Chromatographic device for separating and purifying natural products

Abstract

The utility model belongs to the technical field of separation and purification of natural products, and particularly relates to a chromatographic device for separation and purification of natural products, which comprises a chromatographic component capable of continuously enabling target components in the natural products to fall into a specified collection container, and a material injection component capable of storing the natural products needing to be separated and purified is arranged above the chromatographic component. And a material releasing assembly capable of enabling the natural product to fall into the chromatography assembly regularly and quantitatively is arranged below the material injection assembly. According to the device disclosed by the utility model, a plurality of groups of chromatographic columns are arranged on the rotary table with adjustable rotating speed, and the arrangement of the material releasing assembly is combined, so that natural products in the material injecting assembly can automatically flow into the chromatographic columns at fixed intermittent time, and target components of the natural products can be continuously collected in corresponding containers according to the precipitation time of the target components; therefore, the continuity of chromatography work is improved, and the overall time consumption of separation and purification work is greatly reduced.

Description

TECHNICAL FIELD

[0001] The utility model belongs to natural product separation and purification technical field, specifically relates to a natural product separation and purification chromatography device. BACKGROUND

[0002] Chromatographic separation technology adopts chromatographic column to fill stationary phase, and the mixture to be separated passes through the stationary phase along with the mobile phase, and due to the different action mechanisms of the stationary phase and the substances to be separated, the substances to be separated flow out of the chromatographic column in different retention time sequences, so as to achieve the purpose of separation and purification.

[0003] However, in the prior art, the chromatography device usually needs to completely elute the mixture injected at a time before adding the mixture again for chromatography. Since the elution of each component of the mixture requires a certain time, when the mixture to be chromatographed is large, it often takes a long time to complete the separation and purification work. Therefore, a chromatography device for natural product separation and purification is proposed. UTILITY MODEL CONTENT

[0004] The purpose of the utility model is to provide a chromatography device for natural product separation and purification.

[0005] The technical scheme adopted by the utility model is as follows:

[0006] A chromatography device for natural product separation and purification, comprising a chromatography assembly that can continuously make the target component in the natural product fall into a specified collection container, an injection assembly that can store the natural product to be separated and purified is arranged above the chromatography assembly, and a release assembly that can make the natural product fall into the chromatography assembly at a constant time and quantity is arranged below the injection assembly.

[0007] The chromatography assembly comprises a chromatography piece that can separate and purify the natural product injected by the injection assembly, a rotating piece that can continuously drive the chromatography piece to rotate, a driving piece that can adjust the rotation speed of the rotating piece, and a receiving piece that can receive the natural product flowing out of the injection assembly and collect different components thereof.

[0008] The rotating piece comprises a base, and a turntable is movably installed on the base.

[0009] The chromatography piece comprises a first bracket fixedly connected above the turntable, and a chromatographic column is fixedly installed above the first bracket.

[0010] Preferably, the rotating piece further comprises a gear ring fixedly connected below the turntable.

[0011] Preferably, the driving piece comprises a motor fixedly installed in the base, a coupling fixedly connected to the output end of the motor, a speed reducer fixedly connected to one side of the coupling, and a gear fixedly connected to the output end of the speed reducer.

[0012] Preferably, the chromatography device further comprises a material guide pipe fixedly connected below the chromatography column.

[0013] Preferably, the material receiving device comprises a material receiving hopper fixedly connected above the chromatography column, the base is movably connected with a first collecting box, and the first collecting box is movably connected with a second collecting box.

[0014] Preferably, the base is rotationally connected with the rotary table.

[0015] Preferably, the gear ring is meshingly connected with the gear.

[0016] Preferably, the base and the second collecting box are slidably connected with the first collecting box.

[0017] Preferably, the number of the second collecting boxes is greater than or equal to the number of target components in the natural product to be collected.

[0018] The natural product in the material injection assembly can automatically flow into the chromatography column at a fixed intermittent time, and each target component of the natural product can be continuously collected in a corresponding container according to its elution time, so that the continuity of chromatography work is improved, and the overall time consumption of separation and purification work is greatly reduced. BRIEF DESCRIPTION OF DRAWINGS

[0019] The accompanying drawings are used to provide a further understanding of the present application, and constitute a part of the specification, and are used to explain the present application together with the following specific embodiments, but do not constitute a limitation to the present application. In the drawings:

[0020] Figure 1 is a structural schematic view of the chromatography device for separating and purifying natural products according to the present application;

[0021] Figure 2 is a front view structural schematic view of the chromatography device for separating and purifying natural products according to the present application;

[0022] Figure 3 is Figure 1 another view structural schematic view of

[0023] Figure 4 is Figure 1 a part of the parts of

[0024] Figure 5 is Figure 4 a part of the parts of

[0025] The reference signs are explained as follows:

[0026] 1, chromatography assembly; 101, base; 102, rotary table; 103, gear ring; 104, motor; 105, shaft coupling; 106, speed reducer; 107, gear; 108, first support; 109, chromatography column; 110, material guide pipe; 111, material receiving hopper; 112, first collection box; 113, second collection box; 2, material injection assembly; 201, second support; 202, material tank; 203, pressing valve; 204, material injection pipe; 3, material release assembly; 301, guide cylinder; 302, push rod; 303, spring; 304, arc-shaped push plate. DETAILED DESCRIPTION

[0027] In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second" and the like are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features limited by "first", "second" and the like can explicitly or implicitly include one or more of the features. In the description of the present application, "a plurality of" means two or more, unless otherwise specified.

[0028] In the description of the present application, it should be noted that, unless otherwise specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the communication between two elements inside. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0029] The present application will be further described below by way of examples in conjunction with the drawings.

[0030] As shown in Figures 1-5 A chromatography device for separating and purifying natural products, comprising a chromatography assembly 1 which can continuously make the target component in the natural product fall into a designated collection container, a material injection assembly 2 is arranged above the chromatography assembly 1, which can store natural products that need to be separated and purified, and a material release assembly 3 is arranged below the material injection assembly 2, which can make the natural product fall into the chromatography assembly 1 at a fixed time and a fixed amount.

[0031] In the embodiment, the chromatographic assembly 1 comprises a chromatographic component for separating and purifying natural products injected by the injection assembly 2, a rotating component for continuously rotating the chromatographic component, a driving component for adjusting the rotating speed of the rotating component, and a receiving component for receiving the natural products from the injection assembly 2 and collecting different components of the natural products.

[0032] The rotating component comprises a base 101, a rotating table 102 movably mounted on the base 101, the chromatographic component comprises a first support 108 fixedly connected above the rotating table 102, a chromatographic column 109 fixedly mounted above the first support 108, and the rotating component further comprises a gear ring 103 fixedly connected below the rotating table 102. The driving component comprises a motor 104 fixedly mounted in the base 101, a coupling 105 fixedly connected to an output end of the motor 104, a speed reducer 106 fixedly connected to one side of the coupling 105, a gear 107 fixedly connected to an output end of the speed reducer 106, and the chromatographic component further comprises a guide pipe 110 fixedly connected below the chromatographic column 109. The receiving component comprises a receiving hopper 111 fixedly connected above the chromatographic column 109, and a first collecting box 112 movably connected to the base 101 and a second collecting box 113 movably connected to the first collecting box 112.

[0033] The base 101 is rotationally connected to the rotating table 102, the gear ring 103 is meshingly connected to the gear 107, and the base 101 and the second collecting box 113 are slidably connected to the first collecting box 112. The number of the second collecting box 113 should be greater than or equal to the number of target components in the natural products to be collected.

[0034] The base 101 provides mounting positions for the rotating table 102, the motor 104 and other components. The coupling 105, the speed reducer 106, the gear 107 and the gear ring 103 transmit the rotation of the output end of the motor 104 to the rotating table 102 after reducing the speed and increasing the torque, so that the rotating table 102 can rotate at a desired speed relative to the base 101 with the first support 108 and other components. The chromatographic column 109 is mounted on the rotating table 102 at a certain height by the first support 108. Each component of the natural products separated by the chromatographic column 109 is guided into the first collecting box 112 or the second collecting box 113 by the guide pipe 110. The receiving hopper 111 receives the natural products from the injection assembly 2 and guides them into the chromatographic column 109.

[0035] In the embodiment, the injection assembly 2 comprises a second support 201 fixedly mounted on the base 101, a material tank 202 fixedly mounted above the second support 201, a pressing valve 203 fixedly connected to an outlet end of the material tank 202, and an injection pipe 204 fixedly connected in front of the pressing valve 203.

[0036] The material tank 202 capable of containing natural products is installed at a certain height above the base 101 through the second support 201, the outflow of the natural products in the material tank 202 is controlled through the pressing valve 203, when the pressing valve 203 is pressed, the direction of the natural products flowing out of the material tank 202 is limited through the injection pipe 204.

[0037] In this embodiment: the release assembly 3 includes a guide cylinder 301 fixedly installed in the second support 201, a push rod 302 movably connected in the guide cylinder 301, a spring 303 movably connected on the outer side of the push rod 302, and an arc-shaped push plate 304 fixedly connected on the side close to the second support 201 of the receiving hopper 111.

[0038] The second support 201, the guide cylinder 301 and the spring 303 are all in sliding connection with the push rod 302, and the arc-shaped push plate 304 is integrally formed with a sliding groove; through the cooperation of the guide cylinder 301, the second support 201 and the spring 303, the movable range of the push rod 302 is limited, and the push rod 302 under no external force has a downward moving trend; the arc-shaped push plate 304 which can rotate in the device with the receiving hopper 111 can gradually push the push rod 302 upward to a certain height after being in contact with the push rod 302 and keep for a certain time.

[0039] Working principle: when the device is installed and used for natural product separation and purification, the arc-shaped push plate 304 rotating synchronously will push the push rod 302 upward when in contact with the push rod 302, so that the push rod 302 exerts pressure on the pressing valve 203 to open it for a certain time, so that the natural products in the material tank 202 flow into the receiving hopper 111 connected with the arc-shaped push plate 304 through the pressing valve 203 and the injection pipe 204, and then enter the chromatography column 109 through the receiving hopper 111. Then, under the action of the chromatography column 109, the components in the natural products will flow out of the guide pipe 110 with different elution times;

[0040] When the types of target components of the natural products to be collected are determined, the corresponding number of second collection boxes 113 is arranged on the first collection box 112, and then the speed of the rotating table 102 is adjusted through the motor 104, so that the target components of the natural products in the chromatography column 109 can fall into the corresponding second collection box 113 when the chromatography column 109 rotates one circle with the rotating table 102 by adjusting the placement position of the second collection box 113 on the first collection box 112;

[0041] Therefore, by adjusting the number of chromatography components composed of the chromatography column 109 and the arc-shaped push plate 304 on the rotating table 102, the natural products injected into the injection assembly 2 can be continuously chromatographed, and the target components can be effectively separated and collected.

[0042] The preferred embodiments of the utility model are described in detail above in combination with the drawings, but the utility model is not limited to the above-mentioned embodiments, and various changes can be made within the knowledge range possessed by the technical personnel in the technical field without departing from the purpose of the utility model.

Claims

1. A chromatography apparatus for the separation and purification of natural products, characterized in that: The application relates to a chromatographic assembly (1) for continuously separating and purifying target components in natural products, wherein an injection assembly (2) for storing the natural products to be separated and purified is arranged above the chromatographic assembly (1), and a release assembly (3) for allowing the natural products to fall into the chromatographic assembly (1) in a timed and quantitative manner is arranged below the injection assembly (2). The chromatographic assembly (1) comprises a chromatographic part for separating and purifying the natural products injected by the injection assembly (2), a rotating part for continuously driving the chromatographic part, a driving part for adjusting the rotating speed of the rotating part, and a receiving part for receiving the natural products discharged by the injection assembly (2) and collecting different components of the natural products. The rotating part comprises a base (101), and a rotating table (102) movably arranged on the base (101). The chromatographic part comprises a first support (108) fixedly arranged above the rotating table (102), and a chromatographic column (109) fixedly arranged above the first support (108).

2. The chromatography apparatus for separating and purifying natural products according to claim 1, characterized in that: The rotating part further comprises a gear ring (103) fixedly arranged below the rotating table (102).

3. The chromatography apparatus for separating and purifying natural products according to claim 2, characterized in that: The driving part comprises a motor (104) fixedly arranged in the base (101), a coupling (105) fixedly connected to the output end of the motor (104), a speed reducer (106) fixedly connected to one side of the coupling (105), and a gear (107) fixedly connected to the output end of the speed reducer (106).

4. The chromatography apparatus for separating and purifying natural products according to claim 3, characterized in that: The chromatographic part further comprises a guide pipe (110) fixedly arranged below the chromatographic column (109).

5. The chromatography apparatus for separating and purifying natural products according to claim 4, characterized in that: The receiving part comprises a receiving hopper (111) fixedly arranged above the chromatographic column (109), a first collecting box (112) movably arranged on the base (101), and a second collecting box (113) movably arranged on the first collecting box (112).

6. The chromatography apparatus for separating and purifying natural products according to claim 1, characterized in that: The base (101) is rotationally connected with the rotating table (102).

7. The chromatography apparatus for separating and purifying natural products according to claim 3, characterized in that: The gear ring (103) is meshingly connected with the gear (107).

8. The chromatography apparatus for separating and purifying natural products according to claim 5, characterized in that: The base (101) and the second collecting box (113) are both slidably connected with the first collecting box (112).

9. The chromatography device for separating and purifying natural products according to claim 8, characterized in that: The number of the second collecting box (113) is greater than or equal to the number of target components in the natural products to be collected.

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