Granulator for ceramide solid lipid nanoparticles with uniform particle size

Abstract

The granulator comprises a machine body and a bearing plate, the bearing plate is installed on one side of the machine body, two sets of electric push rods are installed at the top end of the bearing plate, push arms are installed at the output ends of the electric push rods, a supporting plate is arranged above the electric push rods, and the supporting plate is connected with the bearing plate. The device comprises a supporting plate, the supporting plate is connected with a push arm, a rotating plate is arranged above the supporting plate, a movable shaft is movably installed at the center of the supporting plate and connected with the rotating plate, a driving motor is installed at the bottom end of the supporting plate, a driving shaft is installed at the output end of the driving motor, and the surface of the driving shaft is sleeved with a transmission gear. The surface of the movable shaft on one side of the transmission gear is sleeved with a driven gear. According to the utility model, convenient high-hydraulic-pressure shearing processing of homogenized liquid is realized, the liquid can be conveniently input in sequence, and the liquid homogenizing effect is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of granulator, concretely to a ceramide solid lipid nanoparticle granulator with uniform particle size. BACKGROUND

[0002] The high-pressure microjet homogenizer is a new generation of high-pressure homogenizer with a diamond interactive cavity. When the material liquid passes through the unique diamond micro-pore channel (Y type or Z type) under high liquid pressure, it forms a supersonic jet collision, and the strong shear force generated can homogenize the material liquid to a stable and uniform state at the nanometer level, achieving the effects of refining particle size, transparent appearance, increasing stability, active substance delivery, and improving skin feel and taste. It is commonly used in the cosmetics (efficacy wrapped raw materials, finished product homogenization refinement), pharmaceutical (nanoemulsion, liposome, nanoparticle, fat milk, etc.) and other industries. The feed inlet of the traditional homogenizer is a single feed inlet. When a single group of material feeding is completed, manual addition of material is required, which is low in efficiency. In order to improve this situation, a ceramide solid lipid nanoparticle granulator with uniform particle size is proposed.

[0003] As disclosed in the authorized announcement No. CN219701755U, a high-pressure microjet homogenizer includes a base and a homogenizer body, the homogenizer body includes a motor, a transmission device, and a high-pressure cylinder, the transmission device includes a support cylinder, a lead screw, a connecting sleeve, a transition disc, and a push rod, the support cylinder is fixed on the base, the connecting sleeve is sleeved in the support cylinder, the lead screw is arranged in the support cylinder based on a bearing, the lead screw is provided with a threaded section, the connecting sleeve is matched with the threaded section, the lead screw is connected with the driving end of the motor, the connecting sleeve is connected with the push rod, the support cylinder is connected with the transition disc, the push rod is inserted into the high-pressure cylinder through the transition disc, the high-pressure cylinder is connected with the transition disc, the high-pressure cylinder is communicated with a diamond interactive cavity and a feeder, and a one-way valve is arranged.

[0004] It realizes rotation of the lead screw driven by the motor, conversion of the rotation of the lead screw into reciprocating motion of the connecting sleeve, application of force to the slurry by the push rod driven by the connecting sleeve, reduction of fluctuation of the pressure applied to the slurry, reduction of device operation noise, and improvement of device operation stability.

[0005] However, it does not solve the problem that the existing granulator is not convenient for high-pressure shear processing of homogeneous liquid, is not conducive to inputting the liquid in sequence, and affects the effect of liquid homogenization. UTILITY MODEL CONTENTS

[0006] The utility model aims at providing a ceramide solid lipid nanoparticle granulator with uniform particle size to solve the problem that the granulator is not convenient for high-pressure shear processing of homogeneous liquid, is not conducive to inputting the liquid in sequence, and affects the effect of liquid homogenization in the above background technology.

[0007] In order to achieve the above object, the utility model provides the following technical scheme: a ceramide solid lipid nanoparticle granulator with uniform particle size, which comprises a machine body and a bearing plate, the side of the machine body is provided with the bearing plate, the top of the bearing plate is provided with two groups of electric push rods, the output end of the electric push rod is provided with a push arm, the upper side of the electric push rod is provided with a supporting plate, and the supporting plate is connected with the push arm, the upper side of the supporting plate is provided with a rotating plate, the center position of the supporting plate is movably provided with a movable shaft, and the movable shaft is connected with the rotating plate, the bottom end of the supporting plate is provided with a driving motor, the output end of the driving motor is provided with a driving shaft, and the surface of the driving shaft is provided with a transmission gear, the surface of the movable shaft on the side of the transmission gear is provided with a driven gear, and the transmission gear and the driven gear are meshed with each other.

[0008] Preferably, the inside of the rotating plate is provided with multiple groups of placement grooves at equal intervals, and the inside of the placement groove is provided with a feeder.

[0009] Preferably, the inside of the machine body is provided with a hydraulic cylinder, and the output end of the hydraulic cylinder is provided with a piston push rod.

[0010] Preferably, the sidewall of the machine body is provided with a suction cylinder, the piston push rod extends into the inside of the suction cylinder and is slidably connected with the suction cylinder, and the inside of the suction cylinder on the side of the piston push rod is provided with a one-way valve.

[0011] Preferably, the top end of the suction cylinder is provided with a diamond alternating cavity, and the feeder is slidably connected with the suction cylinder.

[0012] Preferably, the inside of the diamond alternating cavity is provided with a Y-shaped diamond micropore, and the Y-shaped diamond micropore is communicated with the suction cylinder.

[0013] Preferably, the top end of the diamond alternating cavity is provided with a cold and hot exchange pipe, and the cold and hot exchange pipe is threadedly connected with the diamond alternating cavity.

[0014] Preferably, the top end of the cold and hot exchange pipe is provided with a discharger, and the discharger is threadedly connected with the cold and hot exchange pipe.

[0015] Compared with the prior art, the utility model has the advantages that the granulator not only realizes convenient high-pressure shearing processing of homogeneous liquid, facilitates the input of the liquid in sequence, but also improves the liquid homogenization effect.

[0016] (1) the inside of multiple groups of feeders is poured into multiple liquid materials in turn, the bottom end of the feeder is provided with a solenoid valve, the solenoid valve is opened, the liquid in the inside of the feeder enters the inside of the suction cylinder, the piston push rod is moved in the inside of the suction cylinder under the drive of the hydraulic cylinder, the liquid is sucked to the left side of the check valve by the piston push rod, the check valve is used to prevent the liquid from flowing back, then the hydraulic cylinder is reversely opened, the piston push rod is extruded by the hydraulic cylinder, the liquid enters the inside of the Y-shaped diamond micro-pore under high hydraulic pressure, and the liquid is homogenized to the state of stable and uniform nanometer under the strong shear force generated by the sonic jet collision when entering, under the continuous action of the hydraulic cylinder, the homogenized liquid enters the inside of the cold heat exchange pipe and is cooled by external cold exchange heat to complete the discharge into the inside of the discharger, so that the homogenization of the liquid is completed, the liquid is conveniently and highly sheared and homogenized, and the liquid homogenization effect is improved;

[0017] (2) when the liquid in the inside of a group of feeders is homogenized, the push arm is moved upwards by the electric push rod, the rotating plate is moved upwards by the push arm through the supporting plate, a plurality of feeders are moved upwards by the rotating plate, the transmission gear is rotated by the drive motor through the drive shaft, the driven gear is rotated by the transmission gear, the rotating plate is rotated by the movable shaft through the driven gear, the next group of feeders is rotated to the upper side of the suction cylinder by the rotating plate, then the electric push rod is reversely opened, the feeder is moved downwards and inserted into the inside of the suction cylinder by the electric push rod, the interface in the top end of the suction cylinder is conical in design, so that the sealing performance between the feeder and the suction cylinder can be ensured, and the above operation is repeated, so that the replacement of the feeders is sequentially completed, and the liquid input is better, and the liquid input convenience is improved. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a three-dimensional structure schematic view of the utility model;

[0019] Figure 2 It is a three-dimensional structure schematic view of the utility model's machine body;

[0020] Figure 3 It is a front view cross section structure schematic view of the utility model;

[0021] Figure 4 It is a three-dimensional perspective structure schematic view of the rotating plate of the utility model;

[0022] Figure 5 It is a three-dimensional structure schematic view of the supporting plate of the utility model.

[0023] In the figure: 1, the body; 2, the bearing plate; 3, the electric push rod; 4, the rotating plate; 5, the feeder; 6, the placing groove; 7, the suction cylinder; 8, the diamond exchange cavity; 9, the cold and hot exchange pipe; 10, the discharger; 11, the hydraulic cylinder; 12, the piston push rod; 13, the Y-shaped diamond micro-pore; 14, the support plate; 15, the movable shaft; 16, the driven gear; 17, the push arm; 18, the driving shaft; 19, the driving motor; 20, the transmission gear; 21, the check valve. DETAILED DESCRIPTION

[0024] In order to further illustrate the technical means and effects adopted by the utility model to achieve the predetermined utility model purposes, the specific embodiments, structures, features and effects according to the utility model will be described in detail as follows in combination with the drawings and preferred embodiments.

[0025] Please refer to Figures 1-5 An embodiment provided by the utility model: a ceramide solid lipid nanoparticle granulator with uniform particle size, comprising a body 1 and a bearing plate 2, the bearing plate 2 is installed on one side of the body 1, two groups of electric push rods 3 are installed at the top end of the bearing plate 2, the output ends of the electric push rods 3 are all installed with push arms 17, a support plate 14 is arranged above the electric push rods 3, and the support plate 14 is connected with the push arms 17, a rotating plate 4 is arranged above the support plate 14, a movable shaft 15 is movably installed at the central position of the support plate 14, and the movable shaft 15 is connected with the rotating plate 4, a driving motor 19 is installed at the bottom end of the support plate 14, a driving shaft 18 is installed at the output end of the driving motor 19, a transmission gear 20 is sleeved on the surface of the driving shaft 18, a driven gear 16 is sleeved on the surface of the movable shaft 15 on one side of the transmission gear 20, and the transmission gear 20 and the driven gear 16 are meshed with each other;

[0026] A plurality of liquid materials are poured into the interiors of the plurality of feeders 5 in sequence, the bottom ends of the feeders 5 are all provided with electromagnetic valves, the electromagnetic valves are opened, the liquids in the interiors of the feeders 5 enter the interiors of the suction cylinders 7, then the hydraulic cylinders 11 are opened, the piston push rods 12 are driven by the hydraulic cylinders 11 to move in the interiors of the suction cylinders 7, the liquids are sucked to the left sides of the check valves 21 by the piston push rods 12, the check valves 21 prevent the liquids from flowing back, then the hydraulic cylinders 11 are opened in reverse, the piston push rods 12 are driven by the hydraulic cylinders 11 to extrude the liquids, the liquids enter the interiors of the Y-shaped diamond micro-pores 13 under high hydraulic pressure, and supersonic jet collision is formed when the liquids enter, strong shear force generated thereby can homogenize the liquids to a stable and uniform state of nanometer level, under the continuous action of the hydraulic cylinders 11, the homogenized liquids enter the interiors of the cold and hot exchange pipes 9 and are cooled by external cold exchange to complete the cooling of the liquids and be discharged into the interiors of the dischargers 10, thereby completing the homogenization of the liquids, realizing convenient high hydraulic shear homogenization of the liquids, and improving the homogenization effect of the liquids;

[0027] The interior of the rotating plate 4 is provided with multiple groups of placement grooves 6 at equal intervals, and the interior of each placement groove 6 is provided with a feeder 5; the interior of the machine body 1 is provided with a hydraulic cylinder 11, and the output end of the hydraulic cylinder 11 is provided with a piston push rod 12;

[0028] A suction cylinder 7 is mounted on the side wall of the machine body 1, and the piston push rod 12 extends into the interior of the suction cylinder 7 and is in sliding connection with the suction cylinder 7, and the interior of the suction cylinder 7 on one side of the piston push rod 12 is provided with a one-way valve 21;

[0029] A diamond interaction cavity 8 is mounted at the top end of the suction cylinder 7, and the feeder 5 is in sliding connection with the suction cylinder 7, and the interior of the diamond interaction cavity 8 is provided with a Y-shaped diamond micro-pore channel 13, and the Y-shaped diamond micro-pore channel 13 is in communication with the suction cylinder 7;

[0030] A cold and hot exchange pipe 9 is mounted at the top end of the diamond interaction cavity 8, and the cold and hot exchange pipe 9 is in threaded connection with the diamond interaction cavity 8, and a discharger 10 is mounted at the top end of the cold and hot exchange pipe 9, and the discharger 10 is in threaded connection with the cold and hot exchange pipe 9;

[0031] When the liquid in the interior of one group of feeders 5 is homogenized, the electric push rod 3 is opened, the push arm 17 is driven upward by the electric push rod 3, the rotating plate 4 is driven upward by the push arm 17 through the supporting plate 14, multiple groups of feeders 5 are driven upward by the rotating plate 4, then the driving motor 19 is opened, the transmission gear 20 is driven to rotate by the driving motor 19 through the driving shaft 18, the driven gear 16 is driven to rotate by the transmission gear 20, the rotating plate 4 is driven to rotate by the driven gear 16 through the movable shaft 15, the next group of feeders 5 is driven to rotate above the suction cylinder 7 by the rotating plate 4, then the electric push rod 3 is opened in reverse, the feeder 5 is driven downward and inserted into the interior of the suction cylinder 7 by the electric push rod 3, because the interface at the top end of the suction cylinder 7 is designed in a conical shape, it can ensure the sealing performance between the feeder 5 and the suction cylinder 7, then the above operation is repeated to sequentially complete the replacement of the feeders 5, so that the liquid can be better inputted, and the convenience of liquid input is improved.

[0032] Working principle: first, a variety of liquid materials are poured into the inside of multiple groups of feeders 5 in turn, the bottom end of the feeder 5 is provided with a solenoid valve, open the solenoid valve, the liquid in the inside of the feeder 5 enters the inside of the suction cylinder 7, the piston push rod 12 is driven by the hydraulic cylinder 11 to move in the inside of the suction cylinder 7, and the liquid is sucked to the left side of the one-way valve 21 by the piston push rod 12, the one-way valve 21 prevents the liquid from flowing back, then reverse open the hydraulic cylinder 11, the piston push rod 12 is driven by the hydraulic cylinder 11 to extrude the liquid, the liquid enters the inside of the Y-shaped diamond micro-pore 13 under high hydraulic pressure, and forms a supersonic jet collision when entering, the strong shear force generated can homogenize the liquid to a stable and uniform state of nanometer level, under the continuous action of the hydraulic cylinder 11, the homogenized liquid enters the inside of the cold heat exchange pipe 9 and is cooled by external cold exchange to complete the cooling and discharge into the inside of the discharger 10, to complete the homogenization of the liquid, when the liquid in the inside of a group of feeders 5 is homogenized, the push arm 17 is driven upward by the electric push rod 3, the rotating plate 4 is driven upward by the push arm 17 through the supporting plate 14, a plurality of feeders 5 are driven upward by the rotating plate 4, the transmission gear 20 is driven to rotate by the driving motor 19 through the driving shaft 18, the driven gear 16 is driven to rotate by the transmission gear 20, the rotating plate 4 is driven to rotate by the driven gear 16 through the movable shaft 15, the next group of feeders 5 is driven to rotate to the top of the suction cylinder 7 by the rotating plate 4, then reverse open the electric push rod 3, the feeder 5 is driven downward by the electric push rod 3 and inserted into the inside of the suction cylinder 7, because the interface inside the top end of the suction cylinder 7 is designed in a conical shape, it can ensure the sealing performance between the feeder 5 and the suction cylinder 7, then repeat the above operation to complete the replacement of the feeder 5 in turn, so as to better input the liquid, the above is the whole use of the ceramide solid lipid nanoparticle granulator with uniform particle size.

[0033] The above is only a preferred embodiment of the present application, and does not limit the present application in any form. Although the present application has been disclosed as a preferred embodiment, it is not intended to limit the present application. Any person skilled in the art can make some changes or modifications to the above disclosed technical content without departing from the technical solution of the present application, and any indirect modification, equivalent change and modification of the above embodiment according to the technical essence of the present application still belong to the scope of the technical solution of the present application.

Claims

1. A ceramide solid lipid nanoparticle granulator with uniform particle size, comprising a machine body (1) and a bearing plate (2), characterized in that: The side of the machine body (1) is provided with a bearing plate (2), the top end of the bearing plate (2) is provided with two groups of electric push rods (3), the output end of the electric push rod (3) is provided with a push arm (17), the upper side of the electric push rod (3) is provided with a supporting plate (14), and the supporting plate (14) is connected with the push arm (17), the upper side of the supporting plate (14) is provided with a rotating plate (4), the center position of the supporting plate (14) is movably provided with a movable shaft (15), and the movable shaft (15) is connected with the rotating plate (4), the bottom end of the supporting plate (14) is provided with a driving motor (19), the output end of the driving motor (19) is provided with a driving shaft (18), the surface of the driving shaft (18) is provided with a transmission gear (20), the surface of the movable shaft (15) on the side of the transmission gear (20) is provided with a driven gear (16), and the transmission gear (20) and the driven gear (16) are meshed with each other.

2. The ceramide solid lipid nanoparticle granulator according to claim 1, wherein: The inside of the rotating plate (4) is provided with a plurality of groups of placement grooves (6) at equal intervals, and the inside of the placement groove (6) is provided with a feeder (5).

3. The ceramide solid lipid nanoparticle granulator of claim 1, wherein the ceramide solid lipid nanoparticle has a particle size of 50 nm to 200 nm. The inside of the machine body (1) is provided with a hydraulic cylinder (11), and the output end of the hydraulic cylinder (11) is provided with a piston push rod (12).

4. The ceramide solid lipid nanoparticle granulator of claim 1, wherein: The side wall of the machine body (1) is provided with a suction cylinder (7), the piston push rod (12) extends into the inside of the suction cylinder (7) and is slidably connected with the suction cylinder (7), and the inside of the suction cylinder (7) on the side of the piston push rod (12) is provided with a one-way valve (21).

5. The ceramide solid lipid nanoparticle granulator of claim 4, wherein the ceramide solid lipid nanoparticle has a particle size of 50 nm to 200 nm. The top end of the suction cylinder (7) is provided with a diamond interaction cavity (8), and the feeder (5) is slidably connected with the suction cylinder (7).

6. The ceramide solid lipid nanoparticle granulator of claim 5, wherein the ceramide solid lipid nanoparticle has a particle size of 50 nm to 200 nm. The inside of the diamond interaction cavity (8) is provided with a Y-shaped diamond micropore (13), and the Y-shaped diamond micropore (13) is communicated with the suction cylinder (7).

7. The ceramide solid lipid nanoparticle granulator of claim 5, wherein the ceramide solid lipid nanoparticle has a particle size of 50 nm to 200 nm. The top end of the diamond interaction cavity (8) is provided with a cold and hot exchange pipe (9), and the cold and hot exchange pipe (9) is threadedly connected with the diamond interaction cavity (8).

8. The ceramide solid lipid nanoparticle granulator of claim 7, wherein the ceramide solid lipid nanoparticle has a particle size of 50 nm to 200 nm. The top end of the cold and hot exchange pipe (9) is provided with a discharger (10), and the discharger (10) is threadedly connected with the cold and hot exchange pipe (9).

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