Real-time monitoring device for solubility of acetylcysteine particles

Abstract

The utility model belongs to the field of medicine dissolution monitoring, and relates to an acetylcysteine particle solubility real-time monitoring device which comprises a base, a weighing device arranged on the upper portion of the base, a resistance tester arranged on one side of the weighing device, a dissolution cup arranged on one side of the resistance tester, and a filter screen arranged in the dissolution cup. A liquid concentration tester is arranged on one side of the filter screen, a wire is arranged on one side of the liquid concentration tester, an extension device is arranged on one side of the wire, and a console is arranged on one side of the extension device. The acetylcysteine particle dissolution monitoring device is complete in structure and complete in function, can effectively monitor the dissolution condition of acetylcysteine particles, avoids the influence caused by measurement errors possibly occurring in a traditional method, reduces the operation risk in the dissolution process, enhances the safety performance, and provides a guarantee for medicine production and quality control.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the field of medicine dissolving monitoring, concretely relates to a kind of acetylcysteine granule solubility real-time monitoring device. BACKGROUND

[0002] Acetylcysteine is an organic compound, mainly used as mucolytic agent, with strong sputum dissolving effect, the sulfhydryl contained in its molecule can make the disulfide bond in sputum glycoprotein polypeptide chain break, thereby reducing the tackiness of sputum, and making sputum liquefy and easy to cough out, also can make the DNA fiber in purulent sputum break, so it can not only dissolve white sputum, but also dissolve purulent sputum. The dissolution rate of its drug granule directly affects its curative effect and bioavailability, so it is of great significance to monitor the solubility of its granule in real time in drug research and production.

[0003] At present, the commonly used solubility monitoring methods on the market include titration method, colorimetric method, spectroscopic method and the like, but these methods have significant shortcomings, such as complicated operation, long reaction time, difficult to monitor the granule dissolution in real time, especially difficult to realize automatic and continuous monitoring in production line. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a kind of acetylcysteine granule solubility real-time monitoring device, can guarantee in the process of acetylcysteine granule dissolution, the joint monitoring of resistance method and dissolution method can detect the real-time state of granule dissolution in time, so as to ensure that there is no problem of inaccurate solubility measurement when working in dissolution process, solve the problem of discontinuous solubility monitoring and poor real-time performance of prior art.

[0005] In order to achieve the above purpose, the utility model adopts the technical scheme that the utility model provides a kind of acetylcysteine granule solubility real-time monitoring device, including base, the base upper portion is provided with weighing device, weighing device one side is provided with resistance tester, resistance tester one side is provided with dissolving cup, dissolving cup is provided with filter screen inside, filter screen one side is provided with liquid concentration tester, liquid concentration tester one side is provided with lead, lead one side is provided with extension device, extension device one side is provided with control cabinet.

[0006] As preferred, the weighing device upper portion is provided with weighing disc.

[0007] As preferred, the resistance tester upper portion is provided with resistance stick group, and the number of resistance stick group is 9 groups.

[0008] As preferred, the dissolving cup bottom is provided with heating device.

[0009] As preferred, the lead one side is provided with illuminating lamp strip.

[0010] Compared with the prior art, the advantages and positive effects of the utility model are that,

[0011] The utility model discloses the complete structure, perfect function can effectively monitor the dissolution condition of acetylcysteine granule, also avoid the influence that the measurement error in traditional method can appear, reduce the operation risk in the dissolution process, strengthen the security performance, provide the guarantee for drug production and quality control;

[0012] The utility model discloses the complete structure, perfect function can effectively monitor the dissolution condition of acetylcysteine granule, also avoid the influence that the measurement error in traditional method can appear, reduce the operation risk in the dissolution process, strengthen the security performance, provide the guarantee for drug production and quality control; BRIEF DESCRIPTION OF DRAWINGS

[0013] In order to more clearly illustrate the technical scheme of the embodiment of the utility model, the following will be to the embodiment description needed to use the drawing a simple introduction, obviously, the following description in the drawing is some embodiments of the utility model, for the ordinary skilled person in the art comes, under the premise of not paying the creative labor intensity, still can obtain other drawings according to these drawings.

[0014] Figure 1 The isometric view of the acetylcysteine granule solubility real-time monitoring device provided for embodiment 1;

[0015] In the above figure, 1, base, 2, weighing device, 3, weighing disc, 4, resistance tester, 5, resistance stick group, 6, dissolution cup, 7, heating device, 8, filter screen, 9, liquid concentration tester, 10, wire, 11, light belt, 12, extension device, 13, control cabinet. DETAILED DESCRIPTION

[0016] In order to more clearly illustrate the technical scheme of the embodiment of the utility model, the following will be to the embodiment description needed to use the drawing a simple introduction, obviously, the following description in the drawing is some embodiments of the utility model, for the ordinary skilled person in the art comes, under the premise of not paying the creative labor intensity, still can obtain other drawings according to these drawings.

[0017] In the following description, a lot of specific details are set forth in order to fully understand the utility model, however, the utility model can also be implemented in other ways different from the description herein, therefore, the utility model is not limited to the specific embodiment disclosed in the following disclosure.

[0018] Embodiment 1, as Figure 1As shown, a kind of acetylcysteine particle solubility real-time monitoring device, including base 1, the upper portion of the base 1 is provided with weighing device 2, weighing device 2 one side is provided with resistance tester 4, resistance tester 4 one side is provided with dissolving cup 6, dissolving cup 6 inside is provided with filter screen 8, filter screen 8 one side is provided with liquid concentration tester 9, liquid concentration tester 9 one side is provided with wire 10, wire one side is provided with extension device 12, extension device 12 one side is provided with control console 13.

[0019] The base 1 is the supporting foundation part of the whole monitoring device, which provides a stable platform to ensure that other components can be placed and operated stably and prevent unnecessary shaking or movement during use. The upper part of the base 1 is provided with a weighing device 2, which is used to accurately weigh the mass of the acetylcysteine particles before they are dissolved. By accurately weighing the data, the mass change after the particles are dissolved can be calculated, so as to monitor the dissolution process in real time. The upper part of the weighing device 2 is provided with a weighing disc 3, which is a container for placing acetylcysteine particles for weighing.

[0020] The weighing device 2 is provided with a resistance tester 4 on one side, which is used to measure the resistance change generated by the particles when passing through the micro-holes. When the particles pass through the micro-holes, they will occupy a certain space, causing the resistance between the two ends of the micro-holes to change. Different size particles will produce different size resistance signals due to the different space occupied. By processing these resistance signals by computer, the particle size distribution information can be accurately obtained, thereby providing necessary particle characteristic data for solubility monitoring. The upper part of the resistance tester 4 is provided with a resistance stick group 5, and the number of resistance stick groups 5 is 9 groups. The resistance stick group 5 is used to ensure the accuracy of the data by repeating the experiment multiple times. Each group in the resistance stick group 5 can be operated independently to ensure the stability and reliability of the test process. By measuring with multiple resistance stick groups, the error of single measurement can be reduced, and the accuracy of the overall measurement can be improved. The dissolving cup 6 is provided on one side of the resistance tester 4, which is used to dissolve the particles after the resistance test. The solution and particles in the dissolving cup interact, which can detect the dissolution condition and dissolution rate of the particles. The bottom of the dissolving cup 6 is provided with a heating device 7, which is used to accelerate the dissolution process. By adjusting the temperature of the heating device 7 to control the dissolution rate, the rapid test of solubility can be realized. The inside of the dissolving cup 6 is provided with a filter screen 8, which is used to extract the particles that have not completely dissolved in the dissolving cup after a certain time of dissolution. The filter screen 8 can take out the undissolved particles from the dissolving solution and dry and weigh them. By comparing the mass of the undissolved particles with the mass before dissolution, the solubility of the particles can be calculated, and the efficiency of the dissolution process and the dissolution characteristics of the particles can be evaluated.

[0021] The liquid concentration tester 9 is provided on one side of the filter screen 8 and is used to monitor the concentration of acetylcysteine in the dissolving solution. By detecting the concentration change of acetylcysteine in the solution, the degree of particle dissolution can be accurately evaluated. This device measures the dissolved components in the solution through optical, electrochemical or other technical principles, thereby providing accurate concentration data for the dissolution process and helping to judge the completion degree of dissolution. The liquid concentration tester 9 is provided on one side of the wire 10, which is used to connect various components in the device, transmit power and signals, and ensure that each device can operate normally and exchange data. The wire 10 is provided on one side of the lighting lamp strip 11, which is used to provide sufficient lighting to ensure that the operator can clearly observe each part when using the device, especially when visual inspection is performed during operation. The wire is provided on one side of the extension device 12, and the main function of the extension device 12 is to physically expand the base 1 to increase the working space. In this way, more experimental bench surfaces can be provided to facilitate the placement of more experimental equipment or the operation of multiple tests. The extension device 12 is provided on one side of the control console 13, which integrates various control and display functions such as temperature adjustment, solubility data recording, concentration monitoring, equipment switching, etc. Through the control console 13, the operator can easily set and adjust the parameters of the device, while monitoring the experimental process in real time to ensure the coordinated operation of each link.

[0022] The contents not described in detail in the description belong to the prior art known to those skilled in the art.

[0023] The above is only a preferred embodiment of the present application, and is not intended to limit the present application in other forms. Any skilled person in the art can modify or change the above disclosed technical content to equivalent embodiments applied to other fields, but any simple modification, equivalent change and modification of the above embodiments made in accordance with the technical essence of the present application without departing from the technical solution content of the present application shall fall within the protection scope of the present application.

Claims

1. An acetylcysteine granule solubility real-time monitoring device, characterized by, Including the base, the upper part of the base is provided with a weighing device, one side of the weighing device is provided with a resistance tester, one side of the resistance tester is provided with a dissolution cup, the inside of the dissolution cup is provided with a filter screen, one side of the filter screen is provided with a liquid concentration tester, one side of the liquid concentration tester is provided with a wire, one side of the wire is provided with an extension device, one side of the extension device is provided with a control console.

2. The device for real-time monitoring of acetylcysteine granule solubility according to claim 1, characterized in that, The upper part of the weighing device is provided with a weighing disc.

3. The device for real-time monitoring of acetylcysteine granule solubility according to claim 1, characterized in that, The upper part of the resistance tester is provided with a resistance stick group, and the number of resistance stick groups is 9 groups.

4. The device for real-time monitoring of acetylcysteine granule solubility according to claim 1, characterized in that, The bottom of the dissolution cup is provided with a heating device.

5. The device for real-time monitoring of acetylcysteine granule solubility according to claim 1, characterized in that, One side of the wire is provided with an illuminating lamp strip.

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