Reaction kettle for purifying medical intermediates

Abstract

The utility model provides a reaction kettle for purification of medical intermediates, which relates to the technical field of purification of medical intermediates and comprises a kettle body, a kettle cover is mounted at the top of the kettle body, a stirring mechanism is arranged on the kettle body and comprises a controller, a motor and five round rods, and a single-head threaded rod is mounted at the output end of the motor. According to the reaction kettle, the stirring mechanism is arranged, so that the reaction kettle for purifying the medical intermediates has an automatic blanking function, that is, after the reaction kettle for purifying the medical intermediates finishes the purification step of the medical intermediates, a worker does not need to manually screw a manual valve at the discharge hole of the reaction kettle; according to the reaction kettle for purifying the medical intermediates, the medical intermediates in the reaction kettle can be discharged without arranging special personnel, so that the labor cost input is reduced, the use effect of the reaction kettle for purifying the medical intermediates is improved, and meanwhile, the use efficiency of the reaction kettle for purifying the medical intermediates is also improved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical intermediate purification technology, and in particular to a reaction vessel for pharmaceutical intermediate purification. Background Technology

[0002] Pharmaceutical intermediates are chemical substances used to produce active pharmaceutical ingredients (APIs) or drugs. They are intermediate products in the production process of APIs and can be transformed into the final APIs through further reactions or processing. In order for intermediates to better participate in subsequent reactions and ensure the efficacy and stability of drugs, pharmaceutical intermediates need to be purified. The purification of pharmaceutical intermediates requires the use of pharmaceutical intermediate purification reaction vessels.

[0003] However, in existing technologies, most existing pharmaceutical intermediate purification reactors, while effectively preventing the entry of external impurities and ensuring the purity of the pharmaceutical intermediate purification process, lack automatic feeding functionality. This means that after the pharmaceutical intermediate purification steps are completed, operators must manually turn the valve at the reactor's outlet to discharge the pharmaceutical intermediates. This requires dedicated personnel for the feeding operation, increasing labor costs and reducing both the effectiveness and efficiency of the pharmaceutical intermediate purification reactor.

[0004] Therefore, we propose a reaction vessel for the purification of pharmaceutical intermediates to solve the technical problems mentioned in the background art. Utility Model Content

[0005] The purpose of this invention is to solve the problem that existing pharmaceutical intermediate purification reactors do not have an automatic feeding function. Specifically, after completing the pharmaceutical intermediate purification process, operators need to manually turn the valve at the reactor's outlet to discharge the pharmaceutical intermediates. This requires dedicated personnel, increasing labor costs and reducing both the effectiveness and efficiency of the reactor. Therefore, this invention proposes a new pharmaceutical intermediate purification reactor.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a reaction vessel for purifying pharmaceutical intermediates, comprising a vessel body, a vessel cover installed on the top of the vessel body, and a stirring mechanism provided on the vessel body;

[0007] The stirring mechanism includes a controller, a motor, and five round rods. The output end of the motor is equipped with a single-threaded rod, and the threaded end of the single-threaded rod is threaded with an internal threaded sleeve. Two annular blocks are fixedly fitted onto the outer wall of the internal threaded sleeve. Two sets of stirring plates are fixed to the outer wall of the internal threaded sleeve, and two sets of perforated plates are fixed to the outer wall of the internal threaded sleeve.

[0008] Preferably, the controller is installed on the outer wall of the vessel body, the motor is installed on the top of the vessel lid, and the controller is electrically connected to the motor.

[0009] Preferably, the top end of the single-threaded rod extends through the bottom of the vessel lid, the bottom end of the internal threaded sleeve is movably fitted inside the outlet of the vessel body, and the top of each of the round rods is fixed to the bottom of the vessel lid.

[0010] Preferably, the bottom end of each of the circular rods movably penetrates the top of the two circular blocks, and the bottom end of each of the circular rods is movably embedded in the bottom of the inner wall of the vessel.

[0011] Preferably, each group of stirring plates has five plates and each group of perforated plates has five perforated plates, and the two groups of stirring plates and the two groups of perforated plates are arranged alternately.

[0012] Preferably, a temperature sensor is installed on the surface of the vessel lid, a collar is movably sleeved on the outer surface of the single-threaded rod, and four supports are fixed on the outer wall of the vessel body near the bottom.

[0013] Preferably, the bottom end of the temperature sensor extends through the surface of the vessel lid, the bottom of the collar is fixed to the top of the internal threaded sleeve, and the temperature sensor is electrically connected to the controller.

[0014] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0015] 1. In this utility model, by setting a stirring mechanism, the pharmaceutical intermediate purification reactor can have an automatic feeding function. That is, after the pharmaceutical intermediate purification step is completed, the pharmaceutical intermediate inside the reactor can be fed out without the need for the operator to manually turn the manual valve at the reactor outlet. This eliminates the need for dedicated personnel to perform the feeding operation, reducing labor costs and improving both the efficiency and effectiveness of the pharmaceutical intermediate purification reactor. Through the cooperation of the controller, motor, single-head threaded rod, ring block, and round rod, the internal threaded sleeve can be driven to move vertically. Through the cooperation of the moving internal threaded sleeve, stirring plate, and perforated plate, the material inside the reactor can be stirred.

[0016] 2. In this utility model, the material inside the vessel can be prevented from contacting the outer surface of the single-threaded rod by the collar, the vessel can be prevented from contacting the ground by the support, and the temperature inside the vessel can be measured by the temperature sensor. Attached Figure Description

[0017] Figure 1 A perspective view of a reaction vessel for purifying pharmaceutical intermediates is provided for this utility model;

[0018] Figure 2 This utility model provides a partial cross-sectional view of a reaction vessel for purifying pharmaceutical intermediates.

[0019] Figure 3 This utility model provides a partial perspective view of a reaction vessel for purifying pharmaceutical intermediates;

[0020] Figure 4 This utility model provides a perspective view of a reaction vessel for purifying pharmaceutical intermediates from another angle.

[0021] Figure 5 This invention provides a partial sectional perspective view of a reaction vessel for purifying pharmaceutical intermediates.

[0022] Legend: 1. Vessel body; 2. Vessel lid; 3. Stirring mechanism; 301. Controller; 302. Motor; 303. Single-threaded rod; 304. Round rod; 305. Internal threaded sleeve; 306. Circular block; 307. Stirring plate; 308. Perforated plate; 4. Temperature sensor; 5. Collar; 6. Support. Detailed Implementation

[0023] To better understand the above-mentioned objectives, features, and advantages of this utility model, the present utility model will be further described below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0024] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed in the following specification.

[0025] like Figures 1-5 As shown, a reaction vessel for purifying pharmaceutical intermediates includes a vessel body 1, a vessel cover 2 installed on the top of the vessel body 1, and a stirring mechanism 3 provided on the vessel body 1.

[0026] The stirring mechanism 3 includes a controller 301, a motor 302, and five round rods 304. A single-threaded rod 303 is installed at the output end of the motor 302. An internal threaded sleeve 305 is threaded onto the threaded end of the single-threaded rod 303. Two annular blocks 306 are fixedly fitted onto the outer wall of the internal threaded sleeve 305. Two sets of stirring plates 307 and two sets of perforated plates 308 are fixed to the outer wall of the internal threaded sleeve 305. The controller 301 is installed on the outer wall of the vessel body 1, and the motor 302 is installed on the top of the vessel cover 2. The controller 301 is electrically connected to the motor 302. The top end of the single-threaded rod 303 extends through the bottom of the vessel cover 2, and the bottom end of the internal threaded sleeve 305 is movably fitted inside the discharge port of the vessel body 1. Each round rod 304... The top of 04 is fixed to the bottom of the lid 2. The bottom end of each rod 304 moves through the top of the two ring blocks 306. The bottom end of each rod 304 is movably embedded in the bottom of the inner wall of the vessel 1. There are five stirring plates 307 in each group and five perforated plates 308 in each group. The two groups of stirring plates 307 and the two groups of perforated plates 308 are arranged alternately. A temperature sensor 4 is installed on the surface of the lid 2. A collar 5 is movably sleeved on the outer surface of the single-threaded rod 303. Four supports 6 are fixed on the outer wall of the vessel 1 near the bottom. The bottom end of the temperature sensor 4 moves through the surface of the lid 2. The bottom of the collar 5 is fixed to the top of the inner threaded sleeve 305. The temperature sensor 4 is electrically connected to the controller 301.

[0027] The desired effect is as follows: when pharmaceutical intermediates are being purified inside the reactor and require stirring, the controller 301 is first connected to an external power supply. Then, the controller 301 is turned on, and the forward and reverse rotation times of the motor 302 are set. Next, the controller 301 starts the motor 302. The started motor 302 drives the single-threaded rod 303 to rotate forward. This forward-rotating single-threaded rod 303, in conjunction with the round rod 304 and the annular block 306, drives the internal threaded sleeve 305 to move vertically downward. Simultaneously, the moving internal threaded sleeve 305 drives two... Each annular block 306, collar 5, stirring plate 307, and perforated plate 308 moves vertically downwards. When the bottom of one of the annular blocks 306 contacts the bottom of the inner wall of the vessel 1, the forward rotation of motor 302 ends. At this time, motor 302 drives single-threaded rod 303 to reverse. The reverse-rotating single-threaded rod 303, in cooperation with annular block 306 and rod 304, drives internal threaded sleeve 305 to move vertically upwards. Simultaneously, the moving internal threaded sleeve 305 drives both annular blocks 306, collar 5, stirring plate 307, and perforated plate 308 to move vertically downwards. The internal threaded sleeve 305 moves vertically upwards until its bottom end returns to its original position. At this point, the reverse rotation of motor 302 ends. Subsequently, with the cooperation of controller 301, motor 302, single-headed threaded rod 303, ring block 306, round rod 304, and internal threaded sleeve 305, each set of stirring plates 307 and perforated plates 308 continuously move vertically upwards and downwards. This continuous movement of the stirring plates 307 and perforated plates 308 stirs the pharmaceutical intermediates inside the vessel 1. Simultaneously, the collar 5 prevents the pharmaceutical intermediates from shifting during stirring. It will contact the single-ended threaded rod 303. When the pharmaceutical intermediate needs to be discharged after completing the operation inside the reactor, the controller 301 starts the motor 302, which drives the single-ended threaded rod 303 to reverse. The reversed single-ended threaded rod 303, with the cooperation of the annular block 306 and the round rod 304, drives the inner threaded sleeve 305 to move vertically upward. When the bottom end of the inner threaded sleeve 305 moves out from the discharge port of the reactor body 1, the pharmaceutical intermediate inside the reactor body 1 can flow out from the discharge port of the reactor body 1. At the same time, the controller 301 stops the movement of the inner threaded sleeve 305.

[0028] Working principle: When pharmaceutical intermediates are being purified inside the reactor and stirring is required, first connect the controller 301 to the external power supply, then turn on the controller 301, set the forward and reverse rotation time of the motor 302, and then start the motor 302 using the controller 301. The started motor 302 will drive the single-threaded rod 303 to rotate forward. The forward-rotating single-threaded rod 303, in conjunction with the round rod 304 and the annular block 306, will drive the internal threaded sleeve 305 to move vertically downward. Simultaneously, the moving internal threaded sleeve 305 will drive the two annular blocks... Block 306, collar 5, each set of stirring plates 307, and each set of perforated plates 308 all move vertically downwards. When the bottom of one of the ring blocks 306 contacts the bottom of the inner wall of the vessel body 1, the forward rotation of motor 302 ends. At this time, motor 302 will drive the single-headed threaded rod 303 to reverse. The reversed single-headed threaded rod 303, in cooperation with the ring block 306 and the rod 304, will drive the inner threaded sleeve 305 to move vertically upwards. At the same time, the moving inner threaded sleeve 305 will drive the two ring blocks 306, collar 5, each set of stirring plates 307, and each set of perforated plates 308 to move vertically upwards. When the bottom end of the internal threaded sleeve 305 returns to its original position, the reverse rotation time of the motor 302 just ends. Subsequently, with the cooperation of the controller 301, motor 302, single-headed threaded rod 303, ring block 306, round rod 304, and internal threaded sleeve 305, each set of stirring plates 307 and each set of perforated plates 308 will continuously move vertically upward and downward. At this time, with the cooperation of each set of stirring plates 307 and each set of perforated plates 308, the pharmaceutical intermediate inside the vessel body 1 can be stirred. At the same time, under the action of the collar 5, the pharmaceutical intermediate can be prevented from being stirred during the stirring process. When the pharmaceutical intermediate needs to be discharged after completing the operation inside the reactor, the single-threaded rod 303 contacts the single-threaded rod 303. At this time, the controller 301 starts the motor 302, which drives the single-threaded rod 303 to reverse. The reversed single-threaded rod 303, with the cooperation of the annular block 306 and the round rod 304, drives the inner threaded sleeve 305 to move vertically upward. When the bottom end of the inner threaded sleeve 305 moves out from the discharge port of the reactor body 1, the pharmaceutical intermediate inside the reactor body 1 can flow out from the discharge port of the reactor body 1. At the same time, the controller 301 stops the movement of the inner threaded sleeve 305.

[0029] Among them, pharmaceutical intermediates are in a liquid state.

[0030] The wiring diagrams of the controller 301 (PLC controller), motor 302 and temperature sensor 4 in this utility model are common knowledge in the field, and their working principles are known technologies. The appropriate model is selected according to actual use, so the controller 301, motor 302 and temperature sensor 4 will not be explained in detail.

[0031] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.

Claims

1. A reaction vessel for purifying pharmaceutical intermediates, characterized in that, It includes a vessel body (1), a vessel lid (2) is installed on the top of the vessel body (1), and a stirring mechanism (3) is provided on the vessel body (1); The stirring mechanism (3) includes a controller (301), a motor (302), and five round rods (304). The output end of the motor (302) is equipped with a single-threaded rod (303). The threaded end of the single-threaded rod (303) is threaded with an internal threaded sleeve (305). The outer wall of the internal threaded sleeve (305) is fixedly fitted with two ring blocks (306). The outer wall of the internal threaded sleeve (305) is fixed with two sets of stirring plates (307) and two sets of perforated plates (308).

2. The reaction vessel for purifying pharmaceutical intermediates according to claim 1, characterized in that: The controller (301) is installed on the outer wall of the vessel body (1), and the motor (302) is installed on the top of the vessel cover (2). The controller (301) is electrically connected to the motor (302).

3. The reaction vessel for purifying pharmaceutical intermediates according to claim 1, characterized in that: The top end of the single-threaded rod (303) extends through the bottom of the lid (2), and the bottom end of the internal threaded sleeve (305) is movably fitted inside the outlet of the body (1). The top of each round rod (304) is fixed to the bottom of the lid (2).

4. The reaction vessel for purifying pharmaceutical intermediates according to claim 1, characterized in that: The bottom end of each of the circular rods (304) is movably inserted through the top of the two circular ring blocks (306), and the bottom end of each of the circular rods (304) is movably embedded in the bottom of the inner wall of the vessel body (1).

5. The reaction vessel for purifying pharmaceutical intermediates according to claim 1, characterized in that: The number of stirring plates (307) in each group is five, and the number of perforated plates (308) in each group is five. The two groups of stirring plates (307) and the two groups of perforated plates (308) are arranged alternately.

6. The reaction vessel for purifying pharmaceutical intermediates according to claim 1, characterized in that: A temperature sensor (4) is installed on the surface of the lid (2), a collar (5) is movably sleeved on the outer surface of the single-threaded rod (303), and four supports (6) are fixed on the outer wall of the vessel body (1) near the bottom.

7. The reaction vessel for purifying pharmaceutical intermediates according to claim 6, characterized in that: The bottom end of the temperature sensor (4) extends through the surface of the lid (2), the bottom of the collar (5) is fixed to the top of the internal threaded sleeve (305), and the temperature sensor (4) is electrically connected to the controller (301).

Images