Tool for preclinical test AD mouse modeling

Abstract

The utility model discloses a preclinical test AD mouse modeling tool which comprises a tool body, one side of the tool body is fixedly connected with a cylinder, an arc-shaped plate is arranged in the cylinder, one side of the arc-shaped plate is provided with a first screw rod, one side of the tool body is symmetrically and fixedly connected with bearing plates, and the bearing plates are fixedly connected with the cylinder. Second screw rods are symmetrically and rotationally connected to one side of the interior of the bearing plate, sliding plates are in threaded connection with the outer sides of the second screw rods, third screw rods are in threaded connection with the interiors of the sliding plates, fixing seats are rotationally connected to one ends of the third screw rods, and the sliding plates are in threaded connection with the third screw rods by rotating the third screw rods. And the head of the laboratory mouse can be conveniently clamped by rotating the clamping plate, the situation that the laboratory mouse shakes in the molding process and the molding effect is affected is prevented, rapid molding is facilitated through the overall structure, and the molding efficiency is greatly improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the biological auxiliary tool technical field, concretely relates to a tool for AD mouse modeling in preclinical test. BACKGROUND

[0002] AD mouse refers to experimental mouse models used for Alzheimer's Disease (AD) research. These models help scientists understand the etiology and pathological mechanisms of AD and test potential treatment methods in the preclinical test phase by simulating certain pathological characteristics of human AD. AD mouse modeling involves a variety of tools and methods, including genetic engineering techniques, viral vectors, stereotactic surgery, immunological tools, drug induction, behavioral tests, neurobiology and molecular biology tools, imaging techniques, and bioinformatics tools. Researchers will choose the most appropriate modeling tools according to the research purpose and specific problems.

[0003] In stereotactic technology, specific reagents or viral vectors need to be accurately injected into specific areas of the mouse brain to induce AD pathological changes in the local area. During the process, the experimental mouse needs to be fixed. The existing technology lacks a tool to fix the mouse head, and generally, the experimenter uses tweezers to fix the head with their hands, increasing the labor of personnel and the efficiency of modeling is not high. UTILITY MODEL CONTENT

[0004] The technical problem to be solved by the utility model is to overcome the defects of the prior art and provide a tool for AD mouse modeling in preclinical test to solve the problem of lack of a tool to fix the mouse head in the prior art, which generally requires the experimenter to use tweezers to fix the head with their hands, increasing the labor of personnel and the efficiency of modeling is not high.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical scheme: a tool for AD mouse modeling in preclinical test, including tool body, one side of tool body is fixedly connected with cylinder, the inside of cylinder is provided with arc-shaped plate, one side of arc-shaped plate is provided with first screw rod, one side of tool body is fixedly connected with supporting plate in pairs, one side of the inside of supporting plate is rotatably connected with second screw rod in pairs, the outside of second screw rod is screw-connected with sliding plate, the inside of sliding plate is screw-connected with third screw rod, one end of third screw rod is rotatably connected with fixing seat, the inside of fixing seat is fixedly connected with first tooth column, the outside of first tooth column is mesh-connected with clamping plate, the bottom of tool body is provided with support frame.

[0006] Preferably, the arc-shaped plate is rotatably connected with the first screw rod through the rotating seat.

[0007] Preferably, the inside of the cylinder is fixedly connected with a threaded cylinder, and the threaded cylinder and the first screw rod are screw-connected.

[0008] Preferably, the supporting plate is internally provided with a through slot, and the supporting plate and the sliding plate are in sliding connection.

[0009] Preferably, the clamping plate is provided with a plurality of.

[0010] Preferably, the supporting frame is fixedly connected with a vacuum chuck at the bottom.

[0011] Preferably, the supporting frame is fixedly connected with a second tooth column at one side.

[0012] Preferably, the cylinder is in meshing connection with the second tooth column through a connecting piece.

[0013] Compared with the prior art, the utility model provides a kind of tools for AD mouse modeling of preclinical test, with the following beneficial effects:

[0014] 1, the utility model discloses arc plate and clamping plate are set, and experimental mouse is placed in cylinder inside before modeling, by rotating first screw rod, first screw rod is in screw thread connection with threaded cylinder, to push arc plate and move, realize the preliminary clamping and fixing of arc plate to experimental mouse, facilitate the subsequent operation of experiment, then by rotating third screw rod, sliding plate is in screw thread connection with third screw rod, to push fixed base and the left and right movement of clamping plate, realize the left and right clamping of experimental mouse head, by rotating clamping plate, the head of experimental mouse is clamped, prevent experimental mouse from shaking in the process of modeling, influence modeling effect, and second screw rod is in screw thread connection with sliding plate, to adjust the front and rear positions of clamping plate, improve the practicality and application range of tool.

[0015] 2, the utility model discloses supporting frame, and supporting frame supports tool, improves the stability of tool, and cylinder is in meshing connection with the second tooth column through connecting piece, to adjust the inclination angle of tool, facilitate experimental personnel to observe mouse brain structure, and combine head fixing tool, so that the experimental stability of AD mouse modeling is improved, and the overall structure is convenient for the rapid modeling of modeling, greatly improves the modeling efficiency.

[0016] The part not involved in the device is the same as or can be realized by the prior art, the utility model has scientific and reasonable structure, uses safe and convenient, and provides great help for people. ACCURACY

[0017] The accompanying drawings are used to provide further understanding of the utility model, and constitute part of the specification, and are used to explain the utility model together with embodiments of the utility model, and do not constitute limitation to the utility model, in the drawings:

[0018] Figure 1 It is the axonometric structure schematic view of one side of a kind of tool for AD mouse modeling of preclinical test proposed by the utility model.

[0019] Figure 2 Another side of the axis measurement structure schematic diagram of the tool for AD mouse modeling of preclinical test is provided in the utility model;

[0020] Figure 3 The support frame structure schematic diagram of the tool for AD mouse modeling of preclinical test is provided in the utility model;

[0021] Figure 4 The arc plate structure schematic diagram of the tool for AD mouse modeling of preclinical test is provided in the utility model;

[0022] Figure 5 The sliding plate structure schematic diagram of the tool for AD mouse modeling of preclinical test is provided in the utility model;

[0023] Figure 6 The clamping plate structure schematic diagram of the tool for AD mouse modeling of preclinical test is provided in the utility model;

[0024] In the drawing: tool body 1, cylinder 2, arc plate 3, rotating seat 4, threaded cylinder 5, first screw 6, supporting plate 7, through slot 8, second screw 9, sliding plate 10, third screw 11, fixed seat 12, first tooth column 13, clamping plate 14, support frame 15, vacuum chuck 16, second tooth column 17, connecting piece 18. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all the other embodiments obtained by the person skilled in the art without creative labor fall within the protection scope of the utility model.

[0026] Please refer to Figures 1-6The utility model provides a technical scheme: a tool for AD mouse modeling of preclinical test, including tool body 1, one side of tool body 1 is fixedly connected with cylinder 2, the inside of cylinder 2 is provided with arc plate 3, one side of arc plate 3 is provided with first screw rod 6, one side of tool body 1 is fixedly connected with the symmetrical bearing plate 7, the inside one side of bearing plate 7 is rotatably connected with the symmetrical second screw rod 9, the outside screw thread connection of second screw rod 9 has sliding plate 10, the inside screw thread connection of sliding plate 10 has third screw rod 11, one end of third screw rod 11 is rotatably connected with fixed seat 12, the inside fixed connection of fixed seat 12 has first tooth column 13, the outside meshing connection of first tooth column 13 has clamping plate 14, by rotating third screw rod 11, sliding plate 10 is screw connected with third screw rod 11, and then the left and right movement of fixed seat 12 and clamping plate 14 is pushed, realizes the left and right clamping of experimental mouse head, and the head of experimental mouse is clamped conveniently by rotating clamping plate 14, prevents experimental mouse from shaking in the process of modeling, influences the modeling effect, and the front and rear position of clamping plate 14 is adjusted conveniently by the screw thread connection of second screw rod 9 and sliding plate 10, improves the practicality and application range of tool, and the bottom of tool body 1 is provided with support frame 15.

[0027] In the utility model, preferably, arc plate 3 is rotatably connected with first screw rod 6 through rotating seat 4.

[0028] In the utility model, preferably, cylinder 2 is fixedly connected with threaded cylinder 5 inside, and threaded cylinder 5 and first screw rod 6 are screw connected, and then arc plate 3 is moved, and the preliminary clamping and fixing of arc plate 3 to experimental mouse are realized, which is convenient for subsequent operation of experiment.

[0029] In the utility model, preferably, bearing plate 7 is provided with through slot 8 inside, and bearing plate 7 and sliding plate 10 are slidingly connected.

[0030] In the utility model, preferably, clamping plate 14 is provided with a plurality of.

[0031] In the utility model, preferably, support frame 15 is fixedly connected with vacuum chuck 16 on the bottom symmetrically.

[0032] In the utility model, preferably, support frame 15 is fixedly connected with second tooth column 17 on the inside one side.

[0033] In the utility model, preferably, cylinder 2 is meshedly connected with second tooth column 17 through connecting piece 18, which is convenient for adjusting the inclination angle of the tool, convenient for experimental personnel to observe the structure of mouse brain, and in combination with the head fixing tool, the stability of AD mouse modeling experiment is improved, the overall structure is convenient for the rapid modeling, and the modeling efficiency is greatly improved.

[0034] The utility model discloses a working principle and use flow: when using, first, place the experimental mouse in the cylinder 2 inside before moulding, through rotating first screw rod 6, first screw rod 6 is connected with the thread cylinder 5 threadedly, and then push arc plate 3 and move, realize the initial clamping of arc plate 3 to experimental mouse and fixed, and the subsequent operation of experiment is convenient, then through rotating third screw rod 11, sliding plate 10 is connected with third screw rod 11 threadedly, and then push the left and right movement of fixed base 12 and clamping plate 14, realize the left and right clamping of experimental mouse head, through rotating clamping plate 14, the head of experimental mouse is conveniently clamped, prevent experimental mouse from shaking in the moulding process, influence moulding effect, and second screw rod 9 is connected with sliding plate 10 threadedly, and the front and rear position of clamping plate 14 is conveniently adjusted, improve the practicality and application scope of tool, then rotate the tool, and the cylinder 2 is connected with second tooth column 17 through connecting piece 18 and engages, realize the adjustment of the inclination angle of tool, and the brain structure of experimental personnel is observed to mouse, and the head fixed tool is combined, make AD mouse moulding experimental stability improve, after adjusting, the specific reagent or virus carrier is accurately injected to the specific area of mouse brain, and the quick moulding is convenient, and moulding efficiency is greatly improved.

[0035] Although the embodiments of the utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made thereto without departing from the principles and spirit of the utility model, and the scope of the utility model is defined by the appended claims and their equivalents.

Claims

1. A tool for preclinical testing of AD mouse modeling, comprising a tool body (1), characterized in that: The tool body (1) is fixedly connected with a cylinder (2) on one side, the cylinder (2) is internally provided with an arc-shaped plate (3), the arc-shaped plate (3) is provided with a first screw rod (6) on one side, the tool body (1) is fixedly connected with a supporting plate (7) on one side, the supporting plate (7) is internally and symmetrically rotatably connected with a second screw rod (9), the second screw rod (9) is externally threadedly connected with a sliding plate (10), the sliding plate (10) is internally threadedly connected with a third screw rod (11), one end of the third screw rod (11) is rotatably connected with a fixing base (12), the fixing base (12) is internally fixedly connected with a first tooth column (13), the first tooth column (13) is externally meshedly connected with a clamping plate (14), and the tool body (1) is provided with a supporting frame (15) at the bottom.

2. The tool for modeling AD in a preclinical test animal of claim 1, wherein: The arc-shaped plate (3) is rotatably connected with the first screw rod (6) through a rotating seat (4).

3. The tool for modeling AD in AD mice for preclinical testing according to claim 1, wherein: The cylinder (2) is internally fixedly connected with a threaded cylinder (5), and the threaded cylinder (5) and the first screw rod (6) are threadedly connected.

4. The tool for modeling AD in AD mice for preclinical testing according to claim 1, wherein: The supporting plate (7) is internally provided with a through groove (8), and the supporting plate (7) and the sliding plate (10) are slidably connected.

5. The tool for modeling AD in AD mice for preclinical testing according to claim 1, wherein: The clamping plate (14) is provided with a plurality of clamping plates.

6. The tool for modeling AD in AD mice for preclinical testing according to claim 1, wherein: The supporting frame (15) is fixedly connected with a vacuum suction disc (16) on one side.

7. The tool for modeling AD in AD mice for preclinical testing according to claim 1, wherein: The supporting frame (15) is internally and fixedly connected with a second tooth column (17) on one side.

8. The tool for modeling AD in a preclinical test AD mouse according to claim 7, wherein: The cylinder (2) is meshedly connected with the second tooth column (17) through a connecting piece (18). The cylinder (2) is meshedly connected with the second tooth column (17) through a connecting piece (18).

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