Automatic management device for cell drug sensitivity detection

Abstract

The utility model relates to the field of biological medicine, in particular to an automatic management device for cell drug sensitivity detection. Comprising a rack, a pretreatment module for preparing a sample tissue into a cell suspension, an automatic culture module for culturing the cell suspension into an organoid, a drug sensitivity detection module for performing a drug contact experiment and drug sensitivity detection on the organoid, a transfer module, a code scanning assembly and a code assigning assembly, the transfer module is used for conveying a to-be-treated sample tissue into the pretreatment module, conveying a cell suspension prepared by the pretreatment module into the automatic culture module, then conveying an organoid obtained by the automatic culture module into the microwell plate, and then conveying the microwell plate into the drug sensitivity detection module; the code scanning assembly is used for detecting the micro-pore plate and pasting an identification label on the corresponding reagent tube and / or the micro-pore plate through the code assigning assembly; according to the utility model, process management can be automatically carried out on drug sensitivity detection, and the automation efficiency of drug sensitivity detection is effectively improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological medicine technical field especially, relate to a cell drug sensitivity detection automation management device. BACKGROUND

[0002] The organoid technology is a new type of tissue organ in-vitro culture technology under the background of the research on mammal development, tissue homeostasis and extracellular matrix being deepened and the stem cell culture experience being increasingly rich, which introduces the self-assembly characteristics of stem cells into three-dimensional culture of cells, and further produces. UTILITY MODEL CONTENTS

[0003] The utility model discloses a cell drug sensitivity detection automation management device, which can manage the process of drug sensitivity detection automation and effectively improve the automation efficiency of drug sensitivity detection.

[0004] In order to achieve the above-mentioned purpose, the utility model adopts the technical scheme of a cell drug sensitivity detection automation management device, which comprises a rack, a pretreatment module for preparing sample tissues into cell suspension, an automatic culture module for culturing cell suspension into organoids, a drug sensitivity detection module for drug contact experiment and drug sensitivity detection on organoids, a transfer module, a code scanning assembly and a code assigning assembly.

[0005] Further improvement of the above-mentioned scheme is that the code scanning assembly comprises a label recognition module arranged on the rack, which is used for recognizing the label code attached to the microplate.

[0006] Further improvement of the above scheme is that the code assignment component comprises a rotating barcode labeling mechanism and a barcode discharging mechanism, the rotating barcode labeling mechanism is used for labeling the corresponding microplate, and the barcode discharging mechanism is used for storing and discharging labels; the rotating barcode labeling mechanism comprises a support seat, a labeling base rotatingly arranged on the support seat in the horizontal direction, a labeling base rotating drive assembly arranged below the support seat, a guide rail arranged on the labeling base, a suction cup sliding drive assembly arranged on the labeling base, and a suction cup assembly slidingly arranged on the guide rail, the suction cup sliding drive assembly is drivingly connected with the suction cup assembly, and the labeling base rotating drive assembly is drivingly connected with the labeling base.

[0007] Further improvement of the above scheme is that the suction cup assembly comprises a suction cup base, a pneumatic suction nozzle arranged in the suction cup base, a vacuum pump arranged on the suction cup base, and a gas path electromagnetic valve arranged on the suction cup base, the vacuum pump and the pneumatic suction nozzle are in communication to form a piston type suction nozzle, and the gas path electromagnetic valve is used for controlling the gas path switch.

[0008] Further improvement of the above scheme is that the suction cup sliding drive assembly comprises a lead screw motor arranged on the labeling base, a lead screw arranged at the power output end of the lead screw motor, a nut threadedly connected with the lead screw, and a lead screw nut seat arranged on the nut, the lead screw nut seat is fixedly connected with the suction cup assembly, and the lead screw motor drives the lead screw to rotate so as to drive the suction cup assembly to move in the horizontal direction.

[0009] Further improvement of the above scheme is that the barcode discharging mechanism comprises a labeling machine main body arranged on the rack, a label storage box arranged in the labeling machine main body, a label drive assembly arranged in the labeling machine main body, a labeling outlet arranged on one side of the labeling machine main body, and label scissors arranged at the labeling outlet.

[0010] Further improvement of the above scheme is that the transfer module comprises a pipe clamping transfer device, a clamping plate transfer device, and a pipetting device, the pipe clamping transfer device is used for clamping and opening the cover, the clamping plate transfer device is used for transporting the microplate, and the pipetting device is used for pipetting.

[0011] Further improvement of the above scheme is that the pipe clamping and transferring device comprises an XYZ-axis movement driving assembly arranged on the rack, a pipe clamping assembly support seat, and a pipe clamping assembly rotatably arranged on the pipe clamping assembly support seat, and the XYZ-axis movement driving assembly is drivingly connected with the pipe clamping assembly support seat.

[0012] Further improvement of the above scheme is that the pipe clamping and transferring device comprises an XYZ-axis movement driving assembly arranged on the rack, a pipe clamping assembly support seat, and a pipe clamping assembly rotatably arranged on the pipe clamping assembly support seat, and the XYZ-axis movement driving assembly is drivingly connected with the pipe clamping assembly support seat.

[0013] Further improvement of the above scheme is that the pipe clamping and transferring device comprises an XYZ-axis movement driving assembly arranged on the rack, a pipe clamping assembly support seat, and a pipe clamping assembly rotatably arranged on the pipe clamping assembly support seat, and the XYZ-axis movement driving assembly is drivingly connected with the pipe clamping assembly support seat.

[0014] The utility model have beneficial effect in at: the utility model discloses the rack, the pretreatment module that sample tissue is made into cell suspension, the automation culture module that cell suspension is cultivated into organoid, the drug sensitive detection module that carries out drug contact experiment and drug sensitive detection to organoid, transfer module, code scanning subassembly, code assignment subassembly, the transfer module is used to send the sample tissue of being handled into the pretreatment module to pretreatment module preparation cell suspension is sent into the automation culture module, then the organoid of automation culture module obtains is sent into the microwell plate, again the microwell plate is sent to the drug sensitive detection module, the code scanning subassembly detects the microwell plate and through the code assignment subassembly to corresponding reagent tube and / or microwell plate pastes the identification label, the utility model discloses the cooperation work of code scanning subassembly and code assignment subassembly, in the experiment process, need not always pay attention to the state of reagent tube and / or microwell plate, also need not manual processing, even if the process is numerous, also can have a good order from the last process to the next step, effectively improve work efficiency BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 It is structure schematic drawing for the utility model.

[0016] Figure 2 It is structure schematic drawing for the utility model clamp pipe transfer device.

[0017] Figure 3 It is structure schematic drawing for the utility model multi-shaft clamp plate mechanical hand subassembly.

[0018] Figure 4 It is structure schematic drawing for the utility model pipette device.

[0019] Figure 5 It is structure schematic drawing for the utility model code scanning subassembly.

[0020] Figure 6 It is internal structure schematic drawing for the utility model rotation bar code labelling mechanism.

[0021] Figure 7 It is structure schematic drawing for the utility model bar code discharge mechanism.

[0022] Figure 8 It is the comparison drawing of the utility model drug sensitive detection device work duration and artificial work duration.

[0023] Figure 9 It is the stability comparison drawing of the utility model drug sensitive detection process and artificial experiment.

[0024] Explanation of reference signs: rack 1, pretreatment module 11, automated culture module 12, drug sensitivity detection module 13, transfer module 14, pinch pipe transfer device 2, XYZ axis motion driving assembly 21, pinch pipe assembly support seat 22, pinch pipe assembly 23, rotary driving assembly 231, rotary seat 232, pinch pipe driving assembly 233, pinch pipe claw 234, anti-skid line 235, clamp plate transfer device 3, multi-axis clamp plate manipulator 31, X-axis sliding rail 311, X-axis driving assembly 312, Y-axis sliding support seat 313, Y-axis driving assembly 314, clamp plate supporting hand assembly 315, clamp plate supporting hand support seat 3151, clamp plate supporting hand sliding seat 3152, clamp plate supporting hand sliding driving assembly 3153, clamp plate supporting hand rotary seat 3154, clamp plate supporting hand rotary driving assembly 3155, L-shaped supporting hand 3156, L-shaped supporting hand driving assembly 3157, pipetting device 4, pipetting manipulator sliding rail 41, pipetting manipulator sliding seat 42, pipetting manipulator support seat 43, pipette 44, pipetting head 441, pipetting manipulator driving assembly 45, code scanning assembly 5, label identification module 51, code assigning assembly 6, rotary barcode labeling mechanism 61, support seat 611, labeling base 612, guide rail 613, suction cup sliding driving assembly 614, screw rod motor 6141, screw rod 6142, nut 6143, screw rod nut seat 6144, suction cup assembly 615, suction cup base 6151, pneumatic suction nozzle 6152, vacuum pump 6153, air path electromagnetic valve 6154, labeling base rotary driving assembly 616, barcode discharging mechanism 62, labeling machine main body 621, label storage box 622, label driving assembly 623, labeling outlet 624, label scissors 625. DETAILED DESCRIPTION

[0025] The utility model will be further described below in combination with the drawings, such as Figures 1-9 The utility model discloses a cell drug sensitivity detection automated management device, including rack 1, pretreatment module 11, automated culture module 12, drug sensitivity detection module 13, transfer module 14, code scanning assembly 5, code assigning assembly 6, through transfer module 14, the sample tissue to be handled is sent into pretreatment module 11, and the sample tissue is prepared to obtain corresponding cell suspension by pretreatment module 11, and the cell suspension prepared is sent into automated culture module 12 by transfer module 14 and is cultured to obtain organoid, and the organoid obtained is sent into the microplate on the workbench by transfer module 14, and the microplate is sent to drug sensitivity detection module 13 by transfer module 14 and carries out corresponding drug contact experiment, drug sensitivity detection, and the code scanning assembly 5 detects the process stage of microplate and is used to paste the identification label of corresponding process stage on the reagent tube and / or microplate by code assigning assembly 6, and realizes the automation process management in cooperation with transfer module 14.

[0026] The utility model discloses a code scanning assembly 5 including setting on the frame 1 label identification module 51, label identification module 51 is used for identifying the label code pasted on the microplate, the utility model discloses label identification assembly sets up the camera, and the information in label code is photographed and identified, and it is convenient for identifying and judging that the current drug sensitivity detection process is in which step.

[0027] The utility model discloses a code assignment assembly 6 including rotating bar code labeling mechanism 61, bar code discharge mechanism 62, rotating bar code labeling mechanism 61 is used for sticking the label to corresponding microplate, and bar code discharge mechanism 62 is used for storing label and transporting label, rotating bar code labeling mechanism 61 includes support seat 611, along horizontal direction rotating setting on the support seat 611 label base 612, setting below support seat 611 label base rotating drive assembly 616, setting on label base 612 guide rail 613, setting on label base 612 suction cup sliding drive assembly 614, sliding setting on guide rail 613 suction cup assembly 615, suction cup sliding drive assembly 614 power output end drive connection suction cup assembly 615, and label base rotating drive assembly 616 drive connection label base 612, suction cup assembly 615 sucks out the label, and rotating suction cup assembly 615 is driven through label base rotating drive assembly 616 and sticks the label on the microplate or reagent tube to be labeled.

[0028] The utility model discloses a suction cup assembly 615 including suction cup base 6151, setting in the pneumatic suction nozzle 6152 of suction cup base 6151, setting on the vacuum pump 6153 of suction cup base 6151, setting on the gas circuit solenoid valve 6154 of suction cup base 6151, and the vacuum pump 6153 and pneumatic suction nozzle 6152 are communicated and form piston type suction nozzle, and the gas circuit solenoid valve 6154 is used for controlling gas circuit switch, and pneumatic suction nozzle 6152 takes the label stability, prevents the label from falling, and the gas circuit solenoid valve 6154 is convenient for controlling pneumatic suction nozzle 6152 switch.

[0029] The utility model discloses a suction cup sliding drive assembly 614 including setting on the screw rod motor 6141 of label base 612, setting on the screw rod 6142 of screw rod motor 6141 power output end, the nut 6143 of screw thread connection on screw rod 6142, setting on the screw rod nut seat 6144 of nut 6143, and screw rod nut seat 6144 is fixedly connected with suction cup assembly 615, and screw rod motor 6141 drives screw rod 6142 rotation and drives suction cup assembly 615 along horizontal direction removal, and screw rod motor 6141 drives screw rod 6142 rotation and pushes suction cup assembly 615 back and forth movement convenient for taking the label, and screw rod 6142 drives stability, prevents the label from falling due to shaking.

[0030] The utility model discaregistering mechanism 62 including setting on the rack 1 labeler main body 621, setting in labeler main body 621 label storage box 622, setting in labeler main body 621 label drive assembly 623, setting in labeler main body 621 one side label outlet 624, setting at label outlet 624 label scissors 625, and label is sent out from label storage box 622 and is sent to label outlet 624 through label drive assembly 623, and label scissors 625 are used for cutting the label that is too much or is sticky together, and the failure rate of label output is reduced.

[0031] The utility model discaregistering system 201 including clamp pipe transfer device 2, clamp plate transfer device 3 for clamping microwell plate, pipette device 4 for sucking and transferring reagent solution, clamp pipe transfer device 2 is used to complete reagent tube clamping and transfer and / or uncapping operation between pretreatment module 18 and automatic culture module 19, clamp plate transfer device 3 is used to complete the operation of clamping microwell plate between drug sensitivity detection module 20, automatic culture module 19 and worktable 17, pipette device 4 is used to complete pipetting operation between automatic culture module 19, drug sensitivity detection module 20 and worktable 17;Compared with the prior organoid workstation, only simple stacking of the processing device or system is carried out, and the staff still needs to cooperate and operate, and the sudden situation of the processing equipment or system cannot be realized The automation in the true sense, and the utility model discaregistering system transfer system 201 is divided into clamp pipe transfer device 2, clamp plate transfer device 3 and pipette device 4, and a series of artificial operations such as transferring microwell plate, transferring reagent tube, pipetting and dropping liquid in organoid culture to drug sensitivity detection can be completed, which replaces all artificial operations that cannot be completed by the equipment in the organoid workstation, and the equipment module of the workstation can completely realize the complete automation of the process from the culture to the drug sensitivity detection of the organoid. Figures 8-9 As shown, 20 samples for drug sensitivity transfer are prepared, each sample is manually and automatically laid 3 groups of drugs, each group of drug has 3 duplicate holes, and Z values of 40 samples are counted after drug sensitivity detection, Z value ≥0.5 is qualified, and the automation stability and manual stability of the utility model workstation are calculated, and it is known that different devices of the utility model workstation cooperate with each module in the workstation, which can not only efficiently and quickly complete a series of work from the culture to the drug sensitivity detection of the organoid, but also effectively avoid the high failure rate and instability of manual operation, and different devices are not affected by each other, and single device failure will not affect the work of another device, which improves the work efficiency and ensures the stability, compared with the low-efficiency manual operation experiment, and can be further applied to the batch organoid culture and drug sensitivity detection work occasion of large batch and large output.

[0032] The utility model discloses clamp pipe transfer device 2 includes setting on the XYZ axle motion drive assembly 21 of rack 1, clamp pipe subassembly support seat 22, the rotation setting of clamp pipe subassembly 23 on the support seat, XYZ axle motion drive assembly 21 drive connection clamp pipe subassembly support seat 22, clamp pipe subassembly 23 includes the rotation drive assembly 231 of rotation setting on the support seat, the rotation seat 232 of rotation connection in the power output end of rotation drive assembly 231, the clamp pipe drive assembly 233 of setting on the rotation seat 232, the clamp pipe claw 234 of sliding connection on the rotation seat 232 along the horizontal direction, clamp pipe drive assembly 233 drive connection clamp pipe claw 234, still be provided with antiskid line 235 on the clamp pipe claw 234, clamp pipe transfer device 2 completes the clamp of reagent pipe between each module and removes the operation of sending, and still be provided with antiskid line 235 on the clamp pipe claw 234, compared with ordinary mechanical hand, the setting of antiskid line 235 can guarantee that the reagent pipe of clamp does not have the problem of slipping, and also can complete the operation of reagent pipe opening, closing, can better be applicable to the work flow of organ related.

[0033] The utility model discloses clamp plate transfer device 3 includes multiaxis clamp plate mechanical hand subassembly 31, and multiaxis clamp plate mechanical hand subassembly 31 includes setting on the X axle slide rail 311 of rack 1, X axle drive subassembly 312, along the X axle direction sliding setting on the Y axle sliding support seat 313 of X axle slide rail 311, Y axle drive subassembly 314, along the Y axle direction sliding setting on the clamp plate toshand subassembly 315 of Y axle sliding support seat 313, X axle drive subassembly 312 drive connection Y axle sliding support seat 313, Y axle drive subassembly 314 drive connection clamp plate toshand subassembly 315, clamp plate toshand subassembly 315 includes clamp plate toshand support seat 3151, along the Y axle direction sliding setting on the clamp plate toshand support seat 3151 on the clamp plate toshand sliding seat 3152, setting on the clamp plate toshand support seat 3151 on the clamp plate toshand sliding drive subassembly 3153, along the horizontal direction rotation setting on the clamp plate toshand sliding seat 3152 on the clamp plate toshand rotation seat 3154, setting on the clamp plate toshand sliding seat 3152 on the clamp plate toshand rotation drive subassembly 3155, two along the X axle direction opposite sliding setting on the clamp plate toshand sliding seat 3152 on the L shape clamping jaw 3156, setting on the clamp plate toshand rotation seat 3154 on the L shape clamping jaw drive subassembly 3157, clamp plate toshand sliding drive subassembly 3153 drive connection clamp plate toshand sliding seat 3152, clamp plate toshand rotation drive subassembly 3155 drive connection clamp plate toshand rotation seat 3154, L shape clamping jaw drive subassembly 3157 drive connection L shape clamping jaw 3156, and L shape clamping jaw 3156 can hold up microporous board also can be opposite L shape clamping jaw 3156 from the collection to hold microporous board, complete the conveyance between each module microporous board or board material.

[0034] The utility model discloses a pipette device 4 includes setting in the rack 1 on the pipette mechanical hand slide rail 41 of X axle direction, the pipette mechanical hand sliding seat 42 of setting on the pipette mechanical hand slide rail 41 of X axle direction sliding, set up on the pipette mechanical hand sliding seat 42 pipette mechanical hand support seat 43, along Y axle direction sliding setting on the pipette support seat pipette 44, set up on the pipette mechanical hand support seat 43 pipette mechanical hand drive assembly 45, pipette mechanical hand drive assembly 45 drive connection pipette 44, and pipette 44 is provided with a plurality of pipette heads 441;Pipette mechanical hand cooperation pipette 44 can complete the operation that needs to move and send solution, reagent in the process of organoid culture to drug sensitivity detection, and pipette 44 is provided with a plurality of pipette heads 441, and simultaneously completes a plurality of pipette operations, effectively improves work efficiency, and can be used for pipetting different reagents, avoids mutual cross infection, and does not need to change pipette head 141, relative to the traditional staff operation pipette, can be better applicable to the working occasion that needs to frequently pipette and change liquid such as organoid culture, drug sensitivity detection.

[0035] Working principle:

[0036] The utility model discloses including including rack 1, preprocessing module 11, automatic culture module 12, drug sensitivity detection module 13, transfer module 14, scan code subassembly 5, code assignment subassembly 6, through transfer module 14 with the sample organization of handling to be sent into preprocessing module 11, by preprocessing module 11, the sample organization is prepared to obtain corresponding cell suspension, the cell suspension prepared is through transfer module 14 and enters automatic culture module 12 and is cultivated to obtain organoid, the organoid obtained is through transfer module 14 and is sent into the microwell plate on the workbench, through transfer module 14 with the microwell plate is sent to drug sensitivity detection module 13 and carries out corresponding drug contact experiment, drug sensitivity detection, through scan code subassembly 5 detection microwell plate the process stage that is in and through code assignment subassembly 6 is used to stick the identification label of corresponding process stage to corresponding reagent tube or microwell plate, cooperation transfer module 14 realizes automatic process management, the utility model discloses through the cooperation work of scan code subassembly 5 and code assignment subassembly 6, in the experimental process, need not always pay attention to the state of reagent tube or microwell plate, also need not manual processing, only need to scan the label that code assignment subassembly 6 sticks through scan code subassembly 5 identification can complete step identification, even if the process is numerous, also can have a good order from the next step of last process, effectively improve work efficiency.

[0037] Of course, the above-mentioned is only the preferred implementation of the utility model, therefore, the equivalent change or modification of the structure, features and principle that is described in the utility model patent application range is included in the utility model patent application range.

Claims

1. A device for automated management of cell drug sensitivity testing, characterized in that: The device comprises a rack (1), a pretreatment module (11) for preparing sample tissues into cell suspension, an automatic culture module (12) for culturing the cell suspension into organoids, a drug sensitivity detection module (13) for performing drug contact experiment and drug sensitivity detection on the organoids, a transfer module (14), a code scanning assembly (5), and a code assigning assembly (6); the transfer module (14) is used for transferring sample tissues to be processed into the pretreatment module (11), transferring the cell suspension prepared by the pretreatment module (11) into the automatic culture module (12), then transferring the organoids obtained by the automatic culture module (12) into a microplate, and transferring the microplate to the drug sensitivity detection module (13); the code scanning assembly (5) detects the microplate and assigns an identification label to the corresponding reagent tube and / or microplate through the code assigning assembly (6).

2. The automatic management device for cell drug sensitivity detection according to claim 1, characterized in that: The code scanning assembly (5) comprises a label identification module (51) arranged on the rack (1), and the label identification module (51) is used for identifying the label code attached to the microplate.

3. The automatic management device for cell drug sensitivity test according to claim 1, characterized in that: The code assigning assembly (6) comprises a rotating barcode labeling mechanism (61) and a barcode discharging mechanism (62); the rotating barcode labeling mechanism (61) is used for attaching labels to corresponding microplates, and the barcode discharging mechanism (62) is used for storing labels and discharging the labels; the rotating barcode labeling mechanism (61) comprises a support seat (611), a labeling base (612) arranged on the support seat (611) and rotating in the horizontal direction, a labeling base rotating drive assembly (616) arranged below the support seat (611), a guide rail (613) arranged on the labeling base (612), a suction cup sliding drive assembly (614) arranged on the labeling base (612), and a suction cup assembly (615) slidingly arranged on the guide rail (613); the suction cup sliding drive assembly (614) is drivingly connected to the suction cup assembly (615), and the labeling base rotating drive assembly (616) is drivingly connected to the labeling base (612).

4. The automatic management device for cell drug sensitivity test according to claim 3, characterized in that: The suction cup assembly (615) comprises a suction cup base (6151), a pneumatic suction nozzle (6152) arranged in the suction cup base (6151), a vacuum pump (6153) arranged on the suction cup base (6151), and a gas path electromagnetic valve (6154) arranged on the suction cup base (6151); the vacuum pump (6153) and the pneumatic suction nozzle (6152) are in communication to form a piston type suction nozzle, and the gas path electromagnetic valve (6154) is used for controlling the gas path switch.

5. The automatic management device for cell drug sensitivity test according to claim 3, characterized in that: The suction cup sliding drive assembly (614) comprises a lead screw motor (6141) arranged on the labeling base (612), a lead screw (6142) arranged at the power output end of the lead screw motor (6141), a nut (6143) threadedly connected to the lead screw (6142), and a lead screw nut seat (6144) arranged on the nut (6143), wherein the lead screw nut seat (6144) is fixedly connected with the suction cup assembly (615), and the lead screw motor (6141) drives the lead screw (6142) to rotate, thereby driving the suction cup assembly (615) to move in the horizontal direction.

6. The automatic management device for cell drug sensitivity test according to claim 3, characterized in that: The bar code discharging mechanism (62) comprises a labeling machine body (621) arranged on the rack (1), a label storage box (622) arranged in the labeling machine body (621), a label driving assembly (623) arranged in the labeling machine body (621), a labeling outlet (624) arranged on one side of the labeling machine body (621), and label scissors (625) arranged at the labeling outlet (624).

7. The automatic management device for cell drug sensitivity test according to claim 1, characterized in that: The transfer module (14) comprises a tube clamping transfer device (2), a clamping plate transfer device (3), and a pipetting device (4), the tube clamping transfer device (2) is used for clamping and opening cover operation, the clamping plate transfer device (3) is used for transporting a microplate, and the pipetting device (4) is used for pipetting operation.

8. The automatic management device for cell drug sensitivity test according to claim 7, characterized in that: The tube clamping transfer device (2) comprises an XYZ-axis motion drive assembly (21) arranged on the rack (1), a tube clamping assembly support seat (22), and a tube clamping assembly (23) rotatably arranged on the tube clamping assembly support seat (22), wherein the XYZ-axis motion drive assembly (21) is drivingly connected with the tube clamping assembly support seat (22); the tube clamping assembly (23) comprises a rotation drive assembly (231) rotatably arranged on the tube clamping assembly support seat (22), a rotation seat (232) drivingly connected with the power output end of the rotation drive assembly (231), a tube clamping drive assembly (233) arranged on the rotation seat (232), and a tube clamping claw (234) slidingly connected with the rotation seat (232) in the horizontal direction, wherein the tube clamping drive assembly (233) is drivingly connected with the tube clamping claw (234), and an anti-skid pattern (235) is further arranged on the tube clamping claw (234).

9. The automatic management device for cell drug sensitivity test according to claim 7, characterized in that: The clamp plate conveying device (3) comprises a multi-axis clamp plate manipulator (31), the multi-axis clamp plate manipulator (31) comprises an X-axis sliding rail (311) arranged on the rack (1), an X-axis driving assembly (312), a Y-axis sliding support seat (313) arranged on the X-axis sliding rail (311) and sliding in the X-axis direction, a Y-axis driving assembly (314), and a clamp plate supporting hand assembly (315) arranged on the Y-axis sliding support seat (313) and sliding in the Y-axis direction, the X-axis driving assembly (312) is drivingly connected with the Y-axis sliding support seat (313), and the Y-axis driving assembly (314) is drivingly connected with the clamp plate supporting hand assembly (315); the clamp plate supporting hand assembly (315) comprises a clamp plate supporting hand support seat (3151), a clamp plate supporting hand sliding seat (3152) arranged on the clamp plate supporting hand support seat (3151) and sliding in the Y-axis direction, a clamp plate supporting hand sliding driving assembly (3153) arranged on the clamp plate supporting hand support seat (3151), a clamp plate supporting hand rotating seat (3154) arranged on the clamp plate supporting hand sliding seat (3152) and rotating in the horizontal direction, a clamp plate supporting hand rotating driving assembly (3155) arranged on the clamp plate supporting hand sliding seat (3152), two L-shaped supporting hands (3156) arranged on the clamp plate supporting hand sliding seat (3152) and sliding in the X-axis direction, and an L-shaped supporting hand (3156) driving assembly arranged on the clamp plate supporting hand rotating seat (3154), the clamp plate supporting hand sliding driving assembly (3153) is drivingly connected with the clamp plate supporting hand sliding seat (3152), the clamp plate supporting hand rotating driving assembly (3155) is drivingly connected with the clamp plate supporting hand rotating seat (3154), and the L-shaped supporting hand (3156) driving assembly is drivingly connected with the L-shaped supporting hand (3156).

10. The automatic management device for cell drug sensitivity test according to claim 7, characterized in that: The pipetting device (4) comprises a pipetting manipulator sliding rail (41) arranged on the rack (1) in the X-axis direction, a pipetting manipulator sliding seat (42) arranged on the pipetting manipulator sliding rail (41) and sliding in the X-axis direction, a pipetting manipulator support seat (43) arranged on the pipetting manipulator sliding seat (42), a pipette (44) arranged on the pipetting support seat and sliding in the Y-axis direction, and a pipetting manipulator driving assembly (45) arranged on the pipetting manipulator support seat (43), the pipetting manipulator driving assembly (45) is drivingly connected with the pipette (44), and the pipette (44) is provided with a plurality of pipetting heads (441).

Images