Device for detecting impurities in fenerenone

Abstract

The utility model discloses a device for detecting impurities in fenerenone, which relates to the technical field of detection of impurities in fenerenone and comprises a bearing plate welded and mounted at the upper end of one side of a high performance liquid chromatograph main body, and an inert gas high pressure tank fixedly mounted at the upper end of the bearing plate, according to the device, some high-pressure inert gas can be filled into the inert gas high-pressure tank by mounting the inert gas high-pressure tank, so that after the device is used, the high-pressure inert gas in the inert gas high-pressure tank is filled into the liquid taking pipeline, and some mobile phases remaining in the liquid taking pipeline can rush out from the interior of the liquid taking pipeline; the inside of the liquid taking pipeline is kept clean, the situation that a mobile phase remaining in the liquid taking pipeline is in contact with air to react and pollute the mobile phase is avoided, a new mobile phase is mixed with the polluted mobile phase in the liquid taking pipeline during subsequent detection, and then the precision of detecting impurities in the fenerenone by the device is guaranteed.

Description

Technical Field

[0001] This utility model relates to the field of impurity detection technology in phenelzine, specifically to a device for detecting impurities in phenelzine. Background Technology

[0002] Nelindone is a nonsteroidal selective mineralocorticoid receptor antagonist that has been shown in preclinical studies to block the harmful effects of mineralocorticoid receptor overactivation. In diabetic patients, mineralocorticoid receptor overactivation is thought to contribute to the progression of chronic kidney disease and cardiovascular damage, potentially driven by metabolic, hemodynamic, or inflammatory and fibrotic factors. Impurity detection in feneldone typically employs high-performance liquid chromatography (HPLC), an analytical method based on the difference in partition coefficients between the stationary and mobile phases. For feneldone impurity detection, a sample containing feneldone and its impurities is dissolved and injected into the chromatograph. The mobile phase carries the sample through a column packed with the stationary phase. Different impurities and feneldone themselves have different retention times in the column due to their different partition coefficients in the stationary and mobile phases, thus achieving separation. The eluent is then detected using a detector such as ultraviolet light to obtain a chromatogram, thereby enabling the detection of impurities in feneldone.

[0003] However, existing methods for detecting impurities in fenelazine using high-performance liquid chromatography (HPLC) require one or more high-precision pumps to deliver the mobile phase (typically a mixture of one or more solvents, such as methanol-water or acetonitrile-water). During pumping, some mobile phase inevitably remains inside the pumping lines. This residual mobile phase reacts with air, causing contamination and affecting the accuracy of subsequent detection. Therefore, these methods do not meet current requirements. To address this, we propose a device for detecting impurities in fenelazine. Utility Model Content

[0004] The purpose of this invention is to provide a device for detecting impurities in felindone, in order to solve the problem mentioned in the background art that when felindone is detected by high performance liquid chromatography (HPLC) using one or more high-precision pumps to transport the mobile phase, some mobile phase inevitably remains inside the pumping pipeline during pumping. These residual mobile phases react with air, causing contamination of the mobile phase and affecting the accuracy of subsequent detection.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a device for detecting impurities in phenelzine, comprising a high-performance liquid chromatograph (HPLC) body:

[0006] A support plate is welded and installed on the upper end of one side of the main body of the high performance liquid chromatograph. An inert gas high-pressure tank is fixedly installed on the upper end of the support plate. A flushing pipe is fixedly installed on the upper end of the inert gas high-pressure tank. A cleaning solution storage tank is fixedly installed on the upper end of the flushing pipe. A first solenoid valve is installed on the lower end of the cleaning solution storage tank. A liquid sampling pipe is fixedly installed on the side of the flushing pipe away from the inert gas high-pressure tank. A connecting pipe is fixedly installed on the lower end of the liquid sampling pipe. A second solenoid valve is installed on the upper end of the connecting pipe. A micro pump is fixedly installed on the lower end of the connecting pipe. A liquid suction hose is fixedly installed on the input end of the micro pump. A detection supplies storage tank is provided on the lower end of the outside of the liquid suction hose.

[0007] A placement plate is welded and installed on the other side of the main body of the high performance liquid chromatograph. A rotating bracket is rotatably mounted on the upper end of the placement plate via a bearing. A collection box is installed inside the upper end of the rotating bracket. A connection port is provided at the upper end of the collection box. A convenient hose is fixedly installed at one end of the liquid collection pipe.

[0008] Preferably, a waste discharge pipe is installed on the side of the rotating support away from the inert gas high-pressure tank, and one end of the waste discharge pipe is embedded inside the collection box.

[0009] Preferably, a safety guardrail is installed on the upper end of the high-performance liquid chromatograph body, and the safety guardrail is welded to the high-performance liquid chromatograph body.

[0010] Preferably, a mounting plate is installed on the upper end of the high-performance liquid chromatograph body, and the mounting plate is welded to the high-performance liquid chromatograph body.

[0011] Preferably, a drive motor is mounted on the lower end of the shelf by screws, and the drive motor is connected to the rotating bracket by a coupling.

[0012] Preferably, the liquid extraction pipe is provided with a support bracket on its exterior, and the support bracket is welded to the fixed mounting plate.

[0013] Preferably, a storage slot is provided inside the collection box on the side near the inert gas high-pressure tank.

[0014] Compared with the prior art, the beneficial effects of this utility model are:

[0015] 1. This utility model, by installing an inert gas high-pressure tank, can fill the tank with high-pressure inert gas. After the device is used, the high-pressure inert gas in the tank is filled into the liquid sampling pipe, allowing some of the mobile phase remaining in the liquid sampling pipe to be flushed out, thus keeping the liquid sampling pipe clean. This prevents the mobile phase remaining in the liquid sampling pipe from reacting with the air and causing contamination. In subsequent tests, the new mobile phase mixes with the contaminated mobile phase in the liquid sampling pipe, thereby ensuring the accuracy of the device in detecting impurities in phenelzine.

[0016] 2. By installing a cleaning fluid storage tank, this utility model allows the cleaning fluid to be introduced into the liquid extraction pipe. The cleaning fluid, combined with high-pressure inert gas, can make the cleaning inside the liquid extraction pipe more efficient and faster, thus enhancing the effectiveness of the device. Attached Figure Description

[0017] Figure 1 This is a three-dimensional perspective view of a device for detecting impurities in phenelzine according to the present invention;

[0018] Figure 2 This is a diagram showing the position distribution of the connecting pipe at the lower end of the liquid extraction pipe according to this utility model;

[0019] Figure 3 This is a schematic diagram of the internal structure of the collection box of this utility model;

[0020] Figure 4 This is a diagram showing the position distribution of the convenient flexible hose at the lower end of the storage slot according to this utility model.

[0021] In the diagram: 1. High-performance liquid chromatograph main body; 2. Support plate; 3. Inert gas high-pressure tank; 4. Flushing tube; 5. Cleaning solution storage tank; 6. First solenoid valve; 7. Liquid collection pipe; 8. Connecting pipe; 9. Second solenoid valve; 10. Micro pump; 11. Liquid suction hose; 12. Testing supplies storage tank; 13. Safety railing; 14. Fixed mounting plate; 15. Support bracket; 16. Storage plate; 17. Drive motor; 18. Rotating bracket; 19. Waste discharge pipe; 20. Collection box; 21. Connection port; 22. Storage slot; 23. Convenience hose. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0023] Please see Figure 1-4 One embodiment of this utility model is a device for detecting impurities in phenelzine, comprising a high-performance liquid chromatograph body 1.

[0024] The support plate 2 is welded to the upper end of one side of the main body 1 of the high-performance liquid chromatograph. An inert gas high-pressure tank 3 is fixedly installed on the upper end of the support plate 2. The inert gas high-pressure tank 3 is filled with high-pressure inert gas. After use, the high-pressure inert gas in the inert gas high-pressure tank 3 is injected into the liquid sampling pipe 7, allowing any remaining mobile phase in the liquid sampling pipe 7 to be flushed out, thus keeping the liquid sampling pipe 7 clean. This prevents the mobile phase remaining in the liquid sampling pipe 7 from reacting with air and becoming contaminated. Furthermore, during subsequent detection, the new mobile phase will not mix with the contaminated mobile phase in the liquid sampling pipe 7, thus ensuring the accuracy of the device in detecting impurities in phenelzine. The inert gas high-pressure tank 3... A flushing pipe 4 is fixedly installed at the upper end, and a cleaning fluid storage tank 5 is fixedly installed at the upper end of the flushing pipe 4. Installing the cleaning fluid storage tank 5 allows the cleaning fluid to flow into the liquid extraction pipe 7. The cleaning fluid, combined with the high-pressure inert gas, can make the cleaning inside the liquid extraction pipe 7 more efficient and faster, enhancing the effect of the device. A first solenoid valve 6 is installed at the lower end of the cleaning fluid storage tank 5. A liquid extraction pipe 7 is fixedly installed on the side of the flushing pipe 4 away from the inert gas high-pressure tank 3. A connecting pipe 8 is fixedly installed at the lower end of the liquid extraction pipe 7. A second solenoid valve 9 is installed at the upper end of the connecting pipe 8. A micro pump 10 is fixedly installed at the lower end of the connecting pipe 8. A suction hose 11 is fixedly installed at the input end of the micro pump 10. A test item storage tank 12 is set at the lower end of the suction hose 11.

[0025] The placement plate 16 is welded to the other side of the main body 1 of the high performance liquid chromatograph. The upper end of the placement plate 16 is rotatably mounted with a rotating bracket 18 via a bearing. The upper end of the rotating bracket 18 is equipped with a collection box 20. The collection box 20 facilitates the collection of waste liquid by the staff, making the device more convenient to use and reducing the difficulty of cleaning the device after the test, making the device more user-friendly. The upper end of the collection box 20 is provided with a connection port 21, and a convenient hose 23 is fixedly installed at one end of the liquid collection pipe 7.

[0026] Please see Figure 1 , Figure 2 , Figure 3 and Figure 4A waste discharge pipe 19 is installed on the side of the rotating support 18 away from the inert gas high-pressure tank 3. One end of the waste discharge pipe 19 is embedded inside the collection box 20. A safety guardrail 13 is installed on the upper end of the high-performance liquid chromatograph body 1. The installation of the safety guardrail 13 can prevent the detection material storage tank 12 from sliding off the upper end of the high-performance liquid chromatograph body 1, thereby enhancing the safety of the device. The safety guardrail 13 is welded to the high-performance liquid chromatograph body 1. A fixed mounting plate 14 is installed on the upper end of the high-performance liquid chromatograph body 1. The fixed mounting plate 14 is welded to the high-performance liquid chromatograph body 1. A drive motor 17 is installed on the lower end of the placement plate 16 by screws. The drive motor 17 is connected to the rotating support 18 by a coupling. A support bracket 15 is provided on the outside of the liquid collection pipe 7. The support bracket 15 is welded to the fixed mounting plate 14. A storage slot 22 is provided on the side of the collection box 20 near the inert gas high-pressure tank 3. The storage slot 22 makes it convenient for staff to place detection and mixing containers inside, making the device more convenient to use.

[0027] Working principle: During use, all second solenoid valves 9 and first solenoid valves 6 are closed, and the inert gas high-pressure tank 3 is also closed. Then, the operator adds some mobile phase and fenelone testing materials to the testing material storage tank 12. The operator then places the testing preparation container inside the storage slot 22 and drives the drive motor 17 to rotate the rotating bracket 18, allowing the convenient hose 23 to extend into the mouth of the testing preparation container. When the operator needs to retrieve a specific substance from the testing material storage tank 12, they simply open the second solenoid valve 9 at the top, and then the micro-channel installed at the top of the testing material storage tank 12... Pump 10 starts to draw the substance from the designated test material storage tank 12 into the liquid collection pipe 7, and then discharges it into the test mixing container. When it is necessary to clean the liquid collection pipe 7, simply close all the second solenoid valves 9, drive motor 17 to rotate the rotating bracket 18, insert the convenient hose 23 into the connection port 21, and then open the inert gas high-pressure tank 3. High-pressure inert gas quickly passes through the flushing pipe 4, the liquid collection pipe 7, and the convenient hose 23, flushing away any residual mobile phase and other test materials inside the liquid collection pipe 7 and the convenient hose 23, keeping the inside of the liquid collection pipe 7 clean. After the initial filling of the liquid extraction pipe 7 with high-pressure inert gas is completed, the first solenoid valve 6 at the lower end of the cleaning fluid storage tank 5 is opened, allowing some cleaning fluid to flow into the liquid extraction pipe 7. Then, the high-pressure inert gas tank 3 fills the liquid extraction pipe 7 with high-pressure inert gas again, so that the cleaning fluid and inert gas work together to clean the inside of the liquid extraction pipe 7. Finally, the high-pressure inert gas tank 3 continues to fill the liquid extraction pipe 7 with high-pressure inert gas to keep the liquid extraction pipe 7 and the inside of the storage tank 22 dry. This device can be equipped with a high-pressure inert gas tank 3, which can be filled with some high-pressure inert gas so that after the device is used, the inside of the high-pressure inert gas tank 3 is dry. High-pressure inert gas is introduced into the liquid sampling pipe 7, allowing some of the mobile phase remaining inside the pipe 7 to be flushed out, thus keeping the inside of the pipe 7 clean. This prevents the mobile phase remaining inside the pipe 7 from reacting with the air and causing contamination. Furthermore, during subsequent testing, the new mobile phase will mix with the contaminated mobile phase inside the pipe 7, ensuring the accuracy of the device in detecting impurities in phenelzine. The cleaning fluid storage tank 5 allows the cleaning fluid to be introduced into the liquid sampling pipe 7. The cleaning fluid, combined with the high-pressure inert gas, makes the cleaning of the inside of the pipe 7 more efficient and faster, enhancing the effectiveness of the device.

[0028] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A device for detecting impurities in phenelzine, comprising a high-performance liquid chromatograph (1), characterized in that: A support plate (2) is welded and installed on the upper end of one side of the main body (1) of the high performance liquid chromatograph. An inert gas high pressure tank (3) is fixedly installed on the upper end of the support plate (2). A flushing pipe (4) is fixedly installed on the upper end of the inert gas high pressure tank (3). A cleaning liquid storage tank (5) is fixedly installed on the upper end of the flushing pipe (4). A first solenoid valve (6) is installed on the lower end of the cleaning liquid storage tank (5). A liquid taking pipe (7) is fixedly installed on the side of the flushing pipe (4) away from the inert gas high pressure tank (3). A connecting pipe (8) is fixedly installed on the lower end of the liquid taking pipe (7). A second solenoid valve (9) is installed on the upper end of the connecting pipe (8). A micro pump (10) is fixedly installed on the lower end of the connecting pipe (8). A suction hose (11) is fixedly installed on the input end of the micro pump (10). A test supplies storage tank (12) is provided on the lower end of the suction hose (11). A placement plate (16) is welded to the other side of the main body (1) of the high performance liquid chromatograph. A rotating bracket (18) is rotatably mounted on the upper end of the placement plate (16) via a bearing. A collection box (20) is installed inside the upper end of the rotating bracket (18). A connection port (21) is provided on the upper end of the collection box (20). A convenient hose (23) is fixedly installed on one end of the liquid collection pipe (7).

2. The device for detecting impurities in phenelzine according to claim 1, characterized in that: The rotating support (18) is equipped with a waste discharge pipe (19) on the side away from the inert gas high-pressure tank (3), and one end of the waste discharge pipe (19) is embedded inside the collection box (20).

3. The device for detecting impurities in phenelzine according to claim 1, characterized in that: A safety guardrail (13) is installed on the upper end of the main body (1) of the high performance liquid chromatograph, and the safety guardrail (13) is welded to the main body (1) of the high performance liquid chromatograph.

4. The device for detecting impurities in phenelzine according to claim 1, characterized in that: A mounting plate (14) is installed on the upper end of the high performance liquid chromatograph body (1), and the mounting plate (14) is welded to the high performance liquid chromatograph body (1).

5. The device for detecting impurities in phenelzine according to claim 1, characterized in that: The lower end of the shelf (16) is fitted with a drive motor (17) by screws, and the drive motor (17) is connected to the rotating bracket (18) by a coupling.

6. The device for detecting impurities in phenelzine according to claim 1, characterized in that: The liquid extraction pipe (7) is provided with a support bracket (15) on the outside, and the support bracket (15) is welded to the fixed mounting plate (14).

7. The device for detecting impurities in phenelzine according to claim 1, characterized in that: A storage trough (22) is provided inside the collection box (20) on the side near the inert gas high-pressure tank (3).

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