Magnetic shielding cell culture cabin device
By installing magnetic shielding and guiding components inside the cell culture chamber, the problems of magnetic field influence and difficulty in controlling the chamber door were solved, achieving both magnetic shielding effectiveness and convenient opening and closing, thus ensuring the stability and repeatability of the experiment.
Patent Information
- Application Number
- CN202423148273.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-19
- Publication Date
- 2025-12-05
- Estimated Expiration
- 2034-12-19
AI Technical Summary
Existing cell culture chambers neglect the influence of magnetic fields on cell culture, and the opening and closing of the chamber doors are difficult to control, resulting in unstable experimental data.
A magnetically shielded cell culture chamber was designed. The magnetic shielding component reduces the residual magnetic field inside the chamber, and the drive component provides assistance. Combined with the guide component, the opening and closing path of the chamber door is planned to ensure that the chamber door opens and closes smoothly.
Magnetic shielding was achieved within the cell culture chamber, and the chamber door was easy to open and close tightly, ensuring the stability and repeatability of the experiment.
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Figure CN223633384U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to cell culture cabin technical field especially a kind of magnetic shielding cell culture cabin device. BACKGROUND
[0002] In biomedical research and cell biology field, cell culture is the important link of research biological cell behavior, drug screening and genetic engineering etc. The growth and differentiation of cells are influenced by a variety of environmental factors, wherein magnetic environment is an important factor. In recent years, research shows that external magnetic field can significantly affect the physiological processes such as growth, proliferation and metabolism of cells. In order to ensure the reliability and repeatability of cell culture experimental data, researchers pay more and more attention to the control of cell culture environment, especially the shielding of geomagnetic interference.
[0003] At present, cell culture cabin mostly considers temperature, pressure, carbon dioxide concentration and other conventional parameters, but ignores the influence of magnetic field on cell culture. In fact, the influence of magnetic field on biomass should also be considered in the culture process. Since electromagnetic valve, magnet and other objects can have a great influence on the magnetic field around the cell culture cabin, the magnetic shielding cell culture cabin is designed without considering the use of electric power assisted opening and closing of cabin door. Except for electric power assisted, the cabin door of cell culture cabin on the market is mostly opened and closed by pure human power, which is difficult to control in opening angle and force. UTILITY MODEL CONTENT
[0004] The technical problem to be solved by the utility model is to provide a magnetic shielding cell culture cabin device in view of the above problems.
[0005] The technical scheme adopted by the utility model is as follows: a magnetic shielding cell culture cabin device, comprising:
[0006] A cabin body assembly is provided with an opening on the side wall thereof;
[0007] A cabin door assembly is arranged at the opening of the cabin body assembly, and the cabin door assembly can block the opening;
[0008] A driving assembly is symmetrically arranged at the top position on both sides of the opening of the cabin body assembly, the driving end of the driving assembly is connected to the wall surface of the cabin door assembly facing the opening, and the driving assembly can provide a pushing force when the cabin door assembly is opened and a pulling force when the cabin door assembly is closed;
[0009] A guide assembly is symmetrically arranged at the bottom position on both sides of the opening of the cabin body assembly, and the guide assembly can make the cabin door assembly move along the guide path when opening and closing;
[0010] A magnetic shielding assembly is arranged inside the cabin assembly and the door assembly, which can reduce the residual magnetic field inside the cabin assembly and the door assembly.
[0011] By the above technical means, the cabin assembly and the door assembly cooperate to form a space environment for cell culture, the magnetic shielding assembly reduces the residual magnetic field in the cabin assembly to create a cell culture space with magnetic shielding effect, and the drive assembly provides part of the thrust and pull force when the door assembly is opened and closed, which can facilitate the opening and closing of the door assembly, and the path of the door assembly is planned by the guide assembly, which can guide the movement of the door assembly along the path.
[0012] In some embodiments, the guide assembly includes a link base, a roller link, a slide rail, a first roller and a second roller, the first end of the roller link is rotatably connected with the first roller, the middle position of the roller link is rotatably connected with the second roller, the second end of the roller link is hinged to the link base, the link base is fixed to the bottom position on both sides of the wall surface of the door assembly, the first roller and the second roller are both slidingly connected in the slide rail, the slide rail is bifurcated and symmetrically installed on both sides of the inner bottom of the cabin assembly, so that the door assembly first translates outward and then rotates outward when opening, and first rotates inward and then translates inward when closing.
[0013] In some embodiments, the slide rail includes a horizontal section and a curved section, the middle position of the horizontal section communicates with the curved section;
[0014] When the first roller and the second roller are both located in the horizontal section, and the door assembly abuts against the opening of the cabin assembly, the door assembly is in a closed state at this time;
[0015] When the second roller moves to the end of the horizontal section close to the door assembly, the first roller corresponds to the entrance of the curved section, and the door assembly is in a translation state at this time;
[0016] When the second roller is located at the end of the horizontal section close to the door assembly, and the first roller moves to the end of the curved section away from the horizontal section, the door assembly is in an open state at this time.
[0017] In some embodiments, the cabin assembly includes at least two inner cabins, a pad plate, a pad block and a connecting plate, the inner cabins are supported by the pad block and the pad plate, and the inner cabins are connected by the connecting plate.
[0018] In some embodiments, the magnetic shielding assembly comprises at least two layers of permalloy layers and degaussing wires, the permalloy layers are arranged alternately with the inner cabin, the permalloy layers and the inner cabin are supported by the pads, and the degaussing wires are arranged in a circle around the four corners of the cabin assembly.
[0019] In some embodiments, the cabin door assembly comprises an inner cabin door, a door frame support, an inner aluminum layer and pads, the door frame support is sequentially provided with the inner aluminum layer and the inner cabin door inside, and the door frame support, the inner aluminum layer and the inner cabin door are supported by the pads.
[0020] In some embodiments, the magnetic shielding assembly comprises door side permalloy and intermediate layer permalloy, the door side permalloy is arranged between the door frame support and the inner aluminum layer, and the intermediate layer permalloy is arranged between the inner aluminum layer and the inner cabin door.
[0021] In some embodiments, the inner side wall surface of the cabin door assembly is provided with double-groove beryllium copper spring sheets capable of shock absorption and sealing through spring fixing strips.
[0022] In some embodiments, the top and bottom of the cabin assembly are provided with a plurality of holes, and ventilation pipes are installed in the holes.
[0023] In some embodiments, the driving assembly adopts a group of nitrogen gas springs, a group of the nitrogen gas springs are arranged on both sides of the opening of the cabin assembly respectively, the driving end of the nitrogen gas spring is correspondingly connected to the inner wall of the cabin door assembly, the top of the cabin assembly is provided with an upper cover, and the upper cover is provided with a groove for conveniently pulling the cabin door assembly.
[0024] The beneficial effects of the present application are as follows:
[0025] 1. The cabin assembly and the cabin door assembly cooperate to form a space environment for cell culture, the magnetic shielding assembly arranged inside the cabin assembly and the cabin door assembly reduces the residual magnetic field inside the cabin assembly, the magnetic shielding material makes the internal space environment have a magnetic shielding effect, avoiding affecting the experimental structure, and the driving assembly provides partial assistance when the cabin door assembly is opened and closed, so as to more conveniently open and close the cabin door assembly, and the guiding assembly can provide a guiding effect of planning a path for the opening and closing process of the cabin door assembly, so as to conveniently adjust the opening and closing angle of the cabin door assembly.
[0026] 2. The sliding rail with a bifurcated structure is adopted to control the movement track of the cabin door, so that when the cabin door is opened, the cabin door assembly first translates outward by a distance, and then is turned downward to be opened, and when the cabin door is closed, the cabin door assembly is first turned upward, and then translates inward, which can make the cabin door assembly and the cabin assembly tightly engage, and ensure the magnetic shielding performance of the cell culture cabin.
[0027] 3. By setting multiple holes on the cabin assembly, the ventilation pipe is correspondingly set in the hole, and the ventilation pipe can provide circulating air for the internal environment of the cabin. BRIEF DESCRIPTION OF DRAWINGS
[0028] Figure 1 is the structural schematic diagram of the present application.
[0029] Figure 2 is the structural schematic diagram of the guiding assembly when the cabin door assembly is in the closed door state.
[0030] Figure 3 is the structural schematic diagram of the guiding assembly when the cabin door assembly is in the translation state.
[0031] Figure 4 is the structural schematic diagram of the guiding assembly when the cabin door assembly is in the open door state.
[0032] BRIEF DESCRIPTION OF DRAWINGS
[0033] 1. Cabin assembly; 2. Cabin door assembly; 3. Slide rail; 4. Nitrogen spring; 5. Connecting rod base; 6. Roller connecting rod; 7. Ventilation pipe; 8. Upper cover; 9. First roller; 10. Second roller.
[0034] This specification includes references to“one embodiment” or“an embodiment”. The occurrence of the phrase“in one embodiment” or“in an embodiment” does not necessarily refer to the same embodiment. Particular features, structures, or characteristics can be combined in any suitable manner in one or more embodiments.
[0035] “includes”, this term is open. As used in the appended claims, this term does not exclude additional structures or steps.
[0036] “first”,“second”, and the like. As used herein, these terms act as labels for nomenclature purposes only, and do not necessarily connote any type of ordering (e.g., spatial, temporal, logical, etc.). DETAILED DESCRIPTION
[0037] In order to make the person skilled in the art better understand the present application, the technical scheme of the present application will be further described in combination with specific embodiments.
[0038] In combination with Figure 1 With Figure 4As shown, the embodiment is a kind of magnetic shielding cell culture cabin device, including cabin body assembly 1, cabin door assembly 2, drive assembly, guide assembly and magnetic shielding assembly, one end side wall of cabin body assembly 1 is equipped with opening, the opening of cabin body assembly 1 is equipped with cabin door assembly 2, cabin door assembly 2 can be sealed to the opening of cabin body assembly 1 It is matched, so that the inside of cabin body assembly 1 forms the space of cell culture.Cabin body assembly 1 and cabin door assembly 2 are equipped with drive assembly, drive assembly is symmetrically arranged at the top position of the opening of cabin body assembly 1, the driving end of drive assembly is connected to the wall surface of cabin door assembly 2 towards opening, drive assembly can provide partial thrust when cabin door assembly 2 opens and provide partial pull when cabin door assembly 2 closes, to facilitate the opening and closing action of cabin door assembly 2.The bottom position of the opening of cabin body assembly 1 is symmetrically equipped with guide assembly, and the guide assembly can make cabin door assembly 2 move along the guide path when opening and closing.The inside of cabin body assembly 1 and cabin door assembly 2 is equipped with magnetic shielding assembly, and the magnetic shielding assembly can reduce the residual magnetic field in the inside of cabin body assembly 1 and cabin door assembly 2.
[0039] In some embodiments, as Figures 2 to 4 As shown, the guide assembly includes a link base 5, a roller link 6, a slide rail 3, a first roller 9 and a second roller 10, the first end of the roller link 6 is rotatably connected with the first roller 9, the middle position of the roller link 6 is rotatably connected with the second roller 10, and the second end of the roller link 6 is hinged to the link base 5. The link base 5 is fixed by screws at the bottom position on both sides of the wall surface of the cabin door assembly 2, and the first roller 9 and the second roller 10 are both slidingly connected in the slide rail 3. In this embodiment, the slide rail 3 is bifurcated and symmetrically installed on the inner bottom of the cabin body assembly 1, so that the cabin door assembly 2 first translates outward and then rotates outward when opening, and first rotates inward and then translates inward when closing. In this embodiment, the number of roller links 6 is two, each of which is provided with a first roller 9 and a second roller 10, and the first roller 9 and the second roller 10 are separated by a distance.
[0040] Further, a positioning block is arranged inside and below the cabin body assembly 1, the slide rail 3 is arranged on the left and right sides of the positioning block, and the slide rail 3 is fixed by bolts. The slide rail 3 includes a horizontal section and a curved section, and the middle position of the horizontal section is in communication with the curved section. When the first roller 9 and the second roller 10 are both located in the horizontal section, and the cabin door assembly 2 abuts against the opening of the cabin body assembly 1, the cabin door assembly 2 is in a closed state at this time; when the second roller 10 moves to the end of the horizontal section close to the cabin door assembly 2, the first roller 9 corresponds to the entrance of the curved section, and the cabin door assembly 2 is in a translational state at this time; when the second roller 10 is located at the end of the horizontal section close to the cabin door assembly 2, and the first roller 9 moves to the end of the curved section away from the horizontal section, the cabin door assembly 2 is in an open state at this time.
[0041] In some embodiments, the cabin assembly 1 comprises at least two layers of inner cabins, cushion plates, cushion blocks and connecting plates, the inner cabins are supported by the cushion blocks and the cushion plates, and the inner cabins are connected by the connecting plates.
[0042] Further, the magnetic shielding assembly comprises at least two layers of permalloy layers and demagnetizing wires, the permalloy layers are arranged alternately with the inner cabins, the permalloy layers are supported by the cushion blocks between the permalloy layers and the inner cabins, and the demagnetizing wires are arranged in a circle around the four corners of the cabin assembly 1.
[0043] By using the magnetic shielding material, the magnetic lines are guided to the inside and surface of the magnetic shielding material by the material characteristics, so as to reduce the residual magnetic field in the cabin, and the internal environment has a magnetic shielding effect.
[0044] In some embodiments, the cabin door assembly 2 comprises an inner door, a door frame support, an inner aluminum layer and a cushion block, the inner aluminum layer and the inner door are sequentially arranged in the door frame support, and the cushion block is arranged between the door frame support, the inner aluminum layer and the inner door.
[0045] Further, the magnetic shielding assembly comprises door side permalloy and intermediate layer permalloy, the door side permalloy is arranged between the door frame support and the inner aluminum layer, and the intermediate layer permalloy is arranged between the inner aluminum layer and the inner door.
[0046] Further, the inner side wall surface of the cabin door assembly 2 is provided with double-groove beryllium copper spring sheets capable of damping and sealing, which are fixed by spring fixing strips.
[0047] In some embodiments, the top and bottom of the cabin assembly 1 are provided with a plurality of holes, the upper and lower hole positions are symmetrical to each other, ventilation pipes 7 are arranged in the holes, and the ventilation pipes 7 can ensure the air circulation of the internal environment.
[0048] In some embodiments, the driving assembly adopts a group of nitrogen gas springs 4, the number of the group of nitrogen gas springs 4 is two, the two nitrogen gas springs 4 are arranged on the two sides of the opening of the cabin assembly 1, the driving end of the nitrogen gas spring 4 is correspondingly connected to the inner wall of the cabin door assembly 2, so that when the cabin door assembly 2 is pulled out, the nitrogen gas spring 4 can generate a boost force, the cabin door assembly 2 can be more easily opened, and the nitrogen gas spring 4 also generates a pulling force as an auxiliary when the door is closed, facilitating access. The top of the cabin assembly 1 and the joint of the cabin door assembly 2 are provided with an upper cover 8, and the upper cover 8 is provided with a groove for pulling the cabin door assembly 2.
[0049] The implementation principle of the magnetic shielding cell culture cabin device of the embodiment is as follows:
[0050] In the device, a plurality of layers of permalloy layers and a permalloy door cover are arranged to shield the magnetic field and avoid the influence of the magnetic field on the experimental results.
[0051] The slide rail 3 in the device is bifurcated, and the slide rail 3 comprises a horizontal section and a curved section. The bifurcated structure of the slide rail 3 enables the door assembly 2 to first translate outward by a distance and then turn downward to open when the door is opened. When the door is closed, the door assembly 2 first turns upward and then translates inward to close. This movement mode enables the door assembly 2 to tightly engage with the cabin assembly 1, thereby ensuring the magnetic shielding performance of the cell culture cabin. Meanwhile, the nitrogen gas spring 4 generates a pushing force and a pulling force as an auxiliary, thereby facilitating the opening and closing of the door assembly 2.
[0052] When the door assembly 2 needs to be opened, the hand is placed in the groove of the upper cover 8 to pull the door assembly 2 outward. The roller connecting rod 6 drives the first roller 9 and the second roller 10 on the lower sides to both translate outward by a distance. At this time, the door assembly 2 synchronously translates outward by a distance. When the second rollers 10 on the two sides reach the limit position of the horizontal section, the first rollers 9 correspond to the entrances of the curved sections, and the door assembly 2 will turn downward. In the process, the nitrogen gas spring 4 is elongated and generates a pushing force to assist the opening of the door assembly 2. When the first rollers 9 on the two sides reach the limit position of the curved sections, the door assembly 2 reaches the maximum opening angle.
[0053] When the door assembly 2 needs to be closed, the door assembly 2 is pushed upward. The first rollers 9 in the curved sections of the slide rail 3 return to the horizontal sections along the bifurcated tracks, the first rollers 9 are horizontal with the second rollers 10, and then the first rollers 9 and the second rollers 10 translate inward together. In the process, the nitrogen gas spring 4 is contracted and generates a pulling force to assist the closing action.
[0054] The above are preferred embodiments of the present application, and are not intended to limit the protection scope of the present application. Therefore, equivalent changes made on the basis of the structure, shape and principle of the present application should be covered within the protection scope of the present application.
Claims
1. A magnetic shielded cell culture pod apparatus, comprising: The application relates to a cabin door opening and closing device. The cabin door opening and closing device comprises a cabin body assembly (1) provided with an opening on a side wall, a cabin door assembly (2) arranged at the opening of the cabin body assembly (1) and capable of sealing the opening, a driving assembly symmetrically arranged at the top of both sides of the opening of the cabin body assembly (1), a driving end of the driving assembly being connected to the wall surface of the cabin door assembly (2) facing the opening, the driving assembly being capable of providing a pushing force when the cabin door assembly (2) is opened and a pulling force when the cabin door assembly (2) is closed, a guiding assembly symmetrically arranged at the bottom of both sides of the opening of the cabin body assembly (1), the guiding assembly being capable of guiding the cabin door assembly (2) to move along a guiding path when the cabin door assembly (2) is opened and closed, and a magnetic shielding assembly arranged inside the cabin body assembly (1) and the cabin door assembly (2), the magnetic shielding assembly being capable of reducing the residual magnetic field inside the cabin body assembly (1) and the cabin door assembly (2). The guiding assembly comprises a connecting rod base (5), a roller connecting rod (6), a slide rail (3), a first roller (9) and a second roller (10), the first end of the roller connecting rod (6) being rotatably connected with the first roller (9), the middle part of the roller connecting rod (6) being rotatably connected with the second roller (10), the second end of the roller connecting rod (6) being hingedly connected to the connecting rod base (5), the connecting rod base (5) being fixed to the bottom of both sides of the wall surface of the cabin door assembly (2), the first roller (9) and the second roller (10) being slidably connected in the slide rail (3), the slide rail (3) being bifurcated and symmetrically arranged at the inner bottom of both sides of the cabin body assembly (1), so that the cabin door assembly (2) is first translated outward and then rotated outward when the door is opened, and the cabin door assembly (2) is first rotated inward and then translated inward when the door is closed. The slide rail (3) comprises a horizontal section and a curved section, the middle part of the horizontal section being communicated with the curved section. When the first roller (9) and the second roller (10) are located in the horizontal section and the cabin door assembly (2) abuts against the opening of the cabin body assembly (1), the cabin door assembly (2) is in a closed state. When the second roller (10) moves to the end of the horizontal section close to the cabin door assembly (2), the first roller (9) corresponds to the entrance of the curved section, and the cabin door assembly (2) is in a translation state.
2. The magnetic shielding cell culture pod device of claim 1, wherein: When the second roller (10) is located at the end of the horizontal section close to the cabin door assembly (2) and the first roller (9) moves to the end of the curved section away from the horizontal section, the cabin door assembly (2) is in an opened state.
3. The magnetic shielding cell culture pod device of claim 2, wherein: The cabin body assembly (1) comprises at least two inner cabins, a cushion plate, cushion blocks and connecting plates, the inner cabins are supported by the cushion blocks and the cushion plate, and the inner cabins are connected by the connecting plates. The magnetic shielding assembly comprises at least two permalloy layers and degaussing wires, the permalloy layers and the inner cabins are alternately arranged, the permalloy layers and the inner cabins are supported by the cushion blocks, and the degaussing wires are arranged around the four corners of the cabin body assembly (1). 4. The magnetic shielding cell culture pod device of claim 1, wherein: 5. The magnetic shielding cell culture pod device of claim 4, wherein: 6. The magnetic shielding cell culture pod device of claim 1, wherein: The cabin door assembly (2) comprises an inner door, a door frame support, an inner aluminum layer and a cushion block, the door frame support is sequentially provided with the inner aluminum layer and the inner door inside, and the door frame support, the inner aluminum layer and the inner door are supported by the cushion block.
7. The magnetic shielding cell culture pod device of claim 6, wherein: The magnetic shielding assembly comprises door side mu metal and intermediate layer mu metal, the door side mu metal is arranged between the door frame support and the inner aluminum layer, and the intermediate layer mu metal is arranged between the inner aluminum layer and the inner door.
8. The magnetic shielding cell culture pod device of claim 6, wherein: The inner side wall surface of the cabin door assembly (2) is provided with double-groove beryllium copper spring sheets capable of shock absorption and sealing.
9. The magnetic shielding cell culture pod device of claim 1, wherein: The top and bottom of the cabin body assembly (1) are provided with a plurality of holes, and ventilation pipes (7) are installed in the holes.
10. The magnetic shielding cell culture pod device of claim 1, wherein: The driving assembly adopts a group of nitrogen gas springs (4), a group of the nitrogen gas springs (4) are respectively arranged on both sides of the opening of the cabin body assembly (1), the driving end of the nitrogen gas spring (4) is correspondingly connected to the inner wall of the cabin door assembly (2), the top of the cabin body assembly (1) and the joint of the cabin door assembly (2) are provided with an upper cover (8), and the upper cover (8) is provided with a groove for conveniently pulling the cabin door assembly (2).