Low-temperature drying freeze-dried powder production equipment
By utilizing the pressure plate assembly and vibration function in the low-temperature drying equipment, the problem of caking of freeze-dried powder during the drying process was solved, achieving uniform drying and preservation of drug activity, thus improving the quality of freeze-dried powder.
Patent Information
- Application Number
- CN202422988876.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-05
- Publication Date
- 2025-11-21
- Estimated Expiration
- 2034-12-05
AI Technical Summary
Freeze-dried powder is prone to clumping during the drying process, resulting in uneven quality, and high-temperature drying may cause the drug components to become inactive.
Low-temperature drying equipment is used, combined with a pressure plate assembly and vibration function, to ensure uniform drying by crushing and shaking the freeze-dried powder, and a scraper is used to clean the adhering substances to prevent high-temperature deactivation.
This method achieves uniform drying of the freeze-dried powder, avoids clumping, preserves drug activity, and improves product quality.
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Figure CN223580458U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the freeze-dried powder production field, concretely is a low temperature drying freeze-dried powder production facility. BACKGROUND
[0002] The freeze-dried powder is sterile powder injection that is formed by freezing liquid medicine into solid state under aseptic environment and sublimating moisture to dry. The freeze-dried powder is sterile powder injection that is formed by freezing liquid medicine into solid state under aseptic environment and sublimating moisture to dry. In short, the water in the liquid medicine is extracted under low temperature environment, and the original drug effect is retained. For drying heat-sensitive products and substances that need to maintain biological activity, freeze-drying is an effective method.
[0003] The freeze-dried powder is sterile powder injection that is formed by freezing liquid medicine into solid state under aseptic environment and sublimating moisture to dry. In short, the water in the liquid medicine is extracted under low temperature environment, and the original drug effect is retained. For drying heat-sensitive products and substances that need to maintain biological activity, freeze-drying is an effective method. SUMMARY
[0004] The embodiment of the application provides a low temperature drying freeze-dried powder production equipment to solve the problems in the background art.
[0005] In order to solve the above technical problems, the utility model provides the following technical scheme: a low temperature drying freeze-dried powder production equipment, characterized by: including the drying cabinet, the drying cabinet includes the box, the box outside front side is hinged with the cabinet door, the box outside right side is installed with the cold air chamber;
[0006] The rotating rod is fixedly installed with a plurality of drying supporting plates, and the drying supporting plates are provided with circular grooves for placing drying trays.
[0007] The box inner cavity is further provided with a pressing plate assembly, the pressing plate assembly comprises a vibrating cylinder, a vibrating base and a connecting plate, the vibrating cylinder is rotatably installed on the top of the box inner cavity, the vibrating base is installed on the bottom of the box inner cavity, the vibrating base is internally provided with a spring, the vibrating bottom plate is placed on the spring, and the vibrating bottom plate can move up and down in the vibrating base.
[0008] The number of the drying support plates and the pressing plates is four, the handle of the lowermost drying support plate is provided with a square hole, and the side edge of the rotating rod is provided with a limiter.
[0009] The surface of the vibrating cylinder is engraved with a sliding groove, the vibrating rod is provided with a sliding block, the sliding block is slidingly installed in the sliding groove, and the sliding block is cylindrical.
[0010] The box is provided with four air outlets at the connecting position of the box and the cold air chamber, and the air outlets are consistent with the drying support plates in height.
[0011] The box inner cavity is provided with a scraper, the scraper comprises a handle and a blade, the blade is attached to the wall of the box inner cavity, the handle is rotatably installed on the top of the box inner cavity, and the number of the blades is two.
[0012] The top of the box shell is provided with a driving motor, the output shaft of the driving motor is connected with the vibrating cylinder, and the output shaft of the driving motor is connected with the handle.
[0013] The drying support plate can be turned out of the box cavity around the rotating rod, after the handle of the drying support plate touches the limiter, the limiter pops out a limiting clamping block, the limiting clamping block is clamped into the square hole, and at this time, the pressing plate can be matched with the circular groove.
[0014] Compared with the prior art, the beneficial effects achieved by the present application are as follows:
[0015] The pressing plate assembly is arranged, the pressing plate is pressed towards the freeze-dried powder in the drying disc during the drying process, part of the freeze-dried powder condensed into blocks can be crushed into powder, the freeze-dried powder can be shaken to a certain extent, the freeze-dried powder is uniformly dried, and the quality is guaranteed; low-temperature drying is adopted to prevent some components in the freeze-dried powder from losing activity due to high temperature. BRIEF DESCRIPTION OF DRAWINGS
[0016] The drawings constituting a part of the present application are used to provide a further understanding of the present application, the illustrative embodiments of the present application and the description thereof are used to explain the present application, and do not constitute an improper limitation on the present application. In the drawings:
[0017] Figure 1 is the overall appearance schematic view of the utility model;
[0018] Figure 2 is the partial structure schematic view of the utility model pressboard assembly part;
[0019] Figure 3 is the partial structure schematic view of the utility model Figure 2 A place in the local enlarged view of the utility model;
[0020] Figure 4 is the structure schematic view of the utility model blowing port place;
[0021] Figure 5 is the structure schematic view of the utility model limiting assembly place;
[0022] Figure 6 is the structure schematic view of the utility model vibration base place;
[0023] Figure 7 is the structure schematic view of the utility model scraper place;
[0024] Figure 8 is the structure schematic view of the utility model dry support plate rotating out of the box body.
[0025] In the figure: 1, box body;2, box door;3, cold air room;4, drive motor;5, pressboard;6, vibration cylinder;7, vibration rod;8, blowing port;9, scraper;10, rotating rod;11, dry support plate;12, stopper;13, vibration base;14, vibration bottom plate;15, connecting plate. DETAILED DESCRIPTION
[0026] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict. The present application will be described in detail below with reference to the accompanying drawings and in combination with embodiments.
[0027] In the description of the present application, it needs to be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, which are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features referred to. Therefore, the features defined with "first", "second" can be explicitly or implicitly included one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise explicitly specified and limited.
[0028] In the description of the present application, it needs to be explained that unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integral connection; it can be mechanical connection, or electrical connection or can communicate with each other; it can be directly connected, or indirectly connected through intermediate medium, it can be the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.
[0029] Please refer to Figure 2 、 Figure 3 、 Figure 5 And Figure 6 A low-temperature drying freeze-dried powder production equipment is characterized by comprising a drying box, the drying box comprising a box body 1, a box door 2 being hingedly connected to the outside of the front side of the box body 1, and a cold air chamber 3 being mounted on the outside of the right side of the box body 1.
[0030] A rotating rod 10 is rotatably mounted at the bottom of the inner cavity of the box body 1, and a plurality of drying supporting plates 11 are fixedly mounted on the rotating rod 10, wherein a circular groove is formed on each of the drying supporting plates 11, and the circular groove is used for placing a drying tray; the cold air chamber 3 can extract the inside of the box body into a vacuum environment and provide cold air.
[0031] The inner cavity of the box body 1 is further provided with a pressing plate assembly, which comprises a vibrating cylinder 6, a vibrating base 13 and a connecting plate 15. The vibrating cylinder 6 is rotatably installed at the top of the inner cavity of the box body 1. The connecting plate 15 is provided with a vibrating bottom plate 14 and a plurality of pressing plates 5. The top of the uppermost pressing plate 5 is fixedly provided with a vibrating rod 7, which is connected with the vibrating cylinder 6. The vibrating base 13 is installed at the bottom of the inner cavity of the box body 1. A spring is arranged in the vibrating base 13. The vibrating bottom plate 14 is arranged on the spring and can move up and down in the vibrating base 13.
[0032] As shown in Figure 2 and Figure 5 , the number of the drying support plates 11 and the pressing plates 5 is four. The handle of the lowermost drying support plate 11 is provided with a square hole. The side edge of the rotating rod 10 is provided with a limiter 12.
[0033] As shown in Figure 3 , the surface of the vibrating cylinder 6 is provided with a sliding groove. The vibrating rod 7 is provided with a sliding block, which is slidingly installed in the sliding groove. The sliding block is cylindrical.
[0034] As shown in Figure 4 , the box body 1 is provided with a blowing port 8 at the connection position with the cold air chamber 3. The number of the blowing ports 8 is four. The height of the blowing port 8 is consistent with that of the drying support plate 11.
[0035] As shown in Figure 7 , a scraper 9 is installed in the inner cavity of the box body 1. The scraper 9 comprises a blade and a handle. The blade is attached to the inner cavity wall of the box body 1. The handle is rotatably installed at the top of the inner cavity of the box body 1. The number of the blades is two.
[0036] As shown in Figure 2 and Figure 7 , a driving motor 4 is installed at the top of the outer shell of the box body 1. The output shaft of the driving motor 4 is connected with the vibrating cylinder 6. The output shaft of the driving motor 4 is connected with the handle.
[0037] As shown in Figure 5 and Figure 8 , the drying support plate 11 can be rotated out of the inner cavity of the box body 1 around the rotating rod 10. When the handle of the drying support plate 11 touches the limiter 12, the limiter 12 pops out a limiting clamping block, which is clamped into the square hole. At this time, the pressing plates 5 can be matched with the circular grooves.
[0038] In use, the staff member rotates the drying tray 11 out, places the drying tray containing the freeze-dried powder into the circular recess of the drying tray 11, and then rotates the drying tray 11 into the box body 1. The lowermost drying tray 11 touches the limiting stopper 12, the limiting stopper 12 pops out the limiting block, the limiting block is clamped into the square hole, the box door 2 is closed, the driving motor 4 is started, the output shaft of the driving motor 4 drives the vibration cylinder 6 to rotate, the slider on the vibration rod 7 slides along the sliding groove on the surface of the vibration cylinder 6, driving the vibration rod 7 to move up and down, the vibration rod 7 drives the pressing plate 5 on the connecting plate 15 and the vibration bottom plate 14 to move up and down, the pressing plate 5 crushes the large freeze-dried powder blocks and provides a certain shaking, the vibration bottom plate 14 moves up and down in the vibration base 15, so that the spring is constantly compressed and rebounded, the cold air chamber 3 draws the box body into a vacuum environment and blows cold air to the drying tray through the air outlet 8 to dry the freeze-dried powder, the output shaft of the driving motor 4 drives the scraper 9 to rotate, the scraper 9 rotates along the cavity wall of the box body 1, scraping the freeze-dried powder attached to the cavity wall, facilitating subsequent staff recovery and utilization, after drying, the box door 2 is opened, the limiting block is pressed, the drying tray 11 is rotated, and the drying tray is taken out.
[0039] The above is only an embodiment of the present application and is not intended to limit the present application. The present application can have various modifications and changes for those skilled in the art. Any modification, equivalent replacement, improvement, etc. within the spirit and principles of the present application shall be included in the scope of the claims of the present application.
Claims
1. A low temperature dry lyophilized powder production apparatus, characterized by: Including dry box, the dry box includes box body (1), the box door (2) is hinged to the outside front side of the box body (1), and the cold air chamber (3) is installed on the outside right side of the box body (1); The rotating rod (10) is rotatably installed on the bottom of the inner cavity of the box body (1), a plurality of drying supporting plates (11) are fixedly installed on the rotating rod (10), a circular groove is formed on the drying supporting plate (11), and the drying plate is placed in the circular groove; The inner cavity of the box body (1) is further provided with a pressing plate assembly, the pressing plate assembly comprises a vibrating cylinder (6), a vibrating base (13) and a connecting plate (15), the vibrating cylinder (6) is rotatably installed on the top of the inner cavity of the box body (1), the vibrating base (13) is installed on the bottom of the inner cavity of the box body (1), the vibrating base (13) is placed in the spring, the vibrating bottom plate (14) is placed on the spring, and the vibrating bottom plate (14) can move up and down in the vibrating base (13).
2. A low temperature dry lyophilized powder production apparatus as claimed in claim 1, wherein: The number of the drying supporting plates (11) and the pressing plates (5) is four, a square hole is formed on the handle of the lowermost drying supporting plate (11), and the limiting stopper (12) is installed on the side edge of the rotating rod (10).
3. A low temperature dry lyophilized powder production apparatus as claimed in claim 1, wherein: The vibrating cylinder (6) is provided with a sliding groove on the surface, the vibrating rod (7) is provided with a sliding block, the sliding block is slidably installed in the sliding groove, and the sliding block is cylindrical.
4. The apparatus for producing a low temperature dried lyophilized powder according to claim 1, characterized by: The blowing port (8) is formed at the connection between the box body (1) and the cold air chamber (3), the number of the blowing ports is four, and the height of the blowing port (8) is consistent with that of the drying supporting plate (11).
5. The apparatus for producing a low temperature dried lyophilized powder according to claim 1, characterized by: The scraper (9) is installed in the inner cavity of the box body (1), the scraper (9) is composed of a blade handle and a blade, the blade is attached to the inner cavity wall of the box body (1), and the blade handle is rotatably installed on the top of the inner cavity of the box body (1).
6. A low temperature dry lyophilized powder production apparatus as claimed in claim 5, characterized in that: The driving motor (4) is installed on the top of the box body (1), the output shaft of the driving motor (4) is connected with the vibrating cylinder (6), and the output shaft of the driving motor (4) is connected with the blade handle.
7. A low temperature dry lyophilized powder production apparatus as claimed in claim 2, wherein: The drying supporting plate (11) can be rotated out of the cavity of the box body (1) around the rotating rod (10), after the handle of the drying supporting plate (11) touches the limiting stopper (12), the limiting stopper (12) pops out the limiting clamping block, the limiting clamping block is clamped into the square hole, and at this time, the pressing plate (5) can cooperate with the circular groove.