Concentration equipment for processing meglumine chlorzolate

Abstract

The utility model relates to the field of medical product processing, in particular to concentration equipment for processing meglumine chlorzolate, which comprises a mounting rack, a concentration tank and a storage tank, the concentration tank is fixed on one side in the mounting rack, a plurality of filtering holes are arranged at the bottom in the concentration tank, and the storage tank is fixed on the other side in the mounting rack. A discharge hopper is arranged at the bottom of the concentration tank corresponding to the outside of the filter-out hole, an electric heating tube with a wiring end extending to the outside is mounted between the bottom in the discharge hopper and the outside of the concentration tank, and the discharge hopper and the bottom of the storage tank are both communicated with a discharge tube. The vacuum pump is used for creating a low-pressure environment, the boiling point of a solvent is reduced, low-temperature evaporation is realized, and the concentration efficiency is greatly improved; through a heating, stirring, condensing and pressure monitoring system which is accurately controlled by an electric heating tube, a motor, a bevel gear and a condenser, the stability of the whole concentration process is ensured, and the quality fluctuation is reduced; safety parts such as a check valve and a pressure gauge can improve safety of the system, and backflow and overpressure risks are prevented.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of pharmaceutical products processing, especially to a concentrating equipment for chlorzoxazone meglumine processing. BACKGROUND

[0002] Chlorzoxazone meglumine is a drug, mainly used for treating transthyretin amyloidosis (ATTR), which is a rare disease, in which abnormal protein (transthyretin) forms insoluble amyloid fibril deposits in different organs and tissues of the body, affecting the function of these parts. ATTR can be hereditary or wild type (non-hereditary), and can affect the heart, nerves and other organs.

[0003] In the production process of chlorzoxazone meglumine, the concentrating equipment is usually used to concentrate the solution after reaction to improve the purity and yield of the product.

[0004] The existing concentrating equipment usually adopts normal pressure or high pressure evaporation technology, which requires high temperature to vaporize the solvent. For example, the boiling point of water is one hundred degrees Celsius under normal pressure, and the boiling point of other organic solvents such as ethanol is also relatively high, about seventy-eight point four degrees Celsius. For heat-sensitive drugs such as chlorzoxazone meglumine, such a high-temperature environment may cause the active ingredients to decompose or denature, thereby seriously affecting the quality and efficacy of the final drug product.

[0005] Therefore, a concentrating equipment for chlorzoxazone meglumine processing is specially designed to reduce the boiling point of the solvent and reduce the quality fluctuation. CONTENT OF THE UTILITY MODEL

[0006] In order to overcome the above-mentioned shortcomings of the existing technology of normal pressure or high pressure evaporation for concentration, which has a high boiling point and may cause the active ingredients of chlorzoxazone meglumine to decompose or denature, the utility model provides a concentrating equipment for chlorzoxazone meglumine processing, which can reduce the boiling point of the solvent and reduce the quality fluctuation.

[0007] The application discloses a concentrating device for chlorzoxazone meglumine processing, which comprises a mounting frame, a concentrating tank and a storage tank, a plurality of filter holes are formed in the bottom of the concentrating tank, a storage tank is fixed to the other side of the mounting frame, a discharge hopper is arranged outside the filter hole in the bottom of the concentrating tank, an electric heating pipe is arranged between the bottom of the discharge hopper and the outside of the concentrating tank, the discharge hopper and the storage tank are both connected with a discharge pipe, a feeding pipe is arranged on one side of the upper portion of the concentrating tank, a vacuum pump is arranged on the front side of the truss of the bottom of the mounting frame, the extraction pipe of the vacuum pump is connected with the other side of the upper portion of the concentrating tank, the top of the concentrating tank and the top of the storage tank are both provided with a cover plate, an air inlet pipe and a liquid outlet pipe are arranged on the top of the cover plates, a check valve is arranged on the air inlet pipe, a condenser is arranged between the discharge end of the air inlet pipe and the liquid inlet end of the liquid outlet pipe, a support extending upwards is arranged on the rear side of the top of the mounting frame, the support is connected with the bottom of the condenser, a condensing pipe is arranged in the condenser, the inlet of the condensing pipe is connected with the discharge end of the air inlet pipe, the outlet of the condensing pipe is connected with the liquid inlet end of the liquid outlet pipe, a peristaltic pump is arranged on the air inlet pipe and the liquid outlet pipe, a motor is arranged on the front side of the top of the mounting frame, an output shaft of the motor extends into the concentrating tank, a horizontal mounting plate is arranged on the upper portion of the concentrating tank, a stirring paddle is rotatably arranged on the mounting plate, and bevel gears are arranged between the top of the stirring paddle and the end of the output shaft of the motor.

[0008] Further, a plurality of through holes are arranged on the stirring paddle.

[0009] Further, a cooling fan is arranged on the condenser, and the air supply end of the cooling fan is embedded in the upper portion of the condenser.

[0010] Further, a butterfly valve is arranged on the discharge pipe, and the butterfly valve is used for controlling the flow rate.

[0011] Further, a heat insulation shell is arranged on the concentrating tank and the storage tank.

[0012] Further, an observation window and a locking rod are arranged, the observation window is hingedly arranged on the outside of the heat insulation shell, the window eaves of the observation window are embedded in the inside of the corresponding concentrating tank and storage tank, a plurality of locking rods are rotatably arranged on the outside of the window eaves, positioning members are arranged on the outside of the observation window and correspond to the positions of the locking rods, and the locking rods are clamped into the corresponding positioning members.

[0013] Further, a pressure gauge is arranged on one side of the top of the cover plate of the concentrating tank and the storage tank.

[0014] Further, adjusting feet are arranged on the bottom of the mounting frame.

[0015] Compared with the prior art, the utility model has the advantages that: the utility model creates low pressure environment with vacuum pump, reduces solvent boiling point, realizes low temperature evaporation, improves concentration efficiency greatly, heating, stirring, condensation and pressure monitoring system of accurate control through electric heating pipe, motor, bevel gear and condenser, guarantee the stability of whole concentration process, reduce quality fluctuation, safety components such as check valve and pressure gauge can improve the safety of system, prevent backflow and overpressure risk. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is the assembly structure schematic drawing of the utility model.

[0017] Figure 2 It is the section view schematic drawing of the utility model condenser after showing condensing pipe and cooling fan.

[0018] Figure 3 It is the section view schematic drawing of the utility model concentration tank after showing stirring paddle and bevel gear etc. component.

[0019] Figure 4 It is the section view schematic drawing of the utility model concentration tank after showing bevel gear and cover plate etc. component.

[0020] Figure 5 It is the three-dimensional structure schematic drawing of the utility model observation window and lock rod.

[0021] Drawing reference: 1, mounting frame, 2, concentration tank, 21, storage tank, 3, electric heating pipe, 4, discharge pipe, 41, feed pipe, 42, butterfly valve, 5, vacuum pump, 6, cover plate, 7, air inlet pipe, 71, liquid outlet pipe, 72, check valve, 8, condenser, 81, condensing pipe, 82, cooling fan, 9, peristaltic pump, 10, motor, 11, bevel gear, 12, mounting plate, 13, stirring paddle, 14, heat insulation shell, 15, observation window, 16, lock rod, 17, pressure gauge. DETAILED DESCRIPTION

[0022] The utility model will now be described more fully hereinafter with reference to the accompanying drawings, in which currently preferred embodiments of the utility model are shown. This utility model may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided for thoroughness and completeness, and fully convey the scope of the utility model to the skilled person.

[0023] Embodiment: a kind of chlorzoxazone acid meglumine processing concentration equipment, such as Figures 1-4As shown, including the mounting frame 1, concentrated tank 2 and storage tank 21, mounting frame 1 as the support structure of the whole device, ensure stable installation of all components, mounting frame 1 bottom each edge corner is equipped with adjusting foot, for horizontal adjustment and fixed equipment, mounting frame 1 inside one side fixed with concentrated tank 2, for storage of concentrated chlorzoxazone meglumine solution, and evaporate operation here, concentrated tank 2 inner bottom is provided with a plurality of filter holes, for filtering out the residual solvent, mounting frame 1 inside the other side is fixed with storage tank 21, storage after condensation recovered liquid solvent or concentrated chlorzoxazone meglumine solution, concentrated tank 2 bottom corresponding filter hole outside is equipped with discharge hopper, the discharge hopper inner bottom and concentrated tank 2 outside between installation has the electric heating tube 3 that wire end extends to outside, the discharge hopper and storage tank 21 bottom all communicate with discharge pipe 4, for discharge a small amount of residual liquid or miscellaneous that has not been evaporated, and discharge the chlorzoxazone meglumine solution that has concentrated well, concentrated tank 2 upper side is communicated with the upward bending shape feed pipe 41, for adding the solution containing chlorzoxazone meglumine to concentrated tank 2, the truss front side of mounting frame 1 inner bottom is equipped with vacuum pump 5, through the extraction pipe, the air in concentrated tank 2 is extracted, forms low pressure environment, reduces the boiling point of solvent, makes evaporation can be carried out at lower temperature, the extraction pipe of vacuum pump 5 is communicated with the upper side of concentrated tank 2, concentrated tank 2 and storage tank 21 top are all sealed with cover plate 6, seal concentrated tank 2 and storage tank 21, prevent outside air from entering influence concentrated effect, two cover plate 6 top central place is communicated with air inlet pipe 7 and liquid outlet pipe 71 respectively, liquid outlet pipe 71 is transported to storage tank 21 after condensation liquid solvent, air inlet pipe 7 and the cover plate 6 communication of concentrated tank 2 are equipped with check valve 72, prevent the liquid after condensation from flowing back to concentrated tank 2, keep the one-way flow characteristics of system, air inlet pipe 7 discharge end and liquid outlet pipe 71 liquid inlet end between installation has condenser 8, air inlet pipe 7 guides the steam generated by evaporation to enter condenser 8, cools the steam generated by evaporation, makes it become liquid solvent again, mounting frame 1 top rear side is equipped with the upward extension support, the support is connected with the bottom of condenser 8, the inside of condenser 8 is traversely communicated with the annular condensing pipe 81, the inlet of condensing pipe 81 is connected with the discharge end of air inlet pipe 7, the outlet of condensing pipe 81 is connected with the liquid inlet end of liquid outlet pipe 71, liquid outlet pipe 71 and the cover plate 6 communication of storage tank 21 are equipped with peristaltic pump 9, for auxiliary delivery and control the flow rate of chlorzoxazone meglumine solution after condensation, mounting frame 1 top front side is equipped with the motor 10 of output shaft extension into concentrated tank 2, the inside of concentrated tank 2 is provided with the horizontal mounting plate 12, the mounting plate 12 is rotatably provided with stirring paddle 13, a plurality of equidistantly arranged through holes are formed in the stirring paddle 13, the top of stirring paddle 13 and the output shaft end of motor 10 are jointly provided with bevel gears 11 that are engaged with each other.

[0024] As Figure 2As shown, it also includes a cooling fan 82. The cooling fan 82 is installed on the upper part of the condenser 8. The air supply end of the cooling fan 82 is embedded in the upper part of the condenser 8. The cooling fan 82 is used to improve condensation efficiency and help to cool down quickly.

[0025] like Figure 1 As shown, it also includes a butterfly valve 42. The discharge pipe 4 is equipped with a butterfly valve 42 for controlling the flow rate, which is used to control the discharge speed and ensure that the concentration process proceeds smoothly.

[0026] like Figure 1 and Figure 4 As shown, it also includes a heat insulation shell 14. Both the concentration tank 2 and the storage tank 21 are covered with heat insulation shells 14 to reduce the impact of external heat on the concentration tank 2 and the storage tank 21, while protecting the operators from high temperature burns.

[0027] like Figure 4 and Figure 5 As shown, it also includes an observation window 15 and locking rods 16. The observation window 15 is hinged to the outside of the insulation sleeve. The observation window 15 allows the operator to check the internal situation at any time. The window sill of the observation window 15 is embedded in the corresponding concentration tank 2 and storage tank 21. Multiple equidistant locking rods 16 are provided on the outside of the window sill along the circumferential direction. Positioning parts are provided on the outside of the observation window 15 along the circumferential direction corresponding to the locking rods 16. The locking rods 16 are engaged in the corresponding positioning parts to ensure that they fit tightly against the concentration tank 2 and storage tank 21 when closed, thus preventing leakage.

[0028] like Figure 1 As shown, it also includes a pressure gauge 17. Pressure gauges 17 are installed on the top right side of the cover plate 6 of both the concentration tank 2 and the storage tank 21 to monitor the pressure changes inside the concentration tank 2 and the storage tank 21 in real time, ensuring that the system is always within the set safety range.

[0029] In use, the solution containing mefenamic acid meglumine is added into the concentration tank 2 through the feeding pipe 41, the concentration tank 2 is ensured to be sealed well with the cover plate 6 of the storage tank 21 to prevent external air from entering to affect the concentration effect, the vacuum pump 5 is started, the air in the concentration tank 2 is extracted through the extraction pipe to form a low-pressure environment, so as to reduce the boiling point of the solvent, so that evaporation can be carried out at a lower temperature, and the effective components of the drug are protected, when the required reduced pressure state is reached, the electric heating pipe 3 at the bottom of the discharge hopper is started, the electric heating pipe 3 directly provides heat for the mefenamic acid meglumine solution in the concentration tank 2, so that the solvent starts to vaporize, at the same time, the motor 10 is started, the output shaft of the motor 10 drives the bevel gear 11 to rotate, the two bevel gears 11 mesh with each other to drive the stirring paddle 13 below the mounting plate 12 to rotate, the rotation of the stirring paddle 13 ensures that the solution is uniformly heated, accelerates the evaporation process, and avoids local overheating, as the solvent continuously evaporates, the generated steam (mainly solvent vapor, but not mefenamic acid meglumine vapor) enters the condenser 8 through the air inlet pipe 7 at the top of the concentration tank 2, the check valve 72 is installed at the connection between the air inlet pipe 7 and the concentration tank 2 to prevent the condensed liquid from flowing back to the concentration tank 2, and the one-way flow characteristics of the system are maintained, the annular condensing pipe 81 in the condenser 8 is responsible for cooling these vapors to make them become liquid solvents again, in order to improve the condensing efficiency, the cooling fan 82 is started to send air to the inside of the condenser 8, helping to quickly cool down and improve the condensing efficiency, the liquid solvent after condensation flows into the storage tank 21 through the liquid outlet pipe 71, and the peristaltic pump 9 assists in conveying the condensed mefenamic acid meglumine solution and controls the flow rate, so that the concentrated mefenamic acid meglumine solution can be effectively transferred to the storage tank 21, and the pressure gauge 17 monitors the pressure changes in the concentration tank 2 and the storage tank 21 in real time, so that the system is always ensured to be within the set safety range, after the concentration is completed, the discharge pipe 4 at the bottom of the concentration tank 2 discharges a small amount of residual liquid or impurities that are not evaporated through the butterfly valve 42, preparing for the next operation, and the discharge pipe 4 of the storage tank 21 is used to discharge the mefenamic acid meglumine solution that has been concentrated, after completing a concentration period, the equipment must be thoroughly cleaned, especially the concentration tank 2 and the condenser 8 part, to remove the possible residual substances, prevent cross contamination, and prepare for the next round of production.

[0030] The embodiments of the utility model are described in detail above combined with the drawings, but the utility model is not limited to the above-mentioned embodiments, within the knowledge range of the person skilled in the art, various changes can be made without departing from the purpose of the utility model.

Claims

1. A concentration device for processing chlorobenzidine meglumine, characterized in that: The system includes a mounting frame (1), a concentration tank (2), and a storage tank (21). The concentration tank (2) is fixed inside one side of the mounting frame (1). Multiple filter holes are provided at the bottom of the concentration tank (2). The storage tank (21) is fixed inside the other side of the mounting frame (1). A discharge hopper is provided at the bottom of the concentration tank (2) corresponding to the filter holes. An electric heating tube (3) with a terminal protruding outward is installed between the bottom of the discharge hopper and the outside of the concentration tank (2). The bottoms of the discharge hopper and the storage tank (21) are both... A discharge pipe (4) is connected to the upper side of the concentration tank (2), and an upwardly curved feed pipe (41) is connected to one side of the upper part of the tank. A vacuum pump (5) is installed on the front side of the truss at the bottom of the mounting frame (1). The extraction pipe of the vacuum pump (5) is connected to the other side of the upper part of the concentration tank (2). Both the concentration tank (2) and the storage tank (21) are sealed with cover plates (6). The top of the two cover plates (6) is connected to an air inlet pipe (7) and a liquid outlet pipe (71) respectively. The air inlet pipe (7) is connected to the concentration tank (21). 2) A check valve (72) is installed at the connection of the cover plate (6). A condenser (8) is installed between the discharge end of the air inlet pipe (7) and the liquid inlet end of the liquid outlet pipe (71). An upwardly extending bracket is provided on the rear side of the top of the mounting bracket (1). The bracket is connected to the bottom of the condenser (8). A condenser tube (81) in a ring shape is transversely connected in the middle of the condenser (8). The inlet of the condenser tube (81) is connected to the discharge end of the air inlet pipe (7), and the outlet of the condenser tube (81) is connected to the liquid inlet end of the liquid outlet pipe (71). A peristaltic pump (9) is installed at the connection between the liquid outlet pipe (71) and the cover plate (6) of the storage tank (21). A motor (10) with its output shaft extending into the concentration tank (2) is installed on the front side of the top of the mounting bracket (1). A horizontal mounting plate (12) is provided in the upper part of the concentration tank (2). A stirring paddle (13) is rotatably mounted on the mounting plate (12). A bevel gear (11) meshes with each other between the top of the stirring paddle (13) and the end of the output shaft of the motor (10).

2. The concentration equipment for processing chlorobenzidine meglumine according to claim 1, characterized in that: The stirring paddle (13) has multiple through holes arranged at equal intervals.

3. The concentration equipment for processing chlorobenzazole meglumine according to claim 2, characterized in that: It also includes a cooling fan (82), which is installed on the upper part of the condenser (8), and the air supply end of the cooling fan (82) is embedded in the upper part of the condenser (8).

4. The concentration equipment for processing chlorobenzazole meglumine according to claim 3, characterized in that: It also includes a butterfly valve (42), and a butterfly valve (42) for controlling the flow rate is installed on the outside of the discharge pipe (4).

5. The concentration equipment for processing chlorobenzazole meglumine according to claim 4, characterized in that: It also includes a heat insulation shell (14), and the outside of the concentration tank (2) and the storage tank (21) are all covered with a heat insulation shell (14).

6. The concentration equipment for processing chlorobenzazole meglumine according to claim 5, characterized in that: It also includes an observation window (15) and a locking bar (16). The observation window (15) is hinged to the outside of the heat insulation sleeve. The window rim of the observation window (15) is embedded inside the corresponding concentration tank (2) and storage tank (21). Multiple equidistant locking bars (16) are provided on the outside of the window rim in a circumferential direction. Positioning elements are provided on the outside of the observation window (15) in a circumferential direction corresponding to the locking bar (16). The locking bar (16) is inserted into the corresponding positioning element.

7. The concentration equipment for processing chlorobenzazole meglumine according to claim 6, characterized in that: It also includes pressure gauges (17), and pressure gauges (17) are installed on one side of the top of the cover plate (6) of the concentration tank (2) and the storage tank (21).

8. The concentration equipment for processing chlorobenzazole meglumine according to claim 7, characterized in that: The mounting bracket (1) has adjustable feet at each corner of the bottom.

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