Mixer capable of being used for preparing LNP in batches at high flow speed

Abstract

The utility model discloses a mixer capable of being used for preparing LNP in batch at high flow velocity, which comprises a mixing box, an oil phase adding pipe, a water phase adding pipe and three groups of guide pipes, the guide pipes are arranged in the oil phase adding pipe and the water phase adding pipe at equal intervals, the lower ends of the guide pipes are inserted into the mixing box, the lower end of the mixing box is fixedly connected with a conveying pipe, and the conveying pipe is communicated with the oil phase adding pipe and the water phase adding pipe. The lower end of the conveying pipe is connected with the static mixer, the cover plate is arranged at the upper end of the mixing box in a clamping mode, and the connecting mechanism is composed of a connecting plate, a connecting block, a fixing plate and a fixing bolt. According to the mixer capable of being used for preparing LNP in batches at a high flow rate, the flow rate is increased by increasing the number of guide pipes in the oil phase adding pipe and the water phase adding pipe, the pore sizes in the guide pipes, the relative angle of the two-phase guide pipes and the liquid outlet distance, two-phase solutions are collected into the conveying pipe through the mixing box after being subjected to liquid outlet impact, then enter the static mixer and are mixed again, and the liquid outlet speed is increased. Therefore, speed and efficiency are improved, and preparation amount is increased.

Description

Technical Field

[0001] This utility model relates to the technical field of LNP mixers, specifically a mixer that can be used for high-flow-rate batch preparation of LNPs. Background Technology

[0002] LNP refers to lipid nanoparticles, and an LNP mixer is a device used to prepare lipid nanoparticles. By using jet mixing mode to fully mix the various components of LNP, LNP products with controllable particle size and narrow particle size distribution can be prepared efficiently and stably.

[0003] However, traditional LNP mixers only have one pair of conduits, resulting in lower preparation speed and efficiency, and smaller preparation volumes. Large-scale preparation relies on multiple pump systems and mixers operating in parallel. This leads to sub-batch production, increased risks due to the large number of pumps and mixers, more control points, and the need for more comprehensive quality control. Furthermore, it is inconvenient to thoroughly clean the interior of the equipment after use, as residues are easily left behind.

[0004] To address these issues, we propose a mixer for high-flow-rate batch preparation of LNPs. Utility Model Content

[0005] The purpose of this invention is to provide a mixer that can be used for high-flow-rate batch preparation of LNPs, in order to solve the problems mentioned in the background art. Traditional LNP mixers only have a pair of conduits, resulting in low preparation speed and efficiency, small preparation volume, and the need to rely on multiple sets of equipment and mixers in parallel to achieve large-scale LNP preparation. Furthermore, it is inconvenient to thoroughly clean the inside of the equipment after use, and residues are easily left behind.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a mixer that can be used for high-flow-rate batch preparation of LNP, comprising a mixing tank, an oil phase addition tube, and an aqueous phase addition tube;

[0007] Also includes:

[0008] Three sets of conduits are arranged at equal intervals in both the oil phase addition pipe and the water phase addition pipe, and the lower ends of the conduits are inserted into the mixing box. The conduits are also inclined in both the oil phase addition pipe and the water phase addition pipe.

[0009] The lower end of the mixing box is fixedly connected to a conveying pipe, and the lower end of the conveying pipe is connected to a static mixer.

[0010] A cover plate is snapped onto the upper end of the mixing tank, and connecting mechanisms are provided on both the front and rear sides of the cover plate.

[0011] The connecting mechanism consists of a connecting plate, a connecting block, a fixing plate, and a fixing bolt.

[0012] Preferably, an oil phase addition pipe is fixedly connected to the left end of the mixing tank, and an aqueous phase addition pipe is fixedly connected to the right end of the mixing tank.

[0013] Preferably, a sealing ring is fitted between the cover plate and the mixing box.

[0014] Preferably, the front and rear sides of the cover plate are fixedly connected to connecting plates, and the middle part of the connecting plate is connected to the connecting block through a slot, and the connecting plate and the connecting block form an up-and-down sliding structure.

[0015] Preferably, a fixing plate is fixedly connected to the side of the upper end of the connecting plate, and a fixing bolt for positioning is threadedly connected to the middle of the fixing plate.

[0016] Preferably, the fixing bolt is inserted into the middle of the connecting block on the side near the mixing box.

[0017] Compared with the prior art, the beneficial effects of this utility model are: This mixer, which can be used for high-flow-rate batch preparation of LNP, increases the flow rate by increasing the number of conduits in the oil phase addition pipe and the water phase addition pipe, as well as by increasing the number of conduits, the size of the internal pores of the conduits, the relative angle between the two phase conduits, and the liquid outlet distance. After liquid outlet, it flows through the mixing box into the delivery pipe and then into the static mixer for further mixing, thereby improving speed and efficiency and increasing the preparation volume. Moreover, after use, the cover plate can be disassembled from the mixing box, which facilitates thorough cleaning of the inside of the mixing box and prevents residue.

[0018] 1. It is equipped with an oil phase addition pipe, a water phase addition pipe and conduits. Both the oil phase addition pipe and the water phase addition pipe are equipped with three sets of conduits. The conduits can increase the flow rate.

[0019] 2. It is equipped with a delivery pipe and a static mixer. After the liquid exits from the conduit, it enters the delivery pipe and then enters the static mixer for mixing again, which improves the speed and efficiency and increases the preparation volume.

[0020] 3. It is equipped with a cover plate and a connecting mechanism. The connecting mechanism releases the limit between the cover plate and the mixing box, and the cover plate is moved away from the top of the mixing box, which facilitates the thorough cleaning of the inside of the mixing box and prevents residue. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0022] Figure 2 This is a frontal sectional view of the present invention.

[0023] Figure 3 This is an exploded structural diagram of the aqueous phase addition pipe and conduit of this utility model;

[0024] Figure 4 This is a schematic diagram of the cover plate and mixing box in the open state of this utility model;

[0025] Figure 5 This utility model Figure 1 Enlarged structural diagram at point A in the middle;

[0026] Figure 6 This is an exploded structural diagram of the connecting plate, connecting block, fixing plate, and fixing bolt of this utility model.

[0027] In the diagram: 1. Mixing tank; 2. Oil phase addition pipe; 3. Water phase addition pipe; 4. Conduit; 5. Delivery pipe; 6. Static mixer; 7. Cover plate; 8. Sealing ring; 9. Connecting mechanism; 10. Connecting plate; 11. Connecting block; 12. Fixing plate; 13. Fixing bolt. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0029] Please see Figures 1-6 The present invention provides the following technical solution.

[0030] Example 1: To address the problems of traditional LNP mixers in the prior art having only one pair of conduits 4, resulting in low preparation speed and efficiency, and small preparation volume, this example provides a mixer for high-flow-rate batch preparation of LNPs. The mixer comprises a mixing chamber 1, an oil phase addition pipe 2, an aqueous phase addition pipe 3, and conduits 4. The left end of the mixing chamber 1 is fixedly connected to the oil phase addition pipe 2, and the right end is fixedly connected to the aqueous phase addition pipe 3. The conduits 4 are arranged at equal intervals in both the oil phase addition pipe 2 and the aqueous phase addition pipe 3, and are inclined in both pipes. The lower end of the conduits 4 is inserted into the mixing chamber 1. Figure 1 , Figure 2 and Figure 3 As shown, the oil phase is added through the oil phase addition pipe 2, and the water phase is added through the water phase addition pipe 3. Multiple sets of conduits 4 are installed in both the oil phase addition pipe 2 and the water phase addition pipe 3 to increase the flow rate. The oil phase and the water phase are added to the mixing tank 1 through the conduits 4 for mixing.

[0031] Example 2: To address the problems existing in the prior art, this example provides the following technical solution: a mixer for high-flow-rate batch preparation of LNPs, comprising a delivery pipe 5 and a static mixer 6. The lower end of the mixing tank 1 is fixedly connected to the delivery pipe 5, and the lower end of the delivery pipe 5 is connected to the static mixer 6. Figure 1 and Figure 2 As shown, the oil phase and water phase are mixed in the mixing tank 1 and then enter the delivery pipe 5, and then enter the static mixer 6 for further mixing, thereby improving the speed and efficiency and increasing the preparation volume.

[0032] Example 3: To address the problem in existing technologies where thorough cleaning of the equipment's interior is inconvenient after use and residues are easily left behind, this example provides a mixer for high-flow-rate batch production of LNP, comprising a cover plate 7, a sealing ring 8, and a connecting mechanism 9. The cover plate 7 is snapped onto the upper end of the mixing chamber 1, and connecting mechanisms 9 are provided on both the front and rear sides of the cover plate 7. Each connecting mechanism 9 consists of a connecting plate 10, a connecting block 11, a fixing plate 12, and a fixing bolt 13. A sealing ring 8 is fitted between the cover plate 7 and the mixing chamber 1. Connecting plates 10 are fixedly connected to both the front and rear sides of the cover plate 7, and the middle of the connecting plate 10 is slotted into the connecting block 11, forming a sliding structure between the connecting plate 10 and the connecting block 11. A fixing plate 12 is fixedly connected to the upper side of the connecting plate 10, and a fixing bolt 13 for positioning is threaded into the middle of the fixing plate 12. The fixing bolt 13, near the mixing chamber 1, is inserted into the middle of the connecting block 11. Figure 1 , Figure 4 , Figure 5 and Figure 6 As shown, after use, by rotating the fixing bolt 13 threaded to the middle of the fixing plate 12, the fixing bolt 13 is removed from the connecting block 11, thereby loosening the limiting position between the connecting plate 10 and the connecting block 11. Then, the cover plate 7 is pulled upward, causing the connecting plate 10 and the connecting block 11 to slide together. The cover plate 7 separates upward from the mixing box 1. Then, the cover plate 7 is flipped and moved at a certain angle, causing the lower end of the connecting plate 10 to rotate at a certain angle with the connecting block 11, as shown in the figure. Figure 4 The state shown facilitates thorough cleaning of the interior of mixing chamber 1, preventing residue.

[0033] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A mixer for high-flow-rate batch preparation of LNP, comprising a mixing chamber (1), an oil phase addition tube (2), and an aqueous phase addition tube (3); Its features are, Also includes: Three sets of conduits (4), the conduits (4) are arranged at equal intervals in the oil phase addition pipe (2) and the water phase addition pipe (3), and the lower end of the conduits (4) is inserted into the mixing box (1). The conduits (4) are inclined in both the oil phase addition pipe (2) and the water phase addition pipe (3). The lower end of the mixing box (1) is fixedly connected to a conveying pipe (5), and the lower end of the conveying pipe (5) is connected to a static mixer (6). Cover plate (7), which is snapped onto the upper end of the mixing box (1), and connecting mechanisms (9) are provided on both the front and rear sides of the cover plate (7); The connecting mechanism (9) consists of a connecting plate (10), a connecting block (11), a fixing plate (12), and a fixing bolt (13).

2. A mixer according to claim 1, which can be used for high-flow-rate batch preparation of LNPs, characterized in that: An oil phase addition pipe (2) is fixedly connected to the left end of the mixing tank (1), and an aqueous phase addition pipe (3) is fixedly connected to the right end of the mixing tank (1).

3. A mixer according to claim 1, which can be used for high-flow-rate batch preparation of LNPs, characterized in that: A sealing ring (8) is fitted between the cover plate (7) and the mixing box (1).

4. A mixer according to claim 3, which can be used for high-flow-rate batch preparation of LNPs, characterized in that: The front and rear sides of the cover plate (7) are fixedly connected with connecting plates (10), and the middle part of the connecting plate (10) is connected to the connecting block (11) by a slot. The connecting plate (10) and the connecting block (11) form an up-and-down sliding structure.

5. A mixer according to claim 4, which can be used for high-flow-rate batch preparation of LNPs, characterized in that: A fixing plate (12) is fixedly connected to the side of the upper end of the connecting plate (10), and a fixing bolt (13) for positioning is threadedly connected to the middle of the fixing plate (12).

6. A mixer according to claim 5, which can be used for high-flow-rate batch preparation of LNPs, characterized in that: The fixing bolt (13) is inserted into the middle of the connecting block (11) on the side near the mixing box (1).

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