Immunodiagnosis detection and analysis device with anti-pollution function

Abstract

The utility model relates to the technical field of immunoassay instruments, in particular to a detection and analysis device with an anti-pollution function for immunodiagnosis, which comprises a fluorescence immunoassay instrument, a kit, a sealing assembly and a cleaning plate, the fluorescence immunoassay analyzer is provided with a detection area, the detection area is rotatably provided with a cover plate, the bottom of the detection area is provided with a placing groove, the placing groove is used for placing a kit, and the detection area is provided with a sliding cavity; a detection sample is linearly placed in the kit; a sealing assembly is arranged above the detection area, the sealing assembly is located above the kit, and when the cover plate closes the detection area, the sealing assembly seals the kit, the kit is sealed through the cover plate and the sealing assembly, so that the airtightness of the kit is guaranteed in the detection process of the fluorescence immunoassay analyzer, and the detection accuracy is improved. The reagent is prevented from volatilizing into the detection area and depositing in the detection area, so that the influence on subsequent light detection analysis of the reagent is avoided.

Description

Technical Field

[0001] This utility model relates to the field of immunoassay analyzer technology, specifically to an immunodiagnostic detection and analysis device with anti-contamination function. Background Technology

[0002] As an advanced biological detection and analysis device, the fluorescence immunoassay analyzer integrates fluorescence immunoassay technology and features high precision and high sensitivity. It is widely used in multiple fields such as medical treatment, food safety, environmental monitoring, biosafety, and scientific research.

[0003] The fluorescence immunoassay analyzer mainly consists of a housing, an optical detection system, and a reagent kit. The housing has a detection area, and the optical detection system is located below the detection area. When the fluorescence immunoassay analyzer is working, the operator adds the sample to be tested and reagents to the reagent kit to complete the sample preparation. Then, the reagent kit is placed in the detection area on the housing, and the sample is detected and analyzed by the optical detection system below the detection area.

[0004] However, during the detection and analysis process, reagents may volatilize. The volatilized reagents may remain and deposit inside the equipment, contaminating the fluorescence immunoassay analyzer and affecting the acquisition and accuracy of fluorescence signals, thus leading to errors in the detection and analysis.

[0005] In view of this, we propose an immunodiagnostic detection and analysis device with anti-pollution function. Utility Model Content

[0006] The purpose of this invention is to provide an immunodiagnostic detection and analysis device with anti-pollution function to solve the problem of inaccurate detection and analysis caused by reagent volatilization mentioned in the background art.

[0007] To achieve the above objectives, this utility model provides the following technical solution:

[0008] An immunodiagnostic detection and analysis device with anti-contamination function includes a fluorescence immunoassay analyzer, a reagent kit, a sealing component, a cleaning plate, and a cleaning plate. The fluorescence immunoassay analyzer has a detection area, and an optical detection system is located below the detection area for detecting the reagent. A cover plate is rotatably mounted on the detection area to seal it, ensuring its airtightness during detection and preventing interference from foreign substances. A placement groove is located at the bottom of the detection area to hold the reagent kit, securing it and preventing it from tipping or shaking under minor external forces. A sliding cavity is provided on the detection area. The reagent kit contains a linearly placed sample. A sealing component is located above the detection area, positioned above the reagent kit. When the cover plate closes the detection area, the sealing component seals the reagent kit. When the cover plate closes, the sealing component slides out synchronously with the rotation of the cover plate, sealing the reagent kit and preventing volatile substances from the reagent kit from diffusing into the detection area and depositing there, thus affecting the detection results of subsequent reagents.

[0009] Preferably, the cover plate is provided with an auxiliary handrail, which makes it easier for the staff to rotate the cover plate to open and close the detection area, thus saving the staff effort and making it easier to rotate the cover plate to drive the sealing component to slide and seal the reagent kit.

[0010] Preferably, the sealing assembly includes a drive wheel, a driven wheel, a double-toothed rack, a central rotating wheel, a driven rack, and a sealing plate; the drive wheel is fixedly connected to the cover plate and rotatably mounted in the sliding cavity; a driven wheel is provided below the drive wheel, and the drive wheel is fixedly mounted on the cover plate and rotates synchronously with the cover plate; the driven wheel is rotatably mounted in the sliding cavity, and meshes with the driven wheel when the drive wheel rotates, thereby driving the driven wheel to rotate; a double-toothed rack is provided below the driven wheel, and drives the double-toothed rack to slide horizontally when the driven wheel rotates; the double-toothed rack has driving teeth and transmission teeth, the driving teeth are perpendicular to the transmission teeth, and the driving teeth mesh with the driven wheel; a central rotating wheel is provided on one side of the transmission teeth, and the double-toothed rack meshes with the driven wheel through the driving teeth. This causes the double-toothed gear to slide horizontally. When the double-toothed gear slides horizontally, it drives the transmission teeth on it to mesh with the central rotating wheel, thereby driving the central rotating wheel to rotate. The central rotating wheel is rotatably installed in the sliding cavity, and the rotational installation between the central rotating wheel and the sliding cavity is the same as that between the central rotating wheel and the central rotating wheel. The central rotating wheel meshes with the driven rack. When the central rotating wheel rotates, it drives the driven rack to slide horizontally. Both the double-toothed rack and the driven rack are equipped with sealing plates. The double-toothed rack and the driven rack slide in opposite directions. When the double-toothed rack and the driven rack slide, they drive the sealing plates fixedly installed on them to slide synchronously. The horizontal sliding of the sealing plates seals the upper end of the reagent kit, ensuring the airtightness of the reagent kit and preventing the volatile substances from the reagent kit from spreading in the detection area and depositing in the detection area, thus affecting the detection results of subsequent reagents.

[0011] Preferably, the sealing plate is provided with sealing protrusions corresponding to the reagent kit, and the sealing protrusions are made of rubber. The sealing protrusions correspond one-to-one with the reagent kit, thereby enhancing the sealing performance of the sealing plate for the reagent kit. The sealing protrusions are made of rubber material, so the sealing protrusions have a certain elasticity and can perfectly fit with the reagent kit, ensuring a tight seal.

[0012] Preferably, a sealing strip is provided on the opposite surfaces of the two sealing plates. The sealing strip is used to ensure the sealing between the two sealing plates. The two sealing plates move from opposite sides to fit together to complete the sealing of the reagent kit. However, the gap between the two sealing plates will affect the overall sealing effect. Therefore, the sealing strip is used to prevent leakage from the gap and affect the overall sealing effect.

[0013] Preferably, the cleaning plate is symmetrically installed in the detection area, and the cleaning plate is located below the sealing plate. The cleaning plate is used to clean the sealing plate and the sealing protrusions on the sealing plate to prevent volatile reagents from depositing on the sealing plate and affecting its use. At the same time, the cleaning plate is installed in the detection area through the slot and the buckle, and the cleaning plate can be cleaned and replaced at regular intervals to ensure the cleaning effect of the cleaning plate.

[0014] Compared with the prior art, the beneficial effects of this utility model are: this utility model achieves the sealing of the reagent kit through the cover plate and sealing component, thereby ensuring the airtightness of the reagent kit during the detection process of the fluorescence immunoassay analyzer, and preventing the reagent from evaporating into the detection area and depositing there, which would affect the subsequent light detection and analysis of the reagent. Attached Figure Description

[0015] Figure 1 This is an overall diagram of the fluorescence immunoassay analyzer of this utility model;

[0016] Figure 2 This is a half-sectional view of the fluorescence immunoassay analyzer of this utility model when it is not in operation;

[0017] Figure 3 This utility model Figure 2 Enlarged view of point A;

[0018] Figure 4 This is a half-sectional view of the sliding cavity of this utility model;

[0019] Figure 5 This utility model Figure 4 Enlarged view of point B;

[0020] Figure 6 This is a schematic diagram of the overall closed component of this utility model;

[0021] Figure 7 This is a half-sectional view of the fluorescence immunoassay analyzer of this utility model in operation;

[0022] Figure 8 This utility model Figure 7 A magnified view of point C.

[0023] In the picture:

[0024] 1. Fluorescence immunoassay analyzer; 11. Detection area; 111. Placement slot; 112. Sliding cavity; 12. Cover plate; 121. Auxiliary handrail;

[0025] 2. Reagent kit;

[0026] 3. Enclosure assembly; 31. Drive wheel; 32. Driven wheel; 33. Double-toothed rack; 331. Driving gear tooth; 332. Transmission gear tooth; 34. Intermediate wheel; 35. Driven rack; 36. Sealing plate; 361. Sealing protrusion;

[0027] 4. Cleaning board. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0029] The fluorescence immunoassay analyzer mainly consists of a housing, an optical detection system, and a reagent kit. The housing has a detection area, and the optical detection system is located below the detection area. When the fluorescence immunoassay analyzer is working, the operator adds the sample to be tested and reagents to the reagent kit to complete the sample preparation. Then, the reagent kit is placed in the detection area on the housing, and the sample is detected and analyzed by the optical detection system below the detection area.

[0030] However, during the detection and analysis process, the organic solvents in the test sample will volatilize. The volatilized test sample remains inside the equipment and deposits, which will contaminate the fluorescence immunoassay analyzer. The volatilized test sample deposits on the optical detection system, such as lenses and filters, which will affect the acquisition and accuracy of fluorescence signals, thus leading to errors in the detection and analysis.

[0031] like Figures 1 to 8 As shown, an immunodiagnostic detection and analysis device with anti-contamination function includes a fluorescence immunoassay analyzer 1, a reagent kit 2, a sealing component 3, and a cleaning plate 4. The fluorescence immunoassay analyzer 1 has a detection area 11, a cover plate 12 rotatably mounted on the detection area 11, a placement groove 111 at the bottom of the detection area 11 for placing the reagent kit 2, and a sliding cavity 112 on the detection area 11. A test sample is linearly placed inside the reagent kit 2. The sealing component 3 is located above the detection area 11, and when the cover plate 12 closes the detection area 11, the sealing component 3 seals the reagent kit 2.

[0032] Specifically, the detection area 11 is used to place the test kit 2. An optical detection system is provided below the detection area 11 for detecting the test kit 2. The cover plate 12 is used to seal the detection area 11 to ensure the airtightness of the detection area 11 during detection and to avoid interference from foreign substances. The test kit 2 consists of a placement box and a test tube. The placement box is used to fix the test tube, and the test tube contains the test kit. The placement slot 111 is used to fix the test kit 2 to prevent the test kit 2 from tipping over or shaking when subjected to minor external forces. At the same time, the placement slot 111 plays a positioning role for the test kit 2, ensuring that the test kit 2 is located in the center of the detection area 11. When the test kit 2 needs to be detected and analyzed, the staff rotates the cover plate 12 to close the detection area 11. The sealing component 3 will slide out synchronously with the rotation of the cover plate 12 and be located above the test kit 2 to seal the test kit 2, preventing the volatile substances of the test kit 2 from spreading in the detection area 11 and depositing in the detection area 11, which would affect the detection results of subsequent reagents.

[0033] Specifically, the fluorescence immunoassay analyzer 1 used in this invention is a digital fluorescence immunoassay analyzer, which performs automated and rapid detection and analysis through a digital analysis system.

[0034] In this embodiment, the cover plate 12 is provided with an auxiliary handrail 121;

[0035] Specifically, the auxiliary handrail 121 facilitates the staff to rotate the cover plate 12, thereby opening and closing the detection area 11, which saves the staff effort and facilitates the rotation of the cover plate 12 to drive the sealing component 3 to slide and seal the reagent kit 2.

[0036] Preferably, the auxiliary handrail 121 is located on the central axis of the cover plate 12, so that when the staff closes the cover plate 12, the force is evenly distributed on the cover plate 12, reducing the difficulty of rotating the cover plate 12 and improving the smoothness of the rotation of the cover plate 12.

[0037] In this embodiment, the enclosed assembly 3 includes a drive wheel 31, a driven wheel 32, a double-toothed rack 33, a central rotating wheel 34, a driven rack 35, and a sealing plate 36. The drive wheel 31 is fixedly connected to the cover plate 12 and is rotatably mounted in the sliding cavity 112. The driven wheel 32 is located below the drive wheel 31. The driven wheel 32 is rotatably mounted in the sliding cavity 112, and a double-toothed rack 33 is located below the driven wheel 32. The double-toothed rack 33 has a driving gear tooth 331 and a transmission gear tooth 332, which are perpendicular to each other. The driving gear tooth 331 meshes with the driven wheel 32. A central rotating wheel 34 is located on one side of the transmission gear tooth 332. The central rotating wheel 34 is rotatably mounted in the sliding cavity 112 and meshes with the driven rack 35. A sealing plate 36 is mounted on both the double-toothed rack 33 and the driven rack 35.

[0038] Specifically, the end of the cover plate 12 connected to the fluorescence immunoassay analyzer 1 is provided with a rotating shaft, and the drive wheel 31 is fixedly installed on the rotating shaft. Simultaneously, the cover plate 12 relies on the contact between the drive wheel 31 and the inner wall of the sliding cavity 112 to ensure its rotational stability. The drive wheel 31, fixedly installed on the cover plate 12, rotates synchronously with the cover plate 12. The sliding cavity 112 has a mounting hole, and the driven wheel 32 is rotatably connected to the mounting hole via a rotating shaft. When the drive wheel 31 rotates, it meshes with the driven wheel 32, thereby driving the driven wheel 32 to rotate. A double-toothed rack 33 is provided below the driven wheel 32. The vertical arrangement of the driving teeth 331 and the transmission teeth 332 of the double-toothed rack 33 is used to achieve a change in the direction of motion, realizing reversal. When the driven wheel 32 rotates, it drives the double-toothed rack 33 to slide horizontally. The double-toothed rack 33, through the driving teeth... 331 meshes with the driven wheel 32, thereby causing itself to slide horizontally. When the double-toothed gear slides horizontally, it drives the transmission gear 332 on it to mesh with the central rotating wheel 34, thereby driving the central rotating wheel 34 to rotate. When the central rotating wheel 34 rotates, it drives the driven rack 35 to slide horizontally. Both the double-toothed rack 33 and the driven rack 35 are provided with limiting posts at their bottom ends, and the sliding cavity 112 is provided with a limiting groove. The double-toothed rack 33 and the driven rack 35 achieve horizontal sliding through the cooperation of the limiting posts and the limiting groove. When the double-toothed rack 33 and the driven rack 35 slide, they drive the sealing plate 36 fixedly installed on them to slide synchronously. The sealing plate 36 slides horizontally to seal the upper end of the reagent kit 2, ensuring the airtightness of the reagent kit 2 and preventing the volatile substances of the reagent kit 2 from spreading in the detection area 11 and depositing in the detection area 11, affecting the detection results of subsequent reagents.

[0039] Preferably, the stepped structure of the driven rack 35 can support the sealing plate 36 that is fixedly connected to the double-tooth rack 33. The fixed connection between the double-tooth rack 33, the driven rack 35, and the sealing plate 36 can be achieved by snap-fit ​​or screw connection, thereby enabling the separation of the sealing plate 36 and the double-tooth rack 33 from the driven rack 35, which facilitates the cleaning and replacement of the sealing plate 36.

[0040] In this embodiment, the sealing plate 36 is provided with a sealing protrusion 361 corresponding to the reagent kit 2, and the sealing protrusion 361 is made of rubber.

[0041] Specifically, the sealing protrusions 361 correspond one-to-one with the reagent kit 2, thereby enhancing the sealing performance of the sealing plate 36 to the reagent kit 2. The sealing protrusions 361 are made of rubber material, so they have a certain elasticity and can fit perfectly with the reagent kit 2 to ensure a tight seal.

[0042] In this embodiment, sealing strips are provided on the opposing surfaces of the two sealing plates 36;

[0043] Specifically, the sealing strip is used to ensure the seal between the two sealing plates 36. The two sealing plates 36 move from opposite sides to fit together and complete the seal of the reagent kit 2. However, the gap between the two sealing plates 36 will affect the overall sealing effect. Therefore, the sealing strip is used to prevent leakage from the gap and thus affect the overall sealing effect.

[0044] In this embodiment, the cleaning plate 4 is symmetrically installed in the detection area 11, and the cleaning plate 4 is located below the sealing plate 36;

[0045] Specifically, the cleaning plate 4 is used to clean the sealing plate 36 and the sealing protrusions 361 on the sealing plate 36. Each sliding movement of the sealing plate 36 will contact the cleaning plate 4, thereby cleaning the sealing plate 36 and preventing volatile reagents from depositing on the sealing plate 36 and affecting its use. At the same time, the cleaning plate 4 is installed in the detection area 11 through the slot and buckle, and the cleaning plate 4 can be cleaned and replaced at regular intervals to ensure the cleaning effect of the cleaning plate 4.

[0046] In use, the immunodiagnostic detection and analysis device with anti-pollution function of this utility model is used by the staff to fix the reagent kit 2 in the detection area 11 through the placement slot 111, and then rotate the cover plate 12 to close the detection area 11 by the auxiliary handle 121. During the rotation of the cover plate 12, the cover plate 12 drives the drive wheel 31 to rotate synchronously, and the drive wheel 31 drives the driven wheel 32 to rotate synchronously. The driven wheel 32 meshes with the drive rack on the double toothed rack 33 to drive the double toothed rack 33 to slide horizontally. When the double toothed rack 33 slides horizontally, it meshes with the central rotating wheel 34 through the transmission wheel teeth 332, thereby driving the driven rack 35 to slide horizontally. When the double toothed rack 33 and the driven rack 35 slide in opposite directions, they synchronously drive the sealing plates 36 installed on them to move synchronously. The sealing plates 36 slide out to seal the reagent kit 2. When the cover plate 12 closes the detection area 11, the two sealing plates 36 just come into contact to complete the sealing of the reagent kit 2.

[0047] After the test is completed, the staff rotates the cover plate 12 to open the test area 11. During the rotation of the cover plate 12, the cover plate 12 drives the drive wheel 31 to reverse, the drive wheel 31 drives the driven wheel 32 to reverse, the driven wheel 32 drives the double toothed rack 33 to slide back to its original position, the double toothed rack 33 drives the driven rack 35 to slide back to its original position through the intermediate rotating wheel 34, the double toothed rack 33 and the driven rack 35 drive the sealing plate 36 to reset. When the cover plate 12 is fully opened, the sealing plate 36 has just completed its reset, and the staff takes out the reagent kit 2.

[0048] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. An immunodiagnostic detection and analysis device with anti-contamination function, characterized in that: Includes a fluorescence immunoassay analyzer (1), a reagent kit (2), and a blocking component (3); The fluorescence immunoassay analyzer (1) has a detection area (11), a cover plate (12) is rotatably installed on the detection area (11), a placement groove (111) is provided at the bottom of the detection area (11), the placement groove (111) is used to place the reagent kit (2), and a sliding cavity (112) is provided on the detection area (11). The test reagents are linearly placed inside the kit (2); A sealing component (3) is provided above the detection area (11). The sealing component (3) is located above the reagent kit (2). When the cover plate (12) closes the detection area (11), the sealing component (3) seals the reagent kit (2).

2. The detection and analysis device according to claim 1, characterized in that: The cover plate (12) is provided with an auxiliary handrail (121).

3. The detection and analysis device according to claim 2, characterized in that: The enclosed assembly (3) includes a drive wheel (31), a driven wheel (32), a double-toothed rack (33), a rotating wheel (34), a driven rack (35), and a sealing plate (36). The drive wheel (31) is fixedly connected to the cover plate (12), the drive wheel (31) is rotatably installed in the sliding cavity (112), and a driven wheel (32) is provided below the drive wheel (31). The driven wheel (32) is rotatably mounted in the sliding cavity (112), and a double-toothed rack (33) is provided below the driven wheel (32). The double-toothed rack (33) is provided with a driving gear tooth (331) and a transmission gear tooth (332). The driving gear tooth (331) and the transmission gear tooth (332) are perpendicular. The driving gear tooth (331) meshes with the driven gear (32). A rotating wheel (34) is provided on one side of the transmission gear tooth (332). The intermediate rotating wheel (34) is rotatably mounted in the sliding cavity (112), and the intermediate rotating wheel (34) meshes with the driven rack (35); Both the double-toothed rack (33) and the driven rack (35) are equipped with sealing plates (36).

4. The detection and analysis device according to claim 3, characterized in that: The sealing plate (36) is provided with a sealing protrusion (361) corresponding to the reagent kit (2), and the sealing protrusion (361) is made of rubber.

5. The detection and analysis device according to claim 4, characterized in that: Sealing strips are provided on the opposing surfaces of the two sealing plates (36).

6. The detection and analysis apparatus according to claim 5, characterized in that: It also includes a cleaning plate (4), which is symmetrically installed in the detection area (11) and is located below the sealing plate (36).

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