Cryopreservation carrier

Abstract

The utility model belongs to the technical field of medical instruments, and discloses a cryopreservation carrier. The cryopreservation carrier comprises a storage body and a cover body, the first end of the storage body is closed, the second end of the storage body is provided with an opening used for storing biological samples, the cover body is partially inserted into the second end of the storage body from the opening or partially inserted into the cover body, and the cover body and the second end of the storage body are in heat sealing connection to completely seal the opening. The cover body and the storage body are independently arranged, when the cover body is partially inserted into the second end of the storage body, the cover body and the storage body are fused through a heat source, the cover body can completely seal the opening of the storage body, then the complete sealing state is achieved, it is ensured that liquid nitrogen cannot enter the cryopreservation carrier in the freezing process, and pipe explosion and sample cross contamination are avoided.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical appliance technical field especially, relate to a freeze storage carrier. BACKGROUND

[0002] Cell freezing is one of the main methods of cell preservation, using freezing technology to place cells in liquid nitrogen low temperature preservation, can make the cell temporarily leave the growth state, need again to recover the cell for experiment.

[0003] In the prior art, the freeze storage carrier includes a storage body and a cover body, the storage body and the cover body are sealed by screwing threads, and cannot achieve complete sealing state, liquid nitrogen is easy to enter the pipe during the freezing process, and there is a risk of pipe explosion and sample cross contamination.

[0004] That is, the existing freeze storage carrier is sealed by screwing threads, and cannot achieve complete sealing state, liquid nitrogen is easy to enter the freeze storage carrier during the freezing process, and there is a risk of pipe explosion and sample cross contamination. UTILITY MODEL CONTENT

[0005] The utility model aims at providing a freeze storage carrier to completely seal the storage body and the cover body, prevent liquid nitrogen from entering the freeze storage carrier during the freezing process, and avoid pipe explosion and sample cross contamination.

[0006] To achieve this purpose, the utility model adopts the following technical solutions:

[0007] The utility model provides a freeze storage carrier, which comprises:

[0008] A storage body, the first end of which is closed and the second end of which is provided with an opening for storing biological samples;

[0009] A cover body, the cover body is partially inserted into the second end of the storage body from the opening, or the second end of the storage body is partially inserted into the cover body;

[0010] The cover body and the second end of the storage body are heat-sealed and connected to completely close the opening.

[0011] As an optional technical solution of the freeze storage carrier, the storage body comprises:

[0012] A main storage section for accommodating the biological samples;

[0013] An extension section, one end of which is connected to the main storage section, and the other end of which is provided with the opening and heat-sealed and connected with the cover body.

[0014] As an optional technical solution of the freeze storage carrier, the wall thickness of the extension section is smaller than that of the main storage section.

[0015] As an optional technical solution of the freezing carrier, the outer side of the storage body is provided with a writing area, and / or the outer side of the storage body is provided with a scale.

[0016] As an optional technical solution of the freezing carrier, the cover body is provided with a first identification block, and / or the storage body is provided with a second identification block.

[0017] As an optional technical solution of the freezing carrier, the first identification block is fixedly connected to the cover body.

[0018] As an optional technical solution of the freezing carrier, the cover body comprises:

[0019] The insertion section is inserted and heat-seal connected to the second end of the storage body;

[0020] The blocking section is connected and radially protrudes outwardly from the insertion section, and the blocking section is in contact with the end face of the second end of the storage body.

[0021] As an optional technical solution of the freezing carrier, the outer peripheral surface of the blocking section is flush with the outer peripheral surface of the second end of the storage body.

[0022] As an optional technical solution of the freezing carrier, the storage body is a circular tube, and the cover body is a tube cap.

[0023] As an optional technical solution of the freezing carrier, the storage body is made of plastic material, and / or the cover body is made of plastic material.

[0024] Beneficial effects:

[0025] The utility model provides a freezing carrier, the freezing carrier includes storage body and cover body, and the first end of storage body is closed and is equipped with the opening for storing biological sample at the second end, and the cover body is partially inserted in the second end of storage body or the second end of storage body is partially inserted in the cover body, and the cover body and the second end of storage body are heat-seal connected to close the opening completely. By separately arranging the cover body and the storage body, when the cover body is partially inserted in the second end of the storage body, the cover body and the storage body are fused by using a heat source, the cover body can completely close the opening of the storage body, and then a completely sealed state is achieved, so that liquid nitrogen cannot enter the inside of the freezing carrier during the freezing process, and pipe explosion and sample cross contamination are avoided. BRIEF DESCRIPTION OF DRAWINGS

[0026] Figure 1 is the split view of the freezing carrier provided by the utility model embodiment;

[0027] Figure 2 is the sectional view of the freezing carrier provided by the utility model embodiment;

[0028] Figure 3is a structure schematic view of the first visual angle of the storage body provided by the embodiment of the utility model;

[0029] Figure 4 is a structure schematic view of the second visual angle of the storage body provided by the embodiment of the utility model;

[0030] Figure 5 is a structure schematic view of the cover body provided by the embodiment of the utility model.

[0031] In the drawing:

[0032] 10, storage body; 11, main storage section; 111, writing area; 12, extension section;

[0033] 20, cover body; 21, insertion section; 22, plugging section;

[0034] 31, first identification block; 32, second identification block;

[0035] A, scale. DETAILED DESCRIPTION

[0036] The utility model will be further explained in detail in combination with the drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the utility model, and not limited to the utility model. In addition, it should be noted that in order to facilitate the description, only the part related to the utility model is shown in the drawing, not all the structures.

[0037] In the description of the utility model, unless otherwise explicitly specified and limited, the terms "connected", "connected", "fixed" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two elements or the interaction relationship of two elements. For ordinary skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances.

[0038] In the utility model, unless otherwise explicitly specified and limited, the first feature "on" or "below" the second feature can include that the first and second features are in direct contact, or the first and second features are not in direct contact but are in contact through another feature between them. Moreover, the first feature "on", "above" and "above" the second feature includes that the first feature is directly above and obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature "below", "below" and "below" the second feature includes that the first feature is directly below and obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0039] In the description of the embodiments, the terms "upper", "lower", "left", "right", and the like orientation or position relationship are based on the orientation or position relationship shown in the drawings, and are only for the convenience of description and simplification of operation, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the utility model. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0040] With the increasing maturity of freezing technology, its application in biological samples is more and more. Freezing is a process of converting from liquid to amorphous solid with glass-like appearance through rapid cooling. When the cooling is rapid, the water in the cell has been replaced, which can avoid the damage of ice crystal formation at low temperature to the cell lipid membrane and cytoskeleton structure, achieve the effect of freezing protection, and improve the survival and development ability of biological sample freezing and resuscitation. The freezing technology has the advantages of simplicity, high efficiency, low cost, high survival rate and the like.

[0041] As shown in Figures 1 to 5 The present embodiment provides a cryopreservation carrier, which comprises a storage body 10 and a cover body 20, the first end of the storage body 10 is closed and the second end is provided with an opening for storing biological samples, the cover body 20 is partially inserted into the second end of the storage body 10 or the second end of the storage body 10 is partially inserted into the cover body 20, and the cover body 20 is heat-sealed and connected with the second end of the storage body 10 to completely close the opening.

[0042] By separately arranging the cover body 20 and the storage body 10, when the cover body 20 is partially inserted into the second end of the storage body 10, the cover body 20 and the storage body 10 are fused by using a heat source, the cover body 20 can completely close the opening of the storage body 10, and then reach a completely sealed state, so as to ensure that liquid nitrogen cannot enter the inside of the cryopreservation carrier during the freezing process, and avoid pipe explosion and sample cross contamination.

[0043] In the present embodiment, the storage body 10 is a circular tube, and the cover body 20 is a tube cap; the storage body 10 is made of plastic material; and the cover body 20 is made of plastic material. In other embodiments, the storage body 10 can also be a box body or a box body, and the cover body 20 is a box cover or a box cover. By arranging the storage body 10 as a circular tube, the biological samples can be placed into the storage body 10 from the opening, which occupies small space and is flexible to take and place; the storage body 10 and the cover body 20 are made of plastic material, for example, polypropylene material, and the cryopreservation carrier made of polypropylene material is translucent, which is convenient for observing the state of the biological samples inside the cryopreservation carrier.

[0044] In the prior art, the currently used cryopreservation carriers mainly include outer-rotation type cryopreservation tubes, inner-rotation type cryopreservation tubes and straight sealing tubes. The outer-rotation type cryopreservation tubes and the inner-rotation type cryopreservation tubes are sealed by screwing the tube cap and the tank body in a threaded manner, and cannot achieve a completely sealed state, which has the risks of tube explosion and sample cross-contamination during use. The mouth of the straight sealing tube is deformed greatly after being sealed, and has poor size consistency, and cannot be used for automatic equipment and has no identification code, which is not conducive to the database tube.

[0045] Further, the storage body 10 includes a main storage section 11 for accommodating biological samples and an extension section 12 connected to the main storage section 11 at one end and provided with an opening and heat-sealedly connected to the cover body 20 at the other end. By arranging the main storage section 11 to accommodate biological samples and the extension section 12 arranged on the main storage section 11, the extension section 12 is heat-sealedly connected to the cover body 20, and the main storage section 11 is not affected and can maintain the original size when the extension section 12 is deformed.

[0046] In the embodiment, the storage body 10 and the cover body 20 are of an integrated structure, and the cover body 20 is partially inserted into the extension section 12 of the storage body 10 from the opening.

[0047] Specifically, the cover body 20 includes an insertion section 21 and a blocking section 22, the insertion section 21 is inserted and heat-sealedly connected to the second end of the storage body 10, and the blocking section 22 is connected and radially protrudes outwardly from the insertion section 21 and is in contact with the end face of the second end of the storage body 10. By arranging the insertion section 21 and the blocking section 22, the insertion section 21 is gradually inserted into the second end of the storage body 10 until the blocking section 22 is in contact with the end face of the second end of the storage body 10, at which time the cover body 20 is assembled in place, and then the insertion section 21 and the storage body 10 are heat-sealed by using a heat source, so as to ensure the relative position of the cover body 20 and the storage body 10.

[0048] In the embodiment, the insertion section 21 is inserted from the opening of the extension section 12, and the outer circumferential surface of the insertion section 21 is heat-sealedly connected to the inner circumferential surface of the extension section 12. The cryopreservation carrier provided in the embodiment is partially inserted by the insertion section 21 and the extension section 12, and is heat-sealed at the insertion position, which is deformed but does not affect the size of the main storage section 11 and the blocking section 22, and can ensure the consistency of the size of the cryopreservation carrier while being completely sealed, and is suitable for automatic equipment.

[0049] Referring to Figure 2The wall thickness of the extension section 12 is less than that of the main storage section 11. The heat sealing connection is achieved by heating the material surface to melt and then bond together. The strength and quality of the heat sealing connection are affected by various factors, and the thickness is a key factor. If the thickness of the extension section 12 is too thick, a higher temperature and a longer time are required to melt and firmly bond. Similarly, if the extension section 12 is inserted into the cover 20, the thickness of the cover 20 also affects the heat sealing.

[0050] Optionally, the outer periphery of the sealing section 22 is flush with the outer periphery of the second end of the storage body 10. By setting the outer periphery of the sealing section 22 flush with the outer periphery of the second end of the storage body 10, the appearance of the cryopreserved carrier is smooth and beautiful after the cover 20 is assembled on the storage body 10, which is convenient for storage and taking out.

[0051] Optionally, a writing area 111 is arranged on the outer side of the storage body 10; and a scale is arranged on the outer side of the storage body 10. In this embodiment, the writing area 111 and the scale A are arranged on the outer side of the main storage section 11. The scale A is arranged to facilitate determination of the amount of biological sample, and the writing area 111 is arranged to facilitate marking of information.

[0052] Further, the cover 20 is provided with a first identification block 31, and the storage body 10 is provided with a second identification block 32. By arranging the identification blocks on the cover 20 and the storage body 10, and arranging identification codes such as two-dimensional codes on the identification blocks, information reading is more convenient and flexible, and sample tracing and sample library management can be achieved. It can be understood that the use of two-dimensional codes to store information and the use of scanning equipment to automatically read two-dimensional codes to obtain information belong to the prior art, and will not be described here.

[0053] In this embodiment, the first identification block 31 is fixedly connected to the cover 20, and the second identification block 32 is fixedly connected to the storage body 10. The identification block is an important basis for sample management, tracing and inquiry. Once the identification block falls off, it will cause many inconveniences in sample storage and use. By fixing the first identification block 31 and the second identification block 32, the stability and readability can be guaranteed, and the risk of falling off of the identification block can be reduced. The fixed connection between the first identification block 31 and the cover 20 and between the second identification block 32 and the storage body 10 includes but is not limited to ultrasonic welding, laser etching, adhesion and clamping.

[0054] In this embodiment, the cross section of the cover 20 is U-shaped, the first identification block 31 is embedded and fixed on the top of the cover 20, and the main storage section 11 of the storage body 10 is provided with a receiving groove, and the second identification block 32 is embedded and fixed in the receiving groove.

[0055] Obviously, the above embodiments of the present application are merely examples for clearly illustrating the present application, and are not intended to limit the implementation modes of the present application. For those skilled in the art, various obvious changes, re-adjustments and replacements can be made without departing from the protection scope of the present application. Here, it is not necessary and also impossible to enumerate all the implementation modes. Any modification, equivalent replacement and improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application claim.

Claims

1. A cryopreservation medium, characterized in that, include: Storage body (10), with a closed first end and an opening at the second end for storing biological samples; A cover (20) is partially inserted into the second end of the storage body (10) from the opening, or the second end of the storage body (10) is partially inserted into the cover (20); The cover (20) is heat-sealed to the second end of the storage body (10) to completely seal the opening.

2. The cryopreservation medium according to claim 1, characterized in that, The storage body (10) includes: The main storage section (11) is used to contain the biological sample; The extension section (12) is connected at one end to the main storage section (11) and at the other end to the opening and is heat-sealed to the cover (20).

3. The cryopreservation medium according to claim 2, characterized in that, The wall thickness of the extension section (12) is less than the wall thickness of the main storage section (11).

4. The cryopreservation medium according to claim 1, characterized in that, The storage body (10) has a writing area (111) on its outer side, and / or the storage body (10) has a scale on its outer side.

5. The cryopreservation medium according to claim 1, characterized in that, The cover (20) is provided with a first identification block (31), and / or the storage body (10) is provided with a second identification block (32).

6. The cryopreservation medium according to claim 5, characterized in that, The first identification block (31) is fixedly connected to the cover (20).

7. The cryopreservation medium according to claim 1, characterized in that, The cover (20) includes: Insertion section (21) is inserted and heat-sealed to the second end of the storage body (10); A blocking section (22) is connected to and radially protrudes outward from the insertion section (21), and the blocking section (22) is in contact with the second end face of the storage body (10).

8. The cryopreservation medium according to claim 7, characterized in that, The outer peripheral surface of the sealing section (22) is flush with the outer peripheral surface of the second end of the storage body (10).

9. The cryopreservation medium according to any one of claims 1-8, characterized in that, The storage body (10) is a round tube, and the cover (20) is a tube cap.

10. The cryopreservation medium according to any one of claims 1-8, characterized in that, The storage body (10) is made of plastic, and / or the cover (20) is made of plastic.

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