Magnetic frame

Abstract

The utility model provides a magnetic frame, and relates to the technical field of biology and medical treatment. The magnetic frame comprises a magnetic frame body and a magnetic fixing piece, a placing space is arranged on one side of the magnetic frame body, and one end, away from the magnetic frame body, of the placing space is open; the two ends of the magnetic fixing piece are arranged on the left side and the right side of the opening of the containing space respectively. According to the magnetic frame, an existing magnetic frame structure is thoroughly changed, and one side of the magnetic frame body is provided with the containing space used for containing the magnetic bead incubation structure and the magnetic fixing belt used for fixing the magnetic bead incubation structure in the containing space, so that the magnetic bead incubation structure of a non-centrifugal tube is fixed.

Description

TECHNICAL FIELD

[0001] The utility model relates to biological and medical technology field more particularly, relate to a magnetic stand. BACKGROUND

[0002] Magnetic stand (Magnetic Stand or Magnetic Rack) is a kind of laboratory tool, is specially designed to fix and operate magnetic material, such as magnetic bead, magnetic bar or other experimental equipment with magnetism. Magnetic stand is usually made of non-magnetic material, such as plastic or stainless steel, its surface is embedded with strong magnet or magnetic strip, can attract and keep magnetic article.

[0003] The current magnetic stand is mostly set to plate structure, is used to fix different volume centrifugal tube, such as existing patent CN202322458239.0 is used for magnetic bead method to extract nucleic acid's magnetic stand, the magnetic stand includes mounting plate and fixed plate, fixed plate is installed in the recess formed in mounting plate, and magnet etc. for adsorbing magnetic bead is set on fixed plate, solve the problem that reagent box can have magnetic bead residue when manually extracting magnetic bead method manually. There is also a problem that magnetic stand is not fixed firmly on magnetic stand when fixing centrifugal tube due to less contact area, magnetic bead focuses slowly, such as CN202121322951.2 a kind of magnetic stand for aerosol in magnetic bead method enrichment nucleic acid. But the above-mentioned magnetic stand does not have universality, also can not be applicable to the current laboratory research and development product, therefore, there is an urgent need for a new type of magnetic stand with universality and applicable to the current laboratory research and development product. SUMMARY

[0004] The utility model aims at at least one of the technical problems existing in prior art. To this end, the utility model provides a kind of magnetic stand;The utility model improves the structure of existing magnetic stand, so that its applicability is wider.

[0005] The application discloses a magnetic stand, the magnetic stand includes magnetic stand main body and magnetic fixing part, magnetic stand main body one side is provided with space, and the end of space away from magnetic stand main body is open;Magnetic fixing part has two ends, and the two ends of magnetic fixing part are respectively arranged at the left side and the right side of the opening of the space.

[0006] In some embodiments, one of the two ends of the magnetic fixing part can be separated relative to the left side or the right side of the opening of the space.

[0007] In some embodiments, the two ends of the magnetic fixing part are a first end and a second end, and the first end or the second end is fixedly arranged at the left side of the opening of the space or can rotate relative to the left side of the opening of the space, and the second end or the first end can be separated relative to the right side of the opening of the space.

[0008] In some embodiments, the magnetic fixing member is provided at least one.

[0009] In some embodiments, the magnetic fixing member is provided as a fixing belt.

[0010] In some embodiments, the bottom of the placing space is provided with a bottom support connected with the main body of the magnetic stand.

[0011] In some embodiments, the bottom support is provided with a limiting hole, and the side of the limiting hole away from the main body of the magnetic stand is provided as an opening.

[0012] In some embodiments, the limiting hole is provided at least one.

[0013] In some embodiments, the limiting hole is provided as a circular arc or a square.

[0014] In some embodiments, the inner wall of the placing space close to one side of the main body of the magnetic stand is provided as a smooth surface or a friction surface.

[0015] The application has the following beneficial effects: 1. The application innovatively discloses a magnetic stand which completely changes the structure of the existing magnetic stand. The placing space for placing the magnetic bead incubation structure is provided on one side of the main body of the magnetic stand, and the magnetic fixing member belt for fixing the magnetic bead incubation structure in the placing space is provided, so as to fix the magnetic bead incubation structure of the non-centrifugal tube. The non-centrifugal tube structure is the magnetic bead incubation structure as described in the following embodiments.

[0016] 2. The application innovatively combines the pipe at the bottom end of the closed magnetic bead incubation structure, and the bottom support provided with the limiting hole is arranged at the bottom end of the magnetic stand, so as to play a fixing role. When in use, the pipe is directly placed into the limiting hole, so as to overcome the problem that the pipe under the magnetic bead incubation structure needs to be inserted from the upper side or the lower side when using the existing magnetic stand, and the use is not convenient. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical scheme in the embodiments of the application, the following will briefly introduce the drawings needed to be used in the embodiment description. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can also be obtained by those skilled in the art without creative labor on the basis of these drawings.

[0018] Figure 1 is a schematic view of the magnetic stand structure provided by at least one embodiment of the application; wherein the limiting hole of the bottom support is provided as a circular arc;

[0019] Figure 2 is a schematic view of the magnetic stand structure provided by another embodiment of the application; wherein the limiting hole of the bottom support is provided as a square;

[0020] Figure 3 is a schematic view of a magnetic bead incubation structure of a non-centrifugal tube provided by the embodiment of the present application;

[0021] In the figure, 1, magnetic force frame main body; 2, magnetic fixing part; 3, placing space; 4, bottom support; 5, limiting hole; 6, inflow pipeline; 7, cell bag connecting pipeline; 8, waste liquid outflow pipeline; 9, pipeline conversion switch; 10, second filter membrane; 11, first filter membrane; 12, sub-packaging port; 13, incubation part; 14, opening. DETAILED DESCRIPTION

[0022] In order to enable personnel in the technical field to better understand the present application scheme, the technical scheme in the embodiments of the present application will be clearly and completely described below in combination with the drawings in the embodiments of the present application.

[0023] The technical scheme in the embodiments of the present application is clearly and completely described below through specific specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present application, not all the embodiments. Those skilled in the art can easily understand other advantages and effects of the present application from the content disclosed in the present application. The present application can also be implemented or applied by other different specific embodiments. In the case of no conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor belong to the scope of protection of the present application.

[0024] The embodiments of the present application and examples thereof will be described in detail below in combination with the drawings.

[0025] Figure 1 And Figure 2 is a schematic view of a magnetic force frame structure provided by the embodiment, and the specific embodiment provides a magnetic force frame. The magnetic force frame comprises a magnetic force frame main body 1 and a magnetic fixing part 2. The magnetic force frame main body 1 is provided with a placing space 3 on one side. The end of the placing space 3 away from the magnetic force frame main body 1 is an opening 14. The magnetic fixing part 2 has two ends. The two ends of the magnetic fixing part 2 are respectively arranged on the left side and the right side of the opening 14 of the placing space 3.

[0026] In some embodiments, one of the two ends of the magnetic fixing part 2 can be separated relative to the left side or the right side of the opening 14 of the placing space 3.

[0027] In some more specific embodiments, the two ends of the magnetic fixing part 2 are respectively a first end and a second end. The first end or the second end is fixedly arranged on the left side of the opening 14 of the placing space 3 or can rotate relative to the left side of the opening 14 of the placing space 3. The second end or the first end can be separated relative to the right side of the opening 14 of the placing space 3.

[0028] In some more specific embodiments, the magnetic fixing member 2 is provided at least one. As shown in Figure 1 and Figure 2 , the magnetic fixing member 2 is provided one.

[0029] In some more specific embodiments, the magnetic fixing member 2 is provided as a fixing belt. As shown in Figure 1 and Figure 2 , the left side of the magnetic fixing belt is fixedly provided or can be rotated relative to one side of the opening 14 of the placement space 3; the right side of the magnetic fixing belt can be separated relative to the opening 14 of the placement space 3.

[0030] In some embodiments, the bottom of the placement space 3 is provided with a bottom support 4, and the bottom support 4 is connected with the magnetic stand body 1.

[0031] In some embodiments, the bottom support 4 is provided with a limiting hole 5, and the limiting hole 5 is provided as an opening 14 away from one side of the magnetic stand body 1.

[0032] In some embodiments, the limiting hole 5 is provided at least one. The number of limiting holes 5 is determined according to the number of pipelines under the magnetic bead incubation structure.

[0033] In some more specific embodiments, as shown in Figure 1 , the limiting hole 5 is provided as a circular arc, as shown in Figure 2 , the limiting hole 5 is provided as a square.

[0034] In some embodiments, the inner wall of the placement space 3 close to one side of the magnetic stand body 1 is provided as a smooth surface or a friction surface.

[0035] In a specific embodiment, the magnetic stand is a cuboid, and in the top view or bottom view of the magnetic stand, the placement space 3 is arc-shaped.

[0036] Figure 3 is a schematic diagram of the magnetic bead incubation structure of the non-centrifugal tube provided by the present embodiment, which includes an inflow pipeline 6, an incubation part 13 and a liquid outflow part in sequence from top to bottom; the liquid outflow part includes a cell bag connecting pipeline 7 and a waste liquid outflow pipeline 8 which are in communication with the incubation part 13, and a pipeline switch 9 for controlling whether the cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8 are in communication. As shown in Figure 3 , in some embodiments, the waste liquid outflow pipeline 8 is provided on one side of the cell bag connecting pipeline 7, the pipeline switch 9 is provided at the connection between the cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8, or the pipeline switch 9 is respectively provided on the cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8. The cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8 are placed in the limiting hole 5 of the bottom support 4.

[0037] In one embodiment, a second filter membrane 10 is arranged in the waste liquid outflow pipeline 8.

[0038] In another embodiment, when the pipeline switching switch 9 is arranged at the connection between the cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8, the pipeline switching switch 9 is arranged as a three-way valve; when the pipeline switching switch 9 is arranged in the cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8 respectively, the pipeline switching switch 9 is arranged as a clamp or other switch facilitating the control of flow.

[0039] In another embodiment, the cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8 are independently communicated with the incubation part 13, and a switch is arranged in each of the cell bag connecting pipeline 7 and the waste liquid outflow pipeline 8. In one embodiment, the switches arranged on the two pipelines are clamps, which respectively control the flow or blockage of liquid in the different pipelines.

[0040] In some embodiments, a first filter membrane 11 is arranged in the inflow pipeline 6, which plays a role of blocking and air permeability.

[0041] In some embodiments, a dispensing port 12 is arranged in the inflow pipeline 6 between the first filter membrane 11 and the incubation part 13, and the dispensing port 12 is heat sealed after dispensing; or a dispensing port 12 is arranged on one side of the incubation part 13. The dispensing port 12 is a preparation magnetic bead dispensing port 12, which is closed after dispensing. Figure 3 The dispensing port 12 in the incubation part 13 is arranged on one side of the incubation part 13.

[0042] In one embodiment, the external shape of the incubation part 13 is a circular arc shape, which is matched with the shape of the side of the placement space 3 close to the magnetic force frame main body 1.

[0043] The use method is as follows:

[0044] 1. Open the magnetic fixing belt of the magnetic force frame, place the cell bag connecting pipeline and the waste liquid outflow pipeline in the limiting hole of the bottom support, and place the magnetic bead incubation structure containing micron magnetic beads on the magnetic force frame, and magnetically fix the belt, and stand for 1 min.

[0045] 2. After the magnetic beads are completely adsorbed to one side, switch the pipeline switching switch to the waste liquid outflow pipeline.

[0046] 3. Connect the syringe containing PBS or culture medium to the syringe connecting port;

[0047] 4. Push the syringe piston to replace the micron magnetic bead storage solution by pressure;

[0048] 5. After the magnetic bead cleaning is completed, switch the pipeline switching switch to the cell bag connecting pipeline;

[0049] 6. Remove the closure package from the magnetic force frame and resuspend the magnetic beads;

[0050] 7. Push syringe piston, to add magnetic beads suspension to the culture bag with cells by compressed air, for subsequent cell sorting experiment.

[0051] Note: If there are magnetic beads left in the last step, the culture medium with cells can be sucked into the closed bag material through the syringe to reduce the residual magnetic beads.

[0052] The combination of the above-mentioned magnetic bead incubation structure and the magnetic stand can effectively reduce the risk of secondary pollution caused by drug liquid residue and realize pre-filled magnetic beads. The structure and the pipeline form a closed system, reducing the transfer process of magnetic beads from a glass packaging container to a needle cylinder, reducing the risk of drug liquid residue and secondary pollution during injection. The use of the structure improves the safety of use, eliminates the need to use a syringe needle, and reduces the safety risk of the operator. In addition, the use of the structure has low requirements for the environment, and a sterile tube sealing machine can be used to connect the fine pipeline in a non-sterile environment, which has low requirements for the environment.

[0053] The following points need to be explained:

[0054] (1) The drawings of the embodiments of the present disclosure only involve the structures involved in the embodiments of the present disclosure, and other structures can be referred to the general design. (2) In the case of no conflict, the embodiments of the present disclosure and the features in the embodiments can be combined to obtain new embodiments.

[0055] The above is only a specific implementation of the present disclosure, but the protection scope of the present disclosure is not limited thereto, and the protection scope of the present disclosure should be subject to the protection scope of the claims. The above-mentioned examples are only used to understand the present disclosure. It should be pointed out that for ordinary skilled in the art, without departing from the principles of the present disclosure, the present disclosure can be improved, and these improvements will also fall within the scope of protection of the claims of the present disclosure.

Claims

1. A magnetic stand, characterized by, The magnetic stand comprises a magnetic stand body and a magnetic fixing part, one side of the magnetic stand body is provided with a placing space, and the end of the placing space away from the magnetic stand body is an opening; the magnetic fixing part has two ends, and the two ends of the magnetic fixing part are respectively arranged on the left side and the right side of the opening of the placing space.

2. The magnetic stand of claim 1, wherein, One of the two ends of the magnetic fixing part can be separated relative to the left side or the right side of the opening of the placing space.

3. The magnetic stand of claim 2, wherein, The two ends of the magnetic fixing part are a first end and a second end, and the first end or the second end is fixedly arranged on the left side of the opening of the placing space or can rotate relative to the left side of the opening of the placing space, and the second end or the first end can be separated relative to the right side of the opening of the placing space.

4. The magnetic stand of claim 1, wherein, The magnetic fixing part is provided with at least one.

5. The magnetic stand of claim 1, wherein, The magnetic fixing part is provided as a fixing belt.

6. The magnetic stand of claim 1, wherein, The bottom of the placing space is provided with a bottom support connected with the magnetic stand body.

7. The magnetic stand of claim 6, wherein, The bottom support is provided with a limiting hole, and the side of the limiting hole away from the magnetic stand body is an opening.

8. The magnetic stand of claim 7, wherein, The limiting hole is provided with at least one.

9. The magnetic stand of claim 7, wherein, The limiting hole is provided as a circular arc or a square.

10. The magnetic stand of claim 1, wherein, The inner wall of the side of the placing space close to the magnetic stand body is provided as a smooth surface or a friction surface.

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