Eluting strip for improving cfDNA (cell-free deoxyribonucleic acid) obtaining rate

Abstract

The utility model discloses an elution strip capable of improving cfDNA acquisition rate, and relates to the technical field of elution strips, the elution strip comprises a four-edge baffle plate and a panel, the panel is fixedly arranged on the upper side of the four-edge baffle plate, a plurality of hole pipes are sequentially and fixedly arranged in the panel from left to right, a transverse plate is arranged on the upper side of the panel, and the transverse plate is arranged on the lower side of the panel. Through holes are formed in the positions, located on the upper sides of the multiple hole pipes, of the interior of the transverse plate, pipe covers are clamped into the multiple through holes, first limiting mechanisms for limiting the pipe covers to move relative to the transverse plate are arranged on the positions, located on one sides of the pipe covers, of the lower surface of the transverse plate, and fixing shells are fixedly arranged on the two sides of the upper surface of the panel; a sliding block is arranged in the fixing shell in a sliding mode, a connecting rod is fixedly arranged on the upper side of the sliding block, and the upper end of the connecting rod extends to the outer side of the fixing shell. According to the utility model, each tube cover can be independently opened and closed, so that sample pollution caused by long-time exposure of other hole tubes when a liquid sample is added can be effectively prevented.

Description

TECHNICAL FIELD

[0001] The utility model relates to elution strip technical field, concretely relates to a kind of elution strip of improving cfDNA acquisition rate. BACKGROUND

[0002] When DNA purification is carried out in DNA processing workstation, the DNA adsorbed by magnetic beads is desorbed in elution solution and DNA solution is stored in elution strip, and the use of elution strip can improve DNA acquisition rate, so the structure of elution strip must match the structure of workstation, and the reaction conditions of magnetic beads and DNA desorption can be met at the same time, to ensure that the workstation completes corresponding automatic operation.

[0003] Among them, the publication number CN209024509U discloses a kind of elution strip for full-automatic DNA extraction, including panel, four perimeter baffle, 8 circular hole tubes connected on panel and tube cover, in the technical scheme, there are still defects:

[0004] In the technical scheme, since multiple tube covers are designed as one body, when opening a certain tube cover, multiple tube covers must be opened at the same time, so it is easy to cause sample pollution due to long-time exposure of other hole tubes when adding liquid sample. UTILITY MODEL CONTENT

[0005] In view of the above problems existing in the prior art elution strip for full-automatic DNA extraction, the utility model is proposed.

[0006] Therefore, the utility model aims at providing a kind of elution strip of improving cfDNA acquisition rate, solve the problem that in the elution strip for full-automatic DNA extraction in prior art, since multiple tube covers are designed as one body, when opening a certain tube cover, multiple tube covers must be opened at the same time, so it is easy to cause sample pollution due to long-time exposure of other hole tubes when adding liquid sample.

[0007] In order to achieve the above purpose, the utility model provides the following technical scheme:

[0008] The utility model provides a kind of elution strip for improving cfDNA acquisition rate, including four-sided baffle and panel, the panel is fixedly arranged on the upper side of four-sided baffle, the inside of the panel is sequentially fixedly arranged with multiple hole tubes from left to right, the upper side of the panel is provided with horizontal plate, the inside of the horizontal plate and the upper side of multiple the hole tubes are all provided with through hole, the inside of multiple the through hole is all clamped with pipe cover, the lower surface of the horizontal plate and the side of the pipe cover are all provided with first limiting mechanism for limiting pipe cover relative to horizontal plate movement, the upper surface of the panel both sides is fixedly provided with fixed shell, the inside of the fixed shell is slidably provided with sliding block, the upper side of the sliding block is fixedly provided with connecting rod, the upper end of the connecting rod extends to the outside of fixed shell, the upper end of the connecting rod is fixedly connected with horizontal plate, the both ends of the sliding block are all provided with cavity, the inside of the cavity is provided with second limiting mechanism for limiting sliding block movement.

[0009] Preferably, the first limiting mechanism includes a threaded rod and a limiting tube, the limiting tube is fixedly arranged on one side of the lower end of the pipe cover, a fixed block is fixedly arranged on one side of the lower surface of the horizontal plate and located at the limiting tube, a threaded hole is formed in the inside of the fixed block, the threaded rod is threadedly sleeved in the inside of the threaded hole, and one end of the threaded rod is inserted into the corresponding limiting tube.

[0010] Preferably, the second limiting mechanism includes a stop block and a clamping block, the stop block is slidably arranged in the inside of the cavity, the clamping block is fixedly arranged on one side of the stop block, a through slot is formed in the side wall of the fixed shell and corresponds to the clamping block, and one end of the clamping block extends to the outside of the cavity and is clamped into the corresponding through slot.

[0011] Preferably, a spring is fixedly arranged on the side of the stop block away from the clamping block, and the other end of the spring is fixedly connected with the inner wall of the cavity.

[0012] Preferably, an inclined surface is formed on the lower side of one end of the outer side of the clamping block.

[0013] Preferably, the longitudinal section of the sliding block and the cavity is rectangular.

[0014] Preferably, the cross section of the sliding block and the fixed shell is rectangular.

[0015] Preferably, a knob is fixedly sleeved on the end of the threaded rod away from the limiting tube.

[0016] Preferably, a pull plate is fixedly arranged on the upper surface of the pipe cover.

[0017] Preferably, an avoiding slot is formed in the inner wall of the through hole and corresponds to the limiting tube.

[0018] In the above technical solution, the technical effect and advantages provided by the utility model are as follows:

[0019] 1. The utility model discloses, through the rotation screw rod, make the one end of screw rod from the spacing tube, that is, remove the spacing of the pipe cover, that is, can separate a certain pipe cover with the corresponding hole pipe alone, that is, can effectively prevent adding liquid sample, other hole pipe is exposed for a long time and causes sample pollution.

[0020] 2. The utility model discloses, through the push of a plurality of clamping blocks from the corresponding through slot, that is, remove the spacing of both sides sliding block, that is, can pull the sliding block upwards, and then make a plurality of pipe covers separate with the corresponding hole pipe simultaneously, convenient for taking out the sample in the hole pipe. BRIEF DESCRIPTION OF DRAWINGS

[0021] In order to make the technical personnel of the prior art or the technical solutions in the embodiments of the present application more clearly understood, the drawings needed to be used in the embodiments will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art according to these drawings.

[0022] Figure 1 A structure diagram of an elution strip for improving cfDNA acquisition rate is provided.

[0023] Figure 2 For Figure 1 The internal structure diagram of the utility model discloses a kind of hole pipe and pipe cover.

[0024] Figure 3 For Figure 2 The structure enlarged diagram of partial A part in the utility model discloses a kind of hole pipe and pipe cover.

[0025] Figure 4 For Figure 2 The structure enlarged diagram of partial B part in the utility model discloses a kind of hole pipe and pipe cover.

[0026] Figure 5 For Figure 1 The perspective view of movable plate in the utility model discloses a kind of hole pipe and pipe cover.

[0027] Mark explanation of drawing:

[0028] 1, four edge baffle; 2, panel; 3, hole pipe; 4, cross plate; 5, pipe cover; 6, fixed shell; 7, connecting rod; 8, sliding block; 9, stop block; 10, clamping block; 11, spring; 12, spacing tube; 13, screw rod; 14, fixed block. DETAILED DESCRIPTION

[0029] In order to make the technical personnel of the prior art or the technical solutions in the embodiments of the present application more clearly understood, the drawings needed to be used in the embodiments will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art according to these drawings.

[0030] The utility model discloses a kind of elution strips for improving cfDNA acquisition rate.

[0031] Embodiment one

[0032] With reference to Figures 1-5 , the elution strip for improving cfDNA acquisition rate comprises a four-edge baffle 1 and a panel 2 fixedly arranged on the upper side of the four-edge baffle 1, a plurality of hole tubes 3 are sequentially fixedly arranged in the panel 2 from left to right, a horizontal plate 4 is arranged on the upper side of the panel 2, a through hole is arranged in the inner part of the horizontal plate 4 and on the upper side of the plurality of hole tubes 3, a tube cover 5 is clamped in the plurality of through holes, a pull plate is fixedly arranged on the upper surface of the tube cover 5, the pull plate facilitates pulling the tube cover 5, a fixed shell 6 is fixedly arranged on both sides of the upper surface of the panel 2, a sliding block 8 is slidingly arranged in the inner part of the fixed shell 6, the cross sections of the sliding block 8 and the fixed shell 6 are both rectangular, so that the sliding block 8 cannot rotate, that is, it can stably slide, a connecting rod 7 is fixedly arranged on the upper side of the sliding block 8, the upper end of the connecting rod 7 extends to the outside of the fixed shell 6, the upper end of the connecting rod 7 is fixedly connected with the horizontal plate 4, and cavities are arranged on both ends of the sliding block 8.

[0033] Embodiment two

[0034] With reference to Figures 1-5 , the lower surface of the horizontal plate 4 and one side of the tube cover 5 are provided with first limiting mechanisms for limiting the movement of the tube cover 5 relative to the horizontal plate 4, the first limiting mechanisms comprise a threaded rod 13 and a limiting tube 12, the limiting tube 12 is fixedly arranged on one side of the lower end of the tube cover 5, a fixed block 14 is fixedly arranged on the lower surface of the horizontal plate 4 and on one side of the limiting tube 12, a threaded hole is arranged in the inner part of the fixed block 14, the threaded rod 13 is threadedly sleeved in the inner part of the threaded hole, one end of the threaded rod 13 is inserted into the corresponding limiting tube 12, a knob is fixedly sleeved with the end of the threaded rod 13 away from the limiting tube 12, the knob facilitates rotating the threaded rod 13, and an avoiding slot is arranged in the inner wall of the through hole and at the position corresponding to the limiting tube 12, so as to prevent the horizontal plate 4 from interfering with the limiting tube 12 as much as possible.

[0035] Embodiment three

[0036] With reference to Figures 1-5 , the inner part of the cavity is provided with a second limiting mechanism for limiting the movement of the sliding block 8, the second limiting mechanism comprises a stop block 9 and a clamping block 10, the stop block 9 is slidingly arranged in the inner part of the cavity, the clamping block 10 is fixedly arranged on one side of the stop block 9, a through slot is arranged in the side wall of the fixed shell 6 and at the position corresponding to the clamping block 10, one end of the clamping block 10 extends to the outside of the cavity and is clamped into the corresponding through slot, a spring 11 is fixedly arranged on the side of the stop block 9 away from the clamping block 10, the other end of the spring 11 is fixedly connected with the inner wall of the cavity, so as to facilitate the reset of the stop block 9, and an inclined surface is arranged on the lower side of the outer side end of the clamping block 10, so that the clamping block 10 can be automatically extruded into the cavity in the process of the sliding block 8 moving downward, the longitudinal section of the stop block 9 and the cavity are both rectangular, so that the stop block 9 cannot rotate, that is, it can stably slide.

[0037] In use, rotating the threaded rod 13 makes one end of the threaded rod 13 away from the limiting tube 12, that is, the limiting of the pipe cover 5 is cancelled, that is, one pipe cover 5 can be separated from the corresponding hole pipe 3, that is, when adding liquid sample, the sample pollution caused by long-time exposure of other hole pipes 3 can be effectively prevented, the multiple clamping blocks 10 are pushed away from the corresponding through grooves, that is, the limiting of the two side sliding blocks 8 is cancelled, that is, the sliding block 8 can be pulled upward, and then the multiple pipe covers 5 are simultaneously separated from the corresponding hole pipes 3, so that the sample in the hole pipe 3 can be taken out conveniently.

[0038] The above only describes some exemplary embodiments of the utility model by way of illustration, without doubt, for ordinary skilled person in the art, the described embodiments can be modified in various different ways without departing from the spirit and scope of the utility model. Therefore, the above drawings and description are illustrative in nature and should not be understood as limiting the scope of protection of the utility model claims.

Claims

1. An elution strip for improving cfDNA yield, comprising a four-sided baffle (1) and a faceplate (2), characterized in that, The panel (2) is fixedly arranged on the upper side of the four-edge baffle (1), a plurality of hole pipes (3) are sequentially fixedly arranged in the panel (2) from left to right, a horizontal plate (4) is arranged on the upper side of the panel (2), a plurality of through holes are arranged in the horizontal plate (4) and located on the upper side of the plurality of hole pipes (3), a pipe cover (5) is clamped in each of the plurality of through holes, a first limiting mechanism for limiting the movement of the pipe cover (5) relative to the horizontal plate (4) is arranged on the lower surface of the horizontal plate (4) and located on one side of the pipe cover (5), a fixed shell (6) is fixedly arranged on both sides of the upper surface of the panel (2), a sliding block (8) is slidably arranged in the fixed shell (6), a connecting rod (7) is fixedly arranged on the upper side of the sliding block (8), the upper end of the connecting rod (7) extends to the outside of the fixed shell (6), the upper end of the connecting rod (7) is fixedly connected with the horizontal plate (4), cavities are arranged in both ends of the sliding block (8), and a second limiting mechanism for limiting the movement of the sliding block (8) is arranged in the cavities.

2. The elution strip for improving cfDNA yield according to claim 1, wherein, The first limiting mechanism comprises a threaded rod (13) and a limiting tube (12), the limiting tube (12) is fixedly arranged on one side of the lower end of the pipe cover (5), a fixed block (14) is fixedly arranged on the lower surface of the horizontal plate (4) and located on one side of the limiting tube (12), a threaded hole is arranged in the fixed block (14), the threaded rod (13) is threadedly sleeved in the threaded hole, and one end of the threaded rod (13) is inserted into the corresponding limiting tube (12).

3. The elution strip for improving cfDNA yield of claim 1, wherein, The second limiting mechanism comprises a stop block (9) and a clamping block (10), the stop block (9) is slidably arranged in the cavity, the clamping block (10) is fixedly arranged on one side of the stop block (9), a through groove is arranged in the side wall of the fixed shell (6) and corresponds to the clamping block (10), and one end of the clamping block (10) extends to the outside of the cavity and is clamped in the corresponding through groove.

4. The elution strip for improving cfDNA yield of claim 3, wherein, A spring (11) is fixedly arranged on the side of the stop block (9) away from the clamping block (10), and the other end of the spring (11) is fixedly connected with the inner wall of the cavity.

5. The elution strip for improving cfDNA yield of claim 3, wherein, An inclined surface is arranged on the lower side of one end of the clamping block (10).

6. The elution strip for improving cfDNA yield of claim 3, wherein, The longitudinal section of the sliding block (8) and the cavity is rectangular.

7. The elution strip for improving cfDNA yield of claim 1, wherein, The cross section of the sliding block (8) and the fixed shell (6) is rectangular.

8. The elution strip for improving cfDNA yield of claim 2, wherein, A knob is fixedly sleeved on the end of the threaded rod (13) away from the limiting tube (12).

9. The elution strip for improving cfDNA yield of claim 1, wherein, A pull plate is fixedly arranged on the upper surface of the pipe cover (5).

10. The elution strip for improving cfDNA yield of claim 2, wherein, An avoiding groove is arranged in the inner wall of the through hole and corresponds to the limiting tube (12). An avoiding groove is arranged in the inner wall of the through hole and corresponds to the limiting tube (12).

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