Freeze dryer for improving freeze-drying efficiency

Abstract

The utility model provides a freeze dryer for improving freeze-drying efficiency, which comprises a freeze dryer main body, the freeze dryer main body comprises a freeze-drying bin for freeze-drying medicines, and the freeze-drying bin is sealed through a box door; a control center which is provided with a touch display screen and is used for controlling the interior of the freeze-drying bin is arranged beside the freeze-drying bin; the freeze-drying device is characterized in that a back plate is arranged on the rear side wall in the freeze-drying bin; the back plate is of a hollow structure; a plurality of air holes are formed in the side wall, close to the freeze-drying bin, of the back plate; an air inlet hole and an air outlet hole are formed in the other side of the back plate; the inner side wall of the freeze-drying bin is movably connected with a material plate; a plurality of air holes are formed in the material plate; according to the utility model, the problems of the traditional freeze dryer in the aspects of gas distribution, material plate fixing and cooling, flow guide design, air permeability and the like are successfully solved, the freeze-drying efficiency is obviously improved, the product quality is ensured, and the energy consumption and the time cost are reduced.

Description

Technical Field

[0001] This utility model relates to the field of freeze dryers, and more particularly to a freeze dryer for improving freeze drying efficiency. Background Technology

[0002] Some drugs are unstable in aqueous solutions and are very sensitive to moisture and heat, such as cytarabine, penicillin, cephalosporins, and carbapenems. Preparing them as sterile lyophilized powders for injection is beneficial for drug stability.

[0003] In the preparation of lyophilized powder injections, lyophilization technology has become an indispensable and crucial step. As the core equipment for realizing this technology, the lyophilizer is of paramount importance for ensuring product quality, improving production efficiency, and reducing costs. With the rapid development of the pharmaceutical and biopharmaceutical industries, the requirements for the quality and quantity of lyophilized products are increasingly demanding. However, traditional lyophilizers have gradually revealed a series of technical problems in practical applications, which urgently need to be addressed.

[0004] Traditional freeze dryers often lack proper planning and guidance for gas flow within the freeze-drying chamber; the gas cannot evenly fill the entire chamber, resulting in low heat and mass transfer efficiency in some areas. This not only significantly prolongs the freeze-drying time and greatly increases energy consumption, but also causes uneven heating of the drug during the freeze-drying process, with some areas being over-dried while others are under-dried. This uneven freeze-drying effect seriously affects the consistency and stability of product quality, making it difficult to meet stringent industry standards and market demands. Utility Model Content

[0005] In order to solve the problem of low freeze-drying efficiency caused by uneven airflow in the prior art, this utility model provides a freeze dryer for improving freeze-drying efficiency;

[0006] The freeze dryer for improving freeze-drying efficiency provided by this utility model adopts the following technical solution:

[0007] A freeze dryer for improving freeze-drying efficiency includes a freeze dryer body, which includes a freeze-drying chamber for freeze-drying pharmaceuticals, the chamber being sealed by a door; a control center with a touch screen display for controlling the interior of the freeze-drying chamber is located next to the chamber; the rear side wall of the freeze-drying chamber is a back panel; the back panel has a hollow structure; a plurality of air holes are formed on one side wall of the back panel near the interior of the freeze-drying chamber; an air inlet and an air outlet are formed on the other side of the back panel; a material plate is movably connected to the inner side wall of the freeze-drying chamber; a plurality of ventilation holes are formed inside the material plate;

[0008] Furthermore, the air holes are arranged in a rectangular array on the back plate; several guide plates are bolted to the same side wall of the back plate and the air holes; the guide plate is a hollow structure with one end open, the opening is aligned with one of the exhaust holes, and is connected to the interior of the back plate.

[0009] Furthermore, there are at least three guide plates, which are respectively disposed between the material plates and between the material plates and the inner wall of the freeze-drying chamber;

[0010] Furthermore, the outer wall of the guide plate is provided with a guide groove; the guide plate disposed between the material plates has its guide grooves on the upper and lower sides; the guide plate disposed between the material plate and the inner wall of the freeze-drying chamber has its guide grooves on the side closer to the material plate.

[0011] Furthermore, the inner wall of the freeze-drying chamber is fitted with a fixed bracket by bolts, and the fixed bracket is a U-shaped guide rail structure; the material plate is slidably connected to the fixed bracket;

[0012] Furthermore, a cold pipe is embedded in and connected to the bottom of the material plate; the cold pipe is arranged in a serpentine structure at the bottom of the material plate; the cold pipe is provided with a liquid inlet and a liquid outlet;

[0013] Furthermore, the material plate has ventilation holes inside; the ventilation holes are distributed in a rectangular array and are located away from the cold pipes.

[0014] In summary, the beneficial effects of this utility model are as follows:

[0015] This invention improves the heat and mass transfer efficiency of gas by optimizing the distribution and flow path of gas within the freeze-drying chamber. This not only effectively shortens the freeze-drying time and reduces overall energy consumption, but also ensures that the medicine is heated evenly during the freeze-drying process, thereby avoiding uneven drying caused by temperature differences and improving the overall quality of the freeze-dried product. Secondly, the improvements to the material plate make it more stable during the freeze-drying process, resulting in more uniform heat transfer. This not only enhances the stability and reliability of the system, but also further improves the efficiency and quality of freeze-drying, ensuring product consistency and stability.

[0016] This invention successfully solves the problems existing in traditional freeze dryers in terms of gas distribution, material plate fixing and cooling, air guiding design and air permeability, significantly improving freeze drying efficiency, ensuring product quality, reducing energy consumption and time costs, and providing strong support for the high-quality development of the pharmaceutical and biopharmaceutical industries. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0018] Figure 2This is a schematic diagram of the freeze-drying zone of the freeze dryer body of this utility model;

[0019] Figure 3 This is a schematic diagram of the air guide plate and back plate of this utility model;

[0020] Figure 4 This is a schematic diagram of the overall structure of the material plate of this utility model.

[0021] As shown in the figure: 1- Freeze dryer body, 2- Door, 3- Control center, 4- Back panel, 41- Air vent, 5- Guide plate, 51- Guide channel, 6- Fixed bracket, 7- Material plate, 71- Cold pipe, 72- Vent. Detailed Implementation

[0022] The following is in conjunction with the appendix Figure 1-4 The present invention will be further described in detail below:

[0023] This utility model discloses a freeze dryer for improving freeze-drying efficiency, applicable to various drugs such as cytarabine powder for injection, penicillin powder for injection, and acyclovir powder for injection. Its structure is as follows: Figure 1-3 As shown, the system includes a freeze dryer body 1, which includes a freeze-drying chamber for freeze-drying pharmaceuticals. The freeze-drying chamber is sealed by a door 2. A control center 3 with a touchscreen display is located next to the freeze-drying chamber for controlling its internal structure. The rear wall of the freeze-drying chamber is a back panel 4, which is hollow. Several air holes 41 are provided on one side of the back panel 4 closest to the interior of the freeze-drying chamber. An air inlet and an air outlet are provided on the other side of the back panel 4. A material plate 7 is movably connected to the inner wall of the freeze-drying chamber. Several ventilation holes 72 are provided inside the material plate 7. In this embodiment, the freeze dryer body 1 is the basic framework of the entire equipment. The freeze-drying chamber provides a sealed space for freeze-drying pharmaceuticals. The sealing of the door 2 ensures environmental stability during the freeze-drying process and prevents interference from external factors. The control center 3 with a touchscreen display allows operators to accurately set and monitor various parameters within the freeze-drying chamber. The hollow back panel 4 serves as a channel for gas flow. Specific gas is introduced through the air inlet. After passing through the back plate 4, the gas is blown out evenly from the air hole 41, realizing uniform gas exchange and heat transfer inside the freeze-drying chamber. This ensures the uniform distribution of gas inside the freeze-drying chamber, improves heat and mass transfer efficiency, thereby accelerating the freeze-drying process, making the freeze-drying of medicines more uniform, and improving product quality.

[0024] In addition, the overall structure of this embodiment is reasonably designed and easy to operate, providing a basic condition for efficient freeze drying, enabling precise control of the freeze drying process, and ensuring the quality and stability of the freeze-dried medicine;

[0025] like Figure 2As shown, the vents 41 are arranged in a rectangular array on the back plate 4; several guide plates 5 are bolted to the same side wall of the back plate 4 and the vents 41; the guide plate 5 is a hollow structure with one end open, the opening is aligned with one of the exhaust vents 41, and is connected to the interior of the back plate 4; in this embodiment, the rectangular array of vents 41 helps to achieve uniform gas injection; the guide plate 5 can guide the flow direction of the gas, making it more concentrated and directional on the drug that needs to be freeze-dried; it further optimizes the gas flow path, enhances the effect of the gas on the drug, and improves the efficiency and uniformity of freeze-drying.

[0026] like Figure 2 , 3 As shown, there are at least three guide plates 5, which are respectively set between the material plates 7 and between the material plates 7 and the inner wall of the freeze-drying chamber. In this embodiment, multiple guide plates 5 are set at different positions, which can fully cover the medicine on the material plates 7, ensuring that each part can receive sufficient gas blowing and heat transfer. This avoids uneven drying in some areas, improves the freeze-drying consistency of the medicine in the entire freeze-drying chamber, and reduces drying time and energy consumption.

[0027] like Figure 2 , 3 As shown, the outer wall of the guide plate 5 is provided with a guide groove 51; the guide plate 5 located between the material plates 7 has its guide groove 51 located on the upper and lower sides; the guide plate 5 located between the material plate 7 and the inner wall of the freeze-drying chamber has its guide groove 51 located on the side closer to the material plate 7; the opening direction of the guide groove 51 is optimized according to the position of the guide plate 5, so that the gas can flow along the preset path and maximize the contact with the medicine; the precise control of the gas flow improves the gas utilization efficiency, further enhances the freeze-drying effect, and ensures the quality and performance of the medicine;

[0028] like Figure 2 As shown, a fixed bracket 6 is bolted to the inner wall of the freeze-drying chamber. The fixed bracket 6 is a U-shaped guide rail structure. The material plate 7 is slidably connected to the fixed bracket 6. In this embodiment, the U-shaped fixed bracket 6 provides stable support and guidance, which makes it easy to install and disassemble the material plate 7, while ensuring the stability of its position during the freeze-drying process. This facilitates the loading, unloading and maintenance of the material plate 7, improves the convenience of operation, ensures the stability of the material plate 7, and helps to improve the efficiency and quality of freeze-drying.

[0029] like Figure 4As shown, a cooling pipe 71 is embedded and connected to the bottom of the material plate 7; the cooling pipe 71 is arranged in a serpentine structure at the bottom of the material plate 7; the cooling pipe 71 is provided with an inlet and an outlet; in this embodiment, the coolant in the cooling pipe 71 enters through the inlet, and after fully contacting the material plate 7 through the serpentine structure, it flows out from the outlet, carrying away heat and achieving cooling of the material; this enhances the cooling effect, accelerates the freezing of water in the medicine, and improves the speed and efficiency of freeze drying;

[0030] like Figure 4 As shown, the material plate 7 has ventilation holes 72 inside; the ventilation holes 72 are distributed in a rectangular array and are opened to avoid the cold pipe 71. In this embodiment, the ventilation holes 72 help the gas to flow between the top and bottom of the material plate 7, promote the overall drying of the medicine, and avoid the cold pipe 71 to avoid affecting the cooling effect; it ensures the flow of gas and heat transfer, improves the uniformity and efficiency of freeze drying, and does not affect the normal operation of the cold pipe 71.

[0031] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. The various components mentioned in this utility model are common technologies in the existing field. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A freeze dryer for improving freeze-drying efficiency, comprising a freeze dryer body (1), the freeze dryer body (1) including a freeze-drying chamber for freeze-drying pharmaceuticals, the freeze-drying chamber being sealed by a door (2); a control center (3) with a touch screen display for controlling the interior of the freeze-drying chamber is provided next to the freeze-drying chamber; characterized in that, The rear side wall inside the freeze-drying chamber is set as a back plate (4); the back plate (4) is a hollow structure; a number of air holes (41) are opened on one side wall of the back plate (4) near the inside of the freeze-drying chamber; an air inlet and an air outlet are opened on the other side of the back plate (4); a material plate (7) is movably connected to the inner side wall of the freeze-drying chamber; a number of ventilation holes (72) are opened inside the material plate (7).

2. A freeze dryer for improving freeze-drying efficiency according to claim 1, characterized in that... The air holes (41) are arranged in a rectangular array on the back plate (4); several guide plates (5) are bolted to the same side wall of the back plate (4) and the air holes (41); the guide plate (5) is a hollow structure with one end open, the opening is aligned with one of the exhaust holes (41) and connected to the interior of the back plate (4).

3. A freeze dryer for improving freeze-drying efficiency according to claim 2, characterized in that... There are at least three guide plates (5), which are respectively arranged between the material plates (7) and between the material plates (7) and the inner wall of the freeze-drying chamber.

4. A freeze dryer for improving freeze-drying efficiency according to claim 3, characterized in that... The outer wall of the guide plate (5) is provided with a guide groove (51); the guide plate (5) provided between the material plate (7) has its guide groove (51) on the upper and lower sides; the guide plate (5) provided between the material plate (7) and the inner wall of the freeze-drying chamber has its guide groove (51) on the side closer to the material plate (7).

5. A freeze dryer for improving freeze-drying efficiency according to claim 1, characterized in that... The inner wall of the freeze-drying chamber is fitted with a fixed bracket (6) by bolts. The fixed bracket (6) is a "U"-shaped guide rail structure. The material plate (7) is slidably connected to the fixed bracket (6).

6. A freeze dryer for improving freeze-drying efficiency according to claim 5, characterized in that... The bottom of the material plate (7) is inlaid with a cold pipe (71); the cold pipe (71) is arranged in a serpentine structure at the bottom of the material plate (7); the cold pipe (71) is provided with an inlet and an outlet.

7. A freeze dryer for improving freeze-drying efficiency according to claim 5, characterized in that... The material plate (7) has ventilation holes (72) inside; the ventilation holes (72) are arranged in a rectangular array and are opened away from the cold pipe (71).

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