Mixer of liquid chromatograph

Abstract

The utility model relates to the technical field of chromatograph accessories, in particular to a mixer of a liquid chromatograph, which comprises a first part provided with a first end, a second end and a liquid inlet flow channel communicated with the first end and the second end; the second part is detachably mounted at the second end, the second part is provided with a mixing cavity, and the mixing cavity is communicated with the liquid inlet runner; and the mixing unit is mounted at the second end and can be accommodated in the mixing cavity. The mixer is divided into the first part and the second part, the first part is detachably connected with the second part, the mixing unit is installed at the second end, close to the second part, of the first part, when the second part is connected with the first part, the mixer works normally, and when the second part is separated from the first part, the mixer is exposed to the outside. And a worker can conveniently and thoroughly clean the device.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of chromatography accessories, and in particular to a mixer of a liquid chromatograph. BACKGROUND

[0002] In the analysis of liquid chromatography in colleges and universities, the use of a mixer is crucial to improving the accuracy and repeatability of the analysis. By mixing solvents in different proportions, a mobile phase suitable for sample separation can be obtained. The mixer can ensure the stability and uniformity of the mobile phase, thereby improving the clarity and resolution of the chromatogram.

[0003] To ensure the normal operation and prolong the service life of the mixer, regular maintenance and maintenance are required, which includes tilting the mixer to remove residues and impurities, ensuring the sealing performance of the mixer and whether the connecting parts are loose, etc. In addition, it is also necessary to replace the aged mixer parts in a timely manner according to the use.

[0004] In the related art, the mixing unit arranged in the mixer is the main component for realizing fluid mixing. By controlling the fluid to pass through the mixing unit, the fluid is divided into multiple streams that continuously pass through the confluence and shunt to fully mix the fluid. In this process, impurities mixed in the fluid are easily attached to the mixing unit.

[0005] The problem with the related art is that to ensure the sealing of the mixer, the mixing unit is generally fully surrounded by the shell, which makes it difficult for the worker to determine whether the cleaning is complete by adding cleaning fluid to the mixing unit through the inlet and outlet of the mixer. This method can easily affect the cleaning efficiency, and the mixing unit as the main component is not convenient to replace and maintain after aging. CONTENT OF THE INVENTION

[0006] To ensure the cleaning efficiency and facilitate the replacement and maintenance of the mixing unit by the worker, the present application provides a mixer of a liquid chromatograph.

[0007] The mixer of the liquid chromatograph provided by the present application adopts the following technical solution:

[0008] A mixer of a liquid chromatograph, a first part having a first end and a second end, and a liquid inlet channel communicating the first end and the second end;

[0009] A second part is detachably mounted on the second end, and the second part has a mixing chamber, and the mixing chamber is in communication with the liquid inlet channel;

[0010] A mixing unit is installed on the second end and can be accommodated in the mixing chamber.

[0011] By adopting the above technical solution, the mixer is divided into a first part and a second part, which are detachably connected. The mixing unit is installed at the second end. When the mixing unit needs to be cleaned, the second part can be removed to expose the mixing unit to the external environment, thereby ensuring that the mixing unit can be thoroughly cleaned.

[0012] Optionally, the mixing unit includes a mounting part and a mixing component, the mixing component being fixed to the mounting part and detachably connected to the first part through the mounting part.

[0013] By adopting the above technical solution, the installation part is detachably connected to the first part, which allows the mixing unit to be separated from the first part, so as to facilitate the later maintenance and replacement of the mixing unit.

[0014] Optionally, the mixing component includes multiple baffles, which are spaced apart and extend away from the first part. Each baffle is configured with a corrugated structure. The fluid can enter the mixing chamber through the inlet channel and be mixed by passing through each baffle.

[0015] By adopting the above technical solution, when the fluid passes through the mixing unit, it is fully mixed through the splitting and merging of multiple baffles.

[0016] Optionally, the mounting portion includes a substrate and ribs. The substrate is annular, the hybrid assembly is fixed inside the substrate, and the ribs are disposed on the end face of the substrate near the first portion and perpendicular to the substrate. Multiple ribs are provided, and each rib is evenly distributed and extends radially along the substrate.

[0017] By adopting the above technical solution, the substrate provides support and fixation for the hybrid component, and the ribs are used to connect the substrate to the first part and ensure the connection strength.

[0018] Optionally, the mounting part further includes a sealing ring, which is fixed in annular shape on the outer peripheral surface of the substrate. A groove is provided on the end face of the second part that mates with the first part, and the sealing ring can be press-fitted into the groove.

[0019] By adopting the above technical solution, when the first part and the second part are connected, the sealing ring is press-fitted at the connection between the first part and the second part, thereby improving the sealing performance of the mixer and preventing fluid leakage from the connection.

[0020] Optionally, a flow guide ring plate is provided at the second end of the first part. The inner diameter of the flow guide ring plate is larger than the inner diameter of the substrate. A plurality of wedge-shaped grooves are formed on the side of the flow guide ring plate facing the outside of the first part. The rib plate is adapted to the wedge-shaped grooves to connect the mixing unit to the first part.

[0021] By adopting the above technical solution, the rib plate and wedge groove are matched to ensure the connection stability between the mixing unit and the first part and avoid loosening of the connection.

[0022] Optionally, the first end is provided with a liquid inlet, which is connected to the liquid inlet channel, and the end of the second part away from the first part is provided with a liquid outlet, which is connected to the mixing chamber. Both the liquid inlet and the liquid outlet are provided with connectors.

[0023] By adopting the above technical solution, the inlet and outlet are set together to allow fluid to flow into and out of the mixer. The connector is used to facilitate the connection of the mixer to other components of the chromatograph through pipelines, so as to realize the supply and discharge of fluid.

[0024] Optionally, the second end is provided with a threaded connection portion, and the end of the second part near the second end is provided with an internal thread to thread the first part and the second part together.

[0025] By adopting the above technical solution, the threaded connection part and the internal thread are matched to realize the connection and separation of the first part and the second part. The structure is simple and the operation is convenient.

[0026] In summary, this application includes at least one of the following beneficial technical effects:

[0027] By dividing the mixer into a first part and a second part, the first part and the second part can be detachably connected, and the mixing unit is installed at the second end of the first part near the second part. When the second part is connected to the first part, the mixer works normally. When the second part is separated from the first part, the mixer is exposed to the outside, which makes it convenient for staff to thoroughly clean it.

[0028] The mixing component is detachably connected to the first part via the mounting part, allowing the mixing unit to be separated from the first part. This facilitates maintenance or replacement of the mixing component when it ages. The sealing ring improves the sealing performance at the connection between the first part / second part and the mixing unit, preventing fluid leakage from the connection. Attached Figure Description

[0029] Figure 1 This is a frontal cross-sectional structural diagram of an embodiment of this application.

[0030] Figure 2 This is a cross-sectional structural diagram of the first part of the embodiment of this application.

[0031] Figure 3 This is a top view of the hybrid unit in an embodiment of this application.

[0032] Figure 4 yes Figure 1 A magnified schematic diagram of the structure at point A in the middle.

[0033] Reference numerals: 1. First part; 11. Liquid inlet channel; 12. Guide ring plate; 13. Threaded connection part; 2. Second part; 21. Mixing chamber; 3. Mixing unit; 31. Mounting part; 311. Base plate; 312. Rib plate; 313. Sealing ring; 32. Mixing assembly; 321. Baffle plate; 4. Connector. Detailed Implementation

[0034] The following is in conjunction with the appendix Figures 1-4 This application will be described in further detail.

[0035] This application discloses a mixer for a liquid chromatograph. (Refer to...) Figure 1 A mixer for a liquid chromatograph includes a mixer housing and a mixing unit 3 installed inside the housing. The mixer is cylindrical in shape with an inlet and an outlet at its two ends. Fluid can enter from the inlet of the mixer, pass through the mixing unit 3 along the axial direction of the mixer to achieve thorough mixing, and then flow out from the outlet to the next process of the chromatograph. Specifically, connectors 4 are installed at both the inlet and outlet of the mixer. The connector 4 at the inlet is connected to the previous process through a pipe, and the connector 4 at the outlet is connected to the next process through a pipe.

[0036] Reference Figure 1 The mixer housing is divided into a first part 1 and a second part 12 along its axial direction. The first part 1 and the second part 12 are detachably connected. The internal space of the first part 1 is a liquid inlet channel 11, and the internal space of the second part 12 is a mixing chamber 21. When the first part 1 and the second part 12 are connected, the liquid inlet channel 11 and the mixing chamber 21 are naturally connected. The first part 1 has a first end and a second end, both of which are connected to the liquid inlet channel 11. The liquid inlet is located at the first end of the first part 1.

[0037] The mixing unit 3 is installed at the second end of the first part 1, and the overall shape of the mixing unit 3 is adapted to the mixing chamber 21. When the first part 1 is connected to the second part 12, the mixing unit 3 is fully placed in the mixing chamber 21. When the fluid enters from the inlet, it enters the mixing chamber 21 through the inlet flow channel 11 and is fully mixed by the mixing unit 3. The outlet is formed at the end of the second part 12 away from the first part 1. The fully mixed fluid continues to flow and finally flows out through the outlet.

[0038] Specifically, the mixing unit 3 consists of a mounting part 31 and a mixing component 32. The mixing component 32 is used to mix the fluids, and the mounting part 31 is used to connect the mixing component 32 to the first part 1. (Refer to...) Figure 3 and Figure 4The mounting part 31 includes a base plate 311 and a rib plate 312. The base plate 311 is annular. The mixing component 32 is fixed to the side of the base plate 311 away from the first part 1, and the rib plate 312 is fixed to the side of the base plate 311 close to the first part 1. A wedge-shaped groove is formed at the second end of the first part 1. The rib plate 312 is adapted to the wedge-shaped groove. The lower end of the wedge-shaped groove is open to allow the rib plate 312 to be inserted. When the rib plate 312 is fully inserted into the wedge-shaped groove, the mounting part 31 can be connected to the first part 1, that is, the mixing unit 3 is connected to the first part 1. Preferably, in order to ensure the connection effect and improve the connection stability, multiple wedge-shaped grooves and rib plates 312 are provided. Multiple rib plates 312 are evenly distributed in annular shape on the base plate 311. Each rib plate 312 extends radially along the base plate 311 and is perpendicular to the base plate 311. The connection and fixation are achieved by the friction between the rib plate 312 and the inner wall of the wedge-shaped groove.

[0039] The mixing component 32 consists of multiple baffles 321, each of which is a corrugated thin plate structure, with adjacent baffles 321 partially staggered. When the fluid enters the mixing chamber 21, it is diverted by each baffle 321. The diverted fluid flows along the bending direction of the baffles 321 and merges with other multiple fluid streams. After multiple diversions and mergings, thorough mixing is achieved. Since the specific structure and arrangement of the baffles 321 adopt conventional technology, they will not be described in detail.

[0040] Furthermore, a flow guide ring plate 12 is formed on the inner wall of the second end of the first part 1. The outer side of the flow guide ring plate 12 is fixedly connected to the inner wall of the first part 1, and the inner side extends slightly towards the middle and is inclined downward, so that the fluid entering the liquid inlet channel 11 can enter the mixing chamber 21 along the flow guide ring plate 12, ensuring that all fluids are mixed after passing through the mixing unit 3.

[0041] Furthermore, the flow guide ring plate 12 is configured such that its lower end face is flush with the lower end face of the first part 1, and the aforementioned wedge groove is formed on the lower end face of the flow guide ring plate 12. When the rib plate 312 is fully inserted into the wedge groove, the upper end face of the substrate 311 and the lower section of the first part 1 are in the same plane.

[0042] Reference Figure 3 The mounting part 31 also includes a sealing ring 313, which is annularly fixed to the outer peripheral surface of the substrate 311. The sealing ring 313 can be made of materials such as rubber or silicone, and its inner side is fixed to the substrate 311 by adhesive bonding or other connection methods. Correspondingly, a groove is formed on the upper end face of the second part 12. When the first part 1 and the second part 12 are connected, the sealing ring 313 is pressed into the groove to seal the connection between the first part 1, the mixing unit 3, and the second part 12, preventing fluid leakage from the connection.

[0043] Reference Figure 1 and Figure 2The first part 1 and the second part 12 can be connected in the following way: a threaded connection part 13 is provided on the side of the first part 1 facing the second part 12. The inner diameter of the threaded connection part 13 is equal to the inner diameter of the first part 1, and the outer diameter is smaller than the outer diameter of the first part 1. An external thread is formed on the outer circumferential surface of the threaded connection part 13. Correspondingly, an internal thread groove is provided on the side of the second part 12 facing the first part 1. Through the cooperation of the threaded connection part 13 and the internal thread groove, the second part 12 can be screwed onto the outside of the first part 1, so that the liquid inlet channel 11 and the mixing chamber 21 are naturally connected. When it is necessary to clean or replace the mixing unit 3, the second part 12 can be unscrewed from the first part 1, and the mixing unit 3 will be exposed to the outside. Then, a sufficient external force along the axial direction of the first part 1 is applied to the mixing unit 3, and the rib plate 312 can be pulled out from the wedge groove, realizing the separation of the mixing unit 3 from the first part 1.

[0044] The implementation principle of the mixer of a liquid chromatograph in this application embodiment is as follows: when the mixer is working, the pump body pumps multiple fluids through the inlet to the inlet channel 11. The fluids are mixed along the inlet channel 11 through the mixing unit 3 in the mixing chamber 21 and then discharged from the outlet.

[0045] When the mixing component 32 needs to be cleaned, the operator can separate the pipe connecting the inlet and outlet connector 4, remove the mixer, and then rotate the second part 12 to completely separate it from the first part 1. After separation, the mixing component 32 is exposed to the outside for easy cleaning. After cleaning, the second part 12 is installed, and then the mixer is reset as a whole.

[0046] When the mixing unit 3 needs to be replaced or disassembled, the operator first unscrews the second part 12, then applies an external force away from the first part 1 to the mixing assembly 32, causing the rib plate 312 to be pulled out of the wedge groove, and the mixing assembly 32 is separated from the first part 1. After maintenance or replacement, the mixing assembly 32 is reinserted and the second part 12 is screwed back on.

[0047] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A mixer for a liquid chromatograph, characterized in that, include: The first part (1) has a first end and a second end, and an inlet channel (11) connecting the first end and the second end. The second part (2) is detachably installed on the second end, and the second part (2) has a mixing chamber (21) which is connected to the liquid inlet channel (11); The mixing unit (3) is installed at the second end and can be accommodated in the mixing chamber (21).

2. The mixer for a liquid chromatograph according to claim 1, characterized in that: The mixing unit (3) includes a mounting part (31) and a mixing component (32). The mixing component (32) is fixed on the mounting part (31) and is detachably connected to the first part (1) through the mounting part (31).

3. The mixer for a liquid chromatograph according to claim 2, characterized in that: The hybrid component (32) includes a plurality of baffles (321) that are spaced apart and extend away from the first part (1), and each baffle (321) is configured as a corrugated structure.

4. The mixer for a liquid chromatograph according to claim 2, characterized in that: The mounting part (31) includes a base plate (311) and a rib plate (312). The base plate (311) is annular. The hybrid assembly (32) is fixed inside the base plate (311). The rib plate (312) is disposed on the end face of the base plate (311) near the first part (1) and perpendicular to the base plate (311). Multiple rib plates (312) are provided. Each rib plate (312) is evenly distributed and extends radially along the base plate (311).

5. The mixer for a liquid chromatograph according to claim 4, characterized in that: The mounting part (31) also includes a sealing ring (313), which is fixed in a ring shape on the outer peripheral surface of the substrate (311). The end face of the second part (2) that mates with the first part (1) is provided with a groove, and the sealing ring (313) can be press-fitted into the groove.

6. The mixer for a liquid chromatograph according to claim 4, characterized in that: The second end of the first part (1) is provided with a flow guide ring plate (12). The inner diameter of the flow guide ring plate (12) is larger than the inner diameter of the substrate (311). The flow guide ring plate (12) has a plurality of wedge-shaped grooves on the side facing the outside of the first part (1). The rib plate (312) is adapted to the wedge-shaped grooves to connect the mixing unit (3) to the first part (1).

7. A mixer for a liquid chromatograph according to any one of claims 1-6, characterized in that: The first end is provided with a liquid inlet, which is connected to the liquid inlet channel (11). The second part (2) is provided with a liquid outlet at the end away from the first part (1), which is connected to the mixing chamber (21). Both the liquid inlet and the liquid outlet are provided with connectors (4).

8. The mixer for a liquid chromatograph according to claim 7, characterized in that: The second end is provided with a threaded connection part (13), and the second part (2) is provided with an internal thread at one end near the second end so as to thread the first part (1) and the second part (2) together.

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