Preparation device of platelet-rich plasma suspension containing blood cells and gel

Abstract

The utility model discloses a device for preparing platelet-rich plasma suspension and gel containing blood cells. Comprising a fixing frame, at least one rapid clamping pipe clamp installed on the fixing frame, a vacuum centrifugal pipe clamped in the rapid clamping pipe clamp, and two suction devices capable of being inserted into the centrifugal pipe from the top or the bottom of the centrifugal pipe. The pusher is used for pushing the aspirator to be inserted into the centrifugal tube; the rotating mechanism is used for driving the pusher to rotate so as to enable the aspirator to face the top or the bottom of the centrifugal tube; the utility model solves the problems of blood pollution, manual operation error and low extraction rate in the manual operation process in the prior art, retains all blood platelets and white blood cells in the blood, retains red blood cells in normal proportion and most plasma proteins, and improves the extraction efficiency. Moreover, the concentration of platelets and leukocytes is constantly about 4 times of the concentration of blood of common normal people, the functions of erythrocyte components are reserved, and the functional effects of various components in the blood can be better exerted.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a device for preparing a suspension and gel of blood cell-rich platelet-rich plasma. Background Technology

[0002] Platelet-rich plasma (PRP) is produced by separating platelets from blood and concentrating them in plasma using density gradient centrifugation, based on the different sedimentation coefficients of various blood components. This concentrated platelet-rich plasma is then injected directly into the lesion site to produce a therapeutic effect. Currently, there are two methods for preparing PRP: one involves centrifuging blood to separate the blood layers, manually extracting platelets and a portion of the plasma, and then mixing them to form concentrated platelet-rich plasma. The other method involves adding blood to a centrifuge tube containing a separating gel and centrifuging again to separate the platelet-rich plasma layer from the red blood cells. A portion of the upper plasma layer is then extracted and discarded, yielding a mixture of the lower plasma and platelets. Regardless of the method, the final PRP product is a concentrated platelet concentration, discarding red blood cells and / or white blood cells. However, this method suffers from problems such as low platelet extraction rate, uncontrollable concentration, poor homogeneity, and waste of platelets, red blood cells, and / or white blood cell functional components. Utility Model Content

[0003] The main purpose of this invention is to solve the above-mentioned problems and provide an apparatus for preparing blood cell-containing platelet-rich plasma suspension and gel.

[0004] The technical solution of this utility model is as follows:

[0005] An apparatus for preparing a blood cell-containing platelet-rich plasma suspension and gel includes a frame, at least one quick-clamping tube clamp mounted on the frame, a vacuum centrifuge tube clamped in the quick-clamping tube clamp, two aspirators that can be inserted into the centrifuge tube from the top or bottom, a pusher for pushing the aspirators into the centrifuge tube, and a rotating mechanism for rotating the pusher so that the aspirators face the top or bottom of the centrifuge tube. The aspirators are mounted on the pushers, enabling the pushers to move the aspirators toward the centrifuge tube, and the rotating mechanism to rotate the pushers from above the centrifuge tube to below the centrifuge tube.

[0006] The vacuum centrifuge tube includes a tube body and caps screwed to both ends of the tube body. The caps include threaded sleeves and rubber plugs disposed inside the threaded sleeves.

[0007] The rotating mechanism includes a base frame, two hollow rings rotatably mounted on the base frame via rollers, a gear ring fixed to one of the hollow rings, two connecting plates symmetrically connected between the two hollow rings, a drive gear meshing with the gear ring, and a rotating motor whose motor shaft is fixed to the drive gear.

[0008] The pusher includes a push cylinder, a movable plate, and four guide pillars. The movable plate is inserted through the hollow positions of the two hollow rings. The push cylinder is mounted on the connecting plate and its lifting head rod is connected to the movable plate. The four guide pillars are fixed on the movable plate and pass through the connecting plate.

[0009] The suction device is fixed on the movable plate. The suction device includes an electric lifting body and a disposable syringe. The electric lifting body includes a guide tube, a lifting head inserted inside the guide tube, a screw fixed to the lifting head, a threaded tube with one end screwed to the screw, a lifting motor with a motor shaft fixed to the other end of the threaded tube, and a receiving plate for fixing the guide tube and the lifting motor. The guide tube is provided with a retaining ring for fixing the syringe barrel of the disposable syringe, and the lifting head is provided with a retaining groove for the top of the syringe rod to be inserted.

[0010] The end of the guide tube is provided with a connector for inserting the disposable syringe.

[0011] The suction device is mounted on the movable plate via an electric slide, and the movable plate is mounted on the slider of the electric slide.

[0012] The beneficial effects of this utility model are as follows: This utility model solves the problems of blood contamination, human error and low extraction rate that are easily caused by manual operation in the prior art. It retains all platelets and white blood cells in the blood (extraction rate close to 100%), retains the normal proportion of red blood cells and most plasma proteins, and the concentration of platelets and white blood cells is constant at about 4 times the concentration in normal human blood. It retains the function of red blood cell components and can better exert the functional effects of various components in the blood. Attached Figure Description

[0013] Figure 1 This is a perspective view of the present invention.

[0014] Figure 2 This is the front view of the present invention.

[0015] Figure 3 This is a schematic diagram of the centrifuge tube of this utility model.

[0016] Figure 4 for Figure 3 A cross-sectional schematic diagram of AA.

[0017] Figure 5 This is a cross-sectional structural diagram of the suction device of this utility model. Detailed Implementation

[0018] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. Preferred embodiments of this utility model are shown in the drawings. However, this utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and complete understanding of the disclosure of this utility model.

[0019] It should be noted that when a component is said to be "fixed to" another component, it can be directly attached to the other component or there may be an intervening component. When a component is said to be "connected to" another component, it can be directly connected to the other component or there may be an intervening component. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0020] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0021] Please refer to Figures 1 to 5This invention provides a preferred embodiment of an apparatus for preparing a blood cell-containing platelet-rich plasma suspension and gel, comprising a fixing frame 10, at least one quick-clamping tube clamp 20 mounted on the fixing frame 10, a vacuum centrifuge tube 30 clamped within the quick-clamping tube clamp 20, two aspirators 40 that can be inserted into the centrifuge tube 30 from the top or bottom, a pusher 50 for pushing the aspirators 40 into the centrifuge tube 30, and a rotating mechanism 60 for rotating the pusher 50 so that the aspirators 40 face the top or bottom of the centrifuge tube 30. The aspirators 40 are mounted on the pusher 50, enabling the pusher 50 to move the aspirators 40 toward the centrifuge tube 30, and the rotating mechanism 60 to rotate the pusher 50 from above the centrifuge tube 30 to below the vacuum centrifuge tube 30. In practical use, the vacuum centrifuge tube 30 is used to hold fresh blood and can be placed in a medical centrifuge for centrifugation. Specifically, the extracted fresh blood is placed into the vacuum centrifuge tube 30, and then the centrifuge tube 30 is placed in a medical centrifuge for centrifugation at a speed of 3600 rpm for 10 minutes. The resulting blood separates into three layers (upper layer is plasma, middle layer is platelets and white blood cells, and lower layer is red blood cells). Then, the centrifuge tube 30 is placed in the quick-clamping tube clamp 20, which clamps the centrifuge tube 30, keeping it in an upright position. The centrifuge tube 10 is shaken, and a suction device is inserted from the top of the centrifuge tube 30 via the pusher 50 to first extract 8 / 11 of the upper plasma layer. Then, the rotating mechanism 60 drives the pusher 50 and the suction device 40 to rotate to the bottom of the centrifuge tube 10. The pusher 50 then pushes the same suction device or another suction device to be inserted from the bottom of the centrifuge tube to extract 2 / 3 of the lower red blood cells. The remaining blood components mixture (all platelets, all white blood cells, all plasma proteins, and a small portion of red blood cells) yields a new whole blood component product called platelet-rich plasma suspension. Finally, other suction devices can be used to add coagulants or other drugs to the suspension to transform it into platelet-rich plasma gel and other complexes.

[0022] In this embodiment, as Figure 2As shown, the rotating mechanism 60 includes a base frame 61, two hollow rings 62 rotatably mounted on the base frame 61 via rollers, a gear ring 63 fixed to one of the hollow rings 62, two connecting plates 64 symmetrically connected between the two hollow rings 62, a drive gear 65 meshing with the gear ring 63, and a rotary motor 66 with its motor shaft fixed to the drive gear 65. When the rotary motor 66 operates, it drives the drive gear 65 to rotate, thereby driving the gear ring 63 to rotate. The gear ring 63 then drives the hollow ring 62 fixed to it to rotate. Since the two hollow rings 62 are connected together by the connecting plate 64, the other hollow ring 62 also rotates.

[0023] In this embodiment, as Figure 2 As shown, the pusher 50 includes a push cylinder 51, a movable plate 52, and four guide pillars 53. The movable plate 52 is inserted through the hollow positions of the two hollow rings 62. The push cylinder 51 is mounted on the connecting plate 64 and its lifting head rod is connected to the movable plate 52. The four guide pillars 53 are fixed on the movable plate 52 and pass through the connecting plate 64, so that the push cylinder 51 pushes the movable plate 52 to move.

[0024] In this embodiment, as Figure 5 As shown, the suction device 40 is fixed on the movable plate 52. The suction device 40 includes an electric lifting body 41 and a disposable syringe 42. It is worth mentioning that the disposable syringe 42 is a commonly available disposable medical sterile injection molding machine.

[0025] The electric lifting body 41 includes a guide tube 411, a lifting head 412 filled inside the guide tube 411, a screw 413 fixed to the lifting head 412, a threaded tube 414 with one end screwed to the screw 413, a lifting motor 415 with the motor shaft fixed to the other end of the threaded tube 414, and a receiving plate 416 for fixing the guide tube 411 and the lifting motor 415. The guide tube 411 is provided with a retaining ring 417 for fixing the syringe barrel 421 of the disposable syringe 42. The lifting head 412 is provided with a retaining groove 418 for the top of the core rod 422 of the disposable syringe to be inserted. When the lifting motor 415 is working, it drives the threaded tube 414 to rotate. Since the outer surface of the lifting head 412 is in close contact with the inside of the guide tube 411, the screw 413 can be screwed into the inside of the threaded tube 414, so as to achieve the effect of driving the lifting head 412 to move on the inner wall of the guide tube 411. When the top of the core rod 422 of the disposable syringe 42 is inserted into the slot 418, the movement of the lifting head 412 can drive the core rod 422 to move. After the disposable syringe 42 draws out the relevant liquid (plasma, red blood cells), the disposable syringe 42 can be removed and discarded.

[0026] In this embodiment, in order to allow any selectable aspirator to extract blood from the centrifuge tube, the aspirator 40 is mounted on the movable plate 52 via an electric slide 70. The movable plate 52 is mounted on the slider of the electric slide 70, so that the aspirator 40 can be moved laterally by the electric slide 70. It is worth mentioning that the electric slide 70 and the quick-clamping tube clamp 20 are commonly used accessories in the mechanical field, and their specific structures will not be described here.

[0027] In this embodiment, as Figure 3 , Figure 4 As shown, the vacuum centrifuge tube 30 includes a tube body 31 and caps 32 respectively screwed to both ends of the tube body 31. The caps 32 include a threaded sleeve 321 and a rubber plug 322 disposed inside the threaded sleeve 321. The function of the rubber plug is to allow the needle of the aspirator to be inserted.

[0028] The present invention aims to solve the problems of blood contamination and human error that are easily caused by manual operation in the prior art. It retains all platelets and white blood cells in the blood (with an extraction rate of nearly 100%), retains a normal proportion of red blood cells and most plasma proteins, and the concentration of platelets and white blood cells is kept constant at about 4 times the concentration in the blood of normal people. It also retains the function of red blood cell components and can better exert the functional effects of various components in the blood.

[0029] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the description and drawings of this utility model, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. An apparatus for preparing a suspension and gel of blood cell- and platelet-rich plasma, characterized in that: The device includes a mounting frame, at least one quick-clamping tube clamp mounted on the mounting frame, a vacuum centrifuge tube clamped within the quick-clamping tube clamp, two aspirators that can be inserted into the centrifuge tube from the top or bottom, a pusher for pushing the aspirators into the centrifuge tube, and a rotating mechanism for rotating the pushers to face the top or bottom of the centrifuge tube. The aspirators are mounted on the pushers, enabling the pushers to move the aspirators toward the centrifuge tube, and the rotating mechanism to rotate the pushers from above the centrifuge tube to below the centrifuge tube.

2. The apparatus for preparing a blood cell- and platelet-rich plasma suspension and gel as described in claim 1, characterized in that, The vacuum centrifuge tube includes a tube body and caps screwed to both ends of the tube body. The caps include threaded sleeves and rubber plugs disposed inside the threaded sleeves.

3. The apparatus for preparing a blood cell- and platelet-rich plasma suspension and gel as described in claim 2, characterized in that, The rotating mechanism includes a base frame, two hollow rings rotatably mounted on the base frame via rollers, a gear ring fixed to one of the hollow rings, two connecting plates symmetrically connected between the two hollow rings, a drive gear meshing with the gear ring, and a rotating motor whose motor shaft is fixed to the drive gear.

4. The apparatus for preparing a blood cell- and platelet-rich plasma suspension and gel as described in claim 3, characterized in that, The pusher includes a push cylinder, a movable plate, and four guide pillars. The movable plate is inserted through the hollow positions of the two hollow rings. The push cylinder is mounted on the connecting plate and its lifting head rod is connected to the movable plate. The four guide pillars are fixed on the movable plate and pass through the connecting plate.

5. The apparatus for preparing a blood cell-containing platelet-rich plasma suspension and gel as described in claim 4, characterized in that, The suction device is fixed on the movable plate. The suction device includes an electric lifting body and a disposable syringe. The electric lifting body includes a guide tube, a lifting head inserted inside the guide tube, a screw fixed to the lifting head, a threaded tube with one end screwed to the screw, a lifting motor with a motor shaft fixed to the other end of the threaded tube, and a receiving plate for fixing the guide tube and the lifting motor. The guide tube is provided with a retaining ring for fixing the syringe barrel of the disposable syringe, and the lifting head is provided with a retaining groove for the top of the syringe rod to be inserted.

6. The apparatus for preparing a blood cell-containing platelet-rich plasma suspension and gel as described in claim 5, characterized in that, The suction device is mounted on the movable plate via an electric slide, and the movable plate is mounted on the slider of the electric slide.

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