Micro-fluidic chip for micro-droplet manufacturing and micro-droplet production equipment thereof
By designing a continuous phase flow channel and a microdroplet collection cavity structure for the microfluidic chip, the problem of low microdroplet production rate was solved, achieving efficient microdroplet production and increasing yield.
Patent Information
- Application Number
- CN202423279434.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2026-01-09
- Estimated Expiration
- 2034-12-30
AI Technical Summary
Existing microfluidic chips have low production rates in microdroplet manufacturing, which cannot meet the needs of mass production.
A microfluidic chip was designed, including a continuous phase channel, a dispersed phase channel, and a microdroplet collection cavity. The continuous phase channel surrounds the second outlet of the dispersed phase channel to form the microdroplet collection cavity. The continuous phase liquid can encapsulate the dispersed phase droplets, thereby improving the production rate.
By increasing the flow rate and encapsulation capacity of the continuous phase liquid, the problem of slow microdroplet production rate was solved, and the yield of microdroplets was increased.
Smart Images
Figure CN223774863U_ABST
Abstract
Description
Technical Field
[0001] This disclosure relates to the field of microdroplet technology, and more particularly to microfluidic chips for microdroplet fabrication and microdroplet production equipment thereof. Background Technology
[0002] Microdroplets are tiny, liquid droplets with small volumes, and they have broad application potential in many fields. Researchers have proposed various methods to efficiently generate microdroplets. One common method is microfluidics. This technology utilizes microchannels and precise fluid control to divide the mother liquor into uniform small droplets. However, most existing microfluidic chips for microdroplet production suffer from low production rates, failing to meet the demands of large-scale production. Summary of the Invention
[0003] In view of the shortcomings of the prior art described above, the purpose of this disclosure is to provide a microfluidic chip for microdroplet fabrication and microdroplet production equipment thereon, thereby solving the problems in the related art.
[0004] The first aspect of this disclosure provides a microfluidic chip for fabricating microdroplets, comprising:
[0005] A continuous phase flow channel for loading a continuous phase liquid, having a first inlet and a first outlet;
[0006] A dispersed phase flow channel, located within the continuous phase flow channel, is used to load a dispersed phase liquid and has a second inlet and a second outlet surrounded by the first outlet; the flow directions of the dispersed phase flow channel and the continuous phase flow channel form a certain angle so that the dispersed phase liquid is cut into microdroplets by the continuous phase liquid at the first outlet at the second outlet.
[0007] The microdroplet collection chamber is connected to the first outlet and the second outlet.
[0008] In an embodiment of the first aspect, at least one of the continuous phase flow channel and the dispersed phase flow channel is provided with a variable diameter section whose inner diameter decreases along the flow direction.
[0009] In an embodiment of the first aspect, the microdroplet collection cavity includes an outlet for discharging microdroplets; the distance between the second outlet and the outlet is adjustable, and the diameter of the microdroplets increases as the distance between the second outlet and the outlet increases.
[0010] In an embodiment of the first aspect, the region within the dispersed phase flow channel that is at least surrounded by the continuous phase flow channel is configured as a first variable diameter section, the inner diameter of which decreases along the flow direction.
[0011] In an embodiment of the first aspect, the region within the continuous phase flow channel that at least surrounds the dispersed phase flow channel is configured as a second variable diameter section, the inner diameter of which decreases along the flow direction.
[0012] In an embodiment of the first aspect, the region within the dispersed phase flow channel that is at least surrounded by the continuous phase flow channel is configured as a first variable diameter section, the inner diameter of which decreases along the flow direction; and the region within the continuous phase flow channel that at least surrounds the dispersed phase flow channel is configured as a second variable diameter section, the inner diameter of which decreases along the flow direction.
[0013] In an embodiment of the first aspect, the continuous phase channel is formed on a first substrate; the dispersed phase channel is formed on a second substrate; the first substrate and the second substrate are detachably connected, and the continuous phase channel and the dispersed phase channel communicate after the first substrate is connected to the second substrate.
[0014] In an embodiment of the first aspect, the second substrate includes a detachably connected second base block and a liquid guide tube, and the dispersed phase flow channel is formed in the second base block and the liquid guide tube; an insertion cavity is provided on the wall surface of the first substrate that is in contact with the second substrate; when the first substrate is connected to the second substrate, the liquid guide tube is inserted into the insertion cavity to form the continuous phase flow channel.
[0015] In an embodiment of the first aspect, a sealing element is provided between the wall surfaces of the first substrate and the second substrate to form a seal on the continuous phase flow channel and the dispersed phase flow channel after the first substrate and the second substrate are connected.
[0016] A second aspect of this disclosure provides an apparatus for producing microdroplets, including the microfluidic chip for microdroplet fabrication.
[0017] As described above, embodiments of this disclosure provide a microfluidic chip for microdroplet fabrication and a microdroplet production apparatus thereof. The microfluidic chip for microdroplet fabrication includes a continuous phase flow channel, a dispersed phase flow channel, and a microdroplet collection chamber. The continuous phase flow channel is for loading a continuous phase liquid and has a first inlet and a first outlet. The dispersed phase flow channel is located within the continuous phase flow channel and is for loading a dispersed phase liquid, having a second inlet and a second outlet surrounded by the first outlet; the flow directions of the dispersed phase flow channel and the continuous phase flow channel form a certain angle, such that the dispersed phase liquid is cut by the continuous phase liquid at the first outlet at the second outlet to form microdroplets. The microdroplet collection chamber is connected to the first outlet and the second outlet. The microdroplet production apparatus includes the microfluidic chip for microdroplet fabrication. The advantage of the above configuration is that the continuous phase flow channel arranged in the circumferential configuration in this embodiment can form a microdroplet collection cavity surrounding the second outlet. The continuous phase liquid in the microdroplet collection cavity can encapsulate a large number of dispersed phase droplets flowing out from the second outlet, solving the problem of slow microdroplet production rate caused by insufficient supply of the continuous phase liquid and improving the yield of microdroplets. Attached Figure Description
[0018] Figure 1 The diagram shown is a schematic representation of the overall structure of the microfluidic chip in an embodiment of this disclosure.
[0019] Figure 2 The following is an embodiment of this disclosure. Figure 1 Enlarged view of A in the middle;
[0020] Figure 3 The diagram shown is a cross-sectional view of the disassembly and connection of the microfluidic chip in an embodiment of this disclosure.
[0021] Figure label:
[0022] 10. First substrate; 101. Continuous phase flow channel; 10101. First inlet; 10102. First outlet; 1011. Second variable diameter section;
[0023] 20. Second substrate; 21. First base block; 22. Liquid guide pipe; 201. Dispersed phase flow channel; 20101. Second inlet; 20102. Second outlet; 2011. First diameter reducing section; 23. Seal;
[0024] 301, Microdroplet collection chamber; 302, Liquid outlet; 3011, Guide section. Detailed Implementation
[0025] The following specific examples illustrate the implementation of this disclosure. Those skilled in the art can easily understand other advantages and effects of this disclosure from the information disclosed herein. This disclosure can also be implemented or applied through other different specific embodiments, and various details in this disclosure can be modified or changed according to different viewpoints and application modules without departing from the spirit of this disclosure. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this disclosure can be combined with each other.
[0026] The embodiments of this disclosure will now be described in detail with reference to the accompanying drawings, so that those skilled in the art to which this disclosure pertains can readily implement it. This disclosure may be embodied in many different forms and is not limited to the embodiments described herein.
[0027] In this disclosure, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic represented in connection with that embodiment or example is included in at least one embodiment or example of this disclosure. Furthermore, the specific features, structures, materials, or characteristics represented may be combined in any suitable manner in any one or a group of embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples represented in this disclosure, as well as the features of those different embodiments or examples.
[0028] Furthermore, the terms "first" and "second" are used for illustrative purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the representation of this disclosure, "a set" means two or more, unless otherwise explicitly specified.
[0029] For the purpose of clarity, devices unrelated to the description are omitted, and the same or similar components throughout the specification are given the same reference numerals.
[0030] Throughout this specification, when it is said that a device is "connected" to another device, this includes not only "direct connection" but also "indirect connection" by placing other components in between. Furthermore, when it is said that a device "comprises" a certain constituent element, unless otherwise stated otherwise, this does not exclude other constituent elements, but rather implies that other constituent elements may be included.
[0031] While the terms first, second, etc., are used in some examples herein to refer to various elements, these elements should not be limited by these terms. These terms are used only to distinguish one element from another. For example, first interface and second interface, etc., are used. Furthermore, as used herein, the singular forms “a,” “an,” and “the” are intended to also include the plural forms unless the context indicates otherwise. It should be further understood that the terms “comprising,” “including,” indicate the presence of the stated feature, step, operation, element, module, item, kind, and / or group, but do not exclude the presence, occurrence, or addition of one or more other features, steps, operations, elements, modules, items, kinds, and / or groups. The terms “or” and “and / or” as used herein are interpreted as inclusive, or mean any one or any combination thereof. Thus, “A, B, or C” or “A, B, and / or C” means “any one of: A; B; C; A and B; A and C; B and C; A, B, and C.” Exceptions to this definition will only occur if the combination of elements, functions, steps, or operations is inherently mutually exclusive in some way.
[0032] The technical terms used herein are for reference only to specific embodiments and are not intended to limit the scope of this disclosure. The singular form used herein includes the plural form unless the statement explicitly indicates otherwise. The word "comprising" as used in this specification means to specify a particular characteristic, region, integer, step, operation, element, and / or component, and does not exclude the presence or addition of other characteristics, regions, integers, steps, operations, elements, and / or components.
[0033] Although not explicitly defined, all terms, including technical and scientific terms used herein, shall have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains. Terms defined in commonly used dictionaries shall be further interpreted as having a meaning consistent with the relevant technical literature and the message of the present disclosure, and shall not be over-interpreted as having an ideal or overly formulaic meaning unless otherwise defined.
[0034] Microdroplets are tiny, liquid droplets with small volumes, and they have broad application potential in many fields. Researchers have proposed various methods to efficiently generate microdroplets. One common method is microfluidics. This technology utilizes microchannels and precise fluid control to divide the mother liquor into uniform small droplets. However, most existing microfluidic chips for microdroplet production suffer from low production rates, failing to meet the demands of large-scale production.
[0035] Based on the above problems, in this embodiment of the present disclosure, the continuous phase flow channel arranged in a ring can form a microdroplet collection cavity surrounding the second outlet. The continuous phase liquid in the microdroplet collection cavity can encapsulate a large number of dispersed phase droplets flowing out from the second outlet, thereby solving the problem of slow microdroplet production rate caused by insufficient supply of the continuous phase liquid and improving the yield of microdroplets.
[0036] Figure 1 The diagram shown is a schematic diagram of the overall structure of the microfluidic chip in an embodiment of this disclosure. Figure 2 The following is an embodiment of this disclosure. Figure 1 A magnified view of A in the diagram. Figure 1 and Figure 2 In this example, the microfluidic chip for microdroplet fabrication includes a continuous phase channel 101, a dispersed phase channel 201, and a microdroplet collection chamber 301. The continuous phase channel 101 is for loading a continuous phase liquid and has a first inlet 10101 and a first outlet 10102. The dispersed phase channel 201, located within the continuous phase channel 101, is for loading a dispersed phase liquid and has a second inlet 20101 and a second outlet 20102 surrounded by the first outlet 10102. The dispersed phase channel 201 and the continuous phase channel 101 form a certain angle, so that the dispersed phase liquid is cut into microdroplets at the second outlet 20102 by the continuous phase liquid at the first outlet 10102. The microdroplet collection chamber 301 is connected to the first outlet 10102 and the second outlet 20102.
[0037] The advantage of the above arrangement is that the continuous phase flow channel 101 arranged in a ring can form a microdroplet collection cavity 301 surrounding the second outlet 20102. The continuous phase liquid in the microdroplet collection cavity 301 can encapsulate a large number of dispersed phase droplets flowing out from the second outlet 20102, solving the problem of slow microdroplet production rate caused by insufficient supply of the continuous phase liquid and increasing the output of microdroplets.
[0038] Microspheres, as a type of microdroplet, have wide applications in many fields, including drug delivery, chemical separation, catalytic reactions, and biomedical applications.
[0039] exist Figure 1 and Figure 2In the example, the region within the dispersed phase flow channel 201 that is at least surrounded by the continuous phase flow channel 101 is implemented as a first variable diameter section 2011, the inner diameter of which decreases along the flow direction. It is understood that as the dispersed phase liquid flows through the first variable diameter section 2011, the flow velocity of the dispersed phase liquid within the dispersed phase flow channel 201 is increased as the inner diameter gradually decreases along the flow direction, thereby increasing the velocity at which the dispersed phase liquid flows out of the second outlet 20102 and forms dispersed phase droplets, and thus increasing the yield of microdroplets.
[0040] exist Figure 1 and Figure 2 In the example, the continuous phase flow channel 101 is configured as a second variable diameter section 1011, at least surrounding a portion of the dispersed phase flow channel 201, with the inner diameter of the second variable diameter section 1011 decreasing along the flow direction. It is understood that as the continuous phase liquid flows through the second variable diameter section 1011, the flow velocity of the continuous phase liquid within the continuous phase flow channel 101 is increased as the inner diameter gradually decreases along the flow direction. This increases the velocity of the continuous phase liquid flowing into the microdroplet collection chamber 301 and allows it to accumulate there in large quantities. This, in turn, enables the encapsulation of a large number of dispersed phase droplets flowing out from the second outlet 20102, preventing the problem of insufficient continuous phase liquid supply leading to the inability of microdroplets to form, and further increasing the yield of microdroplets.
[0041] Exemplarily, the first variable diameter section 2011 and the second variable diameter section 1011 can be implemented individually or simultaneously. In this embodiment, the first variable diameter section 2011 and the second variable diameter section 1011 are implemented simultaneously. Those skilled in the art will understand that the larger the angle between the second variable diameter section 1011 and the liquid flow direction, the greater the cutting force exerted by the continuous phase liquid flowing from the first outlet 10102 along the direction perpendicular to the liquid flow direction on the dispersed phase liquid flowing from the second outlet 20102. That is, the better the cutting effect on the dispersed phase liquid flowing from the second outlet 20102, thereby significantly improving the production rate of microdroplets.
[0042] For example, the inner diameter of the microdroplet collection cavity 301 is larger than the inner diameter of the second outlet 20102. It is understood that the larger inner diameter of the microdroplet collection cavity 301 allows it to accommodate a large amount of continuous phase liquid at the second outlet 20102, thereby enabling the encapsulation of a large number of dispersed phase droplets flowing out of the second outlet 20102 and preventing the problem of insufficient continuous phase liquid supply leading to the inability of microdroplets to form.
[0043] For example, the first outlet 10102, the second outlet 20102, and the microdroplet collection cavity 301 are coaxial. Preferably, the cross-section of the microdroplet collection cavity 301 is circular. That is, the second outlet 20102 is aligned with the first outlet 10102 and the microdroplet collection cavity 301. The advantage of this arrangement is that it can accelerate the flow rate of finished microdroplets formed in the microdroplet collection cavity 301 out of the first outlet 10102, and prevent finished microdroplets from accumulating in the microdroplet collection cavity 301, thereby reducing the microdroplet production rate. In another embodiment, the cross-section of the microdroplet collection cavity 301 may also be rectangular.
[0044] For example, the first inlet 10101 can also be implemented as two or more. When the first inlet 10101 is implemented as two, the two first inlets 10101 are symmetrically arranged. When the first inlet 10101 is implemented as multiple, the multiple first inlets 10101 are circumferentially spaced and uniformly distributed, so as to make the pressure of the continuous phase liquid in the continuous phase flow channel 101 more uniform.
[0045] exist Figure 2 In the example, the microdroplet collection chamber 301 includes an outlet 302 for discharging microdroplets. The aperture of the outlet 302 is smaller than the inner diameter of the microdroplet collection chamber 301. It is understood that the small aperture of the outlet 302 reduces the amount of continuous phase liquid flowing out through the outlet 302, avoiding waste of the continuous phase liquid, while allowing the finished microdroplets to flow out.
[0046] For example, a tapered guide portion 3011 is provided at the connection between the microdroplet collection chamber 301 and the outlet 302. The advantage of this design is that it can guide the microdroplets in the microdroplet collection chamber 301 to flow to the outlet 302, further preventing the accumulation of microdroplets in the microdroplet collection chamber 301 and the blockage of the outlet 302.
[0047] As a further example, the distance between the second outlet 20102 and the liquid outlet 302 is adjustable, and the diameter of the microdroplets increases as the distance between the second outlet 20102 and the liquid outlet 302 increases. Those skilled in the art will understand that, firstly, the greater the distance between the second outlet 20102 and the liquid outlet 302, the smaller the component force (cutting force) perpendicular to the flow direction of the continuous phase liquid on the dispersed phase liquid flowing out of the second outlet 20102 when the continuous phase liquid flows in the microdroplet collection chamber 301, resulting in the dispersed phase liquid flowing out of the second outlet 20102 not being quickly cut into droplets; secondly, the greater the distance between the second outlet 20102 and the liquid outlet 302, the longer the path for the dispersed phase liquid flowing out of the second outlet 20102 to combine with the external continuous phase liquid, ultimately resulting in a larger volume of dispersed phase droplets flowing out of the second outlet 20102 and being cut into them, and the diameter of the final product's microdroplets increases accordingly, and vice versa, the diameter of the final product's microdroplets decreases accordingly, so this will not be elaborated further here.
[0048] Figure 3 The diagram shown is a cross-sectional view illustrating the disassembly and connection of a microfluidic chip in an embodiment of this disclosure. Figure 3 In the example, the continuous phase channel 101 is formed on the first substrate 10; the dispersed phase channel 201 is formed on the second substrate 20; the first substrate 10 and the second substrate 20 are detachably connected, and the continuous phase channel 101 and the dispersed phase channel 201 are connected after the first substrate 10 is connected to the second substrate 20.
[0049] For example, the second substrate 20 includes a detachably connected second base block 21 and a liquid guide tube 22, and the dispersed phase flow channel 201 is formed in the second base block 21 and the liquid guide tube 22; the wall surface of the first substrate 10 that is in contact with the second substrate 20 is provided with an insertion cavity (attached). Figure 3 The liquid guide tube 22 is inserted into the area described above. When the first substrate 10 is connected to the second substrate 20, the liquid guide tube 22 is inserted into the insertion cavity to form the continuous phase flow channel 101 surrounding the dispersed phase flow channel 201. In this embodiment, the second substrate 21 and the liquid guide tube 22 are threaded together. In another embodiment, the disassembly and connection of the second substrate 21 and the liquid guide tube 22 is implemented by first engaging (positioning) and then bolting (fastening).
[0050] As a further example, the second base block 21 is provided with a second sub-channel including a second sub-inlet and a second sub-outlet, and the first end of the liquid guide tube 22 is threadedly connected to the second sub-outlet. That is to say, the dispersed phase flow channel 201 is jointly composed of the second sub-channel and the inner cavity of the liquid guide tube 22, and the second outlet 20102 is formed at the second end of the liquid guide tube 22.
[0051] exist Figure 3 In this embodiment, the distance between the second outlet 20102 and the liquid outlet 302 can be adjusted by adjusting the length of the liquid guide tube 22 screwed into the second sub-outlet.
[0052] Those skilled in the art will understand that the disassembly and connection of the first substrate 10, the second substrate 20, and the liquid guide tube 22 can facilitate the replacement of the liquid guide tube 22 with different inner diameters to produce microdroplets of different diameters; it can also facilitate the periodic cleaning of the continuous phase flow channel 101, the dispersed phase flow channel 201, and the inside of the liquid guide tube 22 to maintain the cleanliness of the chip interior.
[0053] For example, the first base 10 and the second base 20 are connected by bolts. For instance, the first base 10 has a first threaded hole, and the second base 20 has a second threaded hole. In another embodiment, the first base 10 and the second base 20 are connected by snap-fit.
[0054] exist Figure 3 In the example, a seal 23 is provided between the wall surfaces of the first substrate 10 and the second substrate 20 that are in contact with each other, so as to form a seal on the continuous phase flow channel 101 and the dispersed phase flow channel 201 after the first substrate 10 and the second substrate 20 are connected. Exemplarily, the wall surface of the second substrate 20 that is in contact with the first substrate 10 is provided with an annular sealing groove surrounding the liquid guide tube 22, and the seal 23, implemented as a sealing ring, is filled in the annular sealing groove. Further exemplaryly, the insertion cavity is located within the annular sealing groove. It is understood that the seal 23 can improve the sealing effect on the continuous phase flow channel 101 after the first substrate 10 and the second substrate 20 are connected, preventing liquid in the continuous phase flow channel 101 and the dispersed phase flow channel 201 from flowing out from the gap between the first substrate 10 and the second substrate 20.
[0055] This disclosure provides a microdroplet production apparatus, including the microfluidic chip for microdroplet fabrication.
[0056] In summary, this disclosure provides a microfluidic chip for microdroplet fabrication and a microdroplet production apparatus thereof. The microfluidic chip for microdroplet fabrication includes a continuous phase channel, a dispersed phase channel, and a microdroplet collection chamber. The continuous phase channel is for loading a continuous phase liquid and has a first inlet and a first outlet. The dispersed phase channel is located within the continuous phase channel and is for loading a dispersed phase liquid, having a second inlet and a second outlet surrounded by the first outlet. The flow directions of the dispersed phase channel and the continuous phase channel form a certain angle, such that the dispersed phase liquid is cut by the continuous phase liquid at the first outlet at the second outlet to form microdroplets. The microdroplet collection chamber is connected to the first outlet and the second outlet. The microdroplet production apparatus includes the microfluidic chip for microdroplet fabrication. The advantage of the above configuration is that, in this embodiment of the present disclosure, the continuous phase flow channel arranged in a ring can form a microdroplet collection cavity surrounding the second outlet. The continuous phase liquid in the microdroplet collection cavity can encapsulate a large number of dispersed phase droplets flowing out from the second outlet, avoiding the problem of microdroplets failing to form due to insufficient supply of the continuous phase liquid, and improving the yield of microdroplets.
[0057] The above embodiments are merely illustrative of the principles and effects of this disclosure and are not intended to limit this disclosure. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this disclosure. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this disclosure should still be covered by the protection scope of this disclosure.
Claims
1. A microfluidic chip for fabricating microdroplets, characterized in that, include: A continuous phase flow channel for loading a continuous phase liquid, having a first inlet and a first outlet; A dispersed phase flow channel, located within the continuous phase flow channel, is used to load a dispersed phase liquid and has a second inlet and a second outlet surrounded by the first outlet; the flow directions of the dispersed phase flow channel and the continuous phase flow channel form a certain angle so that the dispersed phase liquid is cut into microdroplets by the continuous phase liquid at the first outlet at the second outlet. The microdroplet collection chamber is connected to the first outlet and the second outlet.
2. The microfluidic chip for microdroplet fabrication according to claim 1, characterized in that, At least one of the continuous phase flow channel and the dispersed phase flow channel is provided with a variable diameter section whose inner diameter decreases along the flow direction.
3. The microfluidic chip for microdroplet fabrication according to claim 1, characterized in that, The microdroplet collection chamber includes an outlet for discharging microdroplets; the distance between the second outlet and the outlet is adjustable, and the diameter of the microdroplets increases as the distance between the second outlet and the outlet increases.
4. The microfluidic chip for microdroplet fabrication according to claim 1, characterized in that, The region within the dispersed phase flow channel that is at least surrounded by the continuous phase flow channel is configured as a first variable diameter section, wherein the inner diameter of the first variable diameter section decreases along the flow direction.
5. The microfluidic chip for microdroplet fabrication according to claim 1, characterized in that, The region within the continuous phase flow channel that at least surrounds the dispersed phase flow channel is configured as a second variable diameter section, the inner diameter of which decreases along the flow direction.
6. The microfluidic chip for microdroplet fabrication according to claim 1, characterized in that, The region within the dispersed phase flow channel that is at least surrounded by the continuous phase flow channel is configured as a first variable diameter section, the inner diameter of which decreases along the flow direction; the region within the continuous phase flow channel that at least surrounds the dispersed phase flow channel is configured as a second variable diameter section, the inner diameter of which decreases along the flow direction.
7. The microfluidic chip for microdroplet fabrication according to claim 1, characterized in that, The continuous phase flow channel is formed in a first substrate; the dispersed phase flow channel is formed in a second substrate; the first substrate and the second substrate are detachably connected, and the continuous phase flow channel and the dispersed phase flow channel communicate after the first substrate is connected to the second substrate.
8. The microfluidic chip for microdroplet fabrication according to claim 7, characterized in that, The second substrate includes a detachably connected second base block and a liquid guide tube, and the dispersed phase flow channel is formed in the second base block and the liquid guide tube; the wall surface of the first substrate that is in contact with the second substrate is provided with an insertion cavity; when the first substrate is connected to the second substrate, the liquid guide tube is inserted into the insertion cavity to form the continuous phase flow channel.
9. The microfluidic chip for microdroplet fabrication according to claim 8, characterized in that, A sealing element is provided between the wall surfaces where the first substrate and the second substrate are attached, so as to form a seal on the continuous phase flow channel and the dispersed phase flow channel after the first substrate and the second substrate are connected.
10. A microdroplet production device, characterized in that, include: The microfluidic chip for microdroplet fabrication as described in any one of claims 1-9.