Enoxaparin sodium salifying reaction kettle

Abstract

The utility model relates to the technical field of enoxaparin sodium salifying production, in particular to an enoxaparin sodium salifying reaction kettle which comprises a reaction kettle body, supporting legs are fixed to the two sides of the bottom end of the outer wall of the reaction kettle body, and a batching box is installed on one side of the top end of the outer wall of the reaction kettle body. According to the reaction kettle disclosed by the utility model, after a worker adds ingredients into the reaction kettle body, the speed reducing motor can be started to drive the rotating shaft to rotate, and the rotating shaft can be used for carrying out multi-section position stirring on a mixed solution through the bottom stirring disc and the stirring sleeve plate during rotation; the liquid pump and the liquid feeding pipe are arranged, so that the mixed liquid can circularly flow and can be fully mixed, the reaction time of the heparin and the sodium salt can be shortened, and the production efficiency of salifying the enoxaparin sodium is improved.

Description

Technical Field

[0001] This utility model relates to the field of enoxaparin sodium salt production technology, specifically to an enoxaparin sodium salt formation reactor. Background Technology

[0002] Enoxaparin sodium is a type of low molecular weight heparin (LMWH) primarily used for the prevention and treatment of thrombotic diseases. It is produced through the chemical modification of heparin. In the production process, the modified heparin is reacted with a sodium salt (such as sodium chloride) in a reactor. During this process, the amino or carboxyl groups in the heparin molecule combine with sodium ions to form enoxaparin sodium.

[0003] Existing reactors require mixing and stirring of heparin and sodium salt during the production process. Thorough mixing is essential for producing high-quality enoxaparin sodium. However, the fixed stirring devices in existing reactors can only ensure mixing by extending the stirring time, which prolongs the production time of enoxaparin sodium and thus affects the production efficiency. Therefore, they still have certain shortcomings.

[0004] In conclusion, it is necessary to invent a sodium enoxaparin salt formation reactor. Utility Model Content

[0005] Therefore, this utility model provides an enoxaparin sodium salt formation reactor to solve the problem that the existing reactors with fixed stirring devices can only ensure the mixing effect by extending the stirring time, which leads to the need to extend the production time of enoxaparin sodium.

[0006] To achieve the above objectives, this utility model provides the following technical solution: an enoxaparin sodium salt formation reactor, comprising a reactor body, with support legs fixed on both sides of the bottom of the outer wall of the reactor body, a batching box installed on one side of the top of the outer wall of the reactor body, and a stirring component for stirring the solution installed on the inner wall of the reactor body.

[0007] Preferably, the stirring component includes a rotating seat, which is fixed to the bottom of the inner wall of the reactor body. A geared motor is fixed at the center of the bottom of the outer wall of the reactor body via a support frame. A rotating shaft is fixed to the top output shaft of the geared motor, and the upper end of the rotating shaft is rotatably connected to the top of the inner wall of the reactor body.

[0008] Preferably, the top of the outer wall of the rotating seat is provided with a rotating groove, the inner wall of the rotating groove is rotatably connected to a bottom stirring plate, the upper and lower ends of the outer wall of the bottom stirring plate are fixedly connected to the outer wall of the rotating shaft through through holes, and the top of the outer wall of the bottom stirring plate is fixed with stirring protrusions for stirring.

[0009] Preferably, the inner wall side end of the reaction kettle body and located on both sides of the rotating shaft is provided with a scraper, the side wall of the scraper is in contact with the inner wall of the reaction kettle body, and the opposite side of the scraper is fixedly connected with the outer wall side end of the rotating shaft through a fixed rod.

[0010] Preferably, the side wall of the rotating shaft and located between the upper and lower adjacent two fixed rods is fixedly connected with a stirring sleeve plate, and the end away from the rotating shaft of the plurality of stirring sleeve plates is slidably connected with a sliding plate.

[0011] Preferably, the outer wall of the sliding plate is slidably connected with the inner wall of the corresponding position of the expansion slot, and the inner wall side end of the expansion slot and between the sliding plate insertion end is fixedly connected with a reset spring group for resetting.

[0012] Preferably, the outer wall side end bottom of the reaction kettle body is provided with a liquid pumping pump, the liquid suction end of the liquid pumping pump is communicated with the inner wall side end bottom of the reaction kettle body through a liquid suction pipe, the top liquid outlet end of the liquid pumping pump is communicated with a liquid feeding pipe, and the inner wall side end of the reaction kettle body is fixedly connected with an annular pipe.

[0013] Preferably, the inner wall of the annular pipe is communicated with a plurality of nozzles arranged in an annular array, the upper end of the liquid feeding pipe is communicated with the liquid inlet of the annular pipe, the inner wall of the liquid feeding pipe is rotatably connected with a stirrer for stirring, and the outer wall top end of the liquid feeding pipe and the corresponding position of the stirrer is fixedly connected with a driving motor for driving the stirrer to rotate.

[0014] The beneficial effects of the present application are as follows:

[0015] In the present application, after the personnel adds the ingredients into the reaction kettle body, the speed reducer motor is started to drive the rotating shaft to rotate, and the rotating shaft can perform multi-stage position stirring on the mixed liquid through the bottom stirring disc and the stirring sleeve plate. The liquid pumping pump and the liquid feeding pipe are arranged to ensure the circulation flow of the mixed liquid, so that the mixed liquid can be fully mixed, thereby reducing the reaction time of heparin and sodium salt, and improving the production efficiency of enoxaparin sodium salt. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is an external structure schematic view in the front direction of the present application.

[0017] Figure 2 It is a sectional structure schematic view in the front direction of the present application.

[0018] Figure 3 It is a structure schematic view of the enlarged A in the present application. Figure 2

[0019] Figure 4 ​It is the sectional structure schematic diagram of the stirring sleeve plate in the front view direction of the utility model.

[0020] Figure 5 It is the three-dimensional structure schematic diagram of the bottom stirring disc in the front view direction of the utility model.

[0021] In the figure: 100, reaction kettle body; 110, support leg; 200, speed reducer motor; 210, rotating seat; 220, bottom stirring disc; 221, stirring convex strip; 230, rotating shaft; 240, scraper; 250, stirring sleeve plate; 251, sliding plate; 252, reset spring group; 300, batching box; 400, liquid pumping pump; 410, liquid feeding pipe; 420, annular pipe; 421, spray head; 430, driving motor; 431, stirrer. DETAILED DESCRIPTION

[0022] The preferred embodiments of the utility model are described below in combination with the drawings, and it should be understood that the preferred embodiments described herein are only used to illustrate and explain the utility model, and are not used to limit the utility model.

[0023] Referring to the drawings Figures 1-5 The utility model provides a kind of enoxaparin sodium salt reaction kettle, including reaction kettle body 100, the outer wall bottom end both sides of reaction kettle body 100 are fixed with support leg 110, batching box 300 is installed on the outer wall top end of reaction kettle body 100, the batching box 300 set can be used to store some auxiliary additives, and the bottom end of batching box 300 is provided with addition pipe, the inner wall of reaction kettle body 100 is installed with the stirring component of solution, stirring component includes rotating seat 210, rotating seat 210 is fixed in the inner wall bottom end of reaction kettle body 100, the outer wall bottom end center of reaction kettle body 100 is fixed with speed reducer motor 200 by support frame, the top output shaft of speed reducer motor 200 is fixed with rotating shaft 230, the upper end of rotating shaft 230 is rotatably connected with the inner wall top end of reaction kettle body 100, rotating groove is set in the outer wall top end of rotating seat 210, the inner wall of rotating groove is rotatably connected with bottom stirring disc 220, bottom stirring disc 220 is fixedly connected with the outer wall of rotating shaft 230 through the upper and lower ends of the outer wall of bottom stirring disc 220 and the outer wall of rotating shaft 230 and the bottom stirring disc 220 set are rotatably connected with the outer wall top end of rotating seat 210, the outer wall top end of bottom stirring disc 220 is fixed with the stirring convex strip 221 for stirring, specifically, the speed reducer motor 200 set can drive rotating shaft 230 to rotate after being electrified, and rotating shaft 230 can drive bottom stirring disc 220 to rotate when rotating, and bottom stirring disc 220 can be stirred by stirring convex strip 221 when rotating, so that it is mixed, and the outer wall of the bottom stirring disc 220 set and the inner wall of rotating groove need to be sealed and set, to avoid mixed liquid to enter the gap between the two;

[0024] The inner wall side end of the reaction kettle body 100 and located on both sides of the rotating shaft 230 is provided with a scraper 240, the side wall of the scraper 240 is in contact with the inner wall of the reaction kettle body 100, and the opposite side of the scraper 240 is fixedly connected with the outer wall side end of the rotating shaft 230 through a fixed rod. The scraper 240 is fixed with the outer wall of the rotating shaft 230 through the fixed rod, so that the rotating shaft 230 can drive the scraper 240 to rotate when rotating, and the scraper 240 can scrape off the residual solid raw materials on the inner wall of the reaction kettle body 100 when rotating, avoiding waste. The outer wall side end of the scraper 240 can be avoided to scratch the inner wall of the reaction kettle body 100 by setting a layer of rubber plate, the side wall of the rotating shaft 230 and located between the upper and lower adjacent two fixed rods is fixedly connected with a stirring sleeve plate 250, the end away from the rotating shaft 230 of the plurality of stirring sleeve plates 250 is slidably connected with a sliding plate 251, the side end of the stirring sleeve plate 250 is provided with an expansion slot at the corresponding position of the sliding plate 251, the outer wall of the sliding plate 251 is slidably connected with the inner wall of the expansion slot at the corresponding position, the inner wall side end of the expansion slot and between the insertion end of the sliding plate 251 is fixedly connected with a reset spring group 252 for resetting, the stirring sleeve plate 250 is arranged to stir and mix the heparin and sodium salt at the upper end in the process of rotating the rotating shaft 230, at the same time, when the rotating speed of the rotating shaft 230 is fast enough, the sliding plate 251 will be elongated outward under the action of force, so as to increase the stirring radius, and when the rotating speed of the rotating shaft 230 is low, the sliding plate 251 can be pulled back inward under the action of the reset spring group 252, so as to adjust the stirring radius of the stirring sleeve plate 250;

[0025] The outer wall side end bottom of the reaction kettle body 100 is provided with a liquid pumping pump 400, the liquid suction end of the liquid pumping pump 400 is communicated with the inner wall side end bottom of the reaction kettle body 100 through a liquid suction pipe, the liquid pumping pump 400 arranged can suck the mixed liquid at the bottom end through the liquid suction pipe and deliver into the liquid delivery pipe 410, the top liquid outlet end of the liquid pumping pump 400 is communicated with the liquid delivery pipe 410, the inner wall of the annular pipe 420 fixed above the inner wall side end of the reaction kettle body 100 is communicated with the spray head 421, and the liquid delivery pipe 410 can deliver the mixed liquid into the annular pipe 420, so that the annular pipe 420 sprays the mixed liquid through the spray head 421, so that the mixed liquid in the reaction kettle body 100 can be circulated back and forth, and the situation that the mixing effect is good at the bottom end and poor at the upper end is avoided, a plurality of spray heads 421 are arranged in an annular array, the upper end of the liquid delivery pipe 410 is communicated with the liquid inlet of the annular pipe 420, the inner wall of the liquid delivery pipe 410 is rotatably connected with the stirrer 431 for stirring, the outer wall top end of the liquid delivery pipe 410 and the corresponding position of the stirrer 431 are fixedly connected with the driving motor 430 for driving the stirrer 431 to rotate, and in the process that the liquid delivery pipe 410 delivers the mixed liquid, the driving motor 430 arranged can drive the stirrer 431 to rotate after being electrified, and the stirrer 431 can stir the delivered mixed liquid when rotating, the top end of the stirrer 431 is rotatably connected with the corresponding position of the inner wall top end of the liquid delivery pipe 410, and the bottom output shaft of the driving motor 430 is fixedly connected with the upper end of the stirrer 431.

[0026] The use process of the utility model is as follows: the person skilled in the art can assemble the device according to the above description, then add heparin and sodium salt into the reaction kettle body 100 through the feeding pipe, then add some auxiliary agents through the batching box 300 and the adding pipe, after completion, the personnel can heat the mixed liquid in the reaction kettle body 100 through the heating coil (prior art, not shown in the figure) arranged in the reaction kettle body 100, and simultaneously start the speed reducer 200 by electrifying, so that the speed reducer 200 can drive the rotating shaft 230 to rotate.

[0027] When the rotating shaft 230 rotates, the bottom stirring disc 220 arranged can rotate in the inner wall of the rotating seat 210, and the bottom stirring disc 220 can mix and stir the mixed liquid at the bottom end through the stirring convex strip 221 when rotating, and the middle and upper ends can be mixed and stirred through the rotating stirring sleeve plate 250 and the sliding plate 251, and the scraper 240 arranged can scrape the inner wall of the reaction kettle body 100 when rotating.

[0028] The liquid pump 400 arranged simultaneously can suck the mixed liquid at the bottom end through the liquid suction pipe after being powered on, and deliver the mixed liquid into the liquid delivery pipe 410. The top liquid outlet end of the liquid pump 400 is communicated with the liquid delivery pipe 410. The annular pipe 420 is fixed above the side end of the inner wall of the reaction kettle body 100. The inner wall of the annular pipe 420 is communicated with the spray head 421. The liquid delivery pipe 410 can deliver the mixed liquid into the annular pipe 420, so that the annular pipe 420 sprays the mixed liquid through the spray head 421. Thus, the mixed liquid in the reaction kettle body 100 can be circulated back and forth, avoiding the situation that the mixing effect is good at the bottom end and poor at the upper end. The driving motor 430 arranged simultaneously can drive the stirrer 431 to rotate after being powered on. The stirrer 431 can stir the delivered mixed liquid when rotating. After the solution is mixed, personnel can take out the mixed liquid through the liquid discharge pipe arranged at the bottom of the front end of the outer wall of the reaction kettle body 100.

[0029] The above is only a preferred embodiment of the present application, and any skilled person in the art can modify the technical solutions described above or modify them into equivalent technical solutions. Therefore, any simple modification or equivalent replacement according to the technical solutions of the present application is within the scope of protection of the present application.

Claims

1. A kind of enoxaparin sodium salt formation reaction kettle, including reaction kettle body (100), both sides of the bottom end of the outer wall of the reaction kettle body (100) are fixed with support leg (110), one side of the top end of the outer wall of the reaction kettle body (100) is equipped with batching bin (300), it is characterized by: The inner wall of the reaction kettle body (100) is provided with stirring components for stirring the solution, which comprises a rotating seat (210) fixed at the bottom end of the inner wall of the reaction kettle body (100), a speed reducer motor (200) fixed at the center of the bottom end of the outer wall of the reaction kettle body (100) through a support frame, a rotating shaft (230) fixed at the top output shaft of the speed reducer motor (200), the upper end of the rotating shaft (230) is rotatably connected with the top end of the inner wall of the reaction kettle body (100), a rotating groove is formed in the top end of the outer wall of the rotating seat (210), a bottom stirring disc (220) is rotatably connected with the inner wall of the rotating groove, the outer wall of the bottom stirring disc (220) is fixedly connected with the rotating shaft (230) through the through holes formed in the upper and lower ends of the outer wall, and a stirring convex strip (221) for stirring is fixed at the top end of the outer wall of the bottom stirring disc (220).

2. The enoxaparin sodium salt formation reactor according to claim 1, characterized in that: The inner wall side end of the reaction kettle body (100) and located on both sides of the rotating shaft (230) is provided with a scraper (240), the side wall of the scraper (240) is in contact with the inner wall of the reaction kettle body (100), and the opposite sides of the scraper (240) are fixedly connected with the outer wall side end of the rotating shaft (230) through fixing rods.

3. The enoxaparin sodium salt formation reactor according to claim 2, characterized in that: The side wall of the rotating shaft (230) and located between the upper and lower adjacent two fixing rods is fixed with a stirring sleeve plate (250), the end away from the rotating shaft (230) of the plurality of stirring sleeve plates (250) is slidably connected with a sliding plate (251), and the side end of the stirring sleeve plate (250) is provided with an expansion slot at the corresponding position of the sliding plate (251).

4. The enoxaparin sodium salt formation reactor according to claim 3, characterized in that: The outer wall of the sliding plate (251) is slidably connected with the inner wall of the expansion slot at the corresponding position, and the inner wall side end of the expansion slot and between the insertion end of the sliding plate (251) is fixed with a reset spring group (252) for resetting.

5. The enoxaparin sodium salt formation reactor according to claim 1, characterized in that: The outer wall side end bottom of the reaction kettle body (100) is provided with a liquid pumping pump (400), the liquid suction end of the liquid pumping pump (400) is communicated with the inner wall side end bottom of the reaction kettle body (100) through a liquid suction pipe, the top liquid outlet end of the liquid pumping pump (400) is communicated with a liquid feeding pipe (410), and the inner wall side end of the reaction kettle body (100) is fixed with an annular pipe (420) above.

6. The enoxaparin sodium salt formation reactor according to claim 5, characterized in that: The inner wall of the annular pipe (420) is communicated with a spray head (421), a plurality of spray heads (421) are arranged in an annular array, the upper end of the liquid feeding pipe (410) is communicated with the liquid inlet of the annular pipe (420), a stirrer (431) for stirring is rotatably connected with the inner wall of the liquid feeding pipe (410), and a driving motor (430) for driving the stirrer (431) to rotate is fixed at the top end of the outer wall of the liquid feeding pipe (410) and at the corresponding position of the stirrer (431).

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