Stem cell cryopreservation cooling device

Abstract

The utility model provides a stem cell cryopreservation cooling device which comprises a shell, a frame body is fixedly installed in an inner cavity of the shell, a through hole is formed in the top of the shell, the through hole is communicated with the interior of the shell through the frame body, a semiconductor chilling plate is fixedly installed in the center of the inner cavity of the shell, and the semiconductor chilling plate is communicated with the interior of the shell through the frame body. And a rotating mechanism is arranged above the shell. According to the stem cell cryopreservation device, the semiconductor chilling plates used for cooling the cryopreservation tubes are arranged in the shell, then the cryopreservation tubes can be driven to rotate integrally in the frame body through the arrangement of the rotating mechanism, all positions of the side faces of the cryopreservation tubes can pass through the semiconductor chilling plates, and therefore stem cells in the cryopreservation tubes can be evenly cooled; and the cavity between the shell and the frame body is filled with the heat preservation pad, so that the temperature in the shell can be prevented from being interfered by the outside, and the stem cells in the cryopreservation tube can be further stored conveniently.

Description

TECHNICAL FIELD

[0001] The utility model relates to stem cell cryopreservation technical field, concretely is a stem cell cryopreservation cooling device. BACKGROUND

[0002] Stem cell is a kind of cell with unlimited or immortal self-renewal ability, and can produce at least one type of highly differentiated daughter cell. Stem cell is an ideal carrier for gene therapy of diseases. Hematopoietic stem cells have the characteristics of self-renewal, multi-directional differentiation, long-term hematopoietic reconstruction, easy collection and in-vitro processing, and are one of the most ideal carrier cells for gene therapy.

[0003] The stem cells need to be cooled in a low-temperature environment inside the cryopreservation tube. The existing cooling device is provided with a refrigeration device at the bottom or top of the device, and then the cryopreservation tube is placed in the cooling device for cooling. However, since the cryopreservation tube is fixed in the cooling device, this method cannot uniformly cool the cryopreservation tube, and it is difficult to well preserve the stem cells inside the cryopreservation tube at low temperature. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a stem cell cryopreservation cooling device to solve the problems in the above background.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical scheme.

[0006] A stem cell cryopreservation cooling device, comprising a shell, a rack fixedly installed in the inner cavity of the shell, a through hole provided at the top of the shell, the through hole being communicated with the inside of the shell through the rack, a semiconductor refrigeration sheet fixedly installed at the center of the inner cavity of the shell, and a rotating mechanism provided above the shell.

[0007] The rotating mechanism comprises a top plate, a motor, a rotating shaft, a driving shaft, a rubber roller, a driving gear and a driven gear. The top end of the rotating shaft is rotatably connected to the bottom of the top plate, the end of the rotating shaft is rotatably connected to the top of the shell, the driving shaft is rotatably connected to the center of the shell and the top plate, the motor is fixedly installed on the top of the top plate, the output end of the motor is connected to the top end of the driving shaft, the rubber roller and the driven gear are fixedly installed on the surface of the rotating shaft, and the rubber roller and the driven gear are distributed in the vertical direction on the surface of the rotating shaft. The driving gear is fixedly installed on the surface of the driving shaft and engaged with the driven gear.

[0008] Preferably, the cavity between the inner wall of the shell and the rack is filled with a heat preservation pad.

[0009] Preferably, the top of the shell is detachably connected with a top cover, the top of the top cover is fixedly installed with a handle, and the top cover and the shell are concentrically arranged, the bottom of the shell is fixedly installed with a base, the inside of the base is fixedly installed with a battery compartment, the inside of the battery compartment is installed with a battery, and the battery is electrically connected with the semiconductor refrigerating sheet and the motor.

[0010] Preferably, the side of the base is detachably installed with a protective cover, the protective cover covers the side of the battery compartment, and the base is provided with a heat dissipation groove on the side opposite to the protective cover.

[0011] Preferably, the inner wall of the protective cover is horizontally fixedly connected with a guide rod, one end of the guide rod is fixedly connected to the surface of the battery compartment through bolts, the surface of the protective cover is provided with a counterbore, and the counterbore is communicated with the inside of the guide rod.

[0012] Preferably, the top of the shell is fixedly installed with a connecting portion, the connecting portion is provided as an external thread structure, the inner wall of the top cover is provided as an internal thread structure, the top cover is threadedly connected to the surface of the connecting portion, and the bottom of the top cover abuts against the top of the shell.

[0013] Preferably, a plurality of the frame bodies are circularly arranged on the surface of the shell, and the frame bodies are used for placing the cryopreservation tubes.

[0014] Compared with the prior art, the utility model has the beneficial effects that:

[0015] The utility model sets up the semiconductor refrigerating sheet for cryopreservation tube cooling in the inside of the shell, then drives the whole cryopreservation tube to rotate through the setting of the rotating mechanism in the inside of the frame body, so that the stem cell in the inside of the cryopreservation tube can be uniformly cooled, so as to carry out the cooling of the stem cell, and the cavity between the shell and the frame body is filled through the heat preservation pad, can prevent the temperature in the inside of the shell from being interfered by the outside world, further convenient for the preservation of the stem cell in the inside of the cryopreservation tube. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is the main body structure schematic drawing of the utility model;

[0017] Figure 2 It is the explosion structure schematic drawing of the utility model;

[0018] Figure 3 It is the inside structure schematic drawing of the shell of the utility model;

[0019] Figure 4 It is the main body structure schematic drawing of the rotating mechanism of the utility model.

[0020] In the figure: 1, shell; 2, frame; 3, through hole; 4, semiconductor refrigerating sheet; 5, top plate; 6, motor; 7, rotating shaft; 8, drive shaft; 9, rubber roller; 10, driving gear; 11, driven gear; 12, heat preservation pad; 13, top cover; 14, handle; 15, base; 16, battery compartment; 17, protective cover; 18, heat dissipation groove; 19, guide rod; 20, counterbore; 21, connecting part. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the utility model.

[0022] Please refer to Figures 1-4 The utility model provides a kind of stem cell cryopreservation cooling device.

[0023] Embodiment one

[0024] Including shell 1, the inner cavity of shell 1 is fixedly installed with frame 2, multiple frame 2 is circular array distribution on the surface of shell 1, frame 2 is used to place cryopreserved tube, the top of shell 1 is provided with through hole 3, through hole 3 is communicated with the inside of shell 1 by frame 2, multiple frame 2 is circular array distribution on the surface of shell 1, frame 2 is used to place cryopreserved tube, the central part of the inner cavity of shell 1 is fixedly installed with semiconductor refrigerating sheet 4, the upper portion of shell 1 is provided with rotating mechanism.

[0025] Please refer to Figure 1 、 2 And 3, the inside of shell 1 can be cooled by semiconductor refrigerating sheet 4, cryopreserved tube is inserted into the inside of frame 2 by through hole 3, at this time, the side surface below cryopreserved tube is exposed in the inside of shell 1, so as to be cooled by semiconductor refrigerating sheet 4, and cryopreserved tube can be rotated under the driving of rotating mechanism when being in the inside of frame 2, so that stem cell in the inside of cryopreserved tube can be uniformly cooled.

[0026] The rotating mechanism comprises a top plate 5, a motor 6, a rotating shaft 7, a driving shaft 8, rubber rollers 9, a driving gear 10 and a driven gear 11, the top end of the rotating shaft 7 is rotatably connected to the bottom of the top plate 5, the bottom end of the rotating shaft 7 is rotatably connected to the top of the shell 1, the driving shaft 8 is rotatably connected to the central part of the shell 1 and the top plate 5, the motor 6 is fixedly installed on the top of the top plate 5, the output end of the motor 6 is connected to the top end of the driving shaft 8, the rubber rollers 9 and the driven gear 11 are fixedly installed on the surface of the rotating shaft 7, the rubber rollers 9 and the driven gear 11 are distributed along the vertical direction on the surface of the rotating shaft 7, and the driving gear 10 is fixedly installed on the surface of the driving shaft 8 and is engaged with the driven gear 11.

[0027] Please refer to Figure 2 、 3 and 4, in the embodiment, the motor 6 can drive the driving shaft 8 to rotate, the driving shaft 8 can drive the driving gear 10 to rotate, the driving gear 10 can drive the driven gear 11 to rotate when rotating, and the driven gear 11 drives the rubber rollers 9 to rotate through the rotating shaft 7, since the freeze tube will contact with the rubber rollers 9 when being placed in the frame 2, the freeze tube can be driven to rotate in the frame 2 by the friction force when the rubber rollers 9 rotate, since the semiconductor refrigeration sheet 4 is fixed, the stem cells in the freeze tube can be uniformly close to the semiconductor refrigeration sheet 4 when the freeze tube rotates in the frame 2, so that the stem cells can be uniformly cooled.

[0028] It should be noted that, since the diameter of the driving gear 10 is much larger than the radius of the driven gear 11, the angular velocity of the driven gear 11 is greater than that of the driving gear 10, and in the embodiment, the motor 6 is a speed-regulating motor 6, the rotating speed of the motor 6 can be adjusted, and the driving of the driven gear 11 by the driving gear 10 can control the rotating speed of the rubber rollers 9 within a certain range, so as to realize the driving of the freeze tube.

[0029] It should be known that, in order to prevent the motor 6 from not running due to low temperature in the shell 1, the shell 1 can be filled with temperature insulation material in the embodiment, so as to reduce the influence of low temperature environment on the motor 6, and the cavity between the inner wall of the shell 1 and the frame 2 is filled with heat preservation pad 12, so as to further improve the heat preservation performance of the shell 1.

[0030] Embodiment two

[0031] In the above scheme, the frozen tube can be driven to rotate in the inside of the rack body 2 by the rotating mechanism, so that it can be uniformly cooled, but the semiconductor refrigeration sheet 4 and the motor 6 lack power supply, and the upper part of the frozen tube is exposed to the outside world and can be disturbed by the outside temperature, therefore, the top cover 13 is detachably connected to the top of the shell 1, the handle 14 is fixedly installed on the top of the top cover 13, and the top cover 13 and the shell 1 are coaxially arranged, the bottom of the shell 1 is fixedly installed on the bottom of the shell 1. The battery compartment 16 is fixedly installed in the inside of the bottom seat 15, the battery is installed in the inside of the battery compartment 16, the battery is electrically connected with the semiconductor refrigeration sheet 4 and the motor 6, the connecting portion 21 is fixedly installed on the top of the shell 1, the connecting portion 21 is provided as an external thread structure, the inner wall of the top cover 13 is provided as an internal thread structure, the top cover 13 is screwed on the surface of the connecting portion 21, and the bottom of the top cover 13 abuts against the top of the shell 1, the protective cover 17 is detachably installed on the side of the bottom seat 15, the protective cover 17 covers the side of the battery compartment 16, the heat dissipation groove 18 is arranged on the side of the bottom seat 15 relative to the protective cover 17, the inner wall of the protective cover 17 is fixedly connected with the guide rod 19, one end of the guide rod 19 is fixedly connected to the surface of the battery compartment 16 through bolts, and the surface of the protective cover 17 is provided with the counterbore 20 which is communicated with the inside of the guide rod 19.

[0032] Please refer to Figure 2 , the top of the shell 1 can be sealed by the top cover 13, and the shell 1, the bottom seat 15 and the top cover 13 can be transported as a whole by the handle 14 on the top of the top cover 13, and the handle 14 also facilitates rotating the top cover 13 on the top of the shell 1, so as to realize the assembly and disassembly of the top cover 13 and the shell 1, the battery in the battery compartment 16 can supply power to the semiconductor refrigeration sheet 4 and the motor 6, and the heat generated by the battery and the semiconductor refrigeration sheet 4 during operation can be dissipated to the outside through the heat dissipation groove 18.

[0033] Although the embodiments of the present application have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and modifications can be made to the embodiments without departing from the principles and spirits of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A stem cell cryopreservation cooling device comprising a housing (1), characterized in that: The inner cavity of the shell (1) is fixedly installed with a frame (2), the top of the shell (1) is provided with a through hole (3), the through hole (3) is communicated with the inside of the shell (1) through the frame (2), the center of the inner cavity of the shell (1) is fixedly installed with a semiconductor refrigeration sheet (4), and the top of the shell (1) is provided with a rotating mechanism. The rotating mechanism comprises a top plate (5), a motor (6), a rotating shaft (7), a driving shaft (8), a rubber roller (9), a driving gear (10) and a driven gear (11), the top end of the rotating shaft (7) is rotatably connected to the bottom of the top plate (5), the tail end of the rotating shaft (7) is rotatably connected to the top of the shell (1), the driving shaft (8) is rotatably connected to the center of the shell (1) and the top plate (5), the motor (6) is fixedly installed on the top of the top plate (5), and the output end of the motor (6) is connected with the top end of the driving shaft (8), the rubber roller (9) and the driven gear (11) are both fixedly installed on the surface of the rotating shaft (7), and the rubber roller (9) and the driven gear (11) are distributed in the vertical direction on the surface of the rotating shaft (7), and the driving gear (10) is fixedly installed on the surface of the driving shaft (8) and engaged with the driven gear (11).

2. The stem cell cryopreservation cooling device of claim 1, wherein: The cavity between the inner wall of the shell (1) and the frame (2) is filled with a heat preservation pad (12).

3. The stem cell cryopreservation cooling device of claim 1, wherein: The top of the shell (1) is detachably connected with a top cover (13), the top of the top cover (13) is fixedly installed with a handle (14), and the top cover (13) and the shell (1) are concentrically arranged, the bottom of the shell (1) is fixedly installed with a base (15), the inside of the base (15) is fixedly installed with a battery compartment (16), the inside of the battery compartment (16) is installed with a battery, the battery is electrically connected with the semiconductor refrigeration sheet (4) and the motor (6).

4. The stem cell cryopreservation cooling device of claim 3, wherein: The side of the base (15) is detachably installed with a protective cover (17), the protective cover (17) covers the side of the battery compartment (16), and the base (15) is provided with a heat dissipation groove (18) on the side opposite to the protective cover (17).

5. The stem cell cryopreservation cooling device of claim 4, wherein: The inner wall of the protective cover (17) is fixedly connected with a guide rod (19), one end of the guide rod (19) is fixedly connected to the surface of the battery compartment (16) through a bolt, and the surface of the protective cover (17) is provided with a counterbore (20) communicated with the inside of the guide rod (19).

6. The stem cell cryopreservation cooling device of claim 5, wherein: The top of the shell (1) is fixedly installed with a connecting portion (21), the connecting portion (21) is provided as an external thread structure, the inner wall of the top cover (13) is provided as an internal thread structure, the top cover (13) is threadedly connected to the surface of the connecting portion (21), and the bottom of the top cover (13) abuts against the top of the shell (1).

7. The stem cell cryopreservation cooling device of claim 1, wherein: A plurality of the frames (2) are circularly arranged on the surface of the shell (1), and the frame (2) is used for placing a cryopreservation tube.

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