Trifluoromethylpyridine medical intermediate rectification and purification treatment device

Abstract

The utility model relates to a purification treatment device, belongs to the technical field of medicine production equipment, and in particular relates to a rectification purification treatment device for a trifluoromethylpyridine medical intermediate, which comprises a rectification tower, and a heater is arranged in the rectification tower; according to the device disclosed by the utility model, the material adding assembly is matched with the object carrying box through the fixed seat, the hydraulic machine and the object carrying box, so that the device is convenient to add materials, a user is convenient to observe the residual amount of raw materials in the rectification and purification process through the matching of a connecting box, an observation window and scale marks, and the raw materials can be supplemented in time; according to the auxiliary assembly, the cover plate and the baffle are used for blocking the bottom of the rectifying tower when raw materials are added, the contact area between the interior of the rectifying tower and the outside is reduced, and therefore heat loss is reduced, and the auxiliary assembly is matched with the condensing plate, the connecting pipe, the containing plate, the storage tank, the discharging pipe, the backflow pipe and the valve, so that trifluoromethylpyridine can be conveniently connected, rectified and purified; and the practicability of the device is improved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical production equipment technology, specifically a distillation and purification device for trifluoromethylpyridine pharmaceutical intermediates. Background Technology

[0002] In the production process of pharmaceutical intermediates, the raw materials, intermediate products, and crude products are almost all mixtures, and most of them are homogeneous systems. For further processing and use, these mixtures need to be separated into relatively pure or almost pure substances by distillation.

[0003] Chinese patent CN221491483U discloses a pharmaceutical intermediate distillation apparatus, including a main body. The main body contains a distillation column and a storage tank. A connecting pipe is installed at one end of the distillation column, which contains a condenser plate. A receiving trough is located on the bottom side of the condenser plate, and a telescopic structure is located on the bottom side of the receiving trough. A telescopic sleeve is located at the bottom end of the telescopic structure, and a fixing rod is located at the bottom end of the telescopic sleeve. A raw material basin is located at the bottom end of the fixing rod. A fixed base is located at the bottom end of the distillation column. This patent utilizes a telescopic structure to extend the telescopic sleeve, allowing the raw material basin to extend and retract. This eliminates the need to open the distillation column when replenishing raw materials, preventing excessive heat loss from the internal heating structure. Furthermore, the arc-shaped design of the condenser plate allows the liquid medicine to slide down from the center of the condenser plate, accurately falling into the receiving trough.

[0004] In the above technical solution, during the distillation process, the raw material basin is located inside the distillation column, making it inconvenient to observe the remaining amount of raw material in the raw material box, which prevents users from adding raw material in a timely manner, resulting in a waste of heat.

[0005] Based on this, this application proposes a distillation and purification apparatus for trifluoromethylpyridine pharmaceutical intermediates. Utility Model Content

[0006] To address the aforementioned technical problems, this utility model proposes a distillation and purification device for trifluoromethylpyridine pharmaceutical intermediates. The device allows for observation of the remaining amount of raw material in the container via a feeding assembly, facilitating timely material replenishment by the user. The combination of a cover plate and baffles significantly reduces heat loss during material replenishment. Auxiliary components facilitate connection to distillation operations, enhancing the device's practicality.

[0007] The technical solution for achieving the purpose of this utility model is as follows: a distillation purification device for trifluoromethylpyridine pharmaceutical intermediates, comprising a distillation column, three support columns and a fixing plate fixedly connected to the distillation column, a heater provided inside the distillation column, and a feeding assembly provided inside the distillation column. The feeding assembly includes a fixing seat, a hydraulic press, a loading box, a connecting box, an observation window, a scale line, and a baffle. The fixing seat is fixedly connected to the three support columns, the hydraulic press is fixedly connected to the fixing seat, the loading box is fixedly connected to the output shaft of the hydraulic press, the connecting box is fixedly connected to the loading box, the observation window is fixedly connected to the connecting box, the scale line is opened on the observation window, the baffle is fixedly connected to the connecting box, and the baffle is slidably connected inside the distillation column. An auxiliary component is provided inside the distillation column.

[0008] Preferably, the filling assembly includes a connecting column and a cover plate, wherein the connecting column is fixedly connected to the container and the cover plate is fixedly connected to the connecting column.

[0009] Preferably, the auxiliary components include a condenser plate and a connecting pipe, wherein the condenser plate is disposed inside the distillation column and the connecting pipe is fixedly connected inside the distillation column.

[0010] Preferably, the auxiliary components further include a container plate and a storage tank, the container plate being fixedly connected to one end of the connecting pipe, the storage tank being fixedly connected to the other end of the connecting pipe, and the storage tank being fixedly connected to a fixed plate.

[0011] Preferably, the auxiliary components further include a discharge pipe and a return pipe, wherein the discharge pipe is fixedly connected to the storage tank, the return pipe is fixedly connected to the storage tank, and the return pipe is slidably connected to the cover plate.

[0012] Preferably, the auxiliary component further includes valves, with two valves respectively located on the discharge pipe and the return pipe.

[0013] Compared with existing technologies, the significant advantages of this invention are:

[0014] Firstly, in this utility model, the feeding assembly, through the cooperation of the fixed base, hydraulic press, and loading box, facilitates the feeding of materials into the device. Through the cooperation of the connecting box, observation window, and scale line, the user can easily observe the remaining amount of raw materials during the distillation and purification process and replenish the raw materials in a timely manner. Through the cooperation of the connecting column, cover plate, and baffle, the bottom of the distillation column is blocked by the cover plate and baffle when adding raw materials, reducing the contact area between the inside of the distillation column and the outside environment, thereby reducing heat loss.

[0015] Secondly, in this utility model, the auxiliary components, through the cooperation of a condenser plate, connecting pipe, container plate, storage tank, discharge pipe, reflux pipe and valve, facilitate the connection distillation and purification of trifluoromethylpyridine, thereby improving the practicality of the device. Attached Figure Description

[0016] The present invention will be further explained below with reference to the accompanying drawings and embodiments:

[0017] Figure 1 This is a three-dimensional structural schematic diagram of the present invention;

[0018] Figure 2 This is a cross-sectional view of the internal structure of this utility model;

[0019] Figure 3 This is a cross-sectional view of the internal structure of the auxiliary component in this utility model;

[0020] Figure 4 This is a three-dimensional structural diagram of the material feeding component in this utility model.

[0021] Explanation of reference numerals in the attached figures:

[0022] 1. Distillation column; 2. Support column; 3. Fixing plate; 4. Heater; 5. Feeding assembly; 51. Fixing base; 52. Hydraulic press; 53. Loading box; 54. Connecting column; 55. Cover plate; 56. Connecting box; 57. Observation window; 58. Scale line; 59. Baffle; 6. Auxiliary components; 61. Condensing plate; 62. Connecting pipe; 63. Loading plate; 64. Storage tank; 65. Discharge pipe; 66. Reflux pipe; 67. Valve. Detailed Implementation

[0023] The present invention will now be described in detail, and the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present invention.

[0024] This invention provides an improved distillation and purification apparatus for trifluoromethylpyridine pharmaceutical intermediates. The technical solution of this invention is as follows:

[0025] like Figures 1-4As shown, the distillation purification apparatus for trifluoromethylpyridine pharmaceutical intermediates includes a distillation column 1. Three support columns 2 and a fixing plate 3 are fixedly connected to the distillation column 1. The support columns 2 are located at the bottom of the distillation column 1 and are arranged in a circular array with the center of the distillation column 1 as the center. A heater 4 is installed inside the distillation column 1. A feeding assembly 5 is also installed inside the distillation column 1. The feeding assembly 5 includes a fixing seat 51, a hydraulic press 52, a loading box 53, a connecting box 56, an observation window 57, a scale line 58, and a baffle 59. The fixing seat 51 is fixedly connected to the three support columns 2, and the hydraulic press 52 is secured by bolts. The loading box 53 is fixed on the fixed base 51 and bolted to the output shaft of the hydraulic press 52. The connecting box 56 is fixedly connected to the loading box 53. The observation window 57 is fixedly connected to the connecting box 56. The observation window 57 is made of glass and the scale line 58 is opened on the observation window 57. Through the cooperation of the observation window 57 and the scale line 58, the user can easily observe the remaining amount of raw materials during the distillation and purification process and replenish the raw materials in time. The baffle 59 is fixedly connected to the connecting box 56 and slidably connected to the distillation column 1. The distillation column 1 is equipped with auxiliary components 6.

[0026] Furthermore, such as Figures 2-4 As shown, the feeding assembly 5 includes a connecting column 54 and a cover plate 55. The connecting column 54 is fixedly connected to the container 53, and the cover plate 55 is fixedly connected to the connecting column 54. When adding raw materials, the bottom of the distillation column 1 is blocked by the cover plate 55 and the baffle 59 to reduce the contact area between the inside of the distillation column 1 and the outside, thereby reducing the heat loss.

[0027] Furthermore, such as Figures 1-3 As shown, the auxiliary component 6 includes a condenser plate 61 and a connecting pipe 62. The condenser plate 61 is located inside the distillation column 1 and is situated at the top of the distillation column 1. It is used to condense the sublimated trifluoromethylpyridine. The connecting pipe 62 is fixedly connected inside the distillation column 1.

[0028] Furthermore, such as Figures 1-3 As shown, the auxiliary component 6 also includes a container plate 63 and a storage tank 64. The container plate 63 is fixedly connected to one end of the connecting pipe 62. The cross-section of the container plate 63 is an isosceles trapezoid. The container plate 63 is located directly below the condenser plate 61. The storage tank 64 is fixedly connected to the other end of the connecting pipe 62 and is fixedly connected to the fixing plate 3.

[0029] Furthermore, such as Figure 1 and Figure 3 As shown, the auxiliary component 6 also includes a discharge pipe 65 and a return pipe 66. The discharge pipe 65 is fixedly connected to the storage tank 64, and the return pipe 66 is fixedly connected to the storage tank 64. The return pipe 66 is slidably connected to the cover plate 55. The cross-section of the return pipe 66 is "L" shaped, and the end of the return pipe 66 away from the storage tank 64 is located inside the container 53.

[0030] Furthermore, such as Figure 1 and Figure 3 As shown, the auxiliary component 6 also includes valves 67. Two valves 67 are respectively located on the discharge pipe 65 and the reflux pipe 66. When the valve 67 on the discharge pipe 65 is opened, the trifluoromethylpyridine purified by distillation can be taken out from the storage tank 64. When the valve 67 on the reflux pipe 66 is opened, the trifluoromethylpyridine can be purified by distillation.

[0031] The specific working method is as follows: Heater 4 is started to heat the raw material in the container 53. Due to the different boiling points of the impurities and trifluoromethylpyridine, the trifluoromethylpyridine will sublimate after evaporation. The sublimated trifluoromethylpyridine will contact the condenser plate 61, condense under the action of the condenser plate 61, and slide into the container plate 63. It then flows into the connecting pipe 62 along the container plate 63, and then into the storage tank 64 through the connecting pipe 62. When it is necessary to remove the trifluoromethylpyridine, the valve 67 of the discharge pipe 65 can be opened to remove it from the storage tank 64. When the trifluoromethylpyridine in the storage tank 64 does not meet the usage standard and still needs to be purified by distillation, the valve 67 of the reflux pipe 66 can be opened, and the trifluoromethylpyridine in the storage tank 64 will flow into the reflux pipe 66. The material flows back into the container 53 through tube 66 to continue distillation and purification. As distillation and purification proceed, the amount of raw material in the container 53 will decrease. The remaining amount of raw material in the container 53 can be observed through the scale line 58 on the observation window 57 on the connecting box 56. When the amount of raw material is low, the hydraulic press 52 can be started, and its output shaft moves down, causing the container 53 to move down, and the connecting box 56 to move down as well. When the container 53 separates from the distillation column 1, the bottom of the distillation column 1 will be blocked due to the action of the connecting column 54 and the cover plate 55, reducing the contact area between the inside of the distillation column 1 and the outside, thereby reducing heat loss. After the raw material is added, the hydraulic press 52 is started to reset the container 53 and the connecting box 56, and distillation and purification can continue.

[0032] The technical means disclosed in this utility model are not limited to those described above, but also include technical solutions composed of equivalent substitutions of the above technical features. Matters not covered in this utility model are common knowledge to those skilled in the art.

Claims

1. A distillation purification apparatus for trifluoromethylpyridine pharmaceutical intermediates, comprising a distillation column (1), wherein three support columns (2) and a fixing plate (3) are fixedly connected to the distillation column (1), and a heater (4) is provided inside the distillation column (1), characterized in that: The distillation column (1) is equipped with a feeding assembly (5), which includes a fixed base (51), a hydraulic press (52), a loading box (53), a connecting box (56), an observation window (57), a scale line (58), and a baffle (59). The fixed base (51) is fixedly connected to three support columns (2). The hydraulic press (52) is fixedly connected to the fixed base (51). The loading box (53) is fixedly connected to the output shaft of the hydraulic press (52). The connecting box (56) is fixedly connected to the loading box (53). The observation window (57) is fixedly connected to the connecting box (56). The scale line (58) is opened on the observation window (57). The baffle (59) is fixedly connected to the connecting box (56) and is slidably connected inside the distillation column (1). The distillation column (1) is equipped with an auxiliary assembly (6).

2. The distillation and purification apparatus for trifluoromethylpyridine pharmaceutical intermediates according to claim 1, characterized in that: The feeding assembly (5) includes a connecting column (54) and a cover plate (55). The connecting column (54) is fixedly connected to the container (53), and the cover plate (55) is fixedly connected to the connecting column (54).

3. The distillation and purification apparatus for trifluoromethylpyridine pharmaceutical intermediates according to claim 2, characterized in that: The auxiliary component (6) includes a condenser plate (61) and a connecting pipe (62). The condenser plate (61) is located inside the distillation column (1), and the connecting pipe (62) is fixedly connected inside the distillation column (1).

4. The distillation and purification apparatus for trifluoromethylpyridine pharmaceutical intermediates according to claim 3, characterized in that: The auxiliary component (6) also includes a container plate (63) and a storage tank (64). The container plate (63) is fixedly connected to one end of the connecting pipe (62), and the storage tank (64) is fixedly connected to the other end of the connecting pipe (62). The storage tank (64) is fixedly connected to the fixing plate (3).

5. The distillation and purification apparatus for trifluoromethylpyridine pharmaceutical intermediates according to claim 4, characterized in that: The auxiliary component (6) also includes a discharge pipe (65) and a return pipe (66). The discharge pipe (65) is fixedly connected to the storage tank (64), and the return pipe (66) is fixedly connected to the storage tank (64). The return pipe (66) is slidably connected to the cover plate (55).

6. The distillation and purification apparatus for trifluoromethylpyridine pharmaceutical intermediates according to claim 5, characterized in that: The auxiliary component (6) also includes valves (67), with two valves (67) respectively located on the discharge pipe (65) and the return pipe (66).

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