Colloidal gold immunochromatography analyzer

Abstract

The utility model provides a colloidal gold immunochromatography analyzer which comprises a shell, and one end of the shell is provided with a socket for inserting a reagent card; a mounting seat and a circuit board are arranged in the shell, and a slot for inserting a reagent card is formed in the mounting seat; a battery, a display screen and three groups of photoelectric detection assemblies are arranged on the circuit board, each group of photoelectric detection assembly comprises an LED lamp and a photoelectric detector, and an opening for exposing the display screen is formed in the shell; and the positions of the three groups of photoelectric detection components correspond to the positions of a C line, a blank area and a T line on the reagent card inserted into the slot respectively. According to the utility model, the three groups of photoelectric detection components are arranged on the circuit board and respectively correspond to the three detection positions on the reagent card, so that signals of a C line, a blank area and a T line on the reagent card can be directly acquired through the three groups of photoelectric detection components respectively, and signal acquisition is completed without driving the reagent card to move by virtue of a driving pick-up piece, thereby saving the installation space of the driving component and improving the detection efficiency. And product miniaturization is facilitated.

Description

Technical Field

[0001] This utility model relates to the field of colloidal gold immunochromatographic analysis technology, and in particular to a colloidal gold immunochromatographic analyzer. Background Technology

[0002] Colloidal gold immunochromatography is a rapid detection technique that has emerged in recent years. It is a type of immunoassay that combines antigen-antibody reactions with a sensitive detection system to create a simple, rapid, and sensitive analytical method.

[0003] The test results using colloidal gold reagent cards are usually judged mainly by visual inspection, that is, by observing the color intensity of the test line and control line on the colloidal gold reagent card with the naked eye. The test line is the T line and the control line is the C line. Visual inspection can only make a qualitative judgment on the colloidal gold reagent card, that is, whether an immune effect has been achieved, but it is difficult to obtain the degree of antigen-antibody reaction based on the color intensity of the test line and control line.

[0004] To improve the accuracy of test result interpretation, the operator adds fluorescent material to the detection area of ​​the reagent card. After the test result is displayed in the detection area, the operator irradiates the area with a laser to excite the fluorescent material. The reflected light beam from the detection area is then received by a photocell receiver, which converts the light signal into an electrical signal and transmits it to the mainboard for data analysis. After the test result is displayed in the detection area, the CT line becomes darker, and darker areas reflect the laser more effectively. The laser irradiates the detection area of ​​the reagent card sequentially from one end to the other, and the photocell receiver transmits the changes in the intensity of the reflected light as an electrical signal to the mainboard. The mainboard analyzes the data of the reflected light from the C and T lines to obtain the specific antigen-antibody reaction degree test result.

[0005] Most existing colloidal gold immunochromatographic analyzers acquire signals by moving reagent cards or optical structures using a drive component. For example, Chinese patent CN219142625U discloses a portable colloidal gold reagent card analyzer that uses a drive component to move the reagent card and scan the CT lines on the card, thereby achieving the purpose of reagent card detection. However, the drive component is relatively large, making it difficult to manufacture into a miniaturized product and inconvenient for users to carry. Utility Model Content

[0006] This invention proposes a colloidal gold immunochromatographic analyzer, which solves the problems of existing colloidal gold immunochromatographic analyzers, most of which use driving components to move reagent cards or optical structures to complete signal acquisition. Due to the large size of the driving components, these analyzers are not suitable for miniaturization and are not convenient for users to carry.

[0007] The technical solution of this utility model is implemented as follows:

[0008] This invention provides a colloidal gold immunochromatographic analyzer, comprising a housing, one end of which has a socket for inserting reagent cards; the housing contains a mounting base and a circuit board, the mounting base having a slot for inserting reagent cards; the circuit board has a battery, a display screen, and three sets of photoelectric detection components, each set including an LED and a photodetector; the housing has an opening for the display screen to be exposed; the positions of the three sets of photoelectric detection components correspond to the C-line, blank area, and T-line positions on the reagent card inserted into the slot, respectively.

[0009] This invention sets three sets of photoelectric detection components on the circuit board to correspond to the three detection positions on the reagent card. The signals of the C line, blank area and T line on the reagent card can be directly collected by the three sets of photoelectric detection components. There is no need to use a driving component to move the reagent card to complete the signal acquisition, which saves the installation space of the driving component and facilitates product miniaturization.

[0010] Specifically, the mounting base has three independent first windows, the positions and sizes of which correspond to the positions and sizes of the three LED lights. By having three independent first windows on the mounting base that are respectively matched with the three LED lights, crosstalk of optical signals can be prevented and detection accuracy can be improved.

[0011] Furthermore, the mounting base is provided with a second window, the position of which corresponds to the three photodetectors. The three photodetectors share one second window. The photodetectors adopt an open receiving window, which allows the reflected light to be fully received, thereby improving the detection accuracy.

[0012] Specifically, the mounting base is provided with a plurality of positioning posts, and the circuit board is provided with a plurality of positioning holes that match the positioning posts; the side of the mounting base is provided with a buckle, which cooperates with the edge of the circuit board to fix the circuit board on the mounting base; the cooperation of the positioning posts, positioning holes and buckles facilitates the installation and positioning of the circuit board.

[0013] Specifically, the mounting base is provided with an ejection assembly, and the housing is provided with a trigger button that cooperates with the ejection assembly. By pressing the trigger button, the ejection assembly is driven to eject the reagent card in the slot, so that the reagent card can be ejected after the test is completed.

[0014] Furthermore, the ejection assembly includes an elastic element, and an elastic plate extends rearward from the bottom of the rear end of the mounting base. The rear end of the elastic element is fixedly connected to a connecting plate at the rear end of the elastic plate. A stop block is provided at the front end of the elastic element, and the stop block abuts against the end of the reagent card. A limiting block that cooperates with the stop block is provided on the elastic plate, and the front end of the limiting block is a slope. The trigger button is used to drive the elastic plate to bend and deform downward to cause the limiting block to release the stop block.

[0015] Furthermore, the mounting base has side plates extending rearward on both sides at its tail end, and the bottom of the side plates has guide grooves. The two ends of the stop block have guide blocks that cooperate with the guide grooves. Through the cooperation of the guide grooves and guide blocks, the sliding path of the stop block can be guided and limited.

[0016] Specifically, the elastic plate has receiving portions on both sides of its tail end, and the trigger button has top blocks on both sides of its bottom that cooperate with the receiving portions.

[0017] Furthermore, the circuit board is provided with clearance grooves on both sides for the top block to pass through.

[0018] Specifically, the socket end of the housing is detachably fitted with an end cap, which can provide a sealing and protection function for the socket. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is an exploded schematic diagram of a colloidal gold immunochromatographic analyzer according to the present invention;

[0021] Figure 2 This is a schematic diagram illustrating the assembly process of the mounting base and the circuit board in an embodiment of this utility model.

[0022] Figure 3 This is a schematic diagram of the mounting base in an embodiment of the present utility model;

[0023] Figure 4 This is a schematic diagram of the internal structure of the shell in an embodiment of the present utility model;

[0024] Figure 5 This is a schematic diagram of the assembly structure of the ejection assembly and the mounting base in an embodiment of this utility model;

[0025] In the diagram: 1. Housing; 2. Socket; 3. Mounting base; 4. Circuit board; 5. Slot; 6. Battery; 7. Display screen; 8. LED light; 9. Photodetector; 10. Opening; 11. First window; 12. Second window; 13. Positioning post; 14. Positioning hole; 15. Buckle; 16. Trigger button; 17. Elastic element; 18. Elastic plate; 19. Connecting plate; 20. Stop block; 21. Limiting block; 22. Side plate; 23. Guide groove; 24. Guide block; 25. Receiving part; 26. Top block; 27. Clearance groove; 28. End cap. Detailed Implementation

[0026] The technical solution of this utility model will be clearly and completely described below with reference to its embodiments. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0027] Reference Figures 1 to 5 This utility model provides a colloidal gold immunochromatographic analyzer, including a housing 1, one end of which is provided with a socket 2 for inserting a reagent card; the housing 1 is provided with a mounting base 3 and a circuit board 4 inside, the mounting base 3 is provided with a slot 5 for inserting a reagent card; the circuit board 4 is provided with a battery 6, a display screen 7 and three sets of photoelectric detection components, each set of photoelectric detection components including an LED light 8 and a photoelectric detector 9, and the housing 1 is provided with an opening 10 for the display screen 7 to be exposed; the positions of the three sets of photoelectric detection components correspond to the positions of the C line (quality control line), blank area and T line (test line) on the reagent card inserted into the slot 5, respectively.

[0028] This invention uses three sets of photoelectric detection components on circuit board 4 to correspond to three detection positions on the reagent card. The signals from the C-line, blank area, and T-line on the reagent card can be directly acquired through these three photoelectric detection components. This allows for the acquisition of three characteristic points on the reagent card membrane surface without the need for dynamic scanning. The T-line data reflects the color intensity of the test line after the reagent reaction; the blank area data reflects the sample movement on the reagent card membrane surface, and the data from the blank area can filter out interference noise from the membrane surface; the C-line data reflects the color intensity of the reagent card's control line. This design eliminates the need for a driving mechanism to move the reagent card for signal acquisition, saving installation space for the driving mechanism and facilitating product miniaturization.

[0029] Specifically, such as Figure 2 , 3As shown, the mounting base 3 has three independent first windows 11, the positions and sizes of which correspond to the positions and sizes of the three LED lights 8. By opening three independent first windows 11 on the mounting base 3 and cooperating with the three LED lights 8, the light can be focused, preventing crosstalk of light signals and improving detection accuracy.

[0030] Furthermore, such as Figure 2 , 3 As shown, the mounting base 3 has a second window 12, the position of which corresponds to the three photodetectors 9. The three photodetectors 9 share one second window 12. The photodetectors 9 adopt an open receiving window, which allows the reflected light to be fully received, thereby improving the detection accuracy.

[0031] Specifically, such as Figure 1 , 3 As shown in Figure 4, the mounting base 3 is provided with a plurality of positioning posts 13, and the circuit board 4 is provided with a plurality of positioning holes 14 that match the positioning posts 13; the side of the mounting base 3 is provided with a buckle 15, which cooperates with the edge of the circuit board 4 to fix the circuit board 4 on the mounting base 3; the cooperation of the positioning posts 13, positioning holes 14 and buckle 15 facilitates the installation and positioning of the circuit board 4.

[0032] Specifically, such as Figure 1 , 4 As shown, the mounting base 3 is provided with an ejection assembly, and the housing 1 is provided with a trigger button 16 that cooperates with the ejection assembly. By pressing the trigger button 16, the ejection assembly is driven to eject the reagent card in the slot 5, so that the reagent card can be ejected after the test is completed.

[0033] Furthermore, such as Figures 3 to 5As shown, the ejection assembly includes an elastic element 17 (in this embodiment, the elastic element 17 can be a spring, such as a serpentine spring or other types of springs; it can also be an elastic sheet, a spring sheet, or other types of elastic element 17). The bottom end of the mounting base 3 extends rearward with an elastic plate 18. The tail end of the elastic element 17 is fixedly connected to the connecting plate 19 at the tail end of the elastic plate 18. The front end of the elastic element 17 is provided with a stop block 20, which abuts against the end of the reagent card. The elastic plate 18 is provided with a limiting block 21 that cooperates with the stop block 20. The front end of the limiting block 21 is a slope. The trigger button 16 is used to drive the elastic plate 18 to bend and deform downward, causing the limiting block 21 to release the stop block 20. When the reagent card is inserted, the front end of the reagent card will abut against the stop block 20, thereby compressing the elastic element 17. When the stop block 20 transitions from the slope at the front end of the limiting block 21 to the back of the limiting block 21, the stop block 20 will be blocked by the limiting block 21, and the reagent card will be inserted in place. After the test is completed, pressing the trigger button 16 downward will cause the tail end of the elastic plate 18 to bend and deform downward, which will drive the limiting block 21 to move downward and release the stop block 20. After the stop block 20 is freed from the obstruction of the limiting block 21, it will be quickly slid towards the slot 5 entrance by the restoring force of the elastic element 17, thereby ejecting the reagent card.

[0034] Furthermore, such as Figure 3 , 5 As shown, the mounting base 3 has side plates 22 extending rearward on both sides at its tail end. The bottom of the side plates 22 is provided with guide grooves 23. The two ends of the stop block 20 are provided with guide blocks 24 that cooperate with the guide grooves 23. Through the cooperation of the guide grooves 23 and the guide blocks 24, the sliding path of the stop block 20 can be guided and limited.

[0035] Specifically, such as Figures 3 to 5 As shown, the elastic plate 18 has receiving portions 25 on both sides of its tail end, and the trigger button 16 has top blocks 26 on both sides of its bottom that cooperate with the receiving portions 25, so as to facilitate pushing the elastic plate 18 downward.

[0036] Furthermore, such as Figure 1 , 2 As shown, the circuit board 4 has clearance grooves 27 on both sides for the top block 26 to pass through, which facilitates the cooperation between the top block 26 and the receiving part 25.

[0037] Specifically, such as Figure 1 As shown, the socket 2 end of the housing 1 is detachably fitted with an end cap 28, which can provide a sealing and protection function for the socket 2.

[0038] The working process of the analyzer in this embodiment is as follows:

[0039] First, remove the end cap 28, then insert the reagent card, which has reacted with the sample, into the slot 5 through the insertion port 2. The reagent card pushes the stop block 20 to compress the elastic element 17 until the stop block 20 slides to the back of the limiting block 21. At this time, the C line, blank part, and T line on the reagent card correspond to the three sets of photoelectric detection components on the circuit board 4. Control the three LED lights 8 to illuminate the three positions on the reagent card through the corresponding first window 11. When the light source shines on the reagent card that has reacted with the sample, some light is absorbed, and the remaining unabsorbed light is reflected to the three photoelectric detectors 9. The photoelectric detectors 9 detect the intensity of the reflected light and convert the light signal into an electrical signal, which is then transmitted to the controller. Ideally, the absorbance of the detection line and the control line changes with the concentration of the gold-labeled conjugate. Therefore, the strength of the electrical signal converted by the photoelectric detectors 9 also changes with the concentration of the gold-labeled conjugate. The controller displays the collected signal on the display screen 7, thus completing the detection process of the colloidal gold immunochromatographic analyzer.

[0040] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A colloidal gold immunochromatographic analyzer, characterized by, The utility model provides a reagent card detection device, including the shell (1), one end of the shell (1) is equipped with the mouth (2) of reagent card insertion, the inside of the shell (1) is equipped with the mounting seat (3) and the circuit board (4), be equipped with the slot (5) of reagent card plug connection on the mounting seat (3), be equipped with the battery (6), display screen (7) and 3 groups of photoelectric detection components on the circuit board (4), each group of photoelectric detection components includes an LED lamp (8) and a photoelectric detector (9), the opening (10) of display screen (7) is exposed and is seted up on the shell (1), and the position of 3 groups of photoelectric detection components corresponds with C line, blank area, T line position on the reagent card inserted in the slot (5) respectively.

2. The colloidal gold immunochromatographic analyzer according to claim 1, wherein, The mounting seat (3) is provided with three independent first windows (11), and the positions and sizes of the three first windows (11) correspond to the positions and sizes of the three LED lamps (8) respectively.

3. The colloidal gold immunochromatographic analyzer according to claim 2, wherein the light source is a light emitting diode (LED) or a laser diode (LD). The mounting seat (3) is provided with a second window (12), and the position of the second window (12) corresponds to the three photoelectric detectors (9), and the three photoelectric detectors (9) share one second window (12).

4. The colloidal gold immunochromatographic analyzer according to claim 1, wherein the light source is a light emitting diode (LED) or a laser diode (LD). The mounting seat (3) is provided with a plurality of positioning columns (13), and the circuit board (4) is provided with a plurality of positioning holes (14) matched with the positioning columns (13); the side edge of the mounting seat (3) is provided with a buckle (15), and the buckle (15) is matched with the edge of the circuit board (4) to fix the circuit board (4) on the mounting seat (3).

5. The colloidal gold immunochromatographic analyzer according to claim 1, wherein the light source is a light emitting diode (LED) or a laser diode (LD). The mounting seat (3) is provided with an ejection assembly, and the shell (1) is provided with a trigger button (16) matched with the ejection assembly, and the reagent card in the slot (5) is ejected by pressing the trigger button (16) to drive the ejection assembly.

6. The colloidal gold immunochromatographic analyzer according to claim 5, wherein the light source is a light emitting diode. The ejection assembly includes an elastic element (17), the tail end bottom surface of the mounting seat (3) extends rearward to be provided with an elastic plate (18), the tail end of the elastic element (17) is fixedly connected with the connecting plate (19) at the tail end of the elastic plate (18), the front end of the elastic element (17) is provided with a stop block (20), and the stop block (20) abuts against the end of the reagent card; the elastic plate (18) is provided with a limiting block (21) matched with the stop block (20), and the front end of the limiting block (21) is a slope surface; the trigger button (16) is used to drive the elastic plate (18) to bend and deform downward to release the stop block (20).

7. The colloidal gold immunochromatographic analyzer according to claim 6, wherein the light source is a light emitting diode. The tail end of the mounting seat (3) extends rearward to be provided with a side plate (22) on both sides, the bottom of the side plate (22) is provided with a guide groove (23), and the both ends of the stop block (20) are provided with guide blocks (24) matched with the guide groove (23).

8. The colloidal gold immunochromatographic analyzer according to claim 6, wherein the light source is a light emitting diode (LED) or a laser diode (LD). The tail end of the elastic plate (18) is provided with a receiving part (25) on both sides, and the bottom of the trigger button (16) is provided with top blocks (26) matched with the receiving part (25).

9. The colloidal gold immunochromatographic analyzer according to claim 8, wherein the light source is a light emitting diode. The both sides of the circuit board (4) are provided with avoiding grooves (27) for the top blocks (26) to pass through.

10. The colloidal gold immunochromatographic analyzer of claim 1, wherein, The end cover (28) is detachably installed at the mouth (2) end of the shell (1).

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