Device for synthesizing phenylephrine hydrochloride and recovering catalyst

Abstract

The utility model discloses a device for synthesizing phenylephrine hydrochloride and recovering a catalyst, which comprises a reaction kettle, a first plate-and-frame filter, a cleaning tank, a second plate-and-frame filter, a drying tank and a catalyst recovery tank which are communicated with one another, and a feed liquid outlet of the first plate-and-frame filter is communicated with a feed liquid temporary storage tank; a stirring device is arranged in the reaction kettle, the stirring device comprises a stirring shaft arranged in the reaction kettle and a stirring motor for driving the stirring shaft to rotate, stirring blades are arranged on the stirring shaft, an auxiliary stirring mechanism is arranged at the bottom of the stirring shaft, and the auxiliary stirring mechanism comprises a conical stirring cover arranged on the stirring shaft. A plurality of spiral turbulent flow fins are arranged on the outer side of the conical stirring cover in the circumferential direction; a steam coil pipe is arranged in the drying tank, and an air inlet of the steam coil pipe is communicated with a steam storage tank. According to the device, the catalyst in the reaction can be effectively recovered, waste liquid in the process is recycled, the energy consumption is low, the heat exchange effect is good, and the recovery efficiency of the catalyst is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to organic synthesis device technical field, concretely relates to a device of synthesizing hydrochloric acid deoxyepinephrine and recycling catalyst. BACKGROUND

[0002] Hydrochloric acid deoxyepinephrine is a kind of alpha adrenergic receptor agonist, act on alpha receptor (especially skin, mucous membrane, internal organs etc.), cause blood vessel to contract, peripheral resistance increases, makes systolic pressure and diastolic pressure all rise. With blood pressure rise can stimulate vagus reflex, make heart rate slow down. Hydrochloric acid deoxyepinephrine is a kind of chiral drug, there are two kinds of enantiomers: (R)-hydrochloric acid deoxyepinephrine and (S)-hydrochloric acid deoxyepinephrine. The pharmacological activity and adverse reaction of two kinds of enantiomers have some differences.

[0003] At present, the synthesis of hydrochloric acid deoxyepinephrine mainly takes alpha-benzylmethylamine-3-hydroxyacetophenone hydrochloride as starting material, carries out debenzyl reaction under palladium-carbon catalytic hydrogenation, obtains intermediate debenzyl, and then obtains intermediate racemic deoxyepinephrine after debenzyl material is reduced and freed. With water as solvent, using dextro-tartaric acid as resolving agent for resolution, after free refining, deoxyepinephrine levorotatory is obtained. The above process uses expensive catalyst, if not effectively recycled, the preparation cost of product will increase. UTILITY MODEL CONTENT

[0004] The technical problem to be solved by the utility model is: in view of the deficiencies existing in the prior art, provide a kind of device of synthesizing hydrochloric acid deoxyepinephrine and recycling catalyst, the catalyst in reaction can be effectively recycled in the device, and the waste liquid in process is recycled, energy consumption is low, and heat exchange effect is good, improve the recovery efficiency of catalyst.

[0005] To solve the above technical problems, the technical scheme of the utility model is:

[0006] A kind of device of synthesizing hydrochloric acid deoxyepinephrine and recycling catalyst, including communication reaction kettle, first plate and frame filter, cleaning tank, second plate and frame filter, drying tank, catalyst recovery tank, the material liquid outlet of first plate and frame filter is connected with material liquid temporary storage tank;Stirring device is arranged in the reaction kettle, the stirring device includes the stirring shaft arranged in the reaction kettle and the stirring motor for driving the stirring shaft to rotate, stirring blade is arranged on the stirring shaft, auxiliary stirring mechanism is arranged at the bottom of the stirring shaft, the auxiliary stirring mechanism includes the conical stirring cover arranged on the stirring shaft, a plurality of spiral spoiler fins are arranged on the outer side of the conical stirring cover;Steam coil is arranged in the drying tank, and the gas inlet of the steam coil is connected with the steam storage tank.

[0007] Preferably, the conical stirring cover is connected with the stirring shaft through a connecting rod, and the inner diameter of the small opening end of the conical stirring cover is larger than the outer diameter of the stirring shaft.

[0008] Preferably, the reaction is internally provided with a jacket, the jacket inner wall is provided with baffles, and the baffles are provided with a plurality of turbulence holes.

[0009] Preferably, a plurality of turbulence protrusions are staggered on the inner wall of the reaction kettle.

[0010] Preferably, the steam coil is connected with the cleaning tank through a condenser.

[0011] Preferably, a filter is arranged between the condenser and the cleaning tank.

[0012] Preferably, the steam coil is divided into a plurality of cavities by a plurality of spiral partition plates.

[0013] Due to the adoption of the above technical scheme, the device has at least the following beneficial effects:

[0014] The utility model provides a kind of synthetic salt hydrochloric acid deoxyepinephrine and recovery catalyst's device, including communication's reaction kettle, first plate and frame filter, cleaning tank, second plate and frame filter, drying tank, catalyst recovery tank, the material liquid outlet of first plate and frame filter is connected with material liquid temporary storage tank;Reaction kettle is equipped with stirring device, and stirring device includes the stirring shaft being set in reaction kettle and the stirring motor of driving stirring shaft rotation, and stirring shaft is equipped with stirring blade, and the bottom of stirring shaft is equipped with auxiliary stirring mechanism, and auxiliary stirring mechanism includes the conical stirring cover being set on stirring shaft, and the outside of conical stirring cover is equipped with multiple helical turbulence fins;Steam coil is equipped in drying tank, and the gas inlet of steam coil is connected with steam storage tank.In above-mentioned setting, the combined setting of conical stirring cover, multiple helical turbulence fins and stirring blade greatly improves the heat exchange efficiency in reaction kettle, and catalyst deposition in reaction kettle bottom can be effectively avoided, and catalytic reaction efficiency is influenced;The setting of steam coil can improve drying efficiency.

[0015] The reaction of the device is provided with a jacket, the jacket inner wall is provided with baffles, the baffles are provided with a plurality of turbulence holes, the combined arrangement of the baffles and the turbulence holes makes the fluid generate multiple baffling in the jacket, thereby generating intense disturbance effect, effectively destroying the formation of fluid boundary layer at the jacket inner wall, and increasing heat exchange efficiency.

[0016] The reactor of this device has multiple turbulence protrusions arranged in an alternating pattern on its inner wall. On the one hand, the turbulence protrusions can increase the degree of turbulence by changing the flow path of the fluid, so that the reactants can be mixed more quickly and uniformly. Sufficient mixing can ensure better contact between the reactants, thereby improving the reaction rate and efficiency. On the other hand, the turbulence protrusions not only improve the fluid mixing in the reactor, but also help optimize the entire reaction process. By increasing turbulence, mass and heat transfer between reactants can be promoted, which helps to improve product quality and reduce production costs and energy consumption.

[0017] The outlet of the steam coil in this device is connected to the cleaning tank through a condenser. A filter is installed between the condenser and the cleaning tank. The above setup allows the condensate in the steam coil to be cooled by the condenser and then filtered to remove impurities, which is then used as a cleaning solvent to wash the recovered catalyst, thereby reducing energy consumption.

[0018] The steam coil of this device is divided into multiple chambers by helical baffles. This arrangement increases the contact area between the steam and the coil wall, significantly improving heat exchange efficiency. Furthermore, the helical baffles alter the steam flow path within the coil, creating turbulence or eddies. This turbulence disrupts the laminar flow of the steam, reducing the thermal boundary layer thickness and thus increasing the heat transfer coefficient. By rationally setting the pitch of the helical baffles, this device optimizes the steam velocity distribution within the coil, allowing heat to be better transferred along the surface of the steam coil, improving heat transfer efficiency and overall drying efficiency. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the structure of Embodiment 1 of this utility model;

[0021] Figure 2 yes Figure 1 Enlarged structural diagram at point A;

[0022] Figure 3 This is a schematic diagram showing the connection between the stirring shaft and the conical stirring cover;

[0023] Figure 4 This is a partial cross-sectional view of the steam coil;

[0024] In the diagram, 1. Reactor; 2. First plate and frame filter; 3. Cleaning tank; 4. Drying tank; 5. Catalyst recovery tank; 6. Feed liquid temporary storage tank; 7. Stirring shaft; 8. Stirring motor; 9. Stirring blades; 10. Conical stirring cover; 11. Spiral turbulence fins; 12. Steam coil; 13. Steam storage tank; 14. Connecting rod; 15. Jacket; 16. Baffle; 17. Turbulence hole; 18. Turbulence protrusion; 19. Condenser; 20. Filter; 21. Spiral separator; 22. Cavity; 23. Second plate and frame filter. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present utility model.

[0026] Example 1

[0027] like Figures 1-4 As shown, an apparatus for synthesizing desoxyrepinephrine hydrochloride and recovering the catalyst includes a reactor 1, a first plate and frame filter 2, a washing tank 3, a second plate and frame filter 23, a drying tank 4, and a catalyst recovery tank 5 connected together. The feed outlet of the first plate and frame filter 2 is connected to a feed storage tank 6. The reactor 1 is equipped with a stirring device, which includes a stirring shaft 7 and a stirring motor 8 that drives the stirring shaft 7 to rotate. The stirring shaft 7 is equipped with stirring blades 9, and an auxiliary stirring mechanism is provided at the bottom of the stirring shaft 7. The auxiliary stirring mechanism includes a conical stirring shroud 10 mounted on the stirring shaft 7, and multiple spiral turbulence fins 11 are arranged circumferentially on the outer side of the conical stirring shroud 10. The drying tank 4 is equipped with a steam coil 12, and the inlet of the steam coil 12 is connected to a steam storage tank 13. This setup washes, dries, and recovers the catalyst used in production, avoiding resource waste, and the waste liquid generated during the process is recycled, further reducing energy consumption.

[0028] In this embodiment, the inner diameter of the smaller opening end of the conical stirring cover 10 is larger than the outer diameter of the stirring shaft 7, and the conical stirring cover 10 is connected to the stirring shaft 7 via a connecting rod 14.

[0029] In this embodiment, the reaction vessel is provided with a jacket 15, and the inner wall of the jacket 15 is provided with baffles 16, and the baffles 16 are provided with a plurality of turbulence holes 17; the inner wall of the reaction vessel 1 is provided with a plurality of turbulence protrusions 18 in an alternating manner; the above-mentioned configurations all improve the heat exchange efficiency in the reaction vessel 1 to a certain extent, thereby improving the catalytic reaction efficiency.

[0030] In this embodiment, the outlet of the steam coil 12 is connected to the cleaning tank 20 through the condenser 19; a filter 20 is provided between the condenser 19 and the cleaning tank 3. The liquid condensed in the steam coil 12 is condensed again by the condenser 19 and then filtered by the filter 20 to remove impurities. It is then used as a catalyst to be recovered for washing, which reduces energy consumption and waste liquid generation.

[0031] In this embodiment, the steam coil 12 is divided into multiple cavities 22 by multiple spiral partitions 21; by reasonably setting the pitch of the spiral partitions 21, the flow rate distribution of steam in the coil is optimized, so that heat is better transferred along the surface of the steam coil 12, thereby improving the heat transfer effect and improving the drying efficiency.

[0032] The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An apparatus for synthesizing dephenylephrine hydrochloride and recovering the catalyst, characterized in that: The utility model relates to a kind of reaction kettle, first plate frame filter, cleaning tank, second plate frame filter, drying tank, catalyst recovery tank including communication, the material liquid outlet of the first plate frame filter is connected with material liquid temporary storage tank;The reaction kettle is equipped with stirring device, the stirring device includes the stirring shaft being arranged in reaction kettle and the stirring motor of driving stirring shaft rotation, the stirring blade is equipped on the stirring shaft, the bottom of the stirring shaft is equipped with auxiliary stirring mechanism, the auxiliary stirring mechanism includes the conical stirring cover being arranged on stirring shaft, the outside of the conical stirring cover is circumferentially equipped with multiple helical turbulent fin;The steam coil is equipped in the drying tank, and the gas inlet of the steam coil is connected with steam storage tank.

2. The apparatus for synthesizing phenylephrine hydrochloride and recovering the catalyst according to claim 1, wherein: The inside diameter of the smaller opening end of the conical stirring cover is greater than the outside diameter of the stirring shaft, and the conical stirring cover is connected with the stirring shaft by connecting rod.

3. The apparatus of claim 1, wherein: The reaction is equipped with a jacket, baffles are provided on the inner wall of the jacket, and a plurality of turbulence holes are provided on the baffles.

4. The apparatus of claim 1, wherein: A plurality of turbulence protrusions are provided on the inner wall of the reaction kettle in a staggered manner.

5. The apparatus of claim 1, wherein: The liquid outlet of the steam coil is connected with the cleaning tank through a condenser.

6. An apparatus for synthesizing phenylephrine hydrochloride and recovering a catalyst according to claim 5, wherein: A filter is provided between the condenser and the cleaning tank.

7. The apparatus of claim 1, wherein: The steam coil is divided into a plurality of cavities by a plurality of spiral partition plates.

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