Auxiliary low-temperature operation platform for mouse brain tissue collection

Abstract

The utility model discloses an auxiliary low-temperature operating platform for mouse brain tissue collection, which comprises a dry ice storage tank, a temperature control solvent tank and a mouse brain tissue sampling operating platform, a dry ice storage tray is arranged in the dry ice storage tank, and a full-automatic height controller is arranged between the bottom of the inner side of the dry ice storage tank and the dry ice storage tray; the temperature control solvent tank is of a nested liner structure and is arranged above the dry ice storage tank, and a solvent inlet and a solvent outlet are formed in the two ends of the temperature control solvent tank respectively; the mouse brain tissue sampling operation platform is the inner wall of the temperature control solvent tank, and the inner wall of the temperature control solvent tank is provided with a thermodetector. According to the device, the temperature of the temperature control solvent tank is accurately controlled, so that the brain tissue of the mouse is always collected in a proper low-temperature environment, the structural integrity and the cell viability of the brain tissue are effectively reserved, and the accuracy and the reliability of an experiment are remarkably improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of biomedical experiment equipment, concretely relates to a kind of auxiliary low-temperature operation platform for mouse brain tissue collection. BACKGROUND

[0002] In neuroscience research, mice are widely used as model organisms due to their similar genomic structure and biological characteristics to humans, short breeding cycles, and controllable genetic backgrounds. They play an irreplaceable role in the study of neurological diseases, gene function analysis, and drug development. However, the collection and processing of mouse brain tissue are critical, as high-quality molecular biology and pathology analysis require tissue to be handled in a low-temperature environment to maintain its structural stability and cellular activity. Low-temperature conditions not only help slow down biochemical reactions but also prevent tissue protein denaturation and enzymatic decomposition. However, traditional laboratory equipment has significant shortcomings in maintaining a low-temperature environment, mainly in unstable temperature control, complex operation, and low resource utilization efficiency. To overcome these challenges, cutting-edge technology explores the development of closed-loop temperature control systems, utilizing high-precision sensors and automated systems for dynamic adjustment to ensure consistent temperature stability. Meanwhile, modern scientific research equipment is developing towards automation and intelligentization, achieving automatic monitoring and adjustment of the experimental process through computer control and artificial intelligence technology, reducing human intervention and improving experimental efficiency. In the forefront of neuroscience research, there are strict requirements for the accuracy and repeatability of experimental data, especially in the pathological study of neurological diseases, where high-quality brain tissue samples are crucial for observing pathological characteristics and molecular analysis. Therefore, developing an operation platform that can provide a consistent and stable low-temperature environment during mouse brain tissue collection not only improves the accuracy and reliability of experimental results but also provides a powerful tool and support for basic and applied research. SUMMARY

[0003] The utility model aims to provide a kind of auxiliary low-temperature operation platform for mouse brain tissue collection, and its design aims to solve the problem of unstable temperature control in the prior art, thereby improving the accuracy and reliability of experimental results.

[0004] The technical scheme of the utility model is as follows:

[0005] The utility model provides an auxiliary low temperature operation platform of mouse brain tissue collection, including dry ice storage tank, temperature control solvent tank and mouse brain tissue sampling operation platform, the dry ice storage tank is provided with dry ice storage tray, and the full -automatic height controller is arranged between the inside bottom of dry ice storage tank and dry ice storage tray, the temperature control solvent tank is nested inner chamber structure and is arranged above dry ice storage tank, and the temperature control solvent tank is provided with solvent inlet and solvent outlet respectively at both ends, the mouse brain tissue sampling operation platform is the inner wall of temperature control solvent tank, and the inner wall of temperature control solvent tank is provided with high accuracy temperature instrument.

[0006] Further, the full-automatic height controller includes an electric lifting device arranged below the dry ice storage tray, and the full-automatic height controller automatically adjusts the height of the dry ice storage tray according to real-time temperature data feedback of the high-precision temperature instrument.

[0007] Further, the high-precision temperature instrument can set a target temperature, and can monitor the temperature in the temperature control solvent tank in real time and feed back the temperature data to the full-automatic height controller.

[0008] Further, the dry ice storage tank is provided with a heat insulation layer outside to reduce the influence of external temperature on the sublimation speed of dry ice.

[0009] Further, the dry ice in the dry ice storage tray of the dry ice storage tank sublimates to take away heat, so that the solvent in the temperature control solvent tank is cooled.

[0010] Further, the solvent inlet and the solvent outlet are plugged by high-density rubber plugs.

[0011] Further, the mouse brain tissue sampling operation platform is part of the inner wall of the temperature control solvent tank, which has strong chemical resistance and wear resistance and is suitable for long-term low-temperature operation.

[0012] The utility model has the advantages that:

[0013] The utility model precisely controls the temperature of the temperature control solvent tank, ensures that the mouse brain tissue collection is always carried out in a suitable low-temperature environment, effectively preserves the structural integrity and cell activity of the brain tissue, significantly improves the accuracy and reliability of the experiment, and provides an efficient and stable solution for tissue collection and processing in biomedical research. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 It is the structure schematic diagram of the auxiliary low temperature operation platform of mouse brain tissue collection of the utility model.

[0015] In the drawing, the reference signs include:

[0016] 1: dry ice storage tank

[0017] 11: full-automatic height controller

[0018] 12: dry ice storage tray

[0019] 2: temperature-controlled solvent tank

[0020] 21: solvent inlet

[0021] 22: solvent outlet

[0022] 3: mouse brain tissue sampling operation platform

[0023] 31: high-precision temperature meter DETAILED DESCRIPTION

[0024] The utility model will be further described in detail below in combination with the drawings and examples. It can be understood that the specific examples described herein are only used to explain the utility model and are not limited to the utility model. In addition, it should be noted that only the parts related to the utility model are shown in the drawings for ease of description, not all the structures.

[0025] Embodiment

[0026] The utility model discloses a kind of auxiliary low-temperature operation platforms of mouse brain tissue collection, including dry ice storage tank 1, temperature-controlled solvent tank 2 and mouse brain tissue sampling operation platform 3, dry ice storage tank 1 is provided with dry ice storage tray 12, full-automatic height controller 11 is provided between dry ice storage tank 1 inner side bottom and dry ice storage tray 12;Temperature-controlled solvent tank 2 is nested inner container structure and is arranged above dry ice storage tank 1, and the both ends of temperature-controlled solvent tank 2 are provided with solvent inlet 21 and solvent outlet 22 respectively;Mouse brain tissue sampling operation platform 3 is the inner wall of temperature-controlled solvent tank 2, and the inner wall of temperature-controlled solvent tank 2 is provided with high-precision temperature meter 31.

[0027] Further, the full-automatic height controller includes electric lifting device arranged below dry ice storage tray 12, and full-automatic height controller 11 automatically adjusts the height of dry ice storage tray 12 according to the real-time temperature data feedback of high-precision temperature meter 31, realizes the dynamic control of temperature, and ensures the temperature stability of platform. The automatic adjustment mechanism can quickly respond to temperature change, maintain the temperature stability in tank, and avoid tissue damage caused by temperature fluctuation.

[0028] Further, high-precision temperature meter 31 can set target temperature, and high-precision temperature meter 31 can monitor the temperature in temperature-controlled solvent tank 2 in real time and feed back temperature data to full-automatic height controller 11. User only needs to simply set target temperature, and system can automatically run and adjust without frequent manual intervention.

[0029] Further, the dry ice storage tank 1 is externally provided with a heat insulation layer to reduce the influence of external temperature on the sublimation speed of dry ice, improve the use efficiency of dry ice, and reduce the experimental cost.

[0030] Further, the heat generated by the sublimation of dry ice on the dry ice storage tray 12 in the dry ice storage tank 1 is taken away, so that the solvent in the temperature-controlled solvent tank 2 is cooled.

[0031] Further, the solvent inlet 21 and the solvent outlet 22 are sealed by high-density rubber plugs. The rubber plugs have good sealing performance to prevent solvent leakage during cooling and operation, and facilitate quick replacement and replenishment of the solvent, improving the convenience and safety of operation.

[0032] Further, the mouse brain tissue sampling operation platform 3 is part of the inner wall of the temperature-controlled solvent tank 2, which has strong chemical resistance and wear resistance, and is suitable for long-term low-temperature operation. By maintaining a low-temperature environment, the original hardness and cell activity of the mouse brain tissue are maintained, which is beneficial to subsequent experiments (such as tissue sectioning and microscopic observation), and improves the accuracy and reliability of subsequent experiments.

[0033] The utility model discloses a precise control of the temperature of the temperature-controlled solvent tank, ensures that the mouse brain tissue collection is always carried out in a suitable low-temperature environment, effectively retains the structural integrity and cell activity of the brain tissue, and significantly improves the accuracy and reliability of the experiment.

Claims

1. An auxiliary cryogenic manipulation platform for collecting mouse brain tissue, characterized in that, The device includes a dry ice storage tank (1), a temperature-controlled solvent tank (2), and a mouse brain tissue sampling platform (3). The dry ice storage tank (1) is equipped with a dry ice storage tray (12), and an automatic height controller (11) is installed between the bottom of the dry ice storage tank (1) and the dry ice storage tray (12). The temperature-controlled solvent tank (2) is a nested inner liner structure installed above the dry ice storage tank (1). The two ends of the temperature-controlled solvent tank (2) are respectively provided with a solvent inlet (21) and a solvent outlet (22). The mouse brain tissue sampling platform (3) is the inner wall of the temperature-controlled solvent tank (2), and a high-precision thermometer (31) is installed on the inner wall of the temperature-controlled solvent tank (2).

2. The auxiliary cryogenic operation platform for collecting mouse brain tissue according to claim 1, characterized in that, The fully automatic height controller (11) includes an electric lifting device located below the dry ice storage tray (12). The fully automatic height controller (11) automatically adjusts the height of the dry ice storage tray (12) based on the real-time temperature data feedback from the high-precision thermometer (31).

3. The auxiliary low-temperature operation platform for collecting mouse brain tissue according to claim 2, characterized in that, The high-precision thermometer (31) can be set to a target temperature. At the same time, the high-precision thermometer (31) can monitor the temperature in the temperature-controlled solvent tank (2) in real time and feed the temperature data back to the fully automatic height controller (11).

4. The auxiliary cryogenic manipulation platform for collecting mouse brain tissue according to claim 1, characterized in that, The dry ice storage tank (1) is provided with an insulation layer on the outside to reduce the influence of the outside temperature on the sublimation rate of dry ice.

5. The auxiliary cryogenic manipulation platform for collecting mouse brain tissue according to claim 1, characterized in that, The heat is carried away by the sublimation of dry ice on the dry ice storage tray (12) inside the dry ice storage tank (1), thereby cooling the solvent in the temperature-controlled solvent tank (2).

6. The auxiliary cryogenic manipulation platform for mouse brain tissue collection according to claim 1, characterized in that, The solvent inlet (21) and solvent outlet (22) are sealed by high-density rubber plugs.

7. The auxiliary cryogenic manipulation platform for collecting mouse brain tissue according to claim 1, characterized in that, The mouse brain tissue sampling platform (3) is part of the inner wall of the temperature-controlled solvent bath (2), which has strong chemical resistance and wear resistance and is suitable for long-term low-temperature operation.

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