Split type liquid chromatographic column cleaning device

Abstract

The utility model discloses a split type liquid chromatographic column cleaning device which comprises a main body, a valve assembly and a column support, and the valve assembly and the column support are detachably hung on the side wall of the main body. A shell of the main body is a sheet metal box body, a column cleaning pump is mounted in the box body, and a pump head extends out of a front panel of the main body; a reagent solvent selection valve is mounted at a liquid inlet of the column cleaning pump; an emptying valve is further arranged on the front panel of the main body; a liquid inlet of the emptying valve is connected with a liquid outlet of the column cleaning pump through a pipeline; a shell of the valve assembly is a sheet metal box body, a six-position seven-way valve and a seven-way joint are mounted in the box body, a liquid inlet of the six-position seven-way valve is connected with a liquid outlet of an emptying valve through a pipeline, and liquid outlets at different valve positions are connected with liquid inlets of different chromatographic columns; the seven-way joint is connected with a liquid outlet of the chromatographic column; the column support is composed of a column support installation plate, a guide rail, a column clamp installation plate and a column frame. The main body of the cleaning device can be independently used, so that the use cost is reduced, and the service life of equipment is prolonged.

Description

TECHNICAL FIELD

[0001] The utility model relates to cleaning equipment technical field, specifically, relate to a split type liquid chromatography column cleaning device. BACKGROUND

[0002] Liquid chromatography technology is indispensable precision analysis technology in chemical and biological fields. It plays a vital role in separating, identifying and quantifying components in complex mixtures, and is a valuable tool for researchers, scientists and analysts in various industries. However, the liquid chromatography column will be contaminated by sample residues and impurities during use, affecting the accuracy of the results and even causing damage to the chromatography column. It is necessary to clean the chromatography column in time.

[0003] However, some customers directly use the cleaning program of the chromatograph to clean the chromatography column after completing the detection. This operation is energy-consuming and inefficient, and also occupies the use time of the chromatograph. Some customers use a feed pump to flush the chromatography column. This method can only use one kind of solvent to flush one chromatography column, which is inefficient and cannot clean multiple chromatography columns at the same time. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a split type liquid chromatography column cleaning device, which solves the problem of not being able to clean multiple chromatography columns at the same time in the above background technology. Further, in the application scenario where multiple chromatography columns do not need to be cleaned at the same time, the main body of the cleaning device can be used alone to reduce the use cost of customers. In the application scenario where multiple chromatography columns need to be cleaned at the same time, the valve assembly and column support of the cleaning device can be mounted on the side wall of the main body, so that the device can clean multiple chromatography columns at the same time. Another purpose of the utility model is to add a peristaltic pump in the main device to clean the residual solvent on the plunger rod in the column cleaning pump of the cleaning device, thereby prolonging the service life of the device.

[0005] The utility model relates to a split type liquid chromatography column cleaning device, which comprises a main body, a valve assembly and a column support.

[0006] The shell of the main body is a sheet metal box, and a column cleaning pump is installed in the box. The pump head protrudes from the front panel of the main body. The column cleaning pump 101 is used to flush cleaning solvent into the chromatography column for cleaning. A solvent selection valve is installed at the liquid inlet of the column cleaning pump, which is used to switch the reagent for cleaning the chromatography column. The front panel of the main body is further provided with a vent valve, and the liquid inlet of the vent valve is connected to the liquid outlet of the column cleaning pump through a pipeline, which is used to fill the pump pipeline with liquid before use, detect the pressure of the pipeline and release the pressure after overpressure. The main body further comprises a main body interface, which is connected to the valve assembly interface to transmit power and control signals to the valve assembly.

[0007] The solvent selection valve is connected with different solvent bottles through several pipelines and switches different solvents according to requirements during cleaning of the liquid chromatographic column.

[0008] The main body further comprises a peristaltic pump, the pump head protrudes from the front panel of the main body, the peristaltic pump is connected with the column cleaning pump and the liquid storage bottle through a hose to form a circulation loop, and is used for post-flushing residual solvents on the plunger rod of the column cleaning pump.

[0009] The main body further comprises a touch screen, which is used for controlling overall operation parameters of the cleaning device and displaying operation states.

[0010] The shell of the valve assembly is a sheet metal box body, the box body is internally provided with a six-position seven-way valve and a seven-way joint, the liquid inlet of the six-position seven-way valve is connected with the liquid outlet of the vent valve through a pipeline, then the liquid outlets of different valve positions are connected with different liquid inlets of the chromatographic columns, and the six-position seven-way valve is used for switching the liquid path to an uncleaned chromatographic column for cleaning after cleaning of one chromatographic column. The seven-way joint is connected with the liquid outlet of the chromatographic column, and is used for collecting waste liquid generated by cleaning of multiple chromatographic columns and discharging the waste liquid.

[0011] The column support is assembled by a column support mounting plate, a guide rail and a column clamp mounting plate. The column support mounting plate is used for mounting the valve assembly and the column support on the main body. The guide rail and the column clamp mounting plate are used for mounting the chromatographic column.

[0012] The column support is mounted on the left side panel of the valve assembly, and after being mounted as a whole, is hung on the right side panel of the main body and connected through the main body interface and the valve assembly interface, thereby increasing the column switching function of the main body.

[0013] The split type liquid chromatographic column cleaning device has the advantages and effects that in an application scenario in which multiple chromatographic columns are not needed to be cleaned at the same time, the main body of the cleaning device can be used alone, thereby reducing the use cost of a customer; in an application scenario in which multiple chromatographic columns are needed to be cleaned at the same time, the valve assembly and the column support of the cleaning device can be hung on the side wall of the main body, so that the device can clean multiple chromatographic columns at the same time; in addition, the peristaltic pump is added in the main body, so that residual solvents on the plunger rod in the column cleaning pump of the cleaning device can be cleaned, thereby prolonging the service life of the device. BRIEF DESCRIPTION OF DRAWINGS

[0014] The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the principles of the application. In the drawings:

[0015] Figure 1 is a front axle side view of the utility model

[0016] Figure 2 is a rear axle side view of the utility model

[0017] Figure 3 This is a pipeline connection diagram for this utility model.

[0018] Legend:

[0019] 1-Main body, 101-Column cleaning pump, 102-Peristaltic pump, 103-Solvent selection valve,

[0020] 104-Touchscreen, 105-Liquid reservoir, 106-Vent valve, 107-Main interface,

[0021] 2-Valve module; 201-Six-position seven-way valve; 202-Seven-way connector; 203-Valve assembly interface;

[0022] 3-Column bracket, 301 Column bracket mounting plate, 302 Guide rail, 303 Column clamp mounting plate,

[0023] 304-Column Frame Detailed Implementation

[0024] The structure of this utility model will be further described below with reference to the accompanying drawings.

[0025] The terms "front," "rear," "upper," and "lower" used in the specification and claims are generally used for descriptive purposes and do not necessarily describe exclusive relative positions in detail. Here, for convenience, the side viewed from above is defined as "upper," and the side viewed from below the pump head is defined as "lower."

[0026] like Figure 1 , Figure 2 As shown, a split-type liquid chromatography column cleaning device mainly consists of three parts: a main body 1, a valve assembly 2, and a column support 3. The valve assembly 2 and the column support 3 are detachably mounted on the side wall of the main body 1.

[0027] The main body has a sheet metal casing, inside which a column cleaning pump 101 is installed. The pump head protrudes from the front panel of the main body. The column cleaning pump 101 is used to flush the cleaning solvent into the chromatographic column for cleaning. A solvent selection valve 103 is installed at the inlet of the column cleaning pump 101 to switch the reagent used for cleaning the chromatographic column. The front panel of the main body is further provided with a vent valve 106. The inlet of the vent valve 106 is connected to the outlet of the column cleaning pump 101 through a pipeline. It is used to fill the pump pipeline with liquid before use, detect the pipeline pressure, and release pressure after overpressure. The main body further includes a main body interface 107, which can be connected to the valve assembly interface 203 to transmit power and control signals to the valve assembly 2.

[0028] The solvent selection valve 103 is connected to different solvent bottles through several pipelines and can switch between different solvents as required during the cleaning of the liquid chromatography column.

[0029] The main body further comprises a peristaltic pump 102, the pump head of which protrudes from the front panel of the main body, and the peristaltic pump 102 forms a circulation loop with the column washing pump 101 and the liquid storage bottle 105 through the hose connection column, for post-flushing the residual solvent on the plunger rod of the column washing pump 101.

[0030] The main body further comprises a touch screen 104 for controlling the overall operation parameters of the washing device and displaying the operation state.

[0031] The shell of the valve assembly is a sheet metal box body, and the six-position seven-way valve 201 and the seven-way joint 202 are installed in the box body, the liquid inlet of the six-position seven-way valve 201 is connected with the liquid outlet of the vent valve through a pipeline, then the liquid outlets of different valve positions are connected with different column liquid inlets, and the six-position seven-way valve 201 is used to switch the liquid path to the column to be washed after washing one column. The seven-way joint 202 is connected with the column liquid outlet, and the seven-way joint 202 is used to collect the waste liquid generated by washing a plurality of columns and discharge the waste liquid.

[0032] The column support 3 is assembled by a column support mounting plate 301, a guide rail 302, a column clamp mounting plate 303 and a column support 304. The column support mounting plate 301 is used to mount the valve assembly 2 and the column support 3 on the main body 1. The guide rail 302 and the column clamp mounting plate are used to mount the chromatographic column.

[0033] The implementation process of the column washing function of the utility model is as follows:

[0034] In the application scenario of needing to wash a plurality of chromatographic columns at the same time, the valve assembly 2 and the column support 3 are installed on the side panel of the main body 1, and the function of washing a plurality of chromatographic columns can be realized. First, the corresponding solvent selection valve position, six-position seven-way valve position, flushing flow, flushing time and whether to perform post-flushing of different chromatographic columns are respectively set through the touch screen 104, then the equipment is operated, after the solvent selection valve 103 and the six-position seven-way valve 201 are switched to the specified valve position, the column washing pump 101 is started to wash the chromatographic column with the specified flow, then after the washing time is reached, the column washing pump 101 is stopped, and the solvent selection valve 103 and the six-position seven-way valve 201 are switched to the valve position corresponding to the next chromatographic column, the above steps are repeated until all the chromatographic columns are washed. The pipeline connection is as shown in the drawing. Figure 3

[0035] ​In the application scenario where multiple chromatographic columns do not need to be cleaned at the same time, the valve assembly 2 and the column support 3 are not installed on the main body 1, and the function of cleaning a single chromatographic column can be realized alone, saving the cost of the customer. When running, first specify the solvent selection valve position, flushing flow, flushing time and whether to perform post-flushing through the touch screen 104, then run the equipment, after the solvent selection valve 103 is switched to the specified valve position, the column cleaning pump 101 starts to run to flush the corresponding solvent into the chromatographic column at the specified flow rate for cleaning, then the column cleaning pump 101 stops when the cleaning time is reached, and the flushing is completed.

[0036] Embodiments of the present application are described in detail below, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals represent the same or similar components or components having the same or similar functions throughout. The terms "first", "second", "third", etc. (if any) in the description and claims of the present application and the accompanying drawings are used to distinguish similar objects, and do not necessarily describe a specific order or sequence. It should be understood that such described objects can be interchanged under appropriate circumstances. In the description of the present application, the meaning of "multiple" is two or more, unless otherwise explicitly specified and limited. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion. The direction terms mentioned in the present application, such as: up, down, left, right, front, back, inner, outer, side, etc., are only the direction of the drawings.

[0037] In the description of the present application, it should be noted that, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally connected; it can be mechanical connection, or electrical connection or can communicate with each other; it can be directly connected, or indirectly connected through an intermediate medium, or the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

Claims

1. A split-type liquid chromatography column cleaning device, characterized by: The body, the valve assembly and the column support are detachably mounted on the side wall of the body; The outer shell of the body is a sheet metal box, in which a column cleaning pump is installed for flushing cleaning solvent into the chromatographic column, and the pump head protrudes from the front panel of the body; a reagent solvent selection valve for switching the cleaning reagent of the chromatographic column is installed at the liquid inlet of the column cleaning pump; the front panel of the body is further provided with a vent valve, and the liquid inlet of the vent valve is connected with the liquid outlet of the column cleaning pump through a pipeline; The outer shell of the valve assembly is a sheet metal box, in which a six-position seven-way valve and a seven-way joint are installed, the liquid inlet of the six-position seven-way valve is connected with the liquid outlet of the vent valve through a pipeline, and the liquid outlets of different valve positions are connected with different liquid inlets of the chromatographic column; the seven-way joint is connected with the liquid outlet of the chromatographic column; The column support is composed of a column support mounting plate, a guide rail, a column clamp mounting plate and a column stand, the column support mounting plate is used for mounting the valve assembly and the column support on the body, and the guide rail and the column clamp mounting plate are used for mounting the chromatographic column.

2. The split-type liquid chromatography column cleaning device according to claim 1, characterized in that: The body further comprises a body interface connected with the valve assembly interface to transmit power and control signals to the valve assembly.

3. The split-type liquid chromatography column cleaning device according to claim 1, characterized in that: The body further comprises a peristaltic pump, the pump head of which protrudes from the front panel of the body, and the peristaltic pump forms a circulation loop by connecting the column cleaning pump and the liquid storage bottle through a hose.

4. The split-type liquid chromatography column cleaning device according to claim 1, characterized in that: The body further comprises a touch screen for controlling the overall operation parameters of the cleaning device and displaying the operation state.

5. The split-type liquid chromatography column cleaning device according to claim 1, characterized in that: The column stand is mounted on the left side panel of the valve assembly, and after being integrated, it is externally hung on the right side panel of the body and connected through an interface.

6. The split-type liquid chromatography column cleaning device according to any one of claims 1-5, characterized in that: The solvent selection valve is connected with different solvent bottles through a pipeline.

Images