Freeze dryer in preparation of lipid nanoparticles

Abstract

The freeze dryer comprises an operation box, a box body, a top cover, a conveying pipe and a condensation box, the box body is installed on the top face of the operation box, the whole box body is of a cylindrical structure, the top cover connected with the box body in a sealed mode is installed on the top of the box body, and the conveying pipe is connected with the top cover. The right side of the box body communicates with a splitter plate at the top in the condensation box through a conveying pipe, an exhaust fan is installed on the middle section of the conveying pipe, an electric control valve is installed at the joint of the conveying pipe and the box body, and a plurality of condensation pipes are arranged at the bottom of the splitter plate in a rectangular array mode; the utility model provides a freeze dryer for preparing lipid nanoparticles, which solves the problems that the condensation effect of water vapor is poor, the treatment efficiency is delayed and the sublimation efficiency is reduced in the actual operation of the existing freeze dryer.

Description

Technical Field

[0001] This utility model relates to the field of freeze dryer technology, and in particular to a freeze dryer for the preparation of lipid nanoparticles. Background Technology

[0002] Lipid nanoparticles are lipid vesicles with a uniform lipid core, typically around 100 nanometers in diameter. This unique structure and size endow them with unique physical and chemical properties, enabling them to effectively encapsulate and protect nucleic acid drugs, allowing them to be delivered to target tissues or cells via the circulatory system. The main reasons for freeze-drying lipid nanoparticles include improving long-term stability and facilitating storage and transportation. Freeze-drying protectants play a crucial role in the freeze-drying process, ensuring that the nanoparticles maintain their quality throughout the process. Freeze-drying can significantly improve the long-term stability of nucleic acid drugs, allowing for storage at higher temperatures, especially in areas with insufficient cold chain facilities. Freeze-drying also reduces the need for cold chain maintenance, lowering the risk of product waste due to cold chain failures. In summary, the main purpose of freeze-drying lipid nanoparticles is to improve their long-term stability and facilitate storage and transportation. However, it is also necessary to carefully select appropriate freeze-drying protectants and optimize freeze-drying process parameters to ensure that quality and function are not compromised.

[0003] Currently, in freeze-drying, lipid particles are mixed with a freeze-drying protectant and placed inside a chamber. The chamber is then filled with cold air, causing the lipid particles to cool rapidly to a point far below the freezing point of water, completing the pre-freezing process. Next, a vacuum is created inside the chamber, and the heating device is activated. Heating begins at a lower temperature, causing the frozen water to directly transform from a solid state (ice) to a gaseous state (water vapor), bypassing the liquid stage. This process is called sublimation. During sublimation, precise temperature and pressure control is required to ensure complete sublimation. However, in practice, the condensation effect of water vapor is poor, delaying processing efficiency and thus reducing sublimation efficiency.

[0004] Therefore, it is necessary to provide a freeze dryer for the preparation of lipid nanoparticles to solve the above-mentioned technical problems. Utility Model Content

[0005] In order to overcome the defects of the prior art, this utility model provides a freeze dryer for the preparation of lipid nanoparticles. This solves the problem that the existing freeze dryers have poor water vapor condensation effect during actual operation, which delays the processing efficiency and thus reduces the sublimation efficiency.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0007] A freeze dryer for the preparation of lipid nanoparticles includes: an operating chamber, a chamber body, a top cover, a conveying pipe, and a condenser.

[0008] The top surface of the control box is equipped with a box body, which is a cylindrical structure. The top of the box body is equipped with a top cover that is sealed to it. The right side of the box body is connected to the diversion plate at the top of the condensation box through a conveying pipe. An exhaust fan is installed in the middle section of the conveying pipe. An electrically controlled valve is installed at the connection between the conveying pipe and the box body. Condensation tubes are arranged in a rectangular array at the bottom of the diversion plate. There are multiple condensation tubes.

[0009] In one embodiment, a first support member is installed inside the housing. The first support member consists of a support plate, a rotating shaft, a motor, a first track, a first insert, and a connecting plate. The support plate is a circular plate structure with a rotating shaft installed at the center of its top surface. A motor is installed on the top of the rotating shaft and is located on the top of the top cover. The two are protected by a seal. A first track is installed on the outer side of the support plate. The first track is arranged in a ring. A first insert is arranged in a ring array on the bottom surface of the first track. A connecting plate is installed on the outer circumferential surface of the first track. Multiple connecting plates are arranged in a ring array. The outer end of the connecting plate is connected to the inner circumferential surface of the second support member.

[0010] In one embodiment, the second support member consists of a second track and a second insertion tube, with the second insertion tubes mounted in a ring array on the inner bottom surface of the second track.

[0011] In one embodiment, the first support member and the second support member jointly support the placement box. Insert rods are installed at intervals at the bottom of the placement box, one of which is inserted into the first insertion tube and the other is inserted into the second insertion tube. The placement box contains mixed lipid particles and a freeze-drying protectant. Hanging frames are installed on both sides of the placement box.

[0012] In one embodiment, a material inlet is provided on the left side of the top surface of the top cover, and a sealing cover is installed on the material inlet.

[0013] The beneficial effects of this utility model are as follows:

[0014] (1) This utility model discharges water vapor into the distribution box through the conveying pipe by starting the exhaust fan, so that the water vapor can exchange heat with the cold air in the condenser box inside the condenser tube. By setting multiple condenser tubes arranged in a rectangular array, the water vapor is distributed, so that the water vapor is condensed in a small unit processing mode, which further improves the condensation efficiency.

[0015] (2) This utility model allows for manual operation of a hook rod to hook onto a hanging frame, allowing the placement box to be inserted into the material inlet. The insertion rod of the placement box is simultaneously inserted into the first and second insertion tubes to fix the placement box. The motor is then started to drive the support plate to rotate, which in turn drives the first and second tracks to rotate, allowing the second placement box to be placed into the box. After all the placement boxes are placed in sequence, the sealing cover of the material inlet is closed for processing. After sublimation is completed, the above steps are repeated in reverse to remove the placement box. The design of the first and second support components helps to improve the ease of handling the placement box, thereby effectively improving the subsequent processing efficiency of the placement box. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a detailed view of the disassembled components of this utility model;

[0018] Figure 3 This is a detailed drawing of the internal structure of the box body of this utility model;

[0019] Figure 4 This is a detailed diagram showing the components of this utility model after disassembly.

[0020] The corresponding names of the attached figures are: operation box 1, box body 2, top cover 3, conveying pipe 4, exhaust fan 41, condenser box 5, diverter plate 51, condenser pipe 52, first support member 6, support plate 61, rotating shaft 62, motor 63, first track 64, first insertion tube 65, connecting plate 66, second support member 7, second track 71, second insertion tube 72, placement box 8, insertion rod 81, hanging frame 82. Detailed Implementation

[0021] The present invention will be further described below with reference to the accompanying drawings and embodiments. The embodiments of the present invention include, but are not limited to, the following embodiments.

[0022] like Figures 1-2 As shown, the freeze dryer for preparing lipid nanoparticles provided by this utility model includes: an operation box 1, a box body 2, a top cover 3, a conveying pipe 4, and a condensation box 5;

[0023] like Figures 1-2As shown, a box body 2 is installed on the top surface of the operation box 1. The box body 2 is a cylindrical structure. A top cover 3 is installed on the top of the box body 2 and is sealed to it. The right side of the box body 2 is connected to the diversion plate 51 at the top of the condensing box 5 through a conveying pipe 4. An exhaust fan 41 is installed in the middle section of the conveying pipe 4. An electric control valve is installed at the connection between the conveying pipe 4 and the box body 2. Condensing pipes 52 are arranged in a rectangular array at the bottom of the diversion plate 51. There are multiple condensing pipes 52. When the inside of the box body 2 is in a sublimation state during operation, the exhaust fan 41 is activated to discharge water vapor into the diversion box 51 through the conveying pipe 4. The water vapor exchanges heat with the cold air in the condensing box 5 inside the condensing pipes 52. By setting multiple condensing pipes 52 arranged in a rectangular array, the water vapor is diverted, and the water vapor is condensed in a small unit processing manner, which further improves the condensation efficiency.

[0024] Preferably, in one embodiment, such as Figures 2-4 As shown, a first support member 6 is installed inside the housing 2. The first support member 6 consists of a support plate 61, a rotating shaft 62, a motor 63, a first track 64, a first insertion tube 65, and a connecting plate 66. The support plate 61 is a circular plate structure. The rotating shaft 62 is installed at the center of its top surface. The motor 63 is installed on the top of the rotating shaft 62. The motor 63 is located on the top of the top cover 3. The two are sealed and protected. The first track 64 is installed on the outer side of the support plate 61. The first track 64 is arranged in a ring. The first insertion tube 65 is arranged in a ring array on the inner bottom surface of the first track 64. The connecting plate 66 is installed on the outer peripheral surface of the first track 64. Multiple connecting plates 66 are arranged in a ring array. The outer end of the connecting plate 66 is connected to the inner peripheral surface of the second support member 7.

[0025] Preferably, in one embodiment, such as Figures 3-4 As shown, the second support member 7 consists of a second track 71 and a second insertion tube 72. The second insertion tube 72 is installed in a ring array on the inner bottom surface of the second track 71.

[0026] Preferably, in one embodiment, such as Figures 3-4 As shown, the first support member 6 and the second support member 7 jointly support the placement box 8. Insert rods 81 are installed at intervals at the bottom of the placement box 8. One insert rod 81 is inserted into the first insertion tube 65, and the other insert rod 81 is inserted into the second insertion tube 72. The placement box 8 contains mixed lipid particles and freeze-drying protectant. Hanging frames 82 are installed on both sides of the placement box 8.

[0027] Preferably, in one embodiment, such as Figures 1-4As shown, a material inlet 31 is provided on the left side of the top surface of the top cover 3. The material inlet 31 is equipped with a sealing cover. During operation, the hook rod is manually operated to hook the hanging frame 82 and the placement box 8 is placed into the material inlet 31, so that the insertion rod 81 of the placement box 8 is simultaneously inserted into the first insertion tube 65 and the second insertion tube 72 to fix the placement box 8. The motor 63 is started to drive the support plate 61 to rotate, and then the support plate 61 drives the first track 64 and the second track 71 to rotate, so that the second placement box 8 is placed into the box body 2. After all the placement boxes 8 are placed in sequence, the sealing cover of the material inlet 31 is closed and the processing operation is carried out. After sublimation is completed, the above steps are repeated in reverse to remove the placement box 8. The setting of the first support member 6 and the second support member 7 helps to improve the convenience of the handling of the placement box 8, thereby effectively improving the subsequent processing efficiency of the placement box 8.

[0028] Working principle of this utility model:

[0029] During operation, the exhaust fan 41 is activated to discharge water vapor into the distribution box 51 through the conveying pipe 4, allowing the water vapor to exchange heat with the cold air inside the condenser pipe 52. Multiple condenser pipes 52 arranged in a rectangular array are used to distribute the water vapor, enabling it to condense in small units, further improving condensation efficiency. The placement box 8 is then inserted into the receiving port 31 by manually operating a hook to hook the hanging frame 82, simultaneously inserting the insertion rod 81 of the placement box 8 into the first insertion tube 65 and the second insertion tube 72. After fixing, the motor 63 is started to drive the support plate 61 to rotate, which in turn drives the first track 64 and the second track 71 to rotate, and the second placement box 8 is placed into the box 2. After all the placement boxes 8 are placed in sequence, the sealing cover of the material outlet 31 is closed and the processing operation is carried out. After sublimation is completed, the above steps are repeated in reverse to remove the placement box 8. The setting of the first support member 6 and the second support member 7 helps to improve the convenience of the handling of the placement box 8, thereby effectively improving the subsequent processing efficiency of the placement box 8.

[0030] The above embodiments are merely one of the preferred embodiments of this utility model and should not be used to limit the scope of protection of this utility model. Any modifications or refinements made to the main design concept and spirit of this utility model that are not of substantial significance, but solve the same technical problem as this utility model, should be included within the scope of protection of this utility model.

Claims

1. A freeze-dryer in the preparation of lipid nanoparticles, characterized by, Include: Operation box, box, top cover, conveying pipe, condensing box; The top surface of the operation box is provided with a box body, the box body is in a cylindrical structure, the top of the box body is provided with a top cover in sealed connection, the right side of the box body is communicated with the baffle at the top of the condensing box through the conveying pipe, an exhaust fan is installed in the middle section of the conveying pipe, an electric control valve is installed at the connection between the conveying pipe and the box body, and a plurality of condensing pipes are arranged in a rectangular array at the bottom of the baffle.

2. The freeze dryer for the preparation of a lipid nanoparticle according to claim 1, characterized in that, The box body is internally provided with a first support, which is composed of a support plate, a rotating shaft, a motor, a first track, a first insertion pipe and a connecting plate.

3. The freeze dryer for the preparation of a lipid nanoparticle according to claim 2, characterized in that, The support plate is in a circular plate structure, a rotating shaft is installed at the center of the top surface of the support plate, a motor is installed at the top of the rotating shaft, the motor is located at the top of the top cover and is provided with sealing protection therebetween, a first track is installed on the outer side of the support plate, the first track is arranged in a ring shape, a plurality of first insertion pipes are arranged in a ring array on the inner bottom surface of the first track, a connecting plate is installed on the outer circumferential surface of the first track, a plurality of connecting plates are arranged in a ring array, and the outer side end of the connecting plate is connected with the inner circumferential surface of the second support.

4. The freeze dryer for the preparation of a lipid nanoparticle according to claim 2, characterized in that, The second support is composed of a second track and a second insertion pipe.

5. The freeze dryer for the preparation of a lipid nanoparticle according to claim 1, characterized in that, The first support and the second support jointly support the placing box, a plurality of insertion rods are installed at the bottom of the placing box, one of the insertion rods is inserted into the first insertion pipe, and the other insertion rod is inserted into the second insertion pipe, the mixed lipid particles and the freeze-drying protectant are placed in the placing box, and hanging frames are installed on both sides of the placing box. A material taking opening is formed in the left side of the top surface of the top cover, and a sealing cover is installed in the material taking opening.

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