Dry granulation device for preparing solid preparation

Abstract

The utility model relates to a dry granulation device for preparing a solid preparation, and aims to solve the problems of looseness and low preparation efficiency caused by insufficient binding force among particles in the traditional dry granulation process. The device comprises a driving motor, the driving motor is sleeved with an arc-shaped heat conduction plate, the other end of the heat conduction plate penetrates through and is fixedly connected with an outer shell, a granulation structure is arranged in the device and comprises a separation wheel and a feeding pipe, the feeding pipe is located at the circle center of the separation wheel, and a discharging port is formed in the lower portion of the outer shell. The heat conducting plate is tightly attached to the outside of the separation wheel, heat generated by the motor is transferred to the separation wheel, and particle forming conditions are optimized. The separation wheel is made of a material with good heat-conducting property, a connecting plate is arranged inside the separation wheel, and a spacing plate is sleeved outside the separation wheel to form uniform particles. According to the device, by optimizing a heat transfer and granulation structure, the particle uniformity and the granulation efficiency are improved, and the industrial production requirements are met.

Description

Technical Field

[0001] This invention provides a dry granulation device, belonging to the field of medical injection technology, and particularly relates to a dry granulation device for preparing solid dosage forms. Background Technology

[0002] Dry granulation is a method in which drug and excipient powders are mixed evenly, extruded under pressure into blocks or flakes with a certain hardness, and then granulated through a sieve. Dry granulation is widely used in the field of injectable medicines because it eliminates the humidification and drying steps of wet granulation, resulting in a shorter process chain, reduced probability of production deviations, and lower investment costs.

[0003] During dry granulation, powdered materials are formed into granules under the mechanical pressure of rollers. In this process, unsuitable moisture content may lead to insufficient bonding between particles, resulting in weak cohesion and potentially increased particle dispersibility. Furthermore, the strict control of key parameters such as pressure settings and winding speed during dry granulation directly impacts particle uniformity and preparation efficiency. Failure to optimize these parameters can result in low preparation efficiency, meaning the particle forming rate and quality may not meet the requirements of industrial production, affecting overall production efficiency and cost-effectiveness. Utility Model Content

[0004] In order to overcome the shortcomings of the prior art, this application provides a dry granulation device for preparing solid dosage forms, which solves the problem of low efficiency of existing granulators for solid dosage forms.

[0005] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a dry granulation device for preparing solid dosage forms, including a drive motor, an arc-shaped heat-conducting plate fixedly connected to the outside of the drive motor, an outer shell penetrating the other end of the heat-conducting plate, and a granulation structure inside the outer shell, the granulation structure including a separation wheel placed inside the outer shell and correspondingly connected to the drive motor.

[0006] Preferably, the outer casing has a feeding pipe connected to itself on the side away from the drive motor.

[0007] Preferably, the heat-conducting plate is sleeved on the outside of the separating wheel, and the heat-conducting plate is in close contact with the outside of the separating wheel.

[0008] Preferably, the separating wheel is made of a material with good thermal conductivity, and the separating wheel has a corresponding connecting plate inside, which is penetrated and fixedly connected by the drive shaft of the drive motor.

[0009] Preferably, the connecting plate is fitted with a plurality of evenly distributed spacers, and the spacers are fixedly connected to the separating wheel.

[0010] Preferably, the connection between the feeding pipe and the outer shell is located at the center of the separating wheel, and the lower part of the outer shell is provided with a discharge port that is connected to itself.

[0011] One or more technical solutions provided in the embodiments of this application have at least the following technical effects or advantages:

[0012] This invention utilizes an arc-shaped heat-conducting plate fitted around the drive motor to transfer the heat generated by the motor to the separating wheel, optimizing the moisture content and temperature conditions of the particles under the mechanical pressure of the roller, and enhancing the bonding force between particles. The heat-conducting plate is closely attached to the outside of the separating wheel to ensure uniform temperature and reduce the problem of insufficient particle cohesion. The separating wheel is made of a material with good thermal conductivity and has an internal connecting plate, which is penetrated and fixedly connected by the drive shaft of the drive motor, improving heat conduction efficiency and structural stability. Evenly distributed spacer plates are fitted around the connecting plate and fixedly connected to the separating wheel, contributing to the formation of more uniform particles. The connection point between the feeding pipe and the outer shell is located at the center of the separating wheel, and a discharge port is located at the bottom of the outer shell, ensuring that the powder material enters the granulation area uniformly and effectively discharges the produced particles, improving preparation efficiency. Through these technical solutions, this invention effectively solves the problems of looseness and preparation efficiency in the dry granulation process, meeting the requirements of industrial production.

[0013] Other advantages, objectives and features of this invention will be set forth in part in the description which follows, and in part will be apparent to those skilled in the art from the following examination or study, or may be taught from the practice of this invention. Attached Figure Description

[0014] Figure 1 This is a three-dimensional schematic diagram of a dry granulation apparatus for preparing solid dosage forms according to the present invention;

[0015] Figure 2 This is a cross-sectional view of a dry granulation apparatus for preparing solid dosage forms according to the present invention;

[0016] Figure 3 This is a cross-sectional view of the separating wheel of a dry granulation apparatus for preparing solid dosage forms according to the present invention.

[0017] As shown in the figure:

[0018] 1. Drive motor;

[0019] 11. Heat-conducting plate;

[0020] 2. Outer shell;

[0021] 21. Granulation structure; 22. Separating wheel; 23. Feeding pipe; 24. Connecting plate; 25. Partition plate. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] It should be noted that the terms "vertical," "horizontal," "up," "down," "left," "right," and similar expressions used in this article are for illustrative purposes only and do not represent the only possible implementation.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains; the terminology used herein in the description of this invention is for the purpose of describing particular embodiments only and is not intended to limit the invention; the term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0025] like Figure 1 and Figure 2 As shown, a dry granulation apparatus for preparing solid dosage forms includes a drive motor 1. The drive motor 1 is characterized by having an arc-shaped heat-conducting plate 11 fixedly connected to its exterior. The other end of the heat-conducting plate 11 has an outer shell 2 penetrated by itself. The outer shell 2 has a granulation structure 21 inside, including a separating wheel 22 placed inside the outer shell 2 and correspondingly connected to the drive motor 1. A feeding pipe 23 connected to itself is located on the side of the outer shell 2 away from the drive motor 1, with the feeding pipe 23 and the outer shell 2 connected at the center of the separating wheel 22. An outlet connected to itself is located below the outer shell 2. The heat-conducting plate 11 is fitted over the outside of the separating wheel 22, and the heat-conducting plate 11 is tightly attached to the outside of the separating wheel 22.

[0026] In this embodiment, an arc-shaped heat-conducting plate 11 is fitted around the drive motor 1 to transfer the heat generated by the motor to the separating wheel 22, optimizing the moisture content and temperature conditions of the particles under the mechanical pressure of the roller shaft and enhancing the bonding force between particles. The heat-conducting plate 11 is in close contact with the outside of the separating wheel 22 to ensure uniform temperature of the separating wheel and reduce the problem of insufficient cohesion between particles. The separating wheel 22 is made of a material with good thermal conductivity and has a connecting plate 24 inside. The connecting plate is penetrated and fixedly connected by the drive shaft of the drive motor 1, improving the heat conduction efficiency and structural stability. Evenly distributed spacer plates 25 are fitted around the connecting plate 24 and fixedly connected to the separating wheel 22, which helps to form more uniform particles. The connection position between the feeding pipe 23 and the outer shell 2 is located at the center of the separating wheel 22, and the outer shell 2 has a discharge port at the bottom to ensure that the powder material enters the granulation area evenly and the produced particles are effectively discharged, improving the preparation efficiency. Through these technical solutions, this utility model effectively solves the problems of looseness and preparation efficiency in the dry granulation process and meets the requirements of industrial production.

[0027] like Figure 2 and Figure 3 As shown, the separating wheel 22 is made of a material with good thermal conductivity to improve heat transfer efficiency and ensure that the powder material is heated evenly during dry granulation, thereby improving the granule forming quality. Inside the separating wheel 22, there is a corresponding connecting plate 24, which is penetrated and fixedly connected by the drive shaft of the drive motor 1. This design not only enhances the structural stability of the separating wheel 22 but also allows the driving force to be transmitted to the separating wheel 22 more directly and effectively, improving granulation efficiency. Several evenly distributed spacer plates 25 are fitted around the connecting plate 24. These spacer plates 25 are fixedly connected to the separating wheel 22, and their function is to form multiple material channels during granulation, allowing the powder material to be evenly distributed on the surface of the separating wheel 22. This, in turn, forms granules of uniform size and shape under mechanical pressure, reducing particle dispersion and improving particle uniformity. Furthermore, the connection point between the feeding pipe 23 and the outer shell 2 is located at the center of the separating wheel 22. This design facilitates the direct entry of powder material into the granulation area, reducing material pretreatment time and improving granulation efficiency. A discharge port is provided at the bottom of the outer shell 2, which is connected to the outer shell 2, for collecting and discharging the produced granules, ensuring the continuity and efficiency of the granulation process. Through these technical solutions, this utility model not only solves the problem of looseness caused by insufficient interparticle bonding force in the dry granulation process, but also significantly improves the uniformity and preparation efficiency of granulation, meeting the high efficiency and high quality requirements of industrial production for solid dosage form preparation.

[0028] In use, firstly, the powdered material is fed into the outer shell 2 through the feeding pipe 23. At this time, the connection between the feeding pipe 23 and the outer shell 2 is located at the center of the separating wheel 22, ensuring that the material can directly and evenly enter the granulation area. Next, the drive motor 1 is started, and the heat generated by the motor is transferred to the separating wheel 22 through the arc-shaped heat-conducting plate 11 fitted on its exterior. This optimizes the moisture content and temperature conditions of the particles under the mechanical pressure of the roller, enhancing the bonding force between the particles. At the same time, the heat-conducting plate 11 is in close contact with the outside of the separating wheel 22, ensuring uniform temperature of the separating wheel and reducing the problem of insufficient cohesion between particles. The separating wheel 22 is made of a material with good thermal conductivity and has a connecting plate 2 inside. 4. The connecting plate 24 is penetrated and fixedly connected by the drive shaft of the drive motor 1, which improves the heat conduction efficiency and structural stability. The connecting plate 24 is fitted with uniformly distributed spacer plates 25, which are fixedly connected to the separating wheel 22, which helps to form more uniform particles. Under the mechanical action of the separating wheel 22, the powder material is evenly distributed on the surface of the separating wheel 22 and forms particles of uniform size and regular shape under mechanical pressure. Finally, the obtained particles are discharged through the discharge port under the outer shell 2, ensuring the continuity and efficiency of the granulation process, thereby completing the dry granulation process, improving the uniformity and preparation efficiency of granulation, and meeting the high efficiency and high quality requirements of industrial production for solid dosage form preparation.

[0029] Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make various modifications and alterations without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention should be determined by the claims.

Claims

1. A dry granulation apparatus for preparing solid dosage forms, comprising a drive motor (1), characterized in that: The drive motor (1) is fitted with an arc-shaped heat-conducting plate (11) that is fixedly connected to itself. The other end of the heat-conducting plate (11) is provided with an outer shell (2) that is penetrated by itself. The inner part of the outer shell (2) is provided with a granulation structure (21). The granulation structure (21) includes a separation wheel (22) that is placed inside the outer shell (2) and is correspondingly connected to the drive motor (1).

2. The dry granulation apparatus for preparing solid dosage forms according to claim 1, characterized in that: The outer shell (2) has a feeding pipe (23) connected to itself on the side away from the drive motor (1).

3. The dry granulation apparatus for preparing solid dosage forms according to claim 1, characterized in that: The heat-conducting plate (11) is sleeved on the outside of the separating wheel (22), and the heat-conducting plate (11) is in close contact with the outside of the separating wheel (22).

4. A dry granulation apparatus for preparing solid dosage forms according to claim 1, characterized in that: The separating wheel (22) is made of a material with good thermal conductivity. The separating wheel (22) has a corresponding connecting plate (24) inside. The connecting plate (24) is penetrated and fixedly connected by the drive shaft of the drive motor (1).

5. A dry granulation apparatus for preparing solid dosage forms according to claim 4, characterized in that: The connecting plate (24) is fitted with several evenly distributed spacer plates (25), and the spacer plates (25) and the separating wheel (22) are fixedly connected.

6. A dry granulation apparatus for preparing solid dosage forms according to claim 2, characterized in that: The feeding pipe (23) and the outer shell (2) are connected at the center of the separating wheel (22), and the outer shell (2) has a discharge port connected to itself at the bottom.

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