Bioreactor for cell culture

Abstract

The utility model discloses a bioreactor for cell culture, and relates to the technical field of bioreactors, the bioreactor for cell culture comprises a support frame, the main body of the support frame is of an L-shaped structure, and the bioreactor is provided with a guide block fixedly connected to the bottom end surface of the support frame, through the arrangement of the guide block and the guide teeth, when the bracket is mounted on the guide seat, the guide block can be inserted into the inner position of the guide groove formed in the guide seat, the motor drives the gear to rotate, and the current culture dish can be quickly shaken through meshing transmission between the gear and the guide teeth; by arranging the mounting seat, the clamping push rod and the moving seat, when culture dishes of different specifications are clamped and positioned, the moving seat can be pushed towards the inner side by starting the clamping push rod mounted in the mounting plate; and rapid assembly is realized by clamping and limiting the culture dishes through the clamping plates fixedly connected to the inner sides of the moving seats.

Description

Technical Field

[0001] This utility model relates to the field of bioreactor technology, specifically a bioreactor for cell culture. Background Technology

[0002] Cell culture refers to a method of enabling organisms to survive, grow, reproduce, and maintain their main structures and functions by simulating the in vivo environment (sterility, suitable temperature, pH, and certain nutritional conditions, etc.) outside the body. Cell culture is also called cell cloning technology, and the formal term in biology is cell culture technique. Whether for bioengineering as a whole or for biological cloning technology, cell culture is an indispensable process; cell culture itself is the large-scale cloning of cells. Cell culture technology can cultivate a single cell into a large number of simple single cells or minimally differentiated multicellular organisms. This is an essential step in cloning technology, and cell culture itself is the cloning of cells. Cell culture technology is an important and commonly used technique in cell biology research. It allows for the acquisition of large quantities of cells and the study of cell signal transduction, anabolism, growth, and proliferation. A current patent (CN220812476U) describes a cell culture shaker for use in a bioreactor. It includes a bioreactor chamber, a shaking mechanism inside the chamber, a culture plate on top of the shaking mechanism, several placement slots on the top of the culture plate, culture dishes placed inside the placement slots, a clamping assembly between the placement slots and the culture dishes for holding and fixing them, and a temperature control component inside the culture plate for regulating the ambient temperature during cell culture. This cell culture shaker for a bioreactor uses the clamping assembly to hold and fix the culture dishes, preventing collisions and accidental damage due to shaking, thus improving the protection of the culture dishes. The temperature control component allows for adjustment of the ambient temperature during cell culture, improving the success rate of cell culture.

[0003] Regarding the aforementioned technologies, the inventors believe that the following defects exist: although the temperature can be controlled during use, the lack of an effective uniform shaking structure results in poor shaking effect when shaking in a plane, making it impossible to achieve rapid mixing of cultured cells and solutions. Therefore, we propose a bioreactor for cell culture to solve the above-mentioned problems. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a bioreactor for cell culture, which solves the problem that existing bioreactors, due to the lack of an effective uniform shaking structure, have poor shaking effect when performing in-plane shaking, and cannot achieve rapid mixing of cultured cells and solutions.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a bioreactor for cell culture, comprising a support frame, the main body of which is an L-shaped structure, and two support frames are provided, which are arranged opposite to each other. Mounting plates are fixedly connected to the outer sides of both support frames, and the mounting plates are perpendicular to the support frames. The mounting plates and support frames together form a support structure, and the mounting plates have through holes inside, which are mounting holes. These mounting holes and the mounting plates together form a connection and support structure for the support frame.

[0006] Preferably, the inner side of the support frame is fixedly connected to a bracket, and the main body of the bracket is arranged horizontally. There are two brackets in total, and the two brackets are fixedly connected in a straight line array to the front and rear sides of the two support frames. A motor is installed at the front end of the bracket, and an output shaft is provided at the rear side of the motor.

[0007] Preferably, a gear is installed on the output shaft at the rear of the motor, and the gear and the motor together form a power output structure. Guide seats are also fixedly connected to the inner sides of the two support frames, and the main body of the guide seat is an arc-shaped structure with an arc-shaped groove inside.

[0008] Preferably, the arc-shaped groove inside the guide seat is a guide groove, and the guide groove and the guide seat together form a guide structure. A bracket is placed above the guide seat, and the main body of the bracket is an arc-shaped structure. A guide block is fixedly connected to the bottom surface of the bracket, and the main body of the guide block is an arc-shaped structure.

[0009] Preferably, the bottom end face of the guide block is fixedly connected with guide teeth in an arc-shaped array, and the guide teeth mesh with the gear set on the output shaft of the motor for transmission, and the inner side of the bracket is also fixedly connected with a mounting plate.

[0010] Preferably, the main body of the mounting plate is arranged horizontally, and there are two mounting plates. The two mounting plates are fixedly connected to the left and right sides inside the bracket, and both mounting plates have a horizontal groove inside, in which a clamping push rod is installed.

[0011] Preferably, a movable seat is also installed on the inner side of the clamping push rod, and two locking blocks are fixedly connected to the outer side of the movable seat in opposite directions. A clamping plate is fixedly connected to the side of the movable seat away from the clamping push rod, and a culture dish is clamped and limited on the inner side of the clamping plate.

[0012] Beneficial effects

[0013] This invention provides a bioreactor for cell culture. Compared with the prior art, it has the following advantages:

[0014] This bioreactor for cell culture has a guide block fixedly connected to the bottom surface of the bracket. When the bracket is installed on the guide seat, the guide block can be inserted into the guide groove in the guide seat. Driven by the rotation of the gear by the motor, the meshing transmission between the gear and the guide tooth enables the rapid shaking of the culture dish.

[0015] This bioreactor for cell culture is equipped with a mounting base, a clamping push rod, and a movable seat. When clamping and positioning culture dishes of different sizes, the movable seat can be pushed inward by activating the clamping push rod installed in the mounting plate. The clamping plate fixedly connected to the inside of the movable seat is used to clamp and limit the culture dish, thus achieving rapid assembly and making it more practical. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the disassembled front view of the bioreactor of this utility model;

[0017] Figure 2 This is a schematic diagram of the combined structure of the bioreactor of this utility model;

[0018] Figure 3 This is a top view of the bioreactor of this invention.

[0019] Figure 4 This is a front view schematic diagram of the bioreactor of this utility model;

[0020] Figure 5 This is a schematic diagram of the combined structure of the support frame and guide block of the bioreactor of this utility model;

[0021] Figure 6 This is a schematic diagram of the left-hand structure of the bioreactor of this utility model.

[0022] In the diagram: 1. Support frame; 101. Mounting platform; 102. Mounting hole; 2. Bracket; 201. Motor; 202. Gear; 203. Guide seat; 204. Guide groove; 3. Bracket; 301. Guide block; 302. Guide tooth; 303. Mounting plate; 304. Clamping push rod; 305. Moving seat; 306. Locking block; 307. Clamping plate; 308. Petri dish. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figures 1-6 This utility model provides a technical solution: a bioreactor for cell culture, including a support frame 1. The main body of the support frame 1 is L-shaped, and there are two support frames 1. The two support frames 1 are arranged opposite each other, and an mounting platform 101 is fixedly connected to the outer side of each support frame 1. The mounting platform 101 is perpendicular to the support frame 1, and the mounting platform 101 and the support frame 1 together form a support structure. The mounting platform 101 has a through hole inside, which is a mounting hole 102. The mounting hole 102 and the mounting platform 101 together form a connection support structure for the support frame 1.

[0025] By fixing a mounting platform 101 to the outside of the support frame 1, it is possible to perform a replication support operation on the support frame 1 during use.

[0026] See Figure 2 , Figure 3 The support frame 1 is fixedly connected to the inner side of the bracket 2, and the main body of the bracket 2 is arranged horizontally. There are two brackets 2, and the two brackets 2 are fixedly connected in a straight line array to the front and rear sides of the two support frames 1. The front end of the bracket 2 is equipped with a motor 201, and the rear side of the motor 201 is equipped with an output shaft.

[0027] By installing a motor 201 at the front end of the bracket 2, a stable power output can be provided during use.

[0028] See Figure 1 , Figure 4 A gear 202 is installed on the output shaft at the rear of the motor 201, and the gear 202 and the motor 201 together form a power output structure. A guide seat 203 is also fixedly connected to the inner side of the two support frames 1. The main body of the guide seat 203 is an arc-shaped structure, and an arc-shaped groove is opened inside the guide seat 203.

[0029] By mounting a gear 202 on the rear output shaft of the motor 201, the motor 201 can be used to drive the gear 202 to rotate during operation.

[0030] See Figure 3 , Figure 5The arc-shaped groove inside the guide seat 203 is the guide groove 204, and the guide groove 204 and the guide seat 203 together form a guide structure. A bracket 3 is placed on top of the guide seat 203, and the main body of the bracket 3 is an arc-shaped structure. A guide block 301 is fixedly connected to the bottom surface of the bracket 3, and the main body of the guide block 301 is an arc-shaped structure.

[0031] By fixing a guide block 301 to the bottom surface of the bracket 3, the bracket 3 can be guided by the guide block 301 when it moves.

[0032] See Figure 1 , Figure 2 The bottom end face of the guide block 301 is fixedly connected with guide teeth 302 in an arc array, and the guide teeth 302 mesh with the gear 202 set on the output shaft of the motor 201. The inner side of the bracket 3 is also fixedly connected with a mounting plate 303.

[0033] By fixing a mounting plate 303 to the inside of the bracket 3, the clamping push rod 304 can be guided and installed during use.

[0034] See Figure 4 , Figure 6 The main body of the mounting plate 303 is horizontally arranged, and there are two mounting plates 303. The two mounting plates 303 are fixedly connected to the left and right sides inside the bracket 3 in opposite directions. The interior of the two mounting plates 303 is provided with a horizontal groove, and a clamping push rod 304 is installed inside the horizontal groove.

[0035] By providing a clamping push rod 304 on the inner side of the mounting plate 303, the movable seat 305 can be pushed.

[0036] See Figure 1 , Figure 2 The inner side of the clamping push rod 304 is also equipped with a movable seat 305, and two locking blocks 306 are fixedly connected to the outer side of the movable seat 305 in opposite directions. A clamping plate 307 is fixedly connected to the side of the movable seat 305 away from the clamping push rod 304, and a culture dish 308 is clamped and limited on the inner side of the clamping plate 307.

[0037] The culture dish 308 is clamped and limited on the inside of the clamping plate 307, so that it can be adjusted according to the size of the culture dish 308 when in use.

[0038] During operation, when cells are being cultured, the culture dish 308 can be placed inside the clamping plate 307 located in the two mounting plates 303. The moving seat 305 can be pushed inward by activating the clamping push rod 304 installed inside the transverse groove in the mounting plate 303. When the moving seat 305 moves inward, the clamping operation of the culture dish 308 can be achieved by using the locking block 306 fixedly connected to the outside of the moving seat 305 to move along the transverse groove opened in the mounting plate 303.

[0039] At this point, by placing the cells and culture medium into the interior of the culture dish 308, and by starting the motor 201 installed at the front end of the support 2 to drive the gear 202 to rotate, the rapid shaking of the culture dish 308 is achieved through the meshing transmission of the gear 202 and the guide teeth 302 fixedly connected to the outer peripheral surface of the guide block 301, thereby achieving a more practical purpose.

[0040] In summary, this device, by providing a guide block 301 fixedly connected to the bottom surface of the bracket 3, can achieve rapid guiding of the bracket 3.

[0041] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

Claims

1. A bioreactor for cell culture, comprising a support frame (1), characterized in that: The main body of the support frame (1) is an L-shaped structure, and there are two support frames (1). The two support frames (1) are arranged opposite each other, and the outer sides of the two support frames (1) are fixedly connected to the mounting platform (101). The mounting platform (101) and the support frame (1) are arranged perpendicularly. The mounting platform (101) and the support frame (1) together form a support structure. The mounting platform (101) has a through hole inside, which is a mounting hole (102). The mounting hole (102) and the mounting platform (101) together form a connection support structure for the support frame (1).

2. A bioreactor for cell culture according to claim 1, characterized in that: The inner side of the support frame (1) is fixedly connected to a bracket (2), and the main body of the bracket (2) is arranged horizontally. There are two brackets (2), and the two brackets (2) are fixedly connected in a straight line array to the front and rear sides of the two support frames (1). A motor (201) is installed at the front end of the bracket (2), and an output shaft is provided at the rear side of the motor (201).

3. A bioreactor for cell culture according to claim 2, characterized in that: A gear (202) is installed on the output shaft at the rear of the motor (201), and the gear (202) and the motor (201) together form a power output structure. A guide seat (203) is also fixedly connected to the inner side of the two support frames (1). The main body of the guide seat (203) is an arc-shaped structure, and an arc-shaped groove is opened inside the guide seat (203).

4. A bioreactor for cell culture according to claim 3, characterized in that: The arc-shaped groove inside the guide seat (203) is the guide groove (204), and the guide groove (204) and the guide seat (203) together form a guide structure. A bracket (3) is placed above the guide seat (203), and the main body of the bracket (3) is an arc-shaped structure. A guide block (301) is fixedly connected to the bottom surface of the bracket (3), and the main body of the guide block (301) is an arc-shaped structure.

5. A bioreactor for cell culture according to claim 4, characterized in that: The bottom end face of the guide block (301) is fixedly connected with guide teeth (302) in an arc array, and the guide teeth (302) mesh with the gear (202) set on the output shaft of the motor (201) for transmission, and the inner side of the bracket (3) is also fixedly connected with a mounting plate (303).

6. A bioreactor for cell culture according to claim 5, characterized in that: The main body of the mounting plate (303) is arranged horizontally, and there are two mounting plates (303). The two mounting plates (303) are fixedly connected to the left and right sides inside the bracket (3) in opposite directions. The interior of the two mounting plates (303) is provided with a horizontal groove, and a clamping push rod (304) is installed inside the horizontal groove.

7. A bioreactor for cell culture according to claim 6, characterized in that: The inner side of the clamping push rod (304) is also equipped with a movable seat (305), and two locking blocks (306) are fixedly connected to the outer side of the movable seat (305) in opposite directions. A clamping plate (307) is fixedly connected to the side of the movable seat (305) away from the clamping push rod (304), and a culture dish (308) is clamped and limited on the inner side of the clamping plate (307).

Images