1 This is a schematic diagram of the structure of this utility model;
[0019] Figure 2 This is a schematic diagram of the internal structure of the heating tank of this utility model. Detailed Implementation
[0020] Please see Figure 1-2 This utility model provides a technical solution: a water bath insulation device for CTC enrichment staining equipment, including a heating tank 1, which is a cuboid structure with an open top. A fixing frame 2 is placed inside the heating tank 1. The fixing frame 2 consists of an upper plane and lower legs. Several through holes 201 for fixing filters 5 are equidistantly opened at the upper end of the fixing frame 2. The drain pipe 6 at the tail of the filter 5 passes through the through holes 201 and extends out from the gap between the fixing frame 2 and the heating tank 1. A water pipe 9 extends into the heating tank 1, and the other end of the water pipe 9 is connected to a water pump to inject hot water into the heating tank 1. Both the heating tank 1 and the fixing frame 2 are made of stainless steel. During the experiment, the fixing frame 2 is placed inside the heating tank 1 so that the filter 5 can be inserted into the through holes 201 on the fixing frame 2 for support and fixation when heated in the heating tank 1, increasing the stability of the filter 5 and making it less likely to tip over. Warm water comes into direct contact with the sleeve of filter 5. Due to the high specific heat capacity of water, the heat conduction effect is better and the heating is more uniform.
[0021] The heating tank 1 has a hollow structure, within which a heating device 8 and an insulation layer 7 are installed. The heating device 8 is a heating tape, and the insulation layer 7 is made of asbestos material. The heating tape heats the heating tank 1, while the insulation layer 7 reduces heat loss. The hollow structure effectively slows down the rate at which heat transfer from the inside of the heating tank 1 to the outside, thus achieving a heat preservation effect.
[0022] The heating tank 1 is divided into an outer water bath 101 and an inner water bath 102. An extension plate 1021 is fixedly connected to the upper end of the inner water bath 102, and the extension plate 1021 overlaps the outer water bath 101. Setting the heating tank 1 as having a detachable outer water bath 101 and inner water bath 102 facilitates the installation of the heating device 8 and the insulation layer 7, and also makes it convenient to empty the water from the heating tank 1 after the experiment.
[0023] The heating device 8 is installed on the outer wall of the inner water bath 102, and the insulation layer 7 is installed on the inner wall of the outer water bath 101. The insulation layer 7 inside the outer water bath 101 helps to slow down heat conduction and reduce the impact of external temperature on the internal liquid. The heating device 8 in the inner water bath 102 improves the heating effect and makes the heating of the heating tank 1 more uniform.
[0024] A temperature sensor 4 is installed on the inner wall of the inner water bath 102, and a display panel 3 is provided on the outside of the heating tank 1 to receive the electrical signal from the temperature sensor 4. The temperature sensor 4 can monitor the temperature inside the heating tank 1 and display it on the display panel 3 to remind the experimenter to control the temperature.
[0025] Working principle: First, according to experimental needs, the experimenters install multiple heating cables on the outer wall of the inner water bath 102. Then, the inner water bath 102 is placed inside the outer water bath 101. The bottom ends of several filters 5 are inserted sequentially into the through holes 201 on the fixing frame 2. The drain pipe 6 is connected to the filter 5 from the bottom of the fixing frame 2. Then, the fixing frame 2 is placed into the heating tank 1. After installation, the external heating device is turned on. When the water temperature rises to a suitable temperature (37 degrees Celsius in this embodiment), the water pump is turned on to fill the heating tank 1 with water. After filling is complete, the water pump is turned off. The experimenters can determine the water temperature during the experiment according to the display panel 3 set on the heating tank 1, and then control the temperature and maintain the heat by controlling the number of heating cables turned on.
[0026] Compared with traditional heating sleeves, this water bath insulation device has better heating and insulation effects. The principle of the heating sleeve preheating the filter 5 is that the heat conduction between the two solids, the sleeve and the filter 5, or through the air, is not very effective. However, the heat conduction effect is better when the warm water comes into direct contact with the filter 5, due to the high specific heat capacity of water.
[0027] The structures, proportions, and sizes illustrated in the accompanying drawings are merely for illustrative purposes and to aid those skilled in the art in understanding and reading the content disclosed herein. They are not intended to limit the scope of this utility model and therefore have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to size, without affecting the effectiveness and purpose of this utility model, should still fall within the scope of the technical content disclosed herein. Furthermore, the terms "upper," "lower," "left," "right," "middle," and "one" used in this specification are merely for clarity and not intended to limit the scope of this utility model. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of this utility model's implementation.
[0028] The present invention has been described above with reference to preferred embodiments, but the scope of protection of the present invention is not limited thereto. All technical solutions falling within the scope of the claims are within the scope of protection of the present invention. Various modifications can be made to the present invention, and components can be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way.
Claims
1. A water bath insulation device for a CTC enrichment staining apparatus, characterized in that: The device includes a heating tank (1), a fixing frame (2) is placed inside the heating tank (1), and several through holes (201) for fixing a filter (5) are equidistantly opened at the upper end of the fixing frame (2). The drain pipe (6) at the tail of the filter (5) passes through the through holes (201) and extends out from the gap between the fixing frame (2) and the heating tank (1). A water pipe (9) extends into the heating tank (1), and the other end of the water pipe (9) is connected to a water pump to inject hot water into the heating tank (1).
2. The water bath insulation device for a CTC enrichment staining apparatus according to claim 1, characterized in that: The heating tank (1) has a hollow structure, and a heating device (8) and a heat insulation layer (7) are installed inside the hollow structure.
3. The water bath insulation device for a CTC enrichment staining apparatus according to claim 2, characterized in that: The heating tank (1) is divided into an outer water bath tank (101) and an inner water bath tank (102). An extension plate (1021) is fixedly connected to the upper end of the inner water bath tank (102), and the extension plate (1021) overlaps the outer water bath tank (101).
4. The water bath insulation device for a CTC enrichment staining apparatus according to claim 3, characterized in that: The heating device (8) is installed on the outer wall of the inner water bath (102), and the heat insulation layer (7) is installed on the inner wall of the outer water bath (101).
5. A water bath insulation device for a CTC enrichment staining apparatus according to claim 3 or 4, characterized in that: A temperature sensor (4) is installed on the inner wall of the inner water bath (102), and a display panel (3) is provided on the outside of the heating tank (1) to receive the electrical signal of the temperature sensor (4).