Operation device for mouse head fixing surgery

Abstract

The utility model relates to a mouse head fixing operation device, and belongs to the technical field of animal experiment equipment, the mouse head fixing operation device comprises a heatable bottom plate and a clamp assembly used for limiting upper incisor teeth and mouth of a mouse, two stand columns with holes are fixed on the heatable bottom plate, a cross rod is arranged between the two stand columns with holes in a sliding mode, and the cross rod slides in the vertical direction; long movable arms are arranged on the two stand columns with the holes, one ends of the long movable arms are arranged on the stand columns with the holes in a sliding mode in the vertical direction, the other ends of the long movable arms are arranged in an overhanging mode in the direction away from the clamp assembly, ear rods are arranged at the overhanging ends of the two long movable arms in a sliding mode, and the two ear rods slide in the direction close to or away from each other; the device has the advantages that the head of a mouse is further stabilized, secondary damage to the mouse caused by an operation device is avoided, the body temperature of the animal in the operation process is kept constant, and the success rate of the operation and the accuracy of experimental data are guaranteed.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of animal experiment equipment, in particular to a mouse head fixing operation device. BACKGROUND

[0002] At present, in biomedical research and teaching, mice are widely used in various physiological, pathological and pharmacological research as common experimental animal models. Especially in the fields of neuroscience, ophthalmology, ear-nose-throat, etc., fine microsurgical operation on mice is an indispensable research means.

[0003] In the process of experimental research, the head of the mouse used for experiment needs to be fixed, and the commonly used method for fixing is to buckle the incisor and insert the ear rod into the ear canal on both sides. Keeping the head stable during the operation is a key factor affecting the success rate of the operation and the accuracy of the experimental data.

[0004] However, mice are small in size, active and have fine head structure, and in the process of operation, the tip of the ear rod may damage the skin, muscle, even skull and brain of the mouse, affecting the success rate of the operation and the accuracy of the experimental data. In addition, the body temperature of the mouse in anesthetized state needs to be maintained to ensure the success rate of the operation. CONTENT OF THE INVENTION

[0005] In order to further stabilize the head of the mouse, avoid secondary damage to the mouse by the operation device, maintain the body temperature of the mouse in an anesthetized state, ensure the success rate of the operation and the accuracy of the experimental data, the application provides a mouse head fixing operation device.

[0006] The mouse head fixing operation device provided by the application adopts the following technical scheme:

[0007] A mouse head fixing operation device comprises a heatable bottom plate and a clip assembly for limiting the upper incisor and mouth of the mouse, the clip assembly is located on the heatable bottom plate, a hole column is fixed on the heatable bottom plate, two hole columns are provided and are arranged at intervals, a cross bar is slidably arranged between the two hole columns, the cross bar slides in the vertical direction, and the cross bar is arranged adjacent to the clip assembly; a long movable arm is arranged on each of the two hole columns, one end of the long movable arm is slidably arranged on the hole column in the vertical direction, the other end is arranged in a cantilever shape away from the clip assembly, an ear rod is slidably arranged on the cantilever end of each of the two long movable arms, the two ear rods slide in the direction of approaching or moving away from each other, and a blunt head sleeve is sleeved on the end of each of the two ear rods approaching each other.

[0008] By adopting the technical scheme, the mouse is placed on the heatable bottom plate, the upper incisors and the mouth of the mouse are limited by the clamp assembly, the head of the mouse is located between the two hole-bearing vertical columns, the positions of the two ear bars are adjusted, the blunt head sleeve limits the two sides of the brain of the mouse, the height of the horizontal rod in the vertical direction is adjusted, the horizontal rod just presses the head of the mouse, the further limitation of the head of the mouse is realized, the blunt head sleeve plays a protective role on the two sides of the brain of the mouse, replaces the sharp end of the conventional ear bar, avoids secondary damage to the mouse, and the heating pad maintains the body temperature of the mouse in the anesthetized state, so that the success rate of the operation and the accuracy of the experimental data are ensured.

[0009] Optionally, the end face of the two ear bars close to each other is a circular arc-shaped end face.

[0010] By adopting the technical scheme, the design of the circular arc-shaped end face makes the end of the ear bar close to the mouse more rounded, reduces the damage to the head and even the ears of the mouse, and facilitates the head fixing operation of the newborn and developing mouse in cooperation with the blunt head sleeve.

[0011] Optionally, a low-lying plane area is arranged in the middle of the horizontal rod, the low-lying plane area is recessed in the direction close to the center line of the horizontal rod, and the middle of the low-lying plane area is a horizontal plane.

[0012] By adopting the technical scheme, the position of the horizontal rod in the vertical direction is adjusted, so that the horizontal rod is pressed on the head of the mouse, at this time, the low-lying plane area is in contact with the head of the mouse, and the design of the low-lying plane area increases the contact area with the head of the mouse, and improves the stability of the control of the head of the mouse.

[0013] Optionally, a long hole is arranged on each of the two hole-bearing vertical columns, the long hole is arranged in the vertical direction, a nut is arranged at the end of the horizontal rod, the end of the horizontal rod is screwed with the nut after penetrating through the long hole close to the nut, and the nut is in abutment with the outer wall of the hole-bearing vertical column.

[0014] By adopting the technical scheme, the nut is rotated, then the position of the horizontal rod relative to the hole-bearing vertical column is adjusted, when the horizontal rod is adjusted to the appropriate position, the nut is tightened, so that the horizontal rod is limited on the hole-bearing vertical column, and the operation is simple and convenient.

[0015] Optionally, the blunt head sleeve is made of silica gel.

[0016] By adopting the technical scheme, the softness of silica gel can better fit the head of the mouse, the elasticity of silica gel can well buffer the vibration caused by the struggle of the mouse; the irritability of silica gel material to biological tissues is low, and for the sensitive skin of the mouse, silica gel can reduce the influence on the experimental data.

[0017] Optionally, there is a distance between the ear bar and the corresponding hole-bearing vertical column in the length direction of the long movable arm.

[0018] By adopting the technical scheme, the long active arm makes a distance between the ear rod and the hole column, so that the whole operation space is enlarged, and the operation of different brain areas is facilitated.

[0019] Optionally, the heatable base plate is provided with a semicircular column and a semicircular pressing plate, the semicircular column is fixed on the heatable base plate and located on the side away from the clip assembly, the semicircular pressing plate is spliced and fixed on the semicircular column and forms a circular hole after splicing, the circular hole is used for clamping and limiting the centrifugal tube containing the mouse; and the circular hole is opposite to the clip assembly.

[0020] By adopting the technical scheme, the mouse is loaded into the plastic centrifugal tube, and then the centrifugal tube is fixed in the circular hole to limit and fix the mouse body, so that the conscious mouse operation and related imaging are facilitated.

[0021] Optionally, the heating pad is arranged along the direction of the line connecting the circular hole and the clip assembly; and the two hole columns are distributed on both sides of the heating pad.

[0022] By adopting the technical scheme, the heating pad is arranged to help maintain the body temperature of the mouse during the operation, so as to ensure the success rate of the mouse operation and the accuracy of the experimental data.

[0023] In summary, the present application has at least one of the following beneficial technical effects:

[0024] 1. The cross rod is arranged to further limit the mouse head; the blunt sleeve made of silicone material protects the two sides of the mouse brain, replaces the sharp end of the conventional ear rod, avoids secondary damage to the mouse, ensures the success rate of the operation and the accuracy of the experimental data;

[0025] 2. The design of the arc-shaped end face makes the end of the ear rod close to the mouse more rounded, reduces the damage to the mouse head and even the ear, and facilitates the head fixing operation of the newborn and developing mouse in combination with the blunt sleeve made of silicone material;

[0026] 3. The heating pad is arranged to help maintain the body temperature of the mouse during the operation, so as to ensure the success rate of the mouse operation and the accuracy of the experimental data. BRIEF DESCRIPTION OF DRAWINGS

[0027] Figure 1 is a structural schematic diagram of an embodiment of the present application;

[0028] Figure 2 is a structural schematic diagram of an embodiment of the present application from the perspective of the clip assembly.

[0029] In the figure, 1, the heatable bottom plate; 11, the heating pad; 2, the clip assembly; 3, the hole column; 31, the crossbar; 311, the low valley plane area; 32, the long movable arm; 33, the ear lever; 34, the blunt sleeve; 35, the long hole; 36, the nut; 37, the fixed plate; 38, the screw rod; 39, the first screw; 4, the semicircular column; 41, the semicircular pressing plate; 42, the circular hole; 43, the second screw; 5, the first sliding groove; 6, the second sliding groove. DETAILED DESCRIPTION

[0030] The following will be described in detail with reference to the accompanying drawings. Figures 1-2 The application is further described in detail.

[0031] The application discloses a mouse head fixing operation device.

[0032] Reference Figure 1 A mouse head fixing operation device comprises a heatable bottom plate 1, which is in the shape of a rectangular strip. A heating pad 11 is laid along the length direction of the heatable bottom plate 1, and the heating pad 11 is embedded in the top of the heatable bottom plate 1, that is, the top surface of the heating pad 11 is flush with the top surface of the heatable bottom plate 1. A semicircular column 4, an ear lever 33 and a clip assembly 2 are sequentially arranged along the length direction of the heating pad 11, the semicircular column 4 is provided with a semicircular pressing plate 41, the semicircular column 4 and the semicircular pressing plate 41 cooperate to clamp and limit a centrifugal tube loaded in the mouse body, the ear lever 33 limits the two sides of the mouse head, and the clip assembly 2 limits the upper incisors and mouth of the mouse.

[0033] Reference Figure 1 The heatable bottom plate 1 is provided with a hole column 3, and the hole column 3 is provided with two, which are distributed on the two sides of the heating pad 11. The hole column 3 is fixed on the heatable bottom plate 1, the hole column 3 is provided with a long hole 35, and the long hole 35 is vertically arranged. A crossbar 31 is arranged between the two hole columns 3, the crossbar 31 penetrates through the corresponding long hole 35 at the end, and the crossbar 31 is provided with a nut 36 at the end, the nut 36 is threadedly connected with the end of the crossbar 31, and the nut 36 abuts against the outer wall of the hole column 3 after being screwed on the crossbar 31. The long hole 35 is vertically arranged along the length direction, and the crossbar 31 is vertically arranged along the length direction of the heating pad 11.

[0034] Reference Figure 1 And Figure 2 The middle part of the crossbar 31 is provided with a low valley plane area 311, which is concave along the direction close to the center line of the crossbar 31, the middle part of the low valley plane area 311 is a horizontal plane, and the low valley plane area 311 is provided with two and symmetrically distributed on the two sides of the crossbar 31, that is, the upper and lower sides in the embodiment.

[0035] Reference Figure 1 And Figure 2The top of the hole column 3 is fixed with a fixed plate 37, a first sliding groove 5 is arranged on the hole column 3, the first sliding groove 5 is located on the side of the hole column 3 away from the clip assembly 2, and the first sliding groove 5 is arranged in the vertical direction. Each hole column 3 is provided with a long movable arm 32 and a screw rod 38, the long movable arm 32 is slidingly arranged on the hole column 3, one end of the long movable arm 32 is located in the first sliding groove 5 and slides along the length direction of the first sliding groove 5, the screw rod 38 is vertically arranged, the screw rod 38 penetrates through the fixed plate 37 and then extends into the first sliding groove 5, the screw rod 38 is threadedly connected with the long movable arm 32, and the screw rod 38 is rotationally arranged with the fixed plate 37, that is, the screw rod 38 rotates relative to the fixed plate 37. Rotation of the screw rod 38 can adjust the position of the long movable arm 32 in the vertical direction.

[0036] Referring to Figure 1 and Figure 2 , one end of the long movable arm 32 away from the hole column 3 is horizontally arranged in a cantilever shape in a direction away from the clip assembly 2. The long movable arm 32 is provided with a second sliding groove 6, the second sliding groove 6 is arranged in the horizontal direction and has a length direction along the length direction of the cross rod 31, and the ear rod 33 is located in the second sliding groove 6 and is slidingly arranged relative to the long movable arm 32 in the length direction of the second sliding groove 6, that is, the two ear rods 33 slide in the direction of approaching or moving away from each other. The second sliding groove 6 is located close to the cantilever end of the long movable arm 32, that is, there is a distance between the ear rod 33 and the corresponding hole column 3. The cantilever end of the long movable arm 32 is provided with a first screw 39, the first screw 39 penetrates through the end of the long movable arm 32 and abuts against the outer wall of the ear rod 33, the first screw 39 is threadedly connected with the long movable arm 32, and the first screw 39 is tightened or loosened, so that whether the ear rod 33 is in a locked state relative to the long movable arm 32 can be controlled.

[0037] Referring to Figure 1 , the ear rod 33 is also provided with two corresponding to the two long movable arms 32, that is, one long movable arm 32 is provided with one ear rod 33, and the end faces of the two ear rods 33 approaching each other are both arc-shaped end faces. The end faces of the two ear rods 33 approaching each other are both annularly sleeved with a blunt sleeve 34, and the blunt sleeve 34 is made of silica gel.

[0038] Referring to Figure 1 , the semicircular column 4 is fixed on the heatable bottom plate 1 and located on the side of the ear rod 33 away from the clip assembly 2, the semicircular pressing plate 41 is fixed on the semicircular column 4 and forms a circular hole 42 after splicing, the second screw 43 is arranged on the semicircular pressing plate 41, and the second screw 43 is threadedly connected with the top of the semicircular column 4 after penetrating through the semicircular pressing plate 41. The circular hole 42 clamps and limits the centrifugal tube containing the mouse. The circular hole 42 is opposite to the clip assembly 2, the clip assembly 2 is a prior art and will not be described in detail here, and the clip assembly 2 can limit the mouse's front teeth and mouth.

[0039] The implementation principle of the mouse head fixing operation device is as follows: first, the mouse is placed in a centrifugal tube, the head of the mouse faces the clamp assembly 2, the centrifugal tube is fixed under the semicircular pressing plate 41, that is, in the circular hole 42, the second screw 43 is adjusted so that the centrifugal tube is clamped, the first screw 39 is rotated, the position of the ear rod 33 is adjusted, the blunt head sleeve 34 abuts against the left and right sides of the mouse head, then the first screw 39 is tightened. While the ear rod 33 is fixed, the vertical height of the ear rod 33 can be adjusted by rotating the screw rod 38. After the ear rod 33 is fixed, the vertical height of the cross rod 31 is adjusted by rotating the nut 36, so that the cross rod 31 is just pressed on the mouse head, then the clamp assembly 2 is adjusted, the mouse's front teeth and mouth are limited. After all is fixed, the mouse skull can be opened, the operation is started, the temperature of the heating pad 11 is adjusted to 30 DEG C during the operation, and the mouse is kept warm.

[0040] The embodiments of the specific embodiment are the preferred embodiments of the application, and are not intended to limit the protection scope of the application, so that: any equivalent changes made according to the structure, shape, principle of the application should be covered within the protection scope of the application.

Claims

1. A mouse head fixation surgical procedure device comprising a heatable base plate (1) and a clip assembly (2) for limiting the upper incisors and mouth of a mouse, the clip assembly (2) being located on the heatable base plate (1), characterised in that: The heatable bottom plate (1) is fixed with a hole column (3), the hole column (3) is provided with two and is arranged at intervals, the two hole columns (3) are slidably provided with a cross bar (31), the cross bar (31) slides in the vertical direction, and the cross bar (31) is provided with adjacent clip assemblies (2); two long movable arms (32) are arranged on the two hole columns (3), one end of the long movable arm (32) is slidably arranged on the hole column (3) in the vertical direction, the other end is arranged in a cantilever shape away from the clip assembly (2), the cantilever end of the two long movable arms (32) is slidably provided with an ear rod (33), the two ear rods (33) slide in the direction of approaching or moving away from each other, and the end surfaces of the two ear rods (33) approaching each other are both sleeved with a blunt sleeve (34); the heatable bottom plate (1) is provided with a heating pad (11).

2. The mouse head fixation surgical procedure device of claim 1, wherein: The end surfaces of the two ear rods (33) approaching each other are arc-shaped end surfaces.

3. The mouse head fixation surgical procedure device of claim 1, wherein: The cross bar (31) is provided with a low valley plane area (311) in the middle, the low valley plane area (311) is recessed in the direction of approaching the center line of the cross bar (31) itself, and the middle part of the low valley plane area (311) is a horizontal plane.

4. The mouse head fixation surgical procedure device of claim 3, wherein: Two long holes (35) are formed in the two hole columns (3), the long holes (35) are formed in the vertical direction along the length direction, the end of the cross bar (31) is provided with a nut (36), the end of the cross bar (31) penetrates the long hole (35) close to it and is threadedly connected with the nut (36), and the nut (36) abuts against the outer wall of the hole column (3).

5. The mouse head fixation surgical procedure device of claim 1, wherein: The blunt sleeve (34) is made of silica gel material.

6. The mouse head fixation surgical procedure device of claim 1, wherein: Along the length direction of the long movable arm (32), there is a distance between the ear rod (33) and the corresponding hole column (3).

7. The mouse head fixation surgical procedure device of claim 1, wherein: The heatable bottom plate (1) is provided with a semicircular column (4) and a semicircular pressing plate (41), the semicircular column (4) is fixed on the heatable bottom plate (1) and located on the side of the ear rod (33) away from the clip assembly (2), the semicircular pressing plate (41) is fixed on the semicircular column (4) and forms a circular hole (42) after splicing, the circular hole (42) is used for clamping and limiting the centrifugal tube containing mice; and the circular hole (42) is arranged opposite to the clip assembly (2).

8. The mouse head fixation surgical procedure device of claim 7, wherein: The length direction of the heating pad (11) is arranged along the direction of the line connecting the circular hole (42) and the clip assembly (2); and the two hole columns (3) are distributed on both sides of the heating pad (11).

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