Nucleic acid synthesizer

Abstract

The utility model relates to the technical field of biopharmacy, and discloses a nucleic acid synthesizer which comprises a complete machine shell assembly, and a liquid path assembly, a gas path assembly and a control unit which are arranged on the complete machine shell assembly, the gas path assembly is provided with a plurality of gas output ends, the liquid path assembly is provided with a plurality of reagent input ends, the gas path assembly and the liquid path assembly are both connected with the control unit, and the gas path assembly fills inert gas into the corresponding monomer bottles and the solvent bottles according to instructions of the control unit. The liquid path assembly transmits reagents in the corresponding solvent bottle and the single bottle according to an instruction of the control unit, and the reagents transmitted by the liquid path assembly are subjected to synthetic reaction in the reaction cavity of the synthetic column. The nucleic acid synthesizer has the advantages that liquid mixing is avoided during synthesis of organic solvents, gas mixing is avoided due to the fact that independent gas path systems are arranged between the solvent bottles, current synthesis important parameters can be displayed on the synthesizer in real time in the synthesis process, and the whole synthesizer is simple in structure, high in modular maintenance and the like.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of biosynthesis, specifically to a nucleic acid synthesizer. BACKGROUND

[0002] With the rapid development of molecular biology and biomedical, small nucleic acid solid phase synthesis technology has become an important tool indispensable in research and treatment field. The technology provides strong support for new drug development, gene therapy, gene regulation, and shows a wide application prospect in drug research and development, gene therapy, gene diagnosis and other fields. In addition, small nucleic acid drugs show significant advantages in specificity, simple design, short development cycle, rich target points and deep conversion basis. These advantages make small nucleic acid drugs have broad development prospect and important application value in the field of drug research and development, so the corresponding nucleic acid synthesizer equipment becomes an urgent need.

[0003] The existing nucleic acid synthesizer has the problems of solvent stringing in the synthesis process, gas path system stringing between solvent bottles, inaccurate solvent flow control, and inconvenient local operation and viewing in the event of an emergency during synthesis. UTILITY MODEL CONTENT

[0004] In view of the deficiencies of the prior art, the utility model provides a nucleic acid synthesizer, which solves the problems mentioned in the above background.

[0005] The utility model provides the following technical scheme: a nucleic acid synthesizer, comprising: a whole machine shell assembly and a liquid path assembly, a gas path assembly and a control unit installed on the whole machine shell assembly;

[0006] The gas path assembly has a plurality of gas output ends connected with single bottles or solvent bottles, the liquid path assembly has a plurality of reagent input ends connected with single bottles or solvent bottles, the gas path assembly and the liquid path assembly are connected with the control unit, the gas path assembly fills inert gas into the corresponding single bottle and solvent bottle according to the instruction of the control unit, and the liquid path assembly transmits the reagent in the corresponding solvent bottle and single bottle according to the instruction of the control unit.

[0007] Among them, a synthesis column is arranged in the liquid path assembly, and the reagent transmitted by the liquid path assembly carries out synthesis reaction in the reaction cavity of the synthesis column.

[0008] Preferably, the liquid path assembly comprises a first system pump, a second system pump, a first single valve, a second single valve, a first solvent valve, a second solvent valve, a circulation valve, a first column position valve, a second column position valve and a synthesis column.

[0009] The first monomer valve, the second monomer valve, the first solvent valve and the second solvent valve each have a plurality of inlet ends, the outlet end of the monomer bottle is connected to the inlet end of the first monomer valve or the inlet end of the second monomer valve, the outlet end of the first monomer valve and the outlet end of the second monomer valve are connected to the inlet end of the first solvent valve, and the outlet end of the first solvent valve is connected to the inlet of the first system pump;

[0010] The outlet end of the solvent bottle is connected to the inlet end of the first solvent valve or the inlet end of the second solvent valve, the outlet end of the second solvent valve is connected to the first inlet end of the circulation valve, and the first outlet end of the circulation valve is connected to the inlet of the second system pump.

[0011] The outlet of the first system pump and the outlet of the second system pump are connected to a merging node, the first column valve, the synthesis column and the second column valve are sequentially arranged between the merging node and the second inlet end of the circulation valve, and the first system pump and the second system pump are each provided with an exhaust valve.

[0012] Preferably, the liquid path assembly further comprises a waste liquid valve, and the inlet end of the waste liquid valve is connected to the second outlet end of the circulation valve.

[0013] Preferably, the liquid path assembly further comprises a system pressure sensor, a pre-column pressure sensor, a post-column pressure sensor, a UV detector, a bubble sensor and a conductivity detector.

[0014] The system pressure sensor is arranged between the merging node and the inlet end of the first column valve, the pre-column pressure sensor is arranged at the inlet end of the first column valve, the post-column pressure sensor is arranged at the outlet end of the second column valve, and the UV detector and the conductivity detector are arranged between the outlet end of the second column valve and the second inlet end of the circulation valve.

[0015] Preferably, the whole machine shell assembly comprises a shell metal piece, a display screen mounting block, a front panel, a module mounting plate, a stress metal piece, a water collecting tank, a side panel and a back cover plate.

[0016] The shell metal piece, the front panel, the side panel and the back cover plate are all mounted on the stress metal piece through locking screws and form a machine case together with the stress metal piece.

[0017] The display screen mounting block and the module mounting plate are both mounted on the front panel through locking screws, the lower end of the shell metal piece is provided with a mounting groove, and the water collecting tank is placed in the mounting groove.

[0018] Preferably, a single bottle fixing block is installed on the side panel, and the single bottle is fixed on the side panel through the single bottle fixing block, and the synthesis column is installed on the front panel through a support.

[0019] Preferably, a handle is installed on the side panel, and a plurality of pipeline routing buckles are installed on the surfaces of the front panel and the side panel.

[0020] Preferably, the gas path assembly comprises a total gas source inlet, a first gas path unit and a second gas path unit,

[0021] The inside of the case is provided with a gas path connecting block, and the gas path connecting block has a total gas inlet, and the total gas source inlet is docked with the total gas inlet of the gas path connecting block.

[0022] The first gas path unit and the second gas path unit are connected with the total gas source inlet, the first gas path unit is used for filling inert gas into the single bottle, and the second gas path unit is used for filling inert gas into the solvent bottle.

[0023] The first gas path unit comprises a first pressure gauge, a first pressure regulating valve, a single bottle manifold gas source outlet and a single bottle manifold, the single bottle manifold gas source outlet is connected with the gas inlet of the single bottle manifold, the first pressure gauge and the first pressure regulating valve are arranged at the single bottle manifold gas source outlet and are electrically connected with the control unit, and the gas outlet of the single bottle manifold is connected with the gas inlet of the single bottle.

[0024] The second gas path unit comprises a second pressure gauge, a second pressure regulating valve, a solvent bottle manifold gas source outlet and a solvent bottle manifold, the solvent bottle manifold gas source outlet is connected with the gas inlet of the solvent bottle manifold through a gas pipeline, the second pressure gauge and the second pressure regulating valve are arranged at the solvent bottle manifold gas source outlet and are electrically connected with the control unit, and the gas outlet of the solvent bottle manifold is connected with the gas inlet of the solvent bottle.

[0025] Preferably, the single bottle and the solvent bottle are located on the same side of the case, and the liquid path assembly is installed on the front panel of the case.

[0026] Preferably, the single bottle is used for containing a single reagent, and the solvent bottle is used for containing a synthesis reaction reagent, and the synthesis reaction reagent comprises but is not limited to a cleaning solvent, a deprotection solvent, an activation solvent, an oxidant and a capping solvent.

[0027] Compared with the prior art, the utility model has the following beneficial effects:

[0028] The utility model discloses, through setting whole machine shell subassembly, liquid path subassembly and gas path system, synthetic organic solvent does not string liquid, and there is independent gas path system between solvent bottle and does not string gas, can show the current synthesis important parameter in real time on instrument during synthesis, and the whole machine structure is simple, and instrument can realize modularization installation and dismounting, and maintenance and repair are more convenient. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figure 1 It is the three-dimensional structure schematic diagram of the utility model;

[0030] Figure 2 It is the whole machine shell subassembly structure schematic diagram of the utility model;

[0031] Figure 3 It is the liquid path subassembly structure schematic diagram of the utility model;

[0032] Figure 4 It is the side view structure schematic diagram of the utility model;

[0033] Figure 5 It is the gas path system structure schematic diagram of the utility model;

[0034] Figure 6 It is the liquid path of the utility model.

[0035] In the drawing: 1, shell sheet metal part;2, display screen mounting block;3, front panel;4, module mounting plate;5, stressed sheet metal part;6, water receiving groove;7, side panel;8, pipeline wire arrangement buckle;9, handle;10, back cover plate;11, first system pump;12, exhaust valve;13, system pressure sensor;14, column front pressure sensor;15, column rear pressure sensor;16, synthesis column;17, first column position valve;18, circulating valve;19, UV detector;20, waste liquid valve;21, first monomer valve;22, monomer bottle;23, second solvent valve;24, acetonitrile manifold;25, bubble sensor;26, conductivity meter detector;27, second column position valve;28, second system pump;29, second monomer valve;30, first solvent valve;31, first pressure gauge;32, first pressure regulating valve;33, second pressure gauge;34, second pressure regulating valve;35, total gas source import;36, solvent bottle manifold gas source export;37, monomer bottle manifold gas source export;38, solvent bottle manifold;39, monomer bottle manifold. DETAILED DESCRIPTION

[0036] The technical scheme in the embodiments of the utility model will be described clearly and completely in combination with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by the person skilled in the art without creative labor belong to the protection scope of the utility model.

[0037] Referring to Figures 1-6 The nucleic acid synthesizer comprises: a whole machine shell assembly, and a liquid path assembly, a gas path assembly and a control unit mounted on the whole machine shell assembly; the gas path assembly has a plurality of gas output ends connected with single bottles 22 or solvent bottles, the liquid path assembly has a plurality of reagent input ends connected with the single bottles 22 or the solvent bottles, the gas path assembly and the liquid path assembly are connected with the control unit, the gas path assembly fills inert gas into corresponding single bottles 22 and solvent bottles according to the instruction of the control unit, and the liquid path assembly transmits reagents in the corresponding solvent bottles and single bottles 22 according to the instruction of the control unit; wherein a synthesis column 16 is arranged in the liquid path assembly, and the reagents transmitted by the liquid path assembly perform synthesis reaction in a reaction cavity of the synthesis column 16. The liquid path assembly comprises a first system pump 11, a second system pump 28, a first monomer valve 21, a second monomer valve 29, a first solvent valve 23, a second solvent valve 30, a circulation valve 18, a first column position valve 17, a second column position valve 27 and the synthesis column 16.

[0038] The first monomer valve 21, the second monomer valve 29, the first solvent valve 23 and the second solvent valve 30 each have a plurality of inlet ends, the outlet end of the single bottle 22 is connected with the inlet end of the first monomer valve 21 or the inlet end of the second monomer valve 29, the outlet ends of the first monomer valve 21 and the second monomer valve 29 are connected with the inlet end of the first solvent valve 23, and the outlet end of the first solvent valve 23 is connected with the inlet of the first system pump 11.

[0039] The outlet end of the solvent bottle is connected with the inlet end of the first solvent valve 23 or the inlet end of the second solvent valve 30, the outlet end of the second solvent valve 30 is connected with the first inlet end of the circulation valve 18, and the first outlet end of the circulation valve 18 is connected with the inlet of the second system pump 28.

[0040] The outlet of the first system pump 11 and the outlet of the second system pump 28 are connected to a merging node, the first column position valve 17, the synthesis column 16 and the second column position valve 27 are sequentially arranged between the merging node and the second inlet end of the circulation valve 18, and the first system pump 11 and the second system pump 28 are each provided with an exhaust valve 12.

[0041] The single bottle 22 is used for containing monomer reagents, the solvent bottle is used for containing synthesis reagents, and the synthesis reagents include but are not limited to cleaning solvents, deprotection solvents, activation solvents, oxidizing agents and capping solvents.

[0042] The synthesis column 16 has a reaction cavity, and the monomer reagent and the synthesis reagent transmitted by the liquid path assembly perform a synthesis reaction in the reaction cavity of the synthesis column 16, and a carrier is arranged in the reaction cavity, and the carrier is used for collecting a synthesized product. The control unit is used for controlling switching of the pipeline, and the reagent transmitted by the liquid path assembly is switched according to a step of a synthesis process.

[0043] Preferably, the first system pump 11 and the second system pump 28 are both plunger pumps, and the plunger pumps have a metering function. In this way, the first system pump 11 and the second system pump 28 can accurately control the flow of the reagent during the synthesis process.

[0044] The liquid path assembly further comprises a waste liquid valve 20, and an inlet end of the waste liquid valve 20 is connected with the second outlet end of the circulation valve 18.

[0045] The liquid path assembly further comprises a system pressure sensor 13, a pre-column pressure sensor 14, a post-column pressure sensor 15, a UV detector 19, a bubble sensor 25 and a conductivity detector 26.

[0046] The conductivity detector 26 is used for monitoring the conductivity of the organic solvent, and an operator assists in judging whether the organic solvent is correct according to the detection result of the conductivity. The UV detector 19 is used for detecting the DMT group removed from the CPG, and when the value displayed by the UV detector 19 reaches a certain value, it is judged that the deprotection process is completed. The bubble sensor 25 is used for monitoring whether the liquid path is broken, and prompting the operator to supplement the organic solvent.

[0047] The system pressure sensor 13 is arranged between the confluence node and the inlet end of the first column site valve 17. The pre-column pressure sensor 14 is arranged at the inlet end of the first column site valve 17. The post-column pressure sensor 15 is arranged at the outlet end of the second column site valve 27. The UV detector 19 and the conductivity detector 26 are arranged between the outlet end of the second column site valve 27 and the second inlet end of the circulation valve 18.

[0048] The whole machine shell assembly comprises a shell metal part 1, a display screen mounting block 2, a front panel 3, a module mounting plate 4, a stress metal part 5, a water collecting groove 6, a side panel 7 and a back cover plate 10.

[0049] The shell metal part 1, the front panel 3, the side panel 7 and the back cover plate 10 are all installed on the stress metal part 5 through locking screws, and form a machine case together with the stress metal part 5.

[0050] The display screen mounting block 2 and the module mounting plate 4 are both installed on the front panel 3 through locking screws. The lower end of the shell metal part 1 is provided with a mounting groove, and the water collecting groove 6 is placed in the mounting groove.

[0051] The synthesis column 16 is mounted on the front panel 3 by a support, and the single bottle fixing block is mounted on the side panel 7, and the single bottle 22 is fixed on the side panel 7 by the single bottle fixing block;

[0052] The handle 9 is mounted on the side panel 7, and a plurality of pipeline routing buckles 8 are mounted on the surfaces of the front panel 3 and the side panel 7. Preferably, the handle 9 is a hidden handle, which is convenient to move the instrument and is elegant.

[0053] In the embodiment, the liquid path assembly is mounted on the front panel 3 of the cabinet and is provided with a water collecting groove at the bottom, and the circuit system is arranged on the inner side of the cabinet, so that the liquid leakage of the liquid path assembly in an emergency situation does not cause the failure of the circuit system, and the water and electricity are separated. In addition, the components of the liquid path assembly are arranged on the front panel 3, so that the liquid path can be directly observed in an emergency situation during the early process synthesis and exploration.

[0054] In the embodiment, the nucleic acid synthesizer is provided with eight solvent bottles and twelve single bottles 22, the single bottles 22 are fixed on the right side wall of the cabinet and are arranged in three rows and four columns, and the solvent bottles are placed on the right side of the cabinet.

[0055] In the embodiment, the single bottles 22 and the solvent bottles are both located on the right side of the cabinet, so that the pipeline arrangement does not need to bypass the components, and the pipeline arrangement is more compact and elegant. In addition, the pipeline connection between each component of the liquid path assembly is compact and does not intersect, which can reduce the dead volume of the liquid path, thereby reducing the waste of solvents and greatly saving the cost.

[0056] In the embodiment, the solvent valves and the solvent inlet positions are arranged in sequence, which can prevent the liquid mixing in the synthesis process.

[0057] The gas path assembly comprises a total gas source inlet 35, a first gas path unit and a second gas path unit,

[0058] The cabinet is provided with a gas path connecting block (not shown in the figure) having a total gas inlet, and the total gas source inlet 35 is connected to the total gas inlet of the gas path connecting block;

[0059] The first gas path unit and the second gas path unit are both connected to the total gas source inlet 35, the first gas path unit is used for filling inert gas into the single bottles, and the second gas path unit is used for filling inert gas into the solvent bottles;

[0060] The first gas path unit comprises a first pressure gauge 31, a first pressure regulating valve 32, a single bottle manifold gas source outlet 37 and a single bottle manifold 39, the single bottle manifold gas source outlet 37 is connected to the gas inlet of the single bottle manifold 39, the first pressure gauge 31 and the first pressure regulating valve 32 are both arranged at the single bottle manifold gas source outlet 37 and are electrically connected to the control unit, and the gas outlet of the single bottle manifold 39 is connected to the gas inlet of the single bottle 22.

[0061] The second gas path unit comprises a second pressure gauge 33, a second pressure regulating valve 34, a solvent bottle manifold gas source outlet 36 and a solvent bottle manifold 38, the solvent bottle manifold gas source outlet 36 is connected with the gas inlet of the solvent bottle manifold 38 through a gas pipeline, the second pressure gauge 33 and the second pressure regulating valve 34 are arranged at the solvent bottle manifold gas source outlet 36 and are electrically connected with the control unit, and the gas outlet of the solvent bottle manifold 38 is connected with the gas inlet of the solvent bottle;

[0062] The gas path assembly further comprises an acetonitrile manifold 24, the acetonitrile manifold 24 has one inlet end and multiple outlet ends, the solvent bottle manifold 38 is connected with the solvent bottle manifold gas source outlet 36 through the acetonitrile manifold 24, and the monomer bottle manifold 39 is connected with the monomer bottle manifold gas source outlet 37 through the acetonitrile manifold 24.

[0063] In the embodiment, the total gas source inlet 35, the solvent bottle manifold gas source outlet 36 and the monomer bottle manifold gas source outlet 37 are arranged at one side of the cabinet, and the solvent bottle manifold 38 and the monomer bottle manifold 39 are arranged at the other side of the cabinet.

[0064] During the whole reaction process, the monomer bottle and the solvent bottle need to be filled with argon or nitrogen for protection, so as to achieve the purpose of air isolation.

[0065] Although the embodiments of the utility model have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the utility model, the scope of the utility model is defined by the appended claims and their equivalents.

Claims

1. A nucleic acid synthesizer characterized by, The machine shell assembly and the liquid path assembly, the gas path assembly and the control unit installed on the machine shell assembly; The gas path assembly has a plurality of gas output ends connected with single bottles (22) or solvent bottles, the liquid path assembly has a plurality of reagent input ends connected with single bottles (22) or solvent bottles, the gas path assembly and the liquid path assembly are connected with the control unit, the gas path assembly fills inert gas into corresponding single bottles (22) and solvent bottles according to the instruction of the control unit, and the liquid path assembly transmits reagents in corresponding solvent bottles and single bottles (22) according to the instruction of the control unit. The liquid path assembly is provided with a synthesis column (16), and the reagents transmitted by the liquid path assembly perform synthesis reaction in the reaction cavity of the synthesis column (16). The liquid path assembly comprises a first system pump (11), a second system pump (28), a first single valve (21), a second single valve (29), a first solvent valve (23), a second solvent valve (30), a circulation valve (18), a first column valve (17), a second column valve (27) and a synthesis column (16).

2. The nucleic acid synthesizer of claim 1, wherein, The first single valve (21), the second single valve (29), the first solvent valve (23) and the second solvent valve (30) each have a plurality of inlet ends, the outlet end of the single bottle (22) is connected with the inlet end of the first single valve (21) or the inlet end of the second single valve (29), the outlet end of the first single valve (21) and the outlet end of the second single valve (29) are connected with the inlet end of the first solvent valve (23), and the outlet end of the first solvent valve (23) is connected with the inlet of the first system pump (11). The outlet end of the solvent bottle is connected with the inlet end of the first solvent valve (23) or the inlet end of the second solvent valve (30), the outlet end of the second solvent valve (30) is connected with the first inlet end of the circulation valve (18), and the first outlet end of the circulation valve (18) is connected with the inlet of the second system pump (28). The outlet of the first system pump (11) and the outlet of the second system pump (28) are connected to a merging node, the first column valve (17), the synthesis column (16) and the second column valve (27) are sequentially arranged between the merging node and the second inlet end of the circulation valve (18), and the first system pump (11) and the second system pump (28) are each provided with an exhaust valve (12). The liquid path assembly further comprises a waste liquid valve (20), and the inlet end of the waste liquid valve (20) is connected with the second outlet end of the circulation valve (18).

3. The nucleic acid synthesizer of claim 2, wherein, The liquid path assembly further comprises a system pressure sensor (13), a pre-column pressure sensor (14), a post-column pressure sensor (15), a UV detector (19), a bubble sensor (25) and a conductivity detector (26).

4. The nucleic acid synthesizer of claim 2, wherein, ​ The system pressure sensor (13) is arranged between the junction node and the inlet end of the first column valve (17), the pre-column pressure sensor (14) is arranged at the inlet end of the first column valve (17), the post-column pressure sensor (15) is arranged at the outlet end of the second column valve (27), and the UV detector (19) and the conductivity detector (26) are arranged between the outlet end of the second column valve (27) and the second inlet end of the circulation valve (18).

5. The nucleic acid synthesizer of claim 1, wherein, The whole machine shell assembly comprises a shell sheet metal part (1), a display screen mounting block (2), a front panel (3), a module mounting plate (4), a stress sheet metal part (5), a water collecting groove (6), a side panel (7) and a rear cover plate (10); The shell sheet metal part (1), the front panel (3), the side panel (7) and the rear cover plate (10) are all installed on the stress sheet metal part (5) by locking screws and form a case with the stress sheet metal part (5); The display screen mounting block (2) and the module mounting plate (4) are both installed on the front panel (3) by locking screws, and the lower end of the shell sheet metal part (1) is provided with a mounting groove, and the water collecting groove (6) is placed in the mounting groove.

6. The nucleic acid synthesizer of claim 5, wherein, A single bottle fixing block is installed on the side panel (7), and the single bottle (22) is fixed on the side panel (7) through the single bottle fixing block, and the synthetic column (16) is installed on the front panel (3) through a support.

7. The nucleic acid synthesizer of claim 5, wherein, A handle (9) is installed on the side panel (7), and a plurality of pipeline wire buckles (8) are installed on the surfaces of the front panel (3) and the side panel (7).

8. The nucleic acid synthesizer of claim 5, wherein, The gas path assembly comprises a total gas source inlet (35), a first gas path unit and a second gas path unit, The inside of the case is provided with a gas path connecting block, the gas path connecting block has a total gas inlet, and the total gas source inlet (35) is butted with the total gas inlet of the gas path connecting block; The first gas path unit and the second gas path unit are both connected with the total gas source inlet (35), the first gas path unit is used for filling inert gas into the single bottle, and the second gas path unit is used for filling inert gas into the solvent bottle; The first gas path unit comprises a first pressure gauge (31), a first pressure regulating valve (32), a single bottle manifold gas source outlet (37) and a single bottle manifold (39), the single bottle manifold gas source outlet (37) is connected with the gas inlet of the single bottle manifold (39), the first pressure gauge (31) and the first pressure regulating valve (32) are both arranged at the single bottle manifold gas source outlet (37) and electrically connected with the control unit, and the gas outlet of the single bottle manifold (39) is connected with the gas inlet of the single bottle (22). The second gas path unit comprises a second pressure gauge (33), a second pressure regulating valve (34), a solvent bottle manifold gas source outlet (36) and a solvent bottle manifold (38), the solvent bottle manifold gas source outlet (36) is connected with the air inlet of the solvent bottle manifold (38) through a gas pipeline, the second pressure gauge (33) and the second pressure regulating valve (34) are arranged at the solvent bottle manifold gas source outlet (36) and are electrically connected with the control unit, and the air outlet of the solvent bottle manifold (38) is connected with the air inlet of the solvent bottle.

9. The nucleic acid synthesizer of claim 5, wherein, The monomer bottle and the solvent bottle are located on the same side of the cabinet, and the liquid path assembly is installed on the front panel (3) of the cabinet.

10. The nucleic acid synthesizer of claim 1, wherein, The monomer bottle (22) is used for containing monomer reagents, and the solvent bottle is used for containing synthetic reaction reagents, which include but are not limited to cleaning solvents, deprotection solvents, activation solvents, oxidizing agents and capping solvents.

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