Multi-section type detachable chromatographic column

Abstract

The utility model discloses a multi-section type detachable chromatographic column which comprises a feeding device, a detachable column body and a material receiving device, the feeding device, the detachable column body and the material receiving device are sequentially connected, an embedding groove is annularly formed in the top of the detachable column body, a rubber sealing ring is arranged on the inner side wall of the embedding groove, an embedding block is arranged at the bottom of the detachable column body, and the rubber sealing ring is arranged on the inner side wall of the embedding groove. The embedded block is embedded in the embedded groove, protruding blocks are arranged on the left side and the right side of the embedded groove, air holes are formed in the middles of the protruding blocks and communicated with the embedded groove, the protruding blocks are covered with a cover body, and the air holes are covered with the cover body. According to the utility model, the detachable column bodies are connected between the feeding device and the receiving device, so that the height of the chromatographic column can be adjusted as required; the top and the bottom of the detachable column body are provided with an embedding groove and an embedding block respectively, the inner side of the embedding groove is provided with a rubber sealing ring and an air hole, after the embedding block is embedded into the embedding groove, air is extruded out and then sealed through a cover body, the sealing performance can be improved, and air is prevented from entering; the sealing device is high in sealing degree, convenient to assemble and disassemble and suitable for popularization.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and more specifically to a multi-segment detachable chromatography column. Background Technology

[0002] Chromatography utilizes the differences in partition coefficients of components in certain solvents and their adsorption capacity on adsorbents to separate and purify chemical substances. Chromatographic columns are commonly used equipment for separating mixtures. Most existing chromatographic columns are glass columns, consisting of an integrated reservoir and packed column. In practical use, problems frequently arise such as the feeding device being inseparable from the column, inconvenient feeding, difficulty in disassembly and packing replacement, poor packing efficiency, and difficulties in unloading and cleaning due to the column's length, leading to contamination of the compounds to be separated. Furthermore, larger columns are expensive, and damage to a portion of the column renders the entire column unusable, resulting in high costs. In addition, some columns are made of non-transparent materials, making it impossible to observe the separation process within the column. When problems arise in the chromatographic separation system, timely troubleshooting is difficult, causing inconvenience to experiments and becoming a pressing issue for researchers. To address this issue, the inventors propose a multi-segment detachable chromatography column. By designing the chromatography column as a multi-segment column, it facilitates installation and disassembly, as well as packing and cleaning. It also facilitates troubleshooting by researchers, thereby improving chromatography quality and efficiency.

[0003] To address the inconvenience of loading, unloading, and cleaning chromatography columns, Chinese patent application (publication number CN203816276U) discloses a detachable multi-segment chromatography column for the separation and purification of pharmaceutical intermediates. This utility model includes a feeding device, detachable columns, and a funnel-type receiving device, connected sequentially. Multiple detachable columns are provided, separated by adsorption columns. The core materials added to different adsorption columns can be the same or different. Each detachable column is equipped with an observation window. The front end of the feeding device has an eluent inlet pipe and a pressurizing device. The feeding device, multiple detachable columns, and the funnel-type receiving device are fixed together by connecting flanges. The feeding device is open-type, and the funnel-type receiving device has a throttling valve at its lower end. The number of detachable columns is greater than or equal to one, and the detachable column material is colored plexiglass. This invention can avoid the degradation of easily photodegradable compounds, and the number of detachable chromatography columns and the column core additives in the adsorption column can be adjusted as needed.

[0004] The proposed solution still has some shortcomings in application. Since the chromatography column uses a multi-segment structure, the airtightness of the connections between the segments is crucial. Maintaining good sealing during chromatography is essential to ensure optimal results. Therefore, the sealed connection structure between the segments is critical. Furthermore, because each segment of the column needs to be observed during chromatography, the connections between them must be transparent to avoid obstructing the operator's view. Therefore, the structure of the chromatography column needs improvement to ensure good connection between the segments while facilitating real-time observation and enhancing the overall chromatography effect. Utility Model Content

[0005] The present invention discloses a multi-segment detachable chromatography column, the main purpose of which is to overcome the above-mentioned deficiencies and shortcomings of the prior art.

[0006] The technical solution adopted in this utility model is as follows:

[0007] A multi-segment detachable chromatography column includes a feeding device, several detachable column bodies, and a receiving device. The feeding device, several detachable column bodies, and the receiving device are connected sequentially from top to bottom. The top of each detachable column body is provided with an embedding groove, and the inner sidewall of the embedding groove is provided with a rubber sealing ring. The bottom of each detachable column body is provided with an embedding block, which is movably embedded in the embedding groove. The left and right sides of the embedding groove are provided with protrusions, and the protrusions are provided with vent holes in the middle, which communicate with the embedding groove. The protrusions are covered with caps, which movably cover the vent holes.

[0008] Furthermore, the bottom of the embedding groove has an outer high and inner low structure, and the bottom of the embedding block has a corresponding outer high and inner low structure.

[0009] Furthermore, the outer wall of the protrusion is provided with an external thread, and the inner wall of the cover is provided with an internal thread, which is movably tightened with the external thread.

[0010] Furthermore, the bottom inner side of the cover is fitted and sealed to the air vent.

[0011] Furthermore, a receiving groove is fixedly provided on the top of the receiving device.

[0012] Furthermore, the feeding device, the several detachable columns, and the receiving device are all made of transparent glass, and the outer wall of the detachable column is provided with graduations.

[0013] As can be seen from the above description of this utility model, compared with the prior art, the advantages of this utility model are as follows:

[0014] This invention first connects several detachable columns between a feeding device and a receiving device, employing a multi-segment detachable chromatography column structure. The height of the chromatography column can be adjusted by increasing or decreasing the number of detachable columns according to different chromatography requirements, offering flexible adjustment and a wide range of applications. Next, each detachable column has an embedding groove and an embedding block at its top and bottom, respectively. The detachable columns are connected end-to-end. A rubber sealing ring is located inside the embedding groove, with air holes on both sides. After the embedding block is inserted into the embedding groove, air inside the groove is squeezed out through the air holes and then sealed by the cover, improving the sealing of the detachable column connection, preventing air ingress, ensuring a stable connection structure, and facilitating operation. Finally, after chromatography, the cover is unscrewed to allow the air holes to communicate with the outside, and the embedding block can be pulled out of the embedding groove to complete disassembly. Disassembly is convenient and facilitates column cleaning, achieving two benefits in one. This invention is ingeniously designed, enabling multi-segment chromatography column connection with high sealing performance and convenient assembly and disassembly, making it suitable for widespread application. Attached Figure Description

[0015] Figure 1 This is a front view structural diagram of the present invention.

[0016] Figure 2 This is a front view structural diagram of the detachable column of this utility model.

[0017] Figure 3 This is a top view schematic diagram of the detachable column structure of this utility model.

[0018] Figure 4 This is a side view of the detachable column structure of this utility model. Detailed Implementation

[0019] The specific embodiments of this utility model will be further described below with reference to the accompanying drawings.

[0020] like Figures 1 to 4 As shown, a multi-segment detachable chromatography column includes a feeding device 1, several detachable column bodies 2, and a receiving device 3. The feeding device 1, the several detachable column bodies 2, and the receiving device 3 are connected sequentially from top to bottom. The top of each detachable column body 2 is provided with an embedding groove 4, and the inner wall of the embedding groove 4 is provided with a rubber sealing ring 5. The bottom of each detachable column body 2 is provided with an embedding block 6, which is movably embedded in the embedding groove 4. The left and right sides of the embedding groove 4 are provided with protrusions 7, and the protrusions 7 are provided with vent holes 8 in the middle, which communicate with the embedding groove 4. The protrusions 7 are covered with a cover body 9, which movably covers the vent holes 8.

[0021] Furthermore, the bottom of the embedding groove 4 has an outer high and inner low structure, and the bottom of the embedding block 6 has a corresponding outer high and inner low structure.

[0022] Furthermore, the outer wall of the protrusion 7 is provided with an external thread 71, and the inner wall of the cover 9 is provided with an internal thread accordingly, which is movably tightened with the external thread 71.

[0023] Furthermore, the bottom inner side of the cover 9 is fitted and sealed to the air hole 8.

[0024] Furthermore, the top of the receiving device 3 is fixedly provided with a receiving groove 10.

[0025] Furthermore, the feeding device 1, the plurality of detachable columns 2 and the receiving device 3 are all made of transparent glass, and the outer wall of the detachable column 2 is provided with a scale 21.

[0026] [Example]

[0027] First, the height of the chromatography column is determined according to the experimental requirements, thereby determining the number of detachable columns 2. Next, the insert block 6 at the bottom of one detachable column 2 is inserted into the receiving insert groove 10 on the receiving device 3. Then, several detachable columns 2 are stacked and connected upwards in sequence. Since the receiving insert groove 10 and the insert groove 4 have built-in rubber sealing rings 5, after the insert block 6 is inserted into the insert groove 4, the detachable columns 2 between the upper and lower parts are sealed and connected. The air in the insert groove 4 is squeezed out through the air hole 8. The cover 9 is placed on the protrusion 7 to block the air hole 8, preventing air from entering and also preventing the detachable column 2 from falling off. Finally, after the chromatography operation is completed, the cover 9 is unscrewed from the protrusion 7 to allow the air hole 8 to be connected with the outside air. At this time, the insert block 6 of the detachable column 2 can be pulled out from the insert groove 4 to complete the disassembly, which also facilitates cleaning. The operation is very convenient.

[0028] As can be seen from the above description of this utility model, compared with the prior art, the advantages of this utility model are as follows:

[0029] This invention first connects several detachable columns between a feeding device and a receiving device, employing a multi-segment detachable chromatography column structure. The height of the chromatography column can be adjusted by increasing or decreasing the number of detachable columns according to different chromatography requirements, offering flexible adjustment and a wide range of applications. Next, each detachable column has an embedding groove and an embedding block at its top and bottom, respectively. The detachable columns are connected end-to-end. A rubber sealing ring is located inside the embedding groove, with air holes on both sides. After the embedding block is inserted into the embedding groove, air inside the groove is squeezed out through the air holes and then sealed by the cover, improving the sealing of the detachable column connection, preventing air ingress, ensuring a stable connection structure, and facilitating operation. Finally, after chromatography, the cover is unscrewed to allow the air holes to communicate with the outside, and the embedding block can be pulled out of the embedding groove to complete disassembly. Disassembly is convenient and facilitates column cleaning, achieving two benefits in one. This invention is ingeniously designed, enabling multi-segment chromatography column connection with high sealing performance and convenient assembly and disassembly, making it suitable for widespread application.

[0030] The above are merely specific embodiments of this utility model, but the design concept of this utility model is not limited thereto. Any non-substantial improvements made to this utility model using this concept should be considered as infringing on the protection scope of this utility model.

Claims

1. A multi-segment detachable chromatography column, characterized in that: The device includes a feeding device, several detachable columns, and a receiving device. The feeding device, the several detachable columns, and the receiving device are connected sequentially from top to bottom. The top of each detachable column is provided with an embedding groove, and the inner side wall of the embedding groove is provided with a rubber sealing ring. The bottom of each detachable column is provided with an embedding block, which is movably embedded in the embedding groove. The left and right sides of the embedding groove are provided with protrusions, and the protrusions are provided with air holes in the middle, which are connected to the embedding groove. The protrusions are covered with a cover, which movably covers the air holes.

2. The multi-segment detachable chromatography column according to claim 1, characterized in that: The bottom of the embedding groove has an outer high and inner low structure, and the bottom of the embedding block has a corresponding outer high and inner low structure.

3. The multi-segment detachable chromatography column according to claim 1, characterized in that: The outer wall of the protrusion is provided with an external thread, and the inner wall of the cover is provided with an internal thread accordingly. The internal thread is movably tightened with the external thread.

4. The multi-segment detachable chromatography column according to claim 1, characterized in that: The bottom inner side of the cover is fitted and sealed to fit the air hole.

5. The multi-segment detachable chromatography column according to claim 1, characterized in that: The top of the receiving device is fixed with a receiving groove.

6. The multi-segment detachable chromatography column according to claim 1, characterized in that: The feeding device, the several detachable columns, and the receiving device are all made of transparent glass, and the outer wall of the detachable column is provided with graduations.

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