Multi-layer co-extrusion film type disposable 2D biological reaction bag

Abstract

The utility model discloses a multi-layer co-extrusion film type disposable 2D biological reaction bag which is composed of at least two multi-layer co-extrusion films and comprises a first film and a second film, the first film and the second film are connected in a hot welding mode to form a bag body, partial areas of the first film and the second film are welded to form a first area, a second area and a third area, the first area is located at the two ends of the bag body, and the third area is located at the two ends of the bag body. The third area is located in the middle of the bag body to form a liquid storage space, the second area is located in a transition area between the first area and the third area, a nylon rod is arranged in the first area to promote sufficient liquid shaking, the third area forms a liquid storage space capable of containing liquid medicine, and the third area is connected with a plurality of bag buckles used for being connected with an external pipeline. By means of the mode, the welding temperature of the multi-layer co-extrusion film is optimized, the compatibility and the welding strength of the 2D bag can be improved, the percent of pass is increased, the strength of the bag body is improved, the fracture risk is reduced, liquid medicine can be evenly and efficiently mixed, leakage pollution is avoided, and the liquid medicine is guaranteed to be pure and the sterile environment is guaranteed.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological reaction bag technical field, especially a kind of multilayer coextrusion film formula disposable 2D biological reaction bag. BACKGROUND

[0002] The disposable biological reaction bag of current market widely applies the multilayer film of rilutek or the 7-layer coextrusion film of domestic 9101, and this kind of film material has multilayer structure, and each layer material has different performance and function.

[0003] However, the 2D bag made of the above-mentioned 7-layer coextrusion film in the industry has the following defects:

[0004] 1. The welding temperature of the film material is generally lower than that of the plastic parts, which may cause the film material to be welded through or not firmly welded, resulting in leakage, reducing the yield, and causing the culture environment to be contaminated;

[0005] 2. The film material is soft and has insufficient strength, and if it falls to the ground after being filled with culture solution, it may cause drop injury and rupture;

[0006] 3. The operation of the 2D bag is complex, and the bag is easily squeezed and folded, which causes the liquid medicine to not be able to slide fully and uniformly, and cannot be fully utilized;

[0007] 4. The sealing property of the 2D bag is poor, and leakage easily occurs, which contaminates the liquid medicine in the bag. INVENTION CONTENTS

[0008] The utility model mainly solves the technical problem to provide a kind of multilayer coextrusion film formula disposable 2D biological reaction bag, and the welding temperature of multilayer coextrusion film is optimized, can promote 2D bag compatibility and welding strength, enhance qualified rate, and the strength of bag body increases, reduces the risk of rupture, and is convenient to operate, can make liquid medicine mix evenly and efficiently, avoid leakage pollution, guarantee liquid medicine pure and sterile environment, while promoting grasping stability, reduce the possibility of sliding and rupture.

[0009] To solve the above technical problems, one technical scheme of the utility model is to provide a kind of multilayer coextrusion film formula disposable 2D biological reaction bag, which is composed of at least two pieces of multilayer coextrusion film, including: a first film piece and a second film piece arranged oppositely, the first film piece and the second film piece are connected together by heat welding to form a bag body of the 2D biological reaction bag,

[0010] Part of the first film piece and the second film piece are welded to form a first region, a second region and a third region, the first region is located at both ends of the bag body, the third region is located in the middle of the bag body to form a liquid storage space capable of containing liquid medicine, and the second region is located between the first region and the third region to serve as a transition region,

[0011] The first area is provided with a nylon rod to promote sufficient shaking of the liquid, the third area forms a liquid storage space capable of containing the liquid, and a plurality of bag buckles are connected to the third area to connect external pipelines.

[0012] In a preferred embodiment of the present application, the first diaphragm and the second diaphragm are welded around the periphery, and the transition position between the second area and the first area and the third area is welded.

[0013] In a preferred embodiment of the present application, a nylon rod lumen is formed in the first area, and the nylon rod is installed in the nylon rod lumen.

[0014] In a preferred embodiment of the present application, a second area on the upper part of the bag body is provided with a grab hole for grabbing and carrying the bag body.

[0015] In a preferred embodiment of the present application, at least four bag buckles are connected to the third area, respectively for connecting the liquid inlet pipe, the liquid outlet pipe, the exhaust pipe and the sampling pipe.

[0016] In a preferred embodiment of the present application, the liquid inlet pipe, the liquid outlet pipe, the exhaust pipe and the sampling pipe are sealingly connected to the bag buckles, and the liquid storage space lumen is communicated through the bag buckles.

[0017] The present application has the following advantages: the welding temperature of the multilayer co-extrusion film is close to the welding temperature of the plastic parts, the compatibility is improved, the welding strength is strengthened, the production stability is improved, and the qualified rate of the 2D bag is increased; the overall strength of the 2D bag is increased, which can effectively reduce the risk of bag body rupture caused by scratching and falling; the operation convenience and efficiency are improved, the uniform shaking of the liquid is ensured, the efficiency and uniformity of the liquid mixing are improved; the liquid leakage is prevented, the external pollutants are prevented from entering the bag body, the purity of the liquid is ensured, a sterile culture environment is provided, the bag grabbing capacity is better, and the risk of bag sliding and breaking is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings needed in the embodiment description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0019] Fig. 1 is a structure diagram of a preferred embodiment of the multilayer co-extrusion film type disposable 2D biological reaction bag of the present application;

[0020] Fig. 2 is a sectional view of a preferred embodiment of the multilayer co-extrusion film type disposable 2D biological reaction bag of the present application.

[0021] The reference signs of the components in the drawings are as follows:

[0022] 1, multi-layer co-extrusion film, 2, first area, 3, second area, 4, third area, 5, bag body, 6, welding edge, 7, nylon rod, 8, nylon rod lumen, 9, bag buckle, 10, grab hole. DETAILED DESCRIPTION

[0023] To make the objectives, technical solutions and advantages of the embodiments of the present application clearer, the following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application described and shown in the drawings can be arranged and designed in various different configurations.

[0024] Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed present application, but only represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of the present application.

[0025] The present application relates to a preferred embodiment of a multi-layer co-extrusion film type disposable 2D bioreactor bag.

[0026] Please refer to Figs. 1-2 The multi-layer co-extrusion film type disposable 2D bioreactor bag is composed of at least two pieces of multi-layer co-extrusion film 1, including a first film piece and an oppositely arranged second film piece, the first film piece and the second film piece are connected together by heat welding to form a bag body of the 2D bioreactor bag.

[0027] Among them, the multi-layer co-extrusion film 1 adopts a high-barrier multi-layer composite film for disposable bioreactor with a patent number 2023225547801, which is not described here.

[0028] In this embodiment, part of the first film piece and the second film piece are welded to form a first area 2, a second area 3 and a third area 4, the first area 2 is located at both ends of the bag body 5, the second area 3 is located between the first area 2 and the third area 4 as a transition area, and the third area 4 is located in the middle of the bag body 5.

[0029] Further, the first film piece and the second film piece are welded around to form a welding edge to ensure the sealing property of the bag body; the transition position of the second area 3 and the first area 2 and the third area 4 is welded to form a welding edge 6 to enhance the structural strength of the bag body.

[0030] The multilayer co-extrusion film 1 has excellent learning performance, barrier performance and friction resistance, the film material is close to the melting point temperature of the welded plastic part, the compatibility is improved, the welding strength is strengthened, and thus the bag body strength is improved, and the risk of bag body rupture and leakage is avoided.

[0031] The first area 2 is provided with a nylon rod 7 to facilitate sufficient liquid shaking, the third area 4 forms a liquid storage space capable of accommodating liquid medicine, and a plurality of bag buckles 9 are connected to the third area 4 to connect external pipelines.

[0032] More specifically, the first area 2 is formed with a nylon rod lumen 8, and a nylon rod is installed in the nylon rod lumen, which can be connected to an external device, and the internal liquid of the bag body is shaken by the external device to achieve uniform shaking of the liquid medicine and improve the efficiency and uniformity of the liquid mixing.

[0033] Preferably, at least four bag buckles 9 are connected to the third area 4, respectively for connecting liquid inlet pipes, liquid outlet pipes, exhaust pipes and sampling pipes, and the liquid inlet pipes, liquid outlet pipes, exhaust pipes and sampling pipes are sealed and connected to the bag buckles, and the liquid storage space is communicated through the bag buckles.

[0034] Through the connection of the bag buckle 9, the liquid can be quickly input, output, exhausted and sampled, and the convenience and efficiency of operation are improved, and the sealed connection ensures that the liquid medicine will not leak, and at the same time prevents external pollutants from entering the bag body to ensure the purity of the liquid medicine.

[0035] In addition, the bag buckle 9 on the third area 4 can also be used to connect other different types of pipelines, allowing the bag body to interact with the external system in multiple ways to meet different operation needs.

[0036] Further, a grab hole 10 is arranged on the second area 3 of the upper part of the bag body 5 for grabbing and carrying the bag body, and can also be used as a point for hanging or fixing the bag body to protect the bag body from breaking or deforming and improve the carrying efficiency and protect the liquid medicine in the bag body.

[0037] The preparation process of the multilayer co-extrusion film type disposable 2D biological reaction bag is:

[0038] Two pieces of multilayer co-extrusion film 1, first film and second film, are prepared, and the first film and the second film are placed opposite to each other to ensure that they are correctly aligned to form a bag body of a 2D bag;

[0039] The first area 2, the second area 3 and the third area 4 are divided on the bag body 5, and the first film and the second film are connected by using a hot welding technology, and a welding edge 6 is formed around the first film and the second film, and the welding edge 6 is formed at the transition position between the second area and the first area 2 and the third area 4, thereby forming the basic structure of the bag body;

[0040] The nylon rod 7 is installed in the nylon rod tube cavity 8 formed in the first area 2 and the second area 3;

[0041] The second area 3 at the upper part of the bag body 5 is provided with the grab hole 10, so as to facilitate subsequent grabbing and carrying;

[0042] At least four bag buckles 9 are connected on the third area 4, which are used for connecting the liquid inlet pipe, the liquid outlet pipe, the exhaust pipe and the sampling pipe subsequently.

[0043] The multi-layer co-extrusion film type disposable 2D biological reaction bag has the following beneficial effects:

[0044] The production efficiency is improved: the welding temperature of the multi-layer is close to the welding temperature of the welded plastic parts, the compatibility is improved, the welding strength is strengthened, the production stability is improved, and the qualified rate of the 2D bag is improved.

[0045] The product quality is improved: the overall strength of the 2D bag is increased, which can effectively reduce the risk of bag body rupture and leakage caused by scratching and falling;

[0046] The operation convenience and efficiency are improved, the uniform shaking of the liquid medicine is ensured, and the efficiency and uniformity of the liquid medicine mixing are improved;

[0047] The liquid medicine is prevented from leaking, the external pollutants are prevented from entering the bag body, the purity of the liquid medicine is ensured, a sterile culture environment is provided, the grabbing capacity is better, and the risk of bag sliding and rupture is reduced.

[0048] The above is only an embodiment of the utility model, and does not limit the patent range of the utility model, and any equivalent structure or equivalent process conversion according to the content of the utility model specification, or direct or indirect application in other related technical fields, is also included in the patent protection range of the utility model.

Claims

1. A multi-layer co-extruded disposable 2D bioreactor bag, characterized in that, The application relates to a 2D bioreactor bag formed by at least two pieces of multilayer co-extrusion film, comprising: a first film piece and a second film piece arranged oppositely, the first film piece and the second film piece are connected together by heat welding to form a bag body of the 2D bioreactor bag, Part areas of the first film piece and the second film piece are welded to form a first area, a second area and a third area, the first area is located at two ends of the bag body, the third area is located in the middle of the bag body to form a liquid storage space capable of containing a medicine liquid, and the second area is located between the first area and the third area to serve as a transition area, A nylon rod is arranged in the first area to promote sufficient liquid shaking, the third area forms the liquid storage space capable of containing the medicine liquid, and a plurality of bag buckles are connected to the third area to be connected with external pipelines.

2. The multi-layer co-extruded disposable 2D bioreactor bag of claim 1, wherein, Welding edges are formed around the first film piece and the second film piece, and the second area is formed with a welding edge at a transition position of the first area and the third area.

3. The multi-layer co-extruded film disposable 2D bioreactor bag of claim 1, wherein, A nylon rod cavity is formed in the first area, and the nylon rod is installed in the nylon rod cavity.

4. The multi-layer co-extruded, disposable 2D bioreactor bag of claim 1, wherein, A grab hole is arranged on the second area of the upper part of the bag body to be used for grabbing and carrying the bag body.

5. The multi-layer co-extruded disposable 2D bioreactor bag of claim 1, wherein, At least four bag buckles are connected to the third area, and are respectively used for connecting an inlet pipe, an outlet pipe, an exhaust pipe and a sampling pipe.

6. The multi-layer co-extruded film disposable 2D bioreactor bag of claim 5, wherein, The inlet pipe, the outlet pipe, the exhaust pipe and the sampling pipe are sealedly connected with the bag buckles, and the bag buckles are communicated with the inner cavity of the liquid storage space.

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