Flow cytometer for monitoring residual cells

By introducing limiting and cleaning structures into the flow cytometer, the problem of unstable positioning of the cell cassette in the flow chamber was solved, ensuring stable cell flow and cleaning, and improving the stability and efficiency of monitoring.

CN223650386UActive Publication Date: 2025-12-09SHANGHAI LUYI CELL BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202520264910.4
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-02-19
Publication Date
2025-12-09
Estimated Expiration
2035-02-19

AI Technical Summary

Technical Problem

When monitoring residual cells, existing flow cytometers may experience displacement or tilting within the flow chamber due to improper positioning of the cell cassette, affecting the cell flow path and distribution.

Method used

A flow cytometer including a limiting structure and a cleaning structure was designed. The combination of the limiting groove and the insertion block ensures the stable positioning of the cell box, and the design of gears and cleaning blocks cleans the dust in the through holes to prevent jamming.

Benefits of technology

Stable positioning of the cell box was achieved, avoiding the influence of unstable positioning on the flow path and distribution state. At the same time, it effectively cleaned the dust in the through holes, prevented jamming, and improved the stability and efficiency of monitoring.

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Abstract

The utility model provides a flow cytometer for monitoring residual cells, which relates to the technical field of cell monitoring, and comprises a flow cytometer body, the right side of the top of the front surface of the flow cytometer body is fixedly connected with a button, and the front surface of the flow cytometer body is fixedly connected with a control panel. When the cell box is used, firstly, a user pulls the handle outwards, the action enables the insertion block connected with the handle to move outwards correspondingly until the insertion block is completely separated from the interior of the original limiting groove, and at the moment, the user can conveniently take out an old cell test tube in the cell box and place a new cell test tube into the cell box; a user places a cell box filled with a new cell test tube on the top of a transverse block through a supporting block, after the cell box is stably placed, the user loosens a handle, and at the moment, an insertion block moves towards the inner side under the elastic force action of a spring and is inserted into a limiting groove again, so that the cell box is stabilized.
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Description

TECHNICAL FIELD

[0001] The utility model relates to cell monitoring technical field, concretely relates to a residual cell monitoring flow cytometer. BACKGROUND

[0002] Micro nuclear magnetic resonance principle: cell monitoring technology uses "micro nuclear magnetic resonance" principle, detects human cells through special equipment, and the technology can comprehensively and accurately detect human health conditions without radiation, non-invasive and pain, spectrum resonance, sound resonance and quantum resonance technology: these technologies are integrated in cell monitoring, and the special transmitter (such as earphone type sensor) produces resonance with the cell frequency of each system of the human body, so that the functional information of the cells is read and stored in the computer, microscopic observation: for epidermal cells, smear examination can be used to observe the morphology and structure of cells under a microscope, and blood routine examination can be used to check the number of various cells in the blood through a blood routine analyzer, so as to determine whether there is a disease, live cell imaging analysis system: the system can monitor the changes of cell morphology in real time, such as cell apoptosis process, and the technology can be applied to identify specific cells, drug screening and the like,

[0003] The flow cytometer mainly consists of the following four parts: flow chamber and liquid flow system: the flow chamber is composed of a sample tube, a sheath liquid tube and a nozzle, and is usually made of transparent and stable materials such as optical glass and quartz. The sample tube stores the sample, and the single cell suspension is ejected from the sample tube under the action of liquid flow pressure; the sheath liquid flows from the four sides to the nozzle and is ejected from the nozzle after surrounding the sample. In order to ensure the stability of the liquid flow, the liquid flow velocity is generally limited to less than 10 m / s.

[0004] The existing flow cytometer can monitor residual cells, but when the user places the cell box in the cell instrument, the cell box is not properly positioned, and it can be displaced or tilted in the flow chamber of the flow cytometer. The unstable placement state can directly affect the flow path and distribution state of the cells. UTILITY MODEL CONTENT

[0005] The utility model provides a residual cell monitoring flow cytometer, which solves the problems in the above background technology.

[0006] To solve the above technical problems, the technical scheme of the utility model is as follows:

[0007] The utility model discloses an embodiment provides a kind of residual cell monitoring flow cytometer, including flow cytometer body, the right side fixedly connected with button on the front top of flow cytometer body, the front fixedly connected with control panel of flow cytometer body, the bottom fixedly connected with cross piece in the inner wall of flow cytometer body, the top of cross piece is provided with cell box, the both sides of cross piece are all provided with limit slot, the bottom end inside cell box is provided with limit structure, the limit structure includes through-hole, the through-hole is slidably connected with plug, the outside fixedly connected with handle of plug, the bottom fixedly connected with spring of plug, the outside of spring is fixedly connected with the outside of through-hole, the front and back of plug are all provided with cleaning structure.

[0008] Through the above technical scheme, through the setting of the limiting structure, the cell box can be limited by the limiting structure to prevent deviation during monitoring.

[0009] Further, the cleaning structure includes a horizontal groove, the horizontal groove is located on the front and back of the plug, a cleaning block is arranged in the horizontal groove, a connecting block is fixedly connected to the top of the cleaning block, a gear is fixedly connected to the top of the connecting block, a toothed plate is engaged with the outside of the gear, and the outside of the toothed plate is fixedly connected with the inner wall of the through-hole.

[0010] Through the above technical scheme, through the setting of the cleaning structure, the dust inside the through-hole can be cleaned by rotating the cleaning block, to prevent jamming.

[0011] Further, ventilation openings are formed in the two sides of the flow cytometer body, and a dust screen is fixedly connected in the ventilation openings.

[0012] Through the above technical scheme, through the setting of the ventilation openings and the dust screen, the flow cytometer body can be cooled, and dust is prevented from entering the flow cytometer body.

[0013] Further, baffles are installed on the front and back of the cell box, and mounting ears are fixedly connected to the outside of the baffles.

[0014] Through the above technical scheme, through the setting of the baffles, the plug can be limited, and through the setting of the mounting ears, the baffles and the cell box can be easily installed by the user.

[0015] Further, a pull block is fixedly connected to the top of the flow cytometer body, and an anti-slip pad is fixedly connected to the bottom of the flow cytometer body.

[0016] Through the above technical scheme, the pull block can be easily carried by the user, and the anti-slip pad can increase the anti-slip property of the flow cytometer body.

[0017] Further, the surface of the connecting block is fixedly connected with a fixing block, and the fixing block is located at the top of the plug-in block.

[0018] Through the above technical scheme, the fixing block is arranged to limit the connecting block and the gear, so that the gear is prevented from shaking during rotation.

[0019] Further, the top of the cell box is provided with a placing groove, and the bottom of the front surface of the flow cytometer body is fixedly connected with a supporting block.

[0020] Through the above technical scheme, the fixing block is arranged to limit the connecting block and the gear, so that the gear is prevented from shaking during rotation.

[0021] The above scheme of the utility model has at least the following beneficial effects:

[0022] 1. The utility model discloses a cell box, which comprises a cell box, a handle, a plug-in block, a gear, a connecting block, a cleaning block and a spring.

[0023] 2. The utility model discloses a cell box, which comprises a cell box, a handle, a plug-in block, a gear, a connecting block, a cleaning block and a spring. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 It is the flow cytometer structure schematic view for residual cell monitoring of the utility model;

[0025] Figure 2 It is the baffle schematic view of the utility model;

[0026] Figure 3 It is the cell box schematic view of the utility model;

[0027] Figure 4 It is the plug-in block schematic view of the utility model;

[0028] Figure 5 It is the gear plate schematic view of the utility model.

[0029] MARKS OF THE DRAWINGS:

[0030] 1. Flow cytometer body; 2. Button; 3. Control panel; 4. Horizontal block; 5. Cell box; 6. Limiting groove; 7. Limiting structure; 71. Through hole; 72. Insertion block; 73. Handle; 74. Spring; 8. Cleaning structure; 81. Horizontal groove; 82. Cleaning block; 83. Connecting block; 84. Gear; 85. Toothed plate; 9. Ventilation port; 10. Dustproof screen; 11. Baffle; 12. Mounting ear; 13. Pull block; 14. Anti-slip pad; 15. Fixing block; 16. Placement slot; 17. Support block. Detailed Implementation

[0031] Exemplary embodiments of the present invention will now be described in more detail with reference to the accompanying drawings. While exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this invention will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

[0032] like Figures 1 to 5 As shown, this utility model provides a flow cytometer for residual cell monitoring, including a flow cytometer body 1. A button 2 is fixedly connected to the right side of the top front of the flow cytometer body 1. A control panel 3 is fixedly connected to the front of the flow cytometer body 1. A horizontal block 4 is fixedly connected to the bottom of the inner wall of the flow cytometer body 1. A cell box 5 is provided on the top of the horizontal block 4. Limiting grooves 6 are provided on both sides of the horizontal block 4. A limiting structure 7 is provided at the bottom of the cell box 5. The limiting structure 7 includes a through hole 71. An insert 72 is slidably connected inside the through hole 71. A handle 73 is fixedly connected to the outside of the insert 72. A spring 74 is fixedly connected to the bottom of the insert 72. The outside of the spring 74 is fixedly connected to the outside of the through hole 71. A cleaning structure 8 is provided on both the front and back of the insert 72.

[0033] like Figures 1 to 5 As shown, the cleaning structure 8 includes a transverse groove 81, which is located on the front and back of the insert block 72. A cleaning block 82 is provided inside the transverse groove 81. A connecting block 83 is fixedly connected to the top of the cleaning block 82. A gear 84 is fixedly connected to the top of the connecting block 83. A toothed plate 85 meshes with the outside of the gear 84. The outside of the toothed plate 85 is fixedly connected to the inner wall of the through hole 71.

[0034] like Figures 1 to 5 As shown, ventilation openings 9 are provided on both sides of the flow cytometer body 1, and a dustproof net 10 is fixedly connected inside the ventilation opening 9.

[0035] like Figure 1 Figure 5As shown, baffles 11 are installed on both the front and back of the cell box 5, and mounting ears 12 are fixedly connected to the outer side of the baffles 11.

[0036] like Figures 1 to 5 As shown, a pull block 13 is fixedly connected to the top of the flow cytometer body 1, and an anti-slip pad 14 is fixedly connected to the bottom of the flow cytometer body 1.

[0037] like Figures 1 to 5 As shown, a fixing block 15 is fixedly connected to the surface of the connecting block 83, and the fixing block 15 is located on top of the insert block 72.

[0038] like Figures 1 to 5 As shown, the top of the cell box 5 is provided with a placement slot 16, and a support block 17 is fixedly connected to the bottom of the front of the flow cytometer body 1.

[0039] In this embodiment of the invention, the user first pulls the handle 73 outwards. This action causes the plug 72 connected to the handle 73 to move outwards accordingly until the plug 72 is completely disengaged from its original position in the limiting groove 6. At this point, the user can easily remove the old cell tubes from the cell box 5 and place the new cell tubes inside the cell box 5. The user then places the cell box 5 containing the new cell tubes on top of the horizontal block 4 using the support block 17. After ensuring the cell box 5 is stably positioned, the user releases the handle 73. The elastic force of the spring 74 causes the insert 72 to move inward and re-insert into the limiting groove 6, thereby stably limiting the cell box 5. During the inward movement of the insert 72, it also drives the gear 84 connected to it to rotate inside the gear 84. The rotation of the gear 84 further drives the rotation of the connecting block 83, and the cleaning block 82 connected to the connecting block 83 also rotates. This rotation effectively cleans up any dust that may remain inside the through hole 71, thereby avoiding jamming caused by dust accumulation.

[0040] The above description is the preferred embodiment of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and these improvements and modifications should also be considered within the protection scope of this utility model.

Claims

1. A flow cytometer for residual cell monitoring, comprising a flow cytometer body (1), wherein a button (2) is fixedly connected to the right side of the top front of the flow cytometer body (1), a control panel (3) is fixedly connected to the front of the flow cytometer body (1), a horizontal block (4) is fixedly connected to the bottom of the inner wall of the flow cytometer body (1), and a cell box (5) is provided on the top of the horizontal block (4), characterized in that: Limiting grooves (6) are provided on both sides of the horizontal block (4). A limiting structure (7) is provided at the bottom of the cell box (5). The limiting structure (7) includes a through hole (71). An insert (72) is slidably connected inside the through hole (71). A handle (73) is fixedly connected to the outside of the insert (72). A spring (74) is fixedly connected to the bottom of the insert (72). The outside of the spring (74) is fixedly connected to the outside of the through hole (71). A cleaning structure (8) is provided on both the front and back of the insert (72).

2. The flow cytometer for monitoring residual cells according to claim 1, characterized in that, The cleaning structure (8) includes a transverse groove (81) located on the front and back of the insert block (72). A cleaning block (82) is provided inside the transverse groove (81). A connecting block (83) is fixedly connected to the top of the cleaning block (82). A gear (84) is fixedly connected to the top of the connecting block (83). A toothed plate (85) meshes with the outer side of the gear (84). The outer side of the toothed plate (85) is fixedly connected to the inner wall of the through hole (71).

3. The flow cytometer for monitoring residual cells according to claim 1, characterized in that, The flow cytometer body (1) has ventilation openings (9) on both sides, and a dustproof net (10) is fixedly connected inside the ventilation openings (9).

4. A flow cytometer for monitoring residual cells according to claim 1, characterized in that, The cell box (5) is equipped with baffles (11) on both the front and back sides, and mounting ears (12) are fixedly connected to the outer side of the baffles (11).

5. A flow cytometer for monitoring residual cells according to claim 1, characterized in that, A pull block (13) is fixedly connected to the top of the flow cytometer body (1), and an anti-slip pad (14) is fixedly connected to the bottom of the flow cytometer body (1).

6. A flow cytometer for monitoring residual cells according to claim 2, characterized in that, A fixing block (15) is fixedly connected to the surface of the connecting block (83), and the fixing block (15) is located on top of the insert block (72).

7. A flow cytometer for monitoring residual cells according to claim 1, characterized in that, The cell box (5) has a placement slot (16) on its top, and a support block (17) is fixedly connected to the bottom of the front of the flow cytometer body (1).