Sampling device with pressure control

Abstract

The utility model discloses a sampling device with pressure control, and aims to solve the problem of pressure unbalance of a freeze dryer in multiple sampling processes. The sampling device comprises a mounting connection assembly, a pressure control assembly and a sampling platform which are connected in sequence. The mounting and connecting assembly comprises a flange plate and a sampling channel and is used for communicating the sampling device with the freeze dryer; the pressure control assembly comprises a vacuum isolation valve and a U-shaped air entrainment valve and is used for controlling the pressure balance of the sampling device and the freeze dryer. The sampling device adjusts the opening degree of the air entrainment valve through a PID control algorithm, the accuracy and reliability of pressure control are ensured, and the operation efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of freeze-drying sampling, and in particular to a sampling device with pressure control. Background Technology

[0002] Freeze-drying is a preservation method that involves pre-freezing aqueous substances into a solid state and then sublimating the water content directly into a gaseous state under vacuum. Items dried using this method retain their original chemical and biological properties, making them suitable for long-term storage. Furthermore, they can be restored to their pre-freeze-dried form upon rehydration and maintain their original biochemical characteristics, making it a superior drying method. To determine and optimize freeze-drying process parameters, it is necessary to observe and test samples during the freeze-drying process using sampling devices.

[0003] While existing freeze dryer sampling devices can complete the initial sampling without disrupting the freeze-drying process, problems arise during secondary sampling. This is because the sampling platform is reinstalled after the initial sampling, at which point the internal pressure of the sampling platform is atmospheric pressure, while the freeze dryer is under negative pressure. During secondary sampling, the atmospheric pressure within the sampling platform causes a sharp increase in the internal pressure of the freeze dryer. This not only affects the accuracy of process testing but can also, in severe cases, damage the batch of freeze-dried samples. This pressure imbalance prevents existing sampling devices from meeting the requirements for continuous, multiple sampling operations. Utility Model Content

[0004] The purpose of this invention is to provide a sampling device with pressure control to solve the problem of pressure imbalance that occurs in existing freeze dryer sampling devices during multiple sampling processes.

[0005] To solve the above-mentioned technical problems, this utility model provides a sampling device with pressure control, comprising:

[0006] Install a connection component to connect the sampling device to the freeze dryer;

[0007] A pressure control component is used to control the pressure balance between the sampling device and the freeze dryer;

[0008] The sampling platform is used to hold the samples;

[0009] The installation connection component, the pressure control component, and the sampling platform are connected in sequence.

[0010] Furthermore, the mounting connection assembly includes a flange; the flange is connected to the freeze dryer.

[0011] Furthermore, the mounting connection assembly also includes a sampling channel; one end of the sampling channel is connected to the flange.

[0012] Furthermore, the sampling channel is configured in an arc shape.

[0013] Furthermore, the pressure control component includes a vacuum isolation valve; one end of the vacuum isolation valve is connected to the other end of the sampling channel, and the other end of the vacuum isolation valve is connected to the sampling platform.

[0014] Furthermore, the pressure control component also includes an air mixing valve; the two ends of the air mixing valve are respectively connected to the two ends of the vacuum isolation valve.

[0015] Furthermore, the gas mixing valve is configured as a U-shape.

[0016] Furthermore, it also includes a fixing connector for connecting and securing the mounting connection assembly, the pressure control assembly, and the sampling platform.

[0017] Furthermore, the fixing connector includes a first clamp, which is disposed at the connection between the vacuum isolation valve and the sampling channel.

[0018] Furthermore, the fixing connector also includes a second clamp, which is disposed at the connection between the vacuum isolation valve and the sampling platform.

[0019] Compared with the prior art, the present invention has at least the following beneficial effects:

[0020] This invention achieves precise pressure control between the sampling platform and the freeze-drying chamber by setting a combination structure of a gas-injection valve and a vacuum isolation valve in the sampling device. This ensures that the internal pressure of the freeze-drying chamber remains stable during multiple samplings, effectively avoiding adverse effects on the freeze-dried samples caused by sudden pressure changes. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the sampling device in one embodiment of the present invention.

[0022] Reference numerals: 1. Flange; 2. Gas mixing valve; 3. Sampling platform; 4. First clamp; 5. Vacuum isolation valve; 6. Second clamp; 7. Sampling channel. Detailed Implementation

[0023] The following is a more detailed description of a pressure-controlled sampling device according to the present invention, with reference to the accompanying drawings, which illustrate preferred embodiments of the present invention. It should be understood that those skilled in the art can modify the present invention described herein while still achieving its advantageous effects. Therefore, the following description should be understood as being of general knowledge to those skilled in the art and is not intended to limit the present invention.

[0024] The present invention will be described in more detail below by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer from the following description. It should be noted that the drawings are in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.

[0025] like Figure 1 As shown, this utility model embodiment proposes a sampling device with pressure control, comprising:

[0026] Install a connection component to connect the sampling device to the freeze dryer;

[0027] A pressure control component is used to control the pressure balance between the sampling device and the freeze dryer;

[0028] Sampling platform 3 is used to hold the sample;

[0029] The installation connection component, the pressure control component, and the sampling platform 3 are connected in sequence.

[0030] Specifically, the mounting and connection assembly includes a flange 1 and a sampling channel 7. The flange 1 is connected to the freeze dryer by screws; one end of the sampling channel 7 is connected to the flange 1 and fixed by welding.

[0031] Preferably, the sampling channel 7 is configured in an arc shape.

[0032] In this embodiment, the pressure control component includes a vacuum isolation valve 5 and a gas mixing valve 2, the gas mixing valve 2 being used to balance the pressure between the freeze-drying chamber and the sampling platform 3.

[0033] One end of the vacuum isolation valve 5 is connected to the other end of the sampling channel 7, and the other end of the vacuum isolation valve 5 is connected to the sampling platform 3. The vacuum isolation valve 5 is closed when sampling is not required, and is only opened when sampling is required; when sampling is performed, the vacuum isolation valve 5 immediately closes after the sample falls onto the sampling platform 3.

[0034] The two ends of the gas mixing valve 2 are respectively connected to the two ends of the vacuum isolation valve 5, forming three working states:

[0035] When the gas mixing valve 2 is closed, the vacuum isolation valve 5 is opened, and the sampling platform 3 is connected to the freeze dryer housing through the vacuum isolation valve 5.

[0036] When the gas mixing valve 2 is opened, the vacuum isolation valve 5 is closed, and the sampling platform 3 is connected to the freeze dryer housing through the gas mixing valve 2.

[0037] When the vacuum isolation valve 5 and the gas mixing valve 2 are closed simultaneously, the sampling platform 3 is isolated from the freeze dryer housing.

[0038] Preferably, the gas mixing valve 2 is configured as a U-shape.

[0039] During the rapid and precise pressure control process, the vacuum gauge installed on the freeze dryer housing is used as a signal feedback point for pressure control. Based on the feedback signal and the target pressure, PID control logic is used to output the opening degree of the gas-introducing valve 2, thereby introducing the gas inside the sampling platform 3 into the freeze dryer housing. Since the vacuum pump inside the freeze dryer is always running, when the reading on the vacuum gauge on the freeze dryer housing is slightly less than the target pressure, it indicates that the pressure between the sampling platform 3 and the freeze dryer housing is stabilizing. The specific parameter settings of the PID control algorithm are common practice for those skilled in the art and will not be elaborated further.

[0040] In this embodiment, the sampling device further includes a fixing connector for connecting and fixing the mounting connection assembly, the pressure control assembly, and the sampling platform 3.

[0041] The fixing connection includes a first clamp 4 and a second clamp 6. The first clamp 4 is located at the connection between the vacuum isolation valve 5 and the sampling channel 7, and the vacuum isolation valve 5 and the sampling channel 7 are fixedly connected by screws. The second clamp 6 is located at the connection between the vacuum isolation valve 5 and the sampling platform 3, and the vacuum isolation valve 5 and the sampling platform 3 are fixedly connected by screws.

[0042] The working process of this sampling device is as follows:

[0043] During normal freeze-drying, the vacuum isolation valve 5 and the gas-injecting valve 2 remain closed, isolating the sampling platform 3 from the freeze-drying chamber. When sampling is required, the current pressure value is first read through the vacuum gauge on the freeze-drying chamber. Based on the current pressure value and the preset target pressure value, a PID control algorithm is used to calculate the opening degree of the gas-injecting valve 2. The gas-injecting valve 2 adjusts its opening degree according to the calculation result to achieve pressure balance between the sampling platform 3 and the freeze-drying chamber.

[0044] When the pressure value displayed by the vacuum gauge is lower than the target pressure value, it indicates that the sampling platform 3 and the freeze dryer chamber pressure have reached equilibrium. At this time, close the gas mixing valve 2 and open the vacuum isolation valve 5 to allow the sample to slide into the sampling platform 3. Then close the vacuum isolation valve 5, loosen the screws of the first clamp 4, and remove the sampling platform 3 to complete the sampling operation.

[0045] The specific parameter settings of the PID control algorithm are common practices for those skilled in the art and will not be elaborated further.

[0046] The beneficial effects of this invention are as follows: Through the combined use of the gas-injecting valve 2 and the vacuum isolation valve 5, precise pressure control between the sampling platform 3 and the freeze-drying chamber is achieved, avoiding pressure imbalance during multiple sampling processes. Simultaneously, the use of a PID control algorithm to adjust the opening of the gas-injecting valve 2 ensures the accuracy and reliability of pressure control. Furthermore, the clamp-type connection structure design makes the installation and disassembly of the sampling platform 3 more convenient, improving the operational efficiency of the equipment.

[0047] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A sampling device with pressure control, characterized in that, include: Install a connection component to connect the sampling device to the freeze dryer; A pressure control component is used to control the pressure balance between the sampling device and the freeze dryer; The sampling platform is used to hold the samples; The installation connection component, the pressure control component, and the sampling platform are connected in sequence.

2. The sampling device as described in claim 1, characterized in that, The mounting connection assembly includes a flange; the flange is connected to the freeze dryer.

3. The sampling device as described in claim 2, characterized in that, The mounting connection assembly also includes a sampling channel; one end of the sampling channel is connected to the flange.

4. The sampling device as described in claim 3, characterized in that, The sampling channel is configured in an arc shape.

5. The sampling device as described in claim 3 or 4, characterized in that, The pressure control component includes a vacuum isolation valve; one end of the vacuum isolation valve is connected to the other end of the sampling channel, and the other end of the vacuum isolation valve is connected to the sampling platform.

6. The sampling device as described in claim 5, characterized in that, The pressure control assembly also includes an air mixing valve; the two ends of the air mixing valve are respectively connected to the two ends of the vacuum isolation valve.

7. The sampling device as described in claim 6, characterized in that, The gas mixing valve is configured as a U-shape.

8. The sampling device as described in claim 5, characterized in that, It also includes a fixing connector for connecting and securing the mounting connection assembly, the pressure control assembly, and the sampling platform.

9. The sampling device as described in claim 8, characterized in that, The fixing connector includes a first clamp, which is disposed at the connection between the vacuum isolation valve and the sampling channel.

10. The sampling device as described in claim 9, characterized in that, The fixing connector also includes a second clamp, which is disposed at the connection between the vacuum isolation valve and the sampling platform.

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