High-efficiency sampling device of ultra-high performance liquid chromatography tandem mass spectrometer

Abstract

The utility model discloses a high-efficiency sampling device of an ultra-high performance liquid chromatography tandem mass spectrometer, which comprises a support, and a linkage adjusting mechanism is mounted in the middle of the top end of the support. The device has the beneficial effects that the linkage adjusting mechanism consisting of the racks, the sliding strips, the test tube placing seats, the clamping holes, the motor and the gear is mounted on the support, so that after a sample test tube on one test tube placing seat is used, the gear rotates under the action of the motor, and the gear can be matched with the corresponding rack after rotating; therefore, the used test tube placing seat slides out of the support, and the other test tube placing seat on which the sample test tube is placed is moved into the support, so that the sample test tube on the other test tube placing seat can be continuously fed when the sample test tube on one test tube placing seat is replaced, and the sample test tube on the other test tube placing seat can be conveniently replaced. The interruption of the sample introduction process of the ultra-high performance liquid chromatography tandem mass spectrometer is avoided, and the sample introduction efficiency of the ultra-high performance liquid chromatography tandem mass spectrometer is higher.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of ultra performance liquid chromatography tandem mass spectrometer, specifically relates to a kind of high-efficiency sampling device of ultra performance liquid chromatography tandem mass spectrometer. BACKGROUND

[0002] Ultra performance liquid chromatography tandem mass spectrometer is a kind of analytical instrument combined with ultra performance liquid chromatography and tandem mass spectrometry technology.The existing ultra performance liquid chromatography tandem mass spectrometer sampling device is mainly composed of a sample test tube placing seat, an adjusting mechanism installed on the sample test tube placing seat and a liquid suction needle installed on the adjusting mechanism during negative pressure flushing, which is composed of the adjusting mechanism.The sampling device is used to place the sample test tube on the sample test tube placing seat, and then move the liquid suction needle to the corresponding sample test tube under the action of the adjusting mechanism, so as to suck the sample test tube containing the detection liquid into the sample test tube by means of the liquid suction needle, so as to detect the sample by chromatography mass spectrometry.

[0003] Although the existing ultra performance liquid chromatography tandem mass spectrometer sampling device can realize the suction sampling of the sample to be detected, since there is only one test tube placing seat in the device, it is easy to replace the sample test tube on the test tube placing seat for a long time, which leads to the discontinuity of the sampling process of the ultra performance liquid chromatography tandem mass spectrometer and low sampling efficiency. UTILITY MODEL CONTENT

[0004] (I) Technical problem to be solved

[0005] The technical problem to be solved by the utility model is to provide a high-efficiency sampling device of ultra performance liquid chromatography tandem mass spectrometer, which can ensure the continuous sampling of the sample to be detected by alternating sampling and has high sampling efficiency.

[0006] (II) Technical scheme

[0007] The utility model realizes the following technical scheme: the utility model provides a kind of high-efficiency sampling device of ultra performance liquid chromatography tandem mass spectrometer, including support, the support top middle part is equipped with linkage adjusting mechanism, the linkage adjusting mechanism includes rack, slide, test tube placing seat, clamping hole, motor and gear, wherein the test tube placing seat has two, two test tube placing seat is symmetrically installed on the support upper end two sides, the clamping hole is set to each test tube placing seat, the slide is installed on the test tube placing seat one side wall, the rack is installed on the test tube placing seat other side wall, the rack between two test tube placing seats is provided with the gear, the power input end of the gear is connected with the motor, the support is located on the linkage adjusting mechanism upside and is also equipped with sampling mechanism.

[0008] Furthermore, the sample injection mechanism includes a suction needle, a second electric slide rail, a lifting block, an electric telescopic rod, and a first electric slide rail.

[0009] By adopting the above technical solution, the electric slide rail is mainly used to realize the movement of the suction needle along the length direction of the support, and the electric telescopic rod is mainly used to realize the convenient lifting and lowering adjustment of the suction needle.

[0010] Furthermore, there are two electric slide rails, which are installed in parallel on both sides of the upper end of the support.

[0011] By adopting the above technical solution, the electric slide rail is mainly used to realize the movement of the aspiration needle along the width direction of the support, so as to realize the rapid aspiration of the sample in the test tube through the aspiration needle during sample injection.

[0012] Furthermore, each of the electric slide rails has a sliding block connected to an electric telescopic rod, and the telescopic part of the electric telescopic rod is connected to the electric slide rail.

[0013] By adopting the above technical solution, the electric telescopic rod can not only realize the lifting and lowering of the suction needle, but also ensure the synchronous movement and adjustment of the suction needle on the electric slide rail.

[0014] Furthermore, the electric slide rail has a built-in sliding block connected to the lifting block, and a suction needle is installed on one side of the lifting block.

[0015] By adopting the above technical solution, the hanging block can ensure the reliable installation of the aspiration needle, which is a negative pressure suction sampling needle.

[0016] Furthermore, the motor is connected to the gear coupling, and the gear meshes with the rack.

[0017] By adopting the above technical solution, after the motor drives the gear to rotate, the gear will cooperate with the rack to realize the synchronous movement of the two test tube placement seats, ensuring that when one test tube placement seat enters into the support, the other test tube placement seat slides out from the support.

[0018] Furthermore, the test tube holder is slidably fitted with the support, and the locking hole penetrates through the test tube holder.

[0019] By adopting the above technical solution, the card hole can reliably place the test tube of the sample to be tested.

[0020] Furthermore, a support plate is welded to each side of the bottom end of the support, and the support plate has an inverted L-shaped structure.

[0021] By adopting the above technical solution, the support can ensure stable placement of the support in the ultra-high performance liquid chromatography-tandem mass spectrometer.

[0022] (III) Beneficial Effects

[0023] Compared with the prior art, this utility model has the following advantages:

[0024] To address the problem that existing ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS / MS) sample introduction devices, while capable of sample aspiration and injection, suffer from low efficiency due to the single test tube holder, which leads to prolonged sample tube replacement time and thus discontinuous injection process, this invention addresses this issue. It employs a linkage adjustment mechanism on a support, consisting of a rack, slider, test tube holder, locking hole, motor, and gears. After a sample tube in one holder is used, the motor rotates the gears, which engage with the rack to slide the used test tube holder out of the support. Meanwhile, the other test tube holder, now holding a sample tube, is moved into the support. This ensures that sample tubes in the other holder can continue to be injected while one holder is being replaced, preventing interruptions in the UHPLC-MS / MS injection process and resulting in higher injection efficiency. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the high-efficiency sample introduction device of the ultra-high performance liquid chromatography-tandem mass spectrometer described in this utility model;

[0026] Figure 2 This is a front cross-sectional view of the support in the high-efficiency sample introduction device of the ultra-high performance liquid chromatography-tandem mass spectrometer described in this utility model;

[0027] Figure 3 This is a schematic diagram of the test tube placement seat in the high-efficiency sample introduction device of the ultra-high performance liquid chromatography-tandem mass spectrometer described in this utility model.

[0028] The annotations in the attached figures are explained as follows:

[0029] 1. Sample injection mechanism; 101. Aspiration needle; 102. Electric slide rail II; 103. Lifting block; 104. Electric telescopic rod; 105. Electric slide rail I; 2. Linkage adjustment mechanism; 201. Rack; 202. Slide bar; 203. Test tube holder; 204. Locking hole; 205. Motor; 206. Gear; 3. Support plate; 4. Support. Detailed Implementation

[0030] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present utility model and are not intended to limit the present utility model.

[0031] like Figures 1-3 As shown, this embodiment of an ultra-high performance liquid chromatography-tandem mass spectrometer (UHPLC-MS / MS) high-efficiency sample introduction device includes a support 4. A linkage adjustment mechanism 2 is installed at the center of the top of the support 4. The linkage adjustment mechanism 2 includes a rack 201, a slider 202, a test tube holder 203, a locking hole 204, a motor 205, and a gear 206. There are two test tube holders 203, symmetrically installed on both sides of the upper end of the support 4. Each test tube holder 203 has a locking hole 204. A slider 202 is installed on one side wall of the test tube holder 203. A rack 201 is installed on the other side wall of the tube placement seat 203. A gear 206 is set between the racks 201 on the two tube placement seats 203. The power input end of the gear 206 is connected to a motor 205. A sample feeding mechanism 1 is also installed on the support 4 above the linkage adjustment mechanism 2. After the motor 205 drives the gear 206 to rotate, the gear 206 will cooperate with the rack 201 to realize the synchronous movement of the two tube placement seats 203, ensuring that when one tube placement seat 203 enters into the support 4, the other tube placement seat 203 slides out of the support 4.

[0032] like Figure 1 As shown, in this embodiment, the sample injection mechanism 1 includes a suction needle 101, an electric slide rail 2 102, a lifting block 103, an electric telescopic rod 104, and an electric slide rail 105. The electric slide rail 2 102 is mainly used to realize the movement of the suction needle 101 along the length direction of the support 4, and the electric telescopic rod 104 is mainly used to realize the convenient lifting and lowering adjustment of the suction needle 101.

[0033] like Figure 1 As shown, in this embodiment, there are two electric slide rails 105, which are installed in parallel on both sides of the upper end of the support 4. The electric slide rails 105 are mainly used to realize the movement of the aspiration needle 101 along the width direction of the support 4, so that the sample in the test tube can be quickly aspirated through the aspiration needle 101 during sample injection. Each electric slide rail 105 has a sliding block connected to an electric telescopic rod 104. The telescopic part of the electric telescopic rod 104 is connected to the electric slide rail 105. The electric telescopic rod 104 can not only realize the lifting and lowering of the aspiration needle 101, but also ensure the synchronous movement and adjustment of the aspiration needle 101 with the electric slide rail 105. The sliding block on the electric slide rail 105 is connected to a hanging block 103. The aspiration needle 101 is installed on one side of the hanging block 103. The hanging block 103 can ensure the reliable installation of the aspiration needle 101. The aspiration needle 101 is a negative pressure aspiration sampling needle.

[0034] like Figures 1-3 As shown, in this embodiment, the motor 205 is connected to the gear 206 via a coupling, the gear 206 meshes with the rack 201, the test tube holder 203 slides with the support 4, and the locking hole 204 penetrates the test tube holder 203. The locking hole 204 can reliably place the test tube of the sample to be tested. A support plate 3 is also welded to both sides of the bottom end of the support 4. The support plate 3 has an inverted L-shaped structure. The support 4 can ensure the stable placement of the support 4 in the ultra-high performance liquid chromatography-tandem mass spectrometer.

[0035] The specific implementation process of this embodiment is as follows: When introducing a sample to be tested using an ultra-high performance liquid chromatography-tandem mass spectrometer (UHPLC-MS / MS), the support 4 is first placed at the liquid inlet position in the UHPLC-MS / MS. Then, under the action of the electric slide rail 105, the electric slide rail 202, and the electric telescopic rod 104, the aspiration needle 101 is inserted into the sample tube on the corresponding test tube holder 203 as needed. This allows the sample to be tested to be aspirated from the test tube and sent to the UHPLC-MS / MS for chromatographic and mass spectrometric detection. During the injection process, when one test tube... After the sample tubes on the placement seat 203 are used, the gear 206 rotates under the action of the motor 205. After the gear 206 rotates, it will cooperate with the corresponding rack 201, thereby sliding the used sample tube placement seat 203 out of the support 4. The other sample tube placement seat 203 with the sample tube placed is moved into the support 4. This ensures that when the sample tubes on one sample tube placement seat 203 are replaced, the sample tubes on the other sample tube placement seat 203 can continue to be injected, avoiding the interruption of the ultra-high performance liquid chromatography-tandem mass spectrometry injection process and making the injection efficiency of ultra-high performance liquid chromatography-tandem mass spectrometry higher.

[0036] The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer, characterized in that: The support (4) includes a support base (4), and a linkage adjustment mechanism (2) is installed at the center of the top of the support base (4). The linkage adjustment mechanism (2) includes a rack (201), a slide bar (202), a test tube holder (203), a locking hole (204), a motor (205), and a gear (206). There are two test tube holders (203), which are symmetrically installed on both sides of the upper end of the support base (4). Each test tube holder (203) has a locking hole. Hole (204), a slide bar (202) is installed on one side wall of the test tube placement seat (203), a rack (201) is installed on the other side wall of the test tube placement seat (203), a gear (206) is provided between the racks (201) on the two test tube placement seats (203), the power input end of the gear (206) is connected to the motor (205), and a sample feeding mechanism (1) is also installed on the support (4) above the linkage adjustment mechanism (2).

2. The high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that: The sample injection mechanism (1) includes a suction needle (101), an electric slide rail two (102), a lifting block (103), an electric telescopic rod (104), and an electric slide rail one (105).

3. The high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer according to claim 2, characterized in that: There are two electric slide rails (105), and the two electric slide rails (105) are installed in parallel on both sides of the upper end of the support (4).

4. The high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer according to claim 3, characterized in that: Each of the electric slide rails (105) has a sliding block connected to an electric telescopic rod (104), and the telescopic part of the electric telescopic rod (104) is connected to the electric slide rail (105).

5. The high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer according to claim 2, characterized in that: The electric slide rail (105) has a sliding block connected to the lifting block (103), and a suction needle (101) is installed on one side of the lifting block (103).

6. The high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that: The motor (205) is connected to the gear (206) coupling, and the gear (206) meshes with the rack (201).

7. The high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer according to claim 6, characterized in that: The test tube holder (203) is slidably fitted with the support (4), and the locking hole (204) passes through the test tube holder (203).

8. The high-efficiency sample introduction device for an ultra-high performance liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that: The support (4) is also welded with a support plate (3) on both sides of its bottom end. The support plate (3) has an inverted L-shaped structure.

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