Sample diluent preparation assembly for fluorescence immunochromatography detection reagent
By designing an automated sample diluent preparation component for fluorescence immunochromatographic assay reagents, the problems of low efficiency and contamination in existing technologies have been solved, achieving efficient and automated liquid mixing and low-temperature storage, and ensuring the quality of the diluent.
Patent Information
- Application Number
- CN202423215581.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-25
- Publication Date
- 2025-12-16
- Estimated Expiration
- 2034-12-25
AI Technical Summary
The preparation of sample diluents for existing fluorescence immunochromatographic assay reagents requires the use of multiple devices in combination, which is inefficient. Furthermore, the prepared diluents are easily contaminated during transportation, affecting the dilution effect.
A sample diluent preparation component for fluorescence immunochromatographic assay reagents has been designed, comprising a cavity, a drive disk, a chuck, a liquid tank, an injection tube, and a preparation tank. Through the coordinated use of the injection tube and the preparation tank, an elliptical cam and a reset component are used to achieve automatic mixing of the liquid, and the liquid is cooled and stored in the cavity to avoid contamination.
It achieves efficient mixing and automated preparation of liquids, reduces the need for manual operation, ensures that the diluent is stored at low temperatures, avoids contamination during transportation, and improves the preparation efficiency and quality of the diluent.
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Figure CN223669128U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to diluent preparation technical field, concretely is a fluorescent immunochromatography detection reagent with sample diluent preparation subassembly. BACKGROUND
[0002] Fluorescent immunochromatography detection is a kind of rapid, sensitive quantitative detection method, is widely used in clinical diagnosis and biological research, fluorescent immunochromatography detection reagent with sample diluent includes buffer material, blocking agent, hydrophilic macromolecular substance, surfactant and sodium chloride these components.By the combination of these components, can only be effectively eliminated by sample dilution false positive in immunochromatography detection (such as serum, plasma, whole blood) used in a variety of samples, overcome the influence of matrix effect, realize the accuracy of fluorescent immunochromatography quantitative detection result, and application range is wide.
[0003] At present, fluorescent immunochromatography detection reagent with sample diluent preparation mostly needs multiple equipment combination use, needs manual mixing when preparing, to ensure that diluent is mixed fully, and efficiency is lower, and needs to be transported to storage device for low-temperature storage after preparation, diluent can be contaminated by external factors in the process of transportation, thereby affecting dilution effect. UTILITY MODEL CONTENT
[0004] The utility model aims at providing a fluorescent immunochromatography detection reagent with sample diluent preparation subassembly to solve the problems in the above background.
[0005] To achieve the above object, the utility model provides the following technical scheme: a fluorescent immunochromatography detection reagent with sample diluent preparation subassembly, including cavity, the inside installation of drive disc of cavity, the top middle position of drive disc installs support shaft, the top of support shaft installs chuck, the equidistance of the circumferential surface of chuck is arranged with a plurality of arc grooves, reagent tube is placed at the position of the arc groove of chuck, the both sides of cavity are installed with support, two The top opposite ends of the support are commonly installed with rotating assembly, the inside installation of rotating assembly has a plurality of liquid tanks, the bottom of a plurality of liquid tanks is installed with liquid injection pipe, the below of any one liquid injection pipe is installed with preparation tank, the bottom of preparation tank and the cavity are commonly connected with reset assembly, the outer surface of preparation tank is provided with grommet, one side of grommet is installed with oval cam, the bottom middle position of oval cam is provided with drive machine, one side of preparation tank is installed with flexible pipe, one end of flexible pipe is installed with pure water conveyor, the bottom of preparation tank is installed with telescopic pipe, the bottom of telescopic pipe is installed with liquid discharge pipe, the bottom of liquid discharge pipe extends to the inside of cavity.
[0006] Preferably, the arc-shaped groove of the chuck is provided with a protective baffle below the top end of the driving disc, the protective baffle is an arc-shaped plate member, and the arc-shaped groove is used in cooperation to limit the reagent tube, so that the reagent tube can be stably placed on the circumferential surface of the chuck.
[0007] Preferably, the two ends of the grommet are provided with connecting rods, the bottoms of the two connecting rods are jointly hingedly installed at the top end of the cavity, and the two connecting rods support the preparation tank through the grommet, thereby improving the stability of the preparation tank and preventing the preparation tank from collapsing when being driven to shake.
[0008] Preferably, the front top end of the cavity is hingedly provided with a cover, the cover can seal the cavity, a cooling assembly is arranged in the cavity, the inside of the cavity is in a low-temperature state, the diluted liquid prepared by the preparation tank is conveniently stored, the cover is opened when the diluted liquid is needed to be taken, and the reagent tube driven by the chuck is taken at the opening position.
[0009] Preferably, the inside of the cavity is provided with a first protective door and a second protective door, one end of each of the first protective door and the second protective door is provided with a toothed opening, the two toothed openings are vertically arranged, the two toothed openings are hingedly connected to each other, the first protective door and the second protective door can be rotated at the hinged position of the two toothed openings to achieve an opening and closing effect, the first protective door and the second protective door are closed when the preparation tank shakes, and the first protective door and the second protective door are opened when the liquid injection pipe injects liquid, so that different reagents can be injected.
[0010] Preferably, the rear ends of the two toothed openings are provided with racks, and a gear is jointly meshed and connected between the two racks, when the gear is driven to rotate, the two racks are driven to move in opposite directions, so as to drive the two toothed openings to rotate in opposite directions.
[0011] Compared with the prior art, the utility model has the advantages that:
[0012] 1. The sample diluent preparation assembly for fluorescent immunoassay chromatographic detection reagents is used in cooperation with the liquid injection pipe and the preparation tank, liquid required is injected into the inside of the preparation tank through the liquid injection pipe, the oval cam and the reset assembly are used in cooperation, the oval cam pushes the preparation tank, the reset assembly resets the preparation tank, the preparation tank shakes, the inside liquid is oscillated, the liquid is fully mixed, manual preparation is not needed, and the efficiency is higher.
[0013] 2. The sample diluent preparation assembly for fluorescent immunoassay chromatographic detection reagents is used in cooperation with the liquid injection pipe and the preparation tank, liquid required is injected into the inside of the preparation tank through the liquid injection pipe, the oval cam and the reset assembly are used in cooperation, the oval cam pushes the preparation tank, the reset assembly resets the preparation tank, the preparation tank shakes, the inside liquid is oscillated, the liquid is fully mixed, manual preparation is not needed, and the efficiency is higher. BRIEF DESCRIPTION OF DRAWINGS
[0014] Figure 1 It is the whole structure schematic view of the utility model;
[0015] Figure 2 It is the inner cavity structure schematic view of the utility model;
[0016] Figure 3 It is the utility model's Figure 2 The structure enlarged schematic view of A place in the middle;
[0017] Figure 4 It is the first protective door and the second protective door structure schematic view of the utility model.
[0018] In the drawing: 1, cavity; 2, liquid injection pipe; 3, rotating assembly; 4, support; 5, liquid tank; 6, first protective door; 7, cover; 8, pure water conveyor; 9, hose; 10, preparation tank; 11, gasket ring; 12, oval cam; 13, drive machine; 14, liquid discharge pipe; 15, reagent pipe; 16, support shaft; 17, protective baffle; 18, chuck; 19, reset assembly; 20, telescopic pipe; 21, connecting rod; 22, second protective door; 23, rack; 24, gear; 25, toothed mouth; 26, driving disc. DETAILED DESCRIPTION
[0019] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the utility model.
[0020] In the description of the utility model, it should be explained that the terms "upper", "lower", "inner", "outer", "front end", "rear end", "two ends", "one end", "the other end" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the utility model and simplifying the description, and do not indicate or imply that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the utility model. In addition, the terms "first" and "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.
[0021] As Figures 1 to 4As shown, the sample diluent preparation assembly of the fluorescent immunochromatographic test reagent of the embodiment includes a cavity 1, a driving disc 26 is installed inside the cavity 1, the driving disc 26 contains a driving assembly, which can drive the driving disc 26 to perform intermittent rotary motion, a support shaft 16 is installed at the top middle position of the driving disc 26, a chuck 18 is installed at the top of the support shaft 16, a plurality of arc-shaped grooves are equidistantly arranged on the circumferential surface of the chuck 18, a reagent tube 15 is placed at the position of the arc-shaped groove of the chuck 18, the driving assembly drives the chuck 18 to rotate through the driving disc 26 and the support shaft 16, and the reagent tube 15 is driven to rotate through the arc-shaped groove, so as to facilitate the filling of the diluent, a bracket 4 is installed on both sides of the cavity 1, the two brackets 4 are U-shaped components, a rotating assembly 3 is commonly installed at the top opposite ends of the two brackets 4, a plurality of liquid tanks 5 are installed inside the rotating assembly 3, a liquid injection pipe 2 is installed at the bottom of each liquid tank 5, a liquid can be placed inside the liquid tank 5, the rotating assembly 3 drives the liquid tank 5 to rotate, a preparation tank 10 is installed below any one liquid injection pipe 2, the liquid placed inside the liquid tank 5 is injected into the inside of the preparation tank 10 through the liquid injection pipe 2, an electromagnetic valve is arranged in each liquid injection pipe 2, so as to ensure that the liquid inside each liquid tank 5 can be injected into the inside of the preparation tank 10 according to a certain proportion, a reset assembly 19 is commonly connected between the bottom end of the preparation tank 10 and the cavity 1, a grommet 11 is arranged on the outer surface of the preparation tank 10, an oval cam 12 is installed on one side of the grommet 11, a driving machine 13 is arranged at the bottom middle position of the oval cam 12, the driving machine 13 contains a motor and a speed reducer, the driving machine 13 drives the oval cam 12 to push the preparation tank 10 to shake, the reset assembly 19 contains a spring and a telescopic rod, so that the preparation tank 10 is reset after being pushed by the convex top of the oval cam 12, and the liquid inside the preparation tank 10 is driven to oscillate, so as to ensure that the liquid is fully mixed, a hose 9 is installed on one side of the preparation tank 10, a pure water conveyor 8 is installed at one end of the hose 9, the pure water conveyor 8 contains an electromagnetic valve, so as to ensure that the pure water conveyed can be limited in dose, a telescopic pipe 20 is installed at the bottom end of the preparation tank 10, a liquid discharge pipe 14 is installed at the bottom end of the telescopic pipe 20, the bottom of the liquid discharge pipe 14 extends into the inside of the cavity 1, an electromagnetic valve is arranged in the inside of the telescopic pipe 20, and any one reagent tube 15 is located below the liquid discharge pipe 14, when the diluent inside the preparation tank 10 is oscillated and mixed, the electromagnetic valve of the telescopic pipe 20 can be opened, so as to discharge the diluent inside the preparation tank 10 into the inside of the corresponding reagent tube 15, when the diluent inside a single reagent tube 15 is stored to a certain amount, the reagent tube 15 filled is driven by the chuck 18 to rotate and leave below the liquid discharge pipe 14, so that another reagent tube 15 is located below the liquid discharge pipe 14.
[0022] Specifically, the top end of the driving disc 26 under the arc-shaped groove of the chuck 18 is provided with a protective baffle 17, which is an arc-shaped plate and cooperates with the arc-shaped groove to limit the reagent tube 15, so that the reagent tube 15 can be stably placed on the circumferential surface of the chuck 18.
[0023] Further, the two ends of the grommet 11 are provided with connecting rods 21, and the bottoms of the two connecting rods 21 are jointly hinged to the top end of the cavity 1. The two connecting rods 21 support the preparation tank 10 through the grommet 11, improve the stability of the preparation tank 10, and prevent the preparation tank 10 from collapsing when it is driven to shake.
[0024] Further, the front top end of the cavity 1 is hingedly provided with a cover 7, which can seal the cavity 1. The cavity 1 is provided with a cooling assembly, so that the inside of the cavity 1 is in a low-temperature state, which is convenient for storing the diluted liquid after preparation. When the diluted liquid is needed, the cover 7 is opened, and the reagent tube 15 driven by the chuck 18 is taken out at the opening position.
[0025] Further, the inside of the cavity 1 is provided with a first protective door 6 and a second protective door 22. One end of each of the first protective door 6 and the second protective door 22 is provided with a toothed opening 25, and the two toothed openings 25 are vertically arranged and hingedly connected. The first protective door 6 and the second protective door 22 can be rotated at the hinged position of the two toothed openings 25 to achieve the opening and closing effect. When the preparation tank 10 shakes, the first protective door 6 and the second protective door 22 are closed to seal the preparation tank 10. When the liquid injection pipe 2 injects liquid, the first protective door 6 and the second protective door 22 are opened to facilitate the injection of different reagents.
[0026] Further, the rear end of each of the two toothed openings 25 is provided with a rack 23, and the two racks 23 are jointly meshed with a gear 24. When the gear 24 is driven to rotate, the two racks 23 are driven to move in opposite directions, so as to drive the two toothed openings 25 to rotate in opposite directions.
[0027] The use method of the embodiment is as follows: when preparing the sample diluent for the fluorescent immunochromatographic detection reagent, the corresponding liquid is injected into the plurality of liquid tanks 5, then the first protection door 6 and the second protection door 22 are opened, the rotating assembly 3 drives the liquid tank 5 to rotate, the liquid injection pipe 2 at the bottom of the plurality of liquid tanks 5 is sequentially located above the preparation tank 10, the electromagnetic valve of the liquid injection pipe 2 is used for quantitative injection, the required liquid is injected into the preparation tank 10, then the pure water conveyor 8 is used for conveying the quantitative pure water into the preparation tank 10, when the liquid conveying is completed, the preparation tank 10 is driven by the driving machine 13 and the elliptical cam 12, the reset assembly 19 contains a spring and an extension rod, so that the preparation tank 10 is pushed by the convex top of the elliptical cam 12 and then is reset, the liquid in the preparation tank 10 is shaken and mixed fully, finally the electromagnetic valve of the telescopic pipe 20 is opened, the diluent in the preparation tank 10 is discharged into the corresponding reagent pipe 15, when the diluent in the single reagent pipe 15 is stored to a certain amount, the chuck 18 is rotated to drive the reagent pipe 15 filled to be away from below the liquid discharge port 14, and another reagent pipe 15 is located at the liquid discharge port 14 for filling.
[0028] Finally, it should be noted that: the above only for the preferred embodiments of the utility model, and does not limit the utility model, although the utility model is described in detail with reference to the foregoing embodiments, for the person skilled in the art, it still can modify the technical scheme recorded in the foregoing each embodiment, or equivalent replacement to part of technical features. Any modification, equivalent replacement, improvement etc. within the spirit and principle of the utility model, should be contained in the protection scope of the utility model.
Claims
1. A fluorescent immuno-chromatographic test reagent sample diluent preparation assembly comprising a cavity (1), characterized in that: The inside of the cavity (1) is internally provided with a driving disc (26), the top end of the driving disc (26) is provided with a supporting shaft (16), the top end of the supporting shaft (16) is provided with a chuck (18), the circumferential surface of the chuck (18) is equidistantly provided with a plurality of arc grooves, the chuck (18) is provided with a reagent tube (15) at the position of the arc groove, both sides of the cavity (1) are provided with a bracket (4), the two brackets (4) are U-shaped components, the top of the two brackets (4) is provided with a rotating assembly (3) at the opposite ends, the inside of the rotating assembly (3) is provided with a plurality of liquid tanks (5), the bottom of the plurality of liquid tanks (5) is provided with a liquid injection pipe (2), the lower side of any one of the liquid injection pipes (2) is provided with a preparation tank (10), the bottom end of the preparation tank (10) and the cavity (1) are connected with a reset assembly (19), the outer surface of the preparation tank (10) is provided with a gasket ring (11), one side of the gasket ring (11) is provided with an oval cam (12), the bottom of the oval cam (12) is provided with a driving machine (13), one side of the preparation tank (10) is provided with a hose (9), one end of the hose (9) is provided with a pure water conveyor (8), the bottom end of the preparation tank (10) is provided with a telescopic pipe (20), the bottom end of the telescopic pipe (20) is provided with a liquid outlet (14), the bottom of the liquid outlet (14) extends into the cavity (1).
2. The fluorescent immuno-chromatographic test reagent sample diluent preparation assembly according to claim 1, characterized in that: The top end of the driving disc (26) below the arc groove of the chuck (18) is provided with a protective baffle (17).
3. The fluorescent immuno-chromatographic test reagent sample diluent preparation assembly according to claim 1, characterized in that: Both ends of the gasket ring (11) are provided with a connecting rod (21), the bottom of the two connecting rods (21) is hingedly connected to the top end of the cavity (1).
4. The fluorescent immuno-chromatographic test reagent sample diluent preparation assembly according to claim 1, characterized in that: The front top end of the cavity (1) is hingedly provided with a cover (7).
5. The fluorescent immuno-chromatographic test reagent sample diluent preparation assembly according to claim 1, characterized in that: The inside of the cavity (1) is provided with a first protective door (6) and a second protective door (22), one end of the first protective door (6) and the second protective door (22) is provided with a toothed opening (25), and the two toothed openings (25) are vertically arranged, and the two toothed openings (25) are hingedly connected.
6. The fluorescent immuno-chromatographic test reagent sample diluent preparation assembly according to claim 5, characterized in that: The rear end of the two toothed openings (25) is provided with a rack (23), and the two racks (23) are hingedly connected with a gear (24).