Reaction liquid mixing mechanism

Abstract

The utility model discloses a reaction liquid mixing mechanism, which is used for uniformly mixing reaction liquid containing magnetic beads, and comprises a mounting seat and a plurality of magnetic beads, the uniform mixing assembly comprises a driving motor mounted on the mounting seat and an eccentric cup seat driven by the driving motor to rotate; the upper part of the eccentric cup seat is suitable for placing a reaction cup, and the eccentric cup seat can drive the reaction cup on the eccentric cup seat to shake during rotation so as to uniformly mix reaction liquid in the reaction cup; and the magnet assembly is mounted on the mounting seat and is used for generating magnetic field force which moves towards the cup wall direction of the reaction cup to the magnetic beads in the reaction cup on the eccentric cup seat. Compared with a traditional uniform mixing mode that only a uniform mixing assembly is used, the magnet assembly is additionally arranged for uniform mixing of the reaction liquid, the magnetic field generated by the magnet assembly can scatter the magnetic beads in the reaction liquid and pull the magnetic beads to the cup wall of the reaction cup, the uniform mixing speed of the reaction liquid can be increased, the reaction liquid can be mixed more sufficiently, and the reaction effect is improved. And the accuracy of subsequent test results can be improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to in-vitro diagnosis analysis equipment technical field, concretely relates to a reaction liquid mixing mechanism. BACKGROUND

[0002] Full-automatic chemiluminescence immunoassay analyzer is the equipment that utilizes chemical luminescent reagent direct mark antigen antibody to carry out analysis.

[0003] Magnetic bead cleaning and separation is a key step in the process of chemiluminescence immunoassay.

[0004] However, the existing centrifugal mixing mechanism can only simply utilize the centrifugal force in the rotation process of the reaction liquid to mix the reaction liquid, and the mixing time is long, the mixing effect of the reaction liquid is poor, and the accuracy of the subsequent test results is affected. TECHNICAL SOLUTION

[0005] Therefore, the utility model provides a reaction liquid mixing mechanism to solve the technical problem of slow mixing speed, poor mixing effect and influence on the accuracy of subsequent test results of the existing reaction liquid mixing mechanism.

[0006] To solve the above technical problem, the technical scheme of the utility model is as follows:

[0007] A reaction liquid mixing mechanism comprises:

[0008] A mounting seat;

[0009] A mixing assembly comprising a driving motor and an eccentric cup seat mounted on the mounting seat; the eccentric cup seat is adapted to place a reaction cup above, and the eccentric cup seat can drive the reaction cup above to shake to mix the reaction liquid in the reaction cup when rotating;

[0010] A magnet assembly mounted on the mounting seat, the magnet assembly is used to generate a magnetic field force in the direction of the reaction cup wall for the magnetic beads in the reaction cup on the eccentric cup seat.

[0011] By adopting the technical scheme, in the process of mixing the reaction liquid containing magnetic beads in the reaction cup, in addition to rotating the eccentric cup seat driven by the driving motor to drive the reaction cup to shake to mix the reaction liquid containing magnetic beads in the reaction cup, the magnet assembly is additionally arranged on the mounting seat, the magnetic field generated by the magnet assembly can disperse the magnetic beads in the reaction liquid, and the magnetic beads are pulled to the cup wall of the reaction cup through the magnetic field force, which is beneficial to uniformly adsorbing the magnetic beads on the inner wall of the reaction cup, the mixing rate of the reaction liquid can be increased by cooperation of the magnet assembly and the mixing assembly, the mixing of the reaction liquid is more sufficient, the mixing effect is improved, and the problem of affecting the accuracy of subsequent test results due to insufficient mixing of the reaction liquid is avoided.

[0012] Further, the eccentric cup seat is formed with a reaction cup shaking space above the eccentric cup seat for the reaction cup to shake; the magnet assembly comprises a first magnet and a second magnet located on opposite sides of the reaction cup shaking space, and the S pole of the first magnet and the N pole of the second magnet are oppositely arranged.

[0013] By adopting the technical scheme, a pair of oppositely arranged first magnet and second magnet are used to form a magnetic field at the position of the reaction cup, which is simple in structure and easy to implement.

[0014] Further, the magnet assembly further comprises a magnet mounting bracket fixed on the mounting seat; the first magnet and the second magnet are both mounted on the magnet mounting bracket.

[0015] By adopting the technical scheme, the first magnet and the second magnet are mounted on the same magnet mounting bracket, which has the advantages of simple structure and low cost.

[0016] Further, the magnet mounting bracket is provided with a hollow slot in the middle, the hollow slot is located directly above the eccentric cup seat, and the reaction cup mounted on the eccentric cup seat passes through the hollow slot.

[0017] By adopting the technical scheme, the hollow slot on the magnet mounting bracket can leave space for mounting the reaction cup on the eccentric cup seat, reduce the interference of the magnet mounting bracket on the mounting process of the reaction cup, and facilitate the mounting of the reaction cup on the eccentric cup seat.

[0018] Further, in the direction of the line connecting the first magnet and the second magnet, the distance between the first magnet and the second magnet is adjustable.

[0019] By adopting the technical scheme, the distance between the first magnet and the second magnet is adjustable, which can control the size of the magnetic field force and meet the adsorption effect of different magnetic beads.

[0020] Further, the magnet assembly further comprises an adjusting and locking structure mounted on the magnet mounting bracket, which is used to adjust the distance of the first magnet and the second magnet along the connecting line direction and lock the first magnet and the second magnet on the magnet mounting bracket.

[0021] By adopting the above technical scheme, the first magnet and the second magnet are adjusted and locked in position by the adjusting and locking structure, which is simple in structure and easy to implement.

[0022] Further, the magnet mounting bracket is provided with a first slot, the length direction of the first slot is parallel to the connecting line direction of the first magnet and the second magnet; the adjusting and locking structure comprises a first adjusting and locking bolt connected between the first slot and the first magnet, and the locking position of the first adjusting and locking bolt on the first slot is adjustable.

[0023] By adopting the above technical scheme, the first magnet is adjusted and locked in position by the first adjusting and locking bolt and the first slot, which is simple in structure and easy to implement.

[0024] Further, the magnet mounting bracket is further provided with a second slot, the length direction of the second slot is parallel to the length direction of the first slot; the adjusting and locking structure further comprises a second adjusting and locking bolt connected between the second slot and the second magnet, and the locking position of the second adjusting and locking bolt on the second slot is adjustable.

[0025] By adopting the above technical scheme, the second magnet is adjusted and locked in position by the second adjusting and locking bolt and the second slot, which is simple in structure and easy to implement.

[0026] Further, a first magnet sleeve is sleeved and fixed on the first magnet, and a second magnet sleeve is sleeved and fixed on the second magnet; the first magnet sleeve is connected to the first slot through the first adjusting and locking bolt, and the second magnet sleeve is connected to the second slot through the second adjusting and locking bolt.

[0027] By adopting the above technical scheme, the first magnet and the second magnet are fixed in position by the magnet sleeves, which does not need to open a connecting hole on the magnet for fixing, and facilitates the fixation of the magnet.

[0028] Further, the magnet mounting bracket comprises a horizontal plate and a vertical plate arranged in an L shape; the horizontal plate is fixed on the mounting seat, and the first slot and the second slot are arranged on the vertical plate.

[0029] By adopting the technical scheme, the magnet mounting bracket is designed as an L shape, and the first and second strip-shaped grooves are designed on the vertical plate, so that the influence of the fixing screws between the magnet mounting bracket and the mounting seat on the position adjustment of the magnet can be reduced, and the first and second magnets can be adjusted in a larger interval range.

[0030] In summary, the technical scheme of the utility model has the following advantages:

[0031] 1. The magnet assembly increases the mixing rate of the reaction liquid, improves the mixing effect, and is beneficial to improving the accuracy of subsequent test results.

[0032] 2. The magnetic field generated by the magnet assembly can disperse the magnetic beads in the reaction liquid, and the magnetic beads are pulled to the cup wall of the reaction cup by the magnetic field force, which is beneficial to the uniform adsorption of the magnetic beads on the inner wall of the reaction cup.

[0033] 3. The distance between the first and second magnets is adjustable, the magnetic field force can be controlled, and the adsorption effect of different magnetic beads can be met. BRIEF DESCRIPTION OF DRAWINGS

[0034] In order to more clearly illustrate the specific embodiment of the utility model or the technical scheme in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiment or the prior art description. Obviously, the drawings in the following description are some embodiments of the utility model, and those skilled in the art can also obtain other drawings according to these drawings without creating creative labor.

[0035] Figure 1 It is a schematic view of the connection relationship between the reaction liquid mixing mechanism and the light measuring disc device in the automatic chemiluminescence analysis equipment in the embodiment of the utility model.

[0036] Figure 2 It is a structural schematic view of the reaction liquid mixing mechanism in the embodiment of the utility model.

[0037] Figure 3 It is a schematic view of the position relationship between the magnet assembly and the reaction cup in the embodiment of the utility model.

[0038] Explanation of reference numerals: 100, mounting seat; 200, mixing assembly; 210, driving motor; 220, eccentric cup seat; 300, magnet assembly; 310, first magnet; 320, second magnet; 330, magnet mounting bracket; 331, horizontal plate; 3331, hollow groove; 332, vertical plate; 3321, first strip-shaped groove; 3322, second strip-shaped groove; 340, first adjusting locking bolt; 350, second adjusting locking bolt; 360, first magnet sleeve; 370, second magnet sleeve; 400, reaction cup; 401, cup wall; 500, lifting driving motor. Detailed Implementation

[0039] The technical solution of this utility model will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0040] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0041] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0042] like Figure 1 Figure 3 shows a reaction liquid mixing mechanism, which is mainly used in fully automated chemiluminescence analysis equipment for mixing reaction liquid containing magnetic beads in a reaction cup. The mixing mechanism includes a mounting base 100, a mixing assembly 200, and a magnet assembly 300, both mounted on the mounting base 100. The mixing assembly 200 includes a drive motor 210 mounted on the mounting base 100 and an eccentric cup holder 220 driven to rotate by the drive motor 210. A reaction cup 400 is placed on top of the eccentric cup holder 220, and the rotation of the eccentric cup holder 220 causes the reaction cup 400 to shake, thus mixing the reaction liquid inside the reaction cup 400. The magnet assembly 300 generates a magnetic field force on the magnetic beads inside the reaction cup 400 on the eccentric cup holder 220, causing them to move towards the wall of the reaction cup.

[0043] The reaction liquid mixing mechanism, in the process of mixing the reaction liquid containing magnetic beads in the reaction cup 400, in addition to driving the eccentric cup seat 220 to rotate to drive the reaction cup 400 to shake to mix the reaction liquid containing magnetic beads in the reaction cup 400 by the driving motor 210, additionally provides the magnet assembly 300 on the mounting seat 100, and the magnetic field generated by the magnet assembly 300 can disperse the magnetic beads in the reaction liquid, and the magnetic beads are pulled to the cup wall 401 of the reaction cup 400 by the magnetic field force, which is conducive to the uniform adsorption of the magnetic beads on the cup wall 401 of the reaction cup 400. The cooperation of the magnet assembly 300 and the mixing assembly 200 can increase the mixing rate of the reaction liquid, make the mixing of the reaction liquid more sufficient, improve the mixing effect, and avoid the problem of affecting the accuracy of the subsequent test results due to insufficient mixing of the reaction liquid.

[0044] In some embodiments, as shown in Figure 2 and Figure 3 , the eccentric cup seat 220 is formed with a reaction cup shaking space above the eccentric cup seat 220 for the reaction cup 400 to shake; the magnet assembly 300 includes a first magnet 310 and a second magnet 320 located on opposite sides of the reaction cup shaking space, the first magnet 310 and the second magnet 320 are both block magnets, and the S pole of the first magnet 310 and the N pole of the second magnet 320 are oppositely arranged. The way of forming a magnetic field at the position of the reaction cup 400 by a pair of oppositely arranged first and second magnets 310 and 320 is simple in structure and easy to implement. In other alternative embodiments, the magnet assembly 300 is not limited to including only two oppositely arranged magnets. The magnet assembly 300 can include two pairs of four magnets, or four pairs of eight magnets, or different magnet arrangement modes, as long as the magnet assembly 300 can generate a magnetic field in the reaction cup shaking space, and the direction of the magnetic field force can drive the magnetic beads in the reaction cup 400 to move towards the direction of the reaction cup wall.

[0045] In some embodiments, as shown in Figure 1 and Figure 2 , the magnet assembly 300 further includes a magnet mounting bracket 330 fixed on the mounting seat 100; the first magnet 310 and the second magnet 320 are both mounted on the magnet mounting bracket 330. The mounting mode of the first magnet 310 and the second magnet 320 on the same magnet mounting bracket 330 has the advantages of simple structure and low cost. In other alternative embodiments, the first magnet 310 and the second magnet 320 can be mounted on two mounting brackets that are independent of each other and fixed on the mounting seat 100, or the first magnet 310 and the second magnet 320 can be directly mounted on the mounting seat 100.

[0046] In some embodiments, as shown in Figure 1 and Figure 2As shown, the magnet mounting bracket 330 includes a horizontal plate 331 and a vertical plate 332 arranged in an L shape, the horizontal plate 331 is fixed on the mounting seat 100 by a fixing screw, and the first magnet 310 and the second magnet 320 are both mounted on the vertical plate 332. The middle of the horizontal plate 331 is provided with a hollow slot 3331, and the hollow slot 3331 is located directly above the eccentric cup seat 220, and the reaction cup 400 mounted on the eccentric cup seat 220 passes through the hollow slot 3331. The design of the hollow slot 3331 on the horizontal plate 331 can leave space for the installation of the reaction cup 400 above the eccentric cup seat 220, reduce the interference of the magnet mounting bracket 330 on the installation process of the reaction cup 400, and facilitate the installation of the reaction cup 400 on the eccentric cup seat 220; and the vertical plate 332 can provide a large enough installation space for the first magnet 310 and the second magnet 320. In other alternative embodiments, the magnet mounting bracket 330 can also be in the form of a flat plate.

[0047] In some embodiments, as shown in Figure 1 and Figure 2 As shown, the magnet assembly 300 further includes an adjusting and locking structure mounted on the magnet mounting bracket 330, which is used to adjust the distance between the first magnet 310 and the second magnet 320 along the connecting line direction of the two magnets, and lock the first magnet 310 and the second magnet 320 after adjustment. The structure of the adjustable distance between the first magnet 310 and the second magnet 320 can control the size of the magnetic field force and meet the adsorption effect of different magnetic beads. In other alternative embodiments, the adjusting and locking structure is not limited to adjusting the distance between the first magnet 310 and the second magnet 320 along the connecting line direction of the two magnets, but can also adjust the distance between the first magnet 310 and the second magnet 320 along two parallel but non-collinear directions, as long as it can control the change of the magnetic field force between the first magnet 310 and the second magnet 320.

[0048] Specifically, the vertical plate 332 of the magnet mounting bracket 330 is provided with a first slot 3321 and a second slot 3322, the length directions of the first slot 3321 and the second slot 3322 are the same, and the length direction of the first slot 3321 is parallel to the connecting direction of the first magnet 310 and the second magnet 320. The adjusting and locking structure includes a first adjusting and locking bolt 340 and a second adjusting and locking bolt 350. The first adjusting and locking bolt 340 is connected between the first slot 3321 and the first magnet 310, and the locking position of the first adjusting and locking bolt 340 on the first slot 3321 is adjustable. The second adjusting and locking bolt 350 is connected between the second slot 3322 and the second magnet 320, and the locking position of the second adjusting and locking bolt 350 on the second slot 3322 is adjustable. The position adjustment and locking of the two magnets are realized by the cooperation of the adjusting and locking bolts and the slots, and the structure is simple and easy to realize. In alternative embodiments, the vertical plate 332 of the magnet mounting bracket 330 can be provided with only the first slot 3321 or only the second slot 3322, and the adjusting and locking structure includes only the first adjusting and locking bolt 340 or only the second adjusting and locking bolt 350.

[0049] In some embodiments, as shown in Figure 1 and Figure 2 For the convenience of fixing the first magnet 310 and the second magnet 320 to the magnet mounting bracket 330, a first magnet sleeve 360 is sleeved and fixed on the first magnet 310, and a second magnet sleeve 370 is sleeved and fixed on the second magnet 320. The first magnet sleeve 360 is connected to the first slot 3321 by the first adjusting and locking bolt 340, and the second magnet sleeve 370 is connected to the second slot 3322 by the second adjusting and locking bolt 350. The magnets are fixed in position by the magnet sleeves, and there is no need to open connecting holes on the magnets for fixing, which is convenient for fixing the magnets.

[0050] In some embodiments, as shown in Figure 1 and Figure 2As shown, the reaction liquid mixing mechanism further comprises a lifting driving motor 500 installed on one side of the mounting seat 100, the lifting driving motor 500 is used for driving the driving motor 210 and the eccentric cup seat 220 to perform vertical lifting movement, and then the reaction cup 400 on the eccentric cup seat 220 can also perform lifting movement, during the mixing process of the reaction liquid, the lifting driving motor 500 can drive the eccentric cup seat 220 and the reaction cup 400 thereon to reciprocate between a first position (when in the first position, the lower half of the reaction cup 400 is located in the middle of the first magnet 310 and the second magnet 320) and a second position (when in the second position, the upper half of the reaction cup 400 is located in the middle of the first magnet 310 and the second magnet 320), so that the magnetic beads in the upper reaction liquid and the lower reaction liquid of the reaction cup 400 can be subjected to greater magnetic field force and adsorbed on the cup wall 401 of the reaction cup 400, and the mixing effect of the reaction liquid is further improved.

[0051] In summary, the reaction liquid mixing mechanism has the following advantages:

[0052] 1. The magnet assembly 300 increases the mixing rate of the reaction liquid, improves the mixing effect, and is beneficial to improve the accuracy of subsequent test results.

[0053] 2. The magnetic field generated by the magnet assembly 300 can disperse the magnetic beads in the reaction liquid in the reaction cup 400, and the magnetic beads are pulled to the cup wall 401 of the reaction cup 400 by the magnetic field force, which is beneficial to the uniform adsorption of the magnetic beads on the inner wall of the reaction cup 400.

[0054] 3. The distance between the first magnet 310 and the second magnet 320 is adjustable, the magnetic field force can be controlled, and the adsorption effect of different magnetic beads can be met.

[0055] Obviously, the above embodiments are only examples for clearly illustrating, and not limit the embodiments. For ordinary skilled in the art, other different forms of changes or variations can be made on the basis of the above description. Here, all the embodiments need not and cannot be exhausted. The obvious changes or variations derived therefrom are still within the protection scope of the utility model.

Claims

1. A reaction liquid mixing mechanism, characterized in that, The application relates to a mixing device for reaction cup, which comprises the following components: a mounting base (100); a mixing assembly (200) comprising a driving motor (210) and an eccentric cup seat (220) mounted on the mounting base (100); the eccentric cup seat (220) is adapted to place a reaction cup (400) above, and the eccentric cup seat (220) can drive the reaction cup (400) to shake when rotating to mix the reaction liquid in the reaction cup (400); a magnet assembly (300) mounted on the mounting base (100), which is used for generating a magnetic field force moving towards the reaction cup wall for the magnetic beads in the reaction cup (400) on the eccentric cup seat (220).

2. The reaction solution mixing mechanism according to claim 1, wherein The eccentric cup seat (220) is formed with a reaction cup shaking space above for the reaction cup (400) to shake; the magnet assembly (300) comprises a first magnet (310) and a second magnet (320) located on opposite sides of the reaction cup shaking space, and the S pole of the first magnet (310) and the N pole of the second magnet (320) are oppositely arranged.

3. The reaction solution mixing mechanism according to claim 2, wherein The magnet assembly (300) further comprises a magnet mounting bracket (330) fixed on the mounting base (100); the first magnet (310) and the second magnet (320) are both mounted on the magnet mounting bracket (330).

4. The reaction solution mixing mechanism according to claim 3, wherein The magnet mounting bracket (330) is provided with a hollow groove (3331) in the middle, the hollow groove (3331) is located directly above the eccentric cup seat (220), and the reaction cup (400) mounted on the eccentric cup seat (220) passes through the hollow groove (3331).

5. The reaction solution mixing mechanism according to claim 3, wherein In the connecting line direction of the first magnet (310) and the second magnet (320), the distance between the first magnet (310) and the second magnet (320) is adjustable.

6. The reaction solution mixing mechanism according to claim 5, wherein The magnet assembly (300) further comprises an adjusting and locking structure mounted on the magnet mounting bracket (330), which is used for adjusting the distance of the first magnet (310) and the second magnet (320) along the connecting line direction of the two magnets and locking the first magnet (310) and the second magnet (320) on the magnet mounting bracket (330).

7. The reaction solution mixing mechanism according to claim 6, wherein The magnet mounting bracket (330) is provided with a first slot (3321), the length direction of the first slot (3321) is parallel to the connecting line direction of the first magnet (310) and the second magnet (320); and the adjusting and locking structure comprises a first adjusting and locking bolt (340) connected between the first slot (3321) and the first magnet (310), and the locking position of the first adjusting and locking bolt (340) on the first slot (3321) is adjustable.

8. The reaction solution mixing mechanism according to claim 7, wherein The magnet mounting bracket (330) is further provided with a second slot (3322), the length direction of the second slot (3322) is parallel to the length direction of the first slot (3321); the adjusting and locking structure further comprises a second adjusting and locking bolt (350) connected between the second slot (3322) and the second magnet (320), the locking position of the second adjusting and locking bolt (350) on the second slot (3322) is adjustable.

9. The reaction solution mixing mechanism according to claim 8, wherein A first magnet sleeve (360) is sleeved and fixed on the first magnet (310), and a second magnet sleeve (370) is sleeved and fixed on the second magnet (320); the first magnet sleeve (360) is connected on the first slot (3321) through the first adjusting and locking bolt (340), and the second magnet sleeve (370) is connected on the second slot (3322) through the second adjusting and locking bolt (350).

10. The reaction solution mixing mechanism according to claim 8, wherein The magnet mounting bracket (330) comprises a horizontal plate (331) and a vertical plate (332) arranged in an L shape; the horizontal plate (331) is fixed on the mounting base (100), and the first slot (3321) and the second slot (3322) are arranged on the vertical plate (332).

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