Methyl cyclodextrin impurity removal and purification device

Abstract

The utility model belongs to the technical field of separation devices, and particularly relates to a methyl cyclodextrin impurity removal and purification device which comprises a purification kettle, a plurality of heat exchange tube nests connected to the lower part of the purification kettle, a condenser connected to the top of the purification kettle, a recovery tank connected to the condenser, a drying kettle connected to the bottom of the purification kettle, and a vacuum pump arranged between the purification kettle and the drying kettle, a pure water pipeline is arranged at the top of the purification kettle, a stirring assembly is arranged in the purification kettle, and the top of the drying kettle is connected with a heat exchange tube nest. According to the device disclosed by the utility model, an organic solvent carried in methyl cyclodextrin can be fully removed, and the cyclodextrin structure cannot be damaged.

Description

Technical Field

[0001] This utility model belongs to the field of separation device technology, specifically relating to a methylcyclodextrin purification device. Background Technology

[0002] Methylcyclodextrin is an organic compound widely used in pharmaceuticals, food, cosmetics, and textiles. Its core characteristics include strong inclusion and solubilizing abilities for oil-soluble molecules. Methylcyclodextrin is prepared by alkylation of esters with β-cyclodextrin under alkaline conditions, followed by neutralization, purification with ion exchange resin, and precipitation to obtain the final product.

[0003] The organic solvents used in the synthesis of methylcyclodextrin are mixed in with the methylcyclodextrin solution, and the purification process requires the removal of these organic solvents. Currently, the most commonly used industrial technique is to use thin-film evaporation for primary concentration, followed by deep drying and solvent removal using a dryer, and then combining this with an efficient solvent recovery and explosion-proof system to remove impurities from the methylcyclodextrin. This process effectively removes organic solvents, but it is complex to operate and has a low yield. Utility Model Content

[0004] In view of the shortcomings of the prior art, the technical problem to be solved by this utility model is to provide a methylcyclodextrin purification device to remove organic solvents from methylcyclodextrin products and obtain pure methylcyclodextrin.

[0005] The technical solution adopted by this utility model to solve its technical problem is:

[0006] The methylcyclodextrin purification device of this invention includes a purification vessel, a plurality of heat exchange tubes connected to the lower part of the purification vessel, a condenser connected to the top of the purification vessel, a recovery tank connected to the condenser, a drying vessel connected to the bottom of the purification vessel, a vacuum pump installed between the purification vessel and the drying vessel, a pure water pipe installed at the top of the purification vessel, a stirring assembly installed inside the purification vessel, and the top of the drying vessel connected to the heat exchange tubes.

[0007] in:

[0008] The purification vessel is equipped with a raw material inlet at the top.

[0009] The stirring assembly includes a stirring shaft, with several downward-sloping stirring paddles at the lower part of the stirring shaft and several upward-sloping stirring paddles at the bottom of the stirring shaft.

[0010] The top of the stirring shaft passes through the purification vessel and is connected to a motor.

[0011] The heat exchange tubes include an external heat exchange channel and an internal liquid channel.

[0012] The liquid channels in the heat exchange tubes are connected end to end in sequence. The liquid channel in the tail heat exchange tube is connected to the bottom of the purification vessel, and the liquid channel in the head heat exchange tube is connected to the middle of the purification vessel.

[0013] The heat exchange channels of the several heat exchange tubes are connected in sequence, and the top of the drying kettle is connected to the heat exchange channels in the several heat exchange tubes.

[0014] The heat exchange channel at the bottom of the heat exchange tube is provided with a drain outlet.

[0015] The condenser has a condensate inlet at the bottom and a condensate outlet at the top.

[0016] The drying vessel is equipped with a heat exchange jacket on its exterior.

[0017] The beneficial effects of this utility model are:

[0018] This invention can completely remove the organic solvents carried in methylcyclodextrin without damaging the cyclodextrin structure. By exchanging heat with the cyclodextrin solution through heat exchange tubes, the temperature inside the purification vessel can be ensured to reach the boiling point of the organic solvent. Adding some deionized water during heat exchange can stabilize the state of the methylcyclodextrin solution in the purification vessel. After removing organic impurities, the methylcyclodextrin solution enters the drying vessel for drying. The water in the solution evaporates into water vapor, and the water vapor is transported to the heat exchange tubes to use the residual heat to heat the methylcyclodextrin solution. The use of residual heat can prevent the temperature of the methylcyclodextrin solution from becoming too high, which would affect the methylcyclodextrin structure. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of this utility model;

[0020] In the diagram: 1. Purification vessel; 2. Heat exchange tubes; 3. Condenser; 4. Recovery tank; 5. Drying vessel; 6. Vacuum pump; 7. Pure water pipeline; 8. Raw material inlet; 9. Stirring paddle; 10. Motor; 11. Stirring shaft; 201. Heat exchange channel; 202. Feed liquid channel; 203. Drain outlet; 301. Condensate inlet; 302. Condensate outlet; 501. Heat exchange jacket. Detailed Implementation

[0021] The embodiments of this utility model will be further described below with reference to the accompanying drawings.

[0022] Example 1

[0023] like Figure 1As shown, the methylcyclodextrin purification device of this invention includes a purification vessel 1, a plurality of heat exchange tubes 2 connected to the lower part of the purification vessel 1, a condenser 3 connected to the top of the purification vessel 1, a recovery tank 4 connected to the condenser 3, a drying vessel 5 connected to the bottom of the purification vessel 1, a vacuum pump 6 provided between the purification vessel 1 and the drying vessel 5, a pure water pipe 7 provided at the top of the purification vessel 1, a stirring assembly provided inside the purification vessel 1, and the top of the drying vessel 5 connected to the heat exchange tubes 2.

[0024] The purification vessel 1 is equipped with a raw material inlet 8 at the top.

[0025] The stirring assembly includes a stirring shaft 11, with a plurality of downwardly inclined stirring paddles 9 disposed at the lower part of the stirring shaft 11 and a plurality of upwardly inclined stirring paddles 9 disposed at the bottom of the stirring shaft 11.

[0026] The top of the stirring shaft 11 passes through the purification vessel 1 and is connected to the motor 10.

[0027] The heat exchange tube 2 includes an external heat exchange channel 201 and an internal liquid channel 202.

[0028] The liquid channels 202 in several heat exchange tubes 2 are connected end to end in sequence. The liquid channel 202 in the tail heat exchange tube 2 is connected to the bottom of the purification vessel 1, and the liquid channel 202 in the head heat exchange tube 2 is connected to the middle of the purification vessel 1.

[0029] Several heat exchange tubes 2 have heat exchange channels 201 connected in sequence, and the top of the drying kettle 5 is connected to the heat exchange channels 201 in several heat exchange tubes 2.

[0030] A drain outlet 203 is provided in the heat exchange channel 201 at the bottom of the heat exchange tube 2.

[0031] The condenser 3 has a condensate inlet 301 at the bottom and a condensate outlet 302 at the top.

[0032] The drying vessel 5 is equipped with a heat exchange jacket 501 on its exterior.

[0033] Working principle and process:

[0034] The methylcyclodextrin solution is transported to purification vessel 1 and diluted with deionized water through pure water pipe 7. The methylcyclodextrin solution is then heated through heat exchange tube 2. The presence of organic solvents such as methanol and ethanol in the methylcyclodextrin solution can affect the purity of methylcyclodextrin as impurities. These impurities have low boiling points, and heating through heat exchange tube 2 allows them to evaporate and be removed. The evaporated impurities are then condensed by condenser 3 and transported to recovery tank 4 for recycling. The methylcyclodextrin solution is then transported to drying vessel 5 via vacuum pump 6 for heating to obtain dried methylcyclodextrin. The large amount of steam generated during heating in drying vessel 5 is transported to heat exchange tube 2 for heat exchange, thus achieving resource reuse.

Claims

1. A methylcyclodextrin impurity removal and purification apparatus comprising a purification kettle (1), characterized in that, The lower part of the purification kettle (1) is connected with a plurality of heat exchange pipes (2), the top of the purification kettle (1) is connected with a condenser (3), the condenser (3) is connected with a recovery tank (4), the bottom of the purification kettle (1) is connected with a drying kettle (5), a vacuum pump (6) is arranged between the purification kettle (1) and the drying kettle (5), the top of the purification kettle (1) is provided with a pure water pipeline (7), the inside of the purification kettle (1) is provided with a stirring assembly, and the top of the drying kettle (5) is connected with the heat exchange pipes (2).

2. The methylcyclodextrin impurity removal and purification device of claim 1, wherein, The top of the purification kettle (1) is provided with a raw material inlet (8).

3. The methylcyclodextrin impurity removal and purification device of claim 1, wherein, The stirring assembly comprises a stirring shaft (11), the lower part of the stirring shaft (11) is provided with a plurality of downward inclined stirring paddles (9), and the bottom of the stirring shaft (11) is provided with a plurality of upward inclined stirring paddles (9).

4. The methylcyclodextrin impurity removal and purification device of claim 3, wherein, The top of the stirring shaft (11) penetrates the purification kettle (1) and is connected with a motor (10).

5. The methylcyclodextrin impurity removal and purification device of claim 1, wherein, The heat exchange pipe (2) comprises an external heat exchange channel (201) and an internal liquid channel (202).

6. The methylcyclodextrin impurity removal and purification device of claim 5, wherein, The liquid channels (202) in the plurality of heat exchange pipes (2) are connected in sequence, the liquid channel (202) in the tail end heat exchange pipe (2) is connected with the bottom of the purification kettle (1), and the liquid channel (202) in the head end heat exchange pipe (2) is connected with the middle part of the purification kettle (1).

7. The methylcyclodextrin impurity removal and purification device of claim 5, wherein, The heat exchange channels (201) of the plurality of heat exchange pipes (2) are connected in sequence, and the top of the drying kettle (5) is connected with the heat exchange channels (201) of the plurality of heat exchange pipes (2).

8. The methylcyclodextrin impurity removal and purification device of claim 7, wherein, The heat exchange channel (201) of the bottom of the heat exchange pipe (2) is provided with a drain port (203).

9. The methylcyclodextrin impurity removal and purification device of claim 1, wherein, The lower part of the condenser (3) is provided with a condensate inlet (301), and the upper part of the condenser (3) is provided with a condensate outlet (302).

10. The methylcyclodextrin impurity removal and purification device of claim 1, wherein, The outside of the drying kettle (5) is provided with a heat exchange sleeve (501).

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