18F high-quality-efficiency rapid synthesis device

Abstract

The utility model relates to a high-quality-efficiency rapid synthesis device for 18F. The synthesis quality and efficiency are improved. A target water input pipe and a nitrogen input pipe are sequentially communicated with K2 input, front quantitative pumping and injection and top interconnected QMA column input and output through a head end input three-way valve pipe; a feeding pipe extends into a target waste liquid collection three-way valve pipe at the bottom in the heating catalytic reactor; valve pump pipelines for respectively and quantitatively extracting acetonitrile and trifluoromannose acetonitrile solutions are respectively communicated with the inner top of the heating catalytic reactor; and a discharge pipe led out from the inner bottom of the heating catalytic reactor is sequentially communicated with pure water input, NaOH solution input, rear quantitative pumping and injection, front and rear purification communicated with the tops of the front and rear purification columns, and a rear waste liquid collection three-way valve pipe for outputting finished products. The device has the advantages of being capable of being arranged simply and directly through pipelines, good in intuition, convenient to operate and capable of achieving high-quality-efficiency rapid synthesis.

Description

TECHNICAL FIELD

[0001] The present application relates to an artificial nuclear medicine synthesis device, in particular to an 18F high-quality efficient and fast synthesis device. BACKGROUND

[0002] The prior art document CN113402568A discloses a synthesis system for preparing positron drug 18F-FDG, which comprises an F18 collector and a sealed reaction tube connected with the collector by a pipeline, the reaction tube is provided with a heating device and a fifth control valve at the bottom, and the reaction tube is also connected with a first recovery bottle, a raw material input device and an output device; the raw material input device comprises a first multi-way valve and first and second raw material pushers connected with the first multi-way valve, the raw material pushers comprise injection pumps and raw material bottles connected with the injection pumps, and the raw material bottles of the first and second raw material pushers are used for storing anhydrous acetonitrile and trifluoroacetylmannose acetonitrile solution respectively; the output device comprises a first three-way valve connected with the reaction tube and a transfer bottle connected with the first three-way valve, the transfer bottle is connected with a third raw material pusher, and the raw material bottle of the third raw material pusher is used for storing injection water; the first three-way valve is also connected with a collection branch, the collection branch comprises a second multi-way valve connected with the first three-way valve, a third multi-way valve connected with the second multi-way valve, a fourth multi-way valve connected with the third multi-way valve and a fifth multi-way valve connected with the fourth multi-way valve, a plurality of first purification columns are connected in parallel between the second multi-way valve and the third multi-way valve, the fifth multi-way valve is connected with a plurality of second purification columns, and each second purification column is connected with a product collection bottle; the second multi-way valve is also connected with a fourth raw material pusher, and the raw material bottle of the fourth raw material pusher is used for storing sodium hydroxide solution; the synthesis system further comprises a blowing device connected with the reaction tube, the first multi-way valve, the second multi-way valve and the transfer bottle, and control valves are arranged on the connecting pipelines. The F18 collector comprises a rotatable multi-channel switching valve and a fifth raw material pusher, and further comprises a target water input pipe, a target water output pipe and a QMA column connected in series on the target water output pipe, the target water input pipe, the target water output pipe and the outlet of the fifth raw material pusher are located at different valve ports of the multi-channel switching valve; the raw material bottle of the fifth raw material pusher is used for storing an amino polyether acetonitrile solution containing potassium carbonate. The blowing device is connected with at least one valve port of the multi-channel switching valve. The fourth multi-way valve 12 and the fifth multi-way valve 14 are connected with a second three-way valve, and the second three-way valve is connected with a waste liquid recovery bottle. The reaction tube and the second multi-way valve are connected with the blowing device through a gas flow controller. Further, PLCs are connected with the three-way valves, the multi-way valves, the raw material pushers and the blowing device for control. However, due to the preciousness of the target water raw material, the short half-life of the raw material, the intermediate product and the finished product, a further high-quality efficient and fast synthesis device is needed. SUMMARY

[0003] The novel device aims to overcome the above-mentioned defects of the prior art, and provide an 18F high-quality efficient synthesis device.

[0004] To achieve the above-mentioned purpose, the utility model discloses 18F high-quality efficient synthesis device, its special in target water input pipe and nitrogen input pipe pass through the head end input three -way valve pipe lateral communication K2 input three -way valve pipe, front quantitative injection three -way valve pipe, top interconnection's QMA column input output three -way valve pipe, the feeding pipe stretches into the target waste liquid collection three -way valve pipe of heating catalytic reactor inner bottom, respectively quantitative extraction acetonitrile and trifluoroacetylmannose acetonitrile solution's valve pump pipe road respectively intercommunication heating catalytic reactor top, the discharge pipe that leads from the inner bottom of heating catalytic reactor lateral communication pure water input three -way valve pipe, N a OH solution input three -way valve pipe, rear quantitative injection three -way valve pipe, front and rear purification three -way valve pipe that front and rear purification column top intercommunication, the rear waste liquid collection three -way valve pipe of outward output finished product. The quantitative injection of front quantitative injection three -way valve pipe and rear quantitative injection three -way valve pipe can be respectively quantitative extraction and online injection to the raw material on its upstream pipeline to the downstream QMA column and purification column, significantly improve the corresponding feeding quality. The adjacent setting of top interconnection's QMA column input output three -way valve pipe can realize the high efficiency chromatography of QMA column, and correspondingly reduce the pipeline residual. The adjacent setting of front and rear purification three -way valve pipe that front and rear purification column top intercommunication can also significantly improve the purification quality. The four-way pipeline setting of heating catalytic reactor can significantly reduce the pipeline residual compared with the existing five-way pipeline setting. In short, it has the advantages of simple pipeline setting, good intuitiveness, convenient visual operation and high-quality efficient synthesis.

[0005] As optimization, the target water input pipe is laterally connected to the head end input three-way valve pipe, which is beneficial to reduce the input resistance and reduce the pipeline residual compared with the elbow pipe input. The nitrogen input pipe is downwardly connected to the head end input three-way valve pipe, which is beneficial to prevent liquid material from overflowing into the nitrogen input pipe. The liquid outlet pipe, which is sealed and connected to the K2 input three-way valve pipe, is downwardly connected to the K2 input three-way valve pipe, which is beneficial to improve the material quality. The front quantitative injection cylinder with an electric control mechanism is downwardly connected to the front quantitative injection three-way valve pipe, which is also beneficial to improve the material quality.

[0006] As optimization, the QMA column input three-way valve pipe is upwardly connected to the top interconnection pipe, the QMA column is downwardly connected to the QMA column output three-way valve pipe, and the QMA column top is connected to the top interconnection pipe, which is beneficial to improve the input and output quality. The upper end of the target waste liquid collection bottle is connected to the target waste liquid collection three-way valve pipe downwardly or upwardly, which is more beneficial to exhaust the waste liquid compared with the upward connection. The discharge pipe of the target waste liquid collection three-way valve pipe is downwardly sealed and extended into the bottom of the heating catalytic reactor, which ensures that the material is added to the bottom of the heating catalytic reactor.

[0007] As optimization, the upper end cap of the filter gas permeable needle is provided with an upper end communication pipe of the anhydrous acetonitrile bottle, and the lower end of the pipe is communicated with the anhydrous acetonitrile three-way valve pipe and the metering delivery pump thereof, and then downwardly communicated with the top of the heated catalytic reactor; the upper end cap of the filter gas permeable needle of the trifluoro-mannose acetonitrile solution bottle is provided with an upper end communication pipe, and the lower end of the pipe is communicated with the trifluoro-mannose acetonitrile solution three-way valve pipe and the metering delivery pump thereof, and then downwardly communicated with the top of the heated catalytic reactor, and the three-way valve pipe and the metering delivery pump thereof are sequentially arranged from upstream to downstream, so that the feeding can be controlled with high quality and efficiency, and the metering delivery pump can be maintained during the control.

[0008] As optimization, the transverse output end of the anhydrous acetonitrile three-way valve pipe and the transverse output end of the trifluoro-mannose acetonitrile solution three-way valve pipe are transversely connected through a standby three-way valve pipe, and the standby three-way valve pipe can be used to cope with the need for feeding in excess of the normal feeding amount by being used in combination and connected with a standby feeding bottle.

[0009] As optimization, the anhydrous acetonitrile bottle and the trifluoro-mannose acetonitrile solution bottle, the three-way valve pipes and the metering delivery pumps and the pipelines thereof are higher than the heated catalytic reactor, which can significantly improve the visibility of feeding and ensure reliable feeding.

[0010] As optimization, the pure water input pipe is downwardly communicated with the pure water input three-way valve pipe; the N a OH solution bottle is downwardly communicated with the liquid outlet pipe, and the lower end of the pipe is sealed and communicated with the N a OH solution input three-way valve pipe, and the rear quantitative injection cylinder with an electric control mechanism is downwardly communicated with the rear quantitative injection and extraction three-way valve pipe.

[0011] As optimization, the front end of the front purification column is downwardly communicated with the front purification three-way valve pipe, the rear end of the rear purification column is downwardly communicated with the rear purification three-way valve pipe, and the top ends of the front purification column and the rear purification column are communicated through the top interconnection pipe, which can simplify the pipeline and ensure the purification quality; the upper end cap of the filter gas permeable needle of the rear waste liquid collection bottle is downwardly or upwardly communicated with the rear waste liquid collection three-way valve pipe, and upward communication is more conducive to completely discharging waste liquid than downward communication.

[0012] As optimization, the rear waste liquid collection three-way valve pipe is transversely communicated with the product output pipe, which is conducive to reducing the output resistance and reducing the pipeline residue compared with the elbow output.

[0013] As optimization, the target water input pipe and the nitrogen gas input pipe are sequentially downwardly and transversely communicated with the K2 input three-way valve pipe, the front quantitative injection and extraction three-way valve pipe, the QMA column input and output three-way valve pipe connected at the top, and the target waste liquid collection three-way valve pipe with the feeding pipe extending into the bottom of the heated catalytic reactor through the head end input three-way valve pipe; the discharge pipe from the inner bottom of the heated catalytic reactor is sequentially downwardly and transversely communicated with the pure water input three-way valve pipe, the N aThe system uses a three-way valve for inputting OH solution, a three-way valve for quantitative injection, a three-way valve connecting the tops of the front and rear purification columns, and a three-way valve for collecting waste liquid to output the finished product. This design improves the efficiency of both feeding and output.

[0014] After adopting the above technical solution, the new 18F high-efficiency and rapid synthesis equipment has the advantages of simplified and direct pipeline setup, good intuitiveness and convenient operation, significantly reduced material residue in the pipeline, and high-efficiency and rapid synthesis. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the first embodiment of the 18F high-efficiency and rapid synthesis device of this utility model. Figure 2 This is a schematic diagram of the second embodiment of the 18F high-efficiency and rapid synthesis device of this utility model. Detailed Implementation

[0016] Example 1, as Figure 1 As shown, the 18F high-efficiency and rapid synthesis device of this utility model consists of a target water input pipe 11 and a nitrogen input pipe 12 connected laterally to a K2 input three-way valve pipe 2, a pre-quantitative injection three-way valve pipe 31, and top-connected QMA column input / output three-way valve pipes 41 and 42 via a head-end input three-way valve pipe 1. A feed pipe extends into the target waste liquid collection three-way valve pipe 51 at the bottom of the heated catalytic reactor 6. Valve pumps for quantitatively extracting acetonitrile and trifluoromannose acetonitrile solutions are connected to the top of the heated catalytic reactor 6. An outlet pipe extending from the bottom of the heated catalytic reactor 6 is laterally connected to a pure water input three-way valve pipe 7, a N2 input three-way valve pipe 8, and a nitrogen input three-way valve pipe 9. a The system includes an OH solution inlet three-way valve 8, a post-quantitative injection three-way valve 32, and pre- and post-purification three-way valves 91 and 92 connected at the top of the purification columns 93 and 94. A post-waste liquid collection three-way valve 52 outputs the finished product. The quantitative injectors in the pre- and post-quantitative injection three-way valves can quantitatively extract raw materials from their upstream pipelines and add them online to the downstream QMA and purification columns, significantly improving feed efficiency. The adjacent arrangement of the top-interconnected QMA column inlet and outlet three-way valves reduces pipeline residue while achieving high-efficiency QMA column chromatography. The adjacent arrangement of the pre- and post-purification three-way valves connected at the top of the purification columns also significantly improves purification efficiency. Compared to the existing five-way pipeline arrangement, the four-way pipeline arrangement of the heated catalytic reactor significantly reduces pipeline residue. In summary, it offers advantages such as simplified pipeline setup, intuitive operation, and high-efficiency, rapid synthesis.

[0017] Specifically, the target water input pipe 11 is connected to the head input three-way valve pipe 1 through the lateral connection, the nitrogen input pipe 12 is connected to the head input three-way valve pipe 1 downward, the liquid outlet pipe of the potassium carbonate-containing amino polyether acetonitrile solution bottle 20 with a deep filter gas permeation needle head is connected to the K2 input three-way valve pipe 2 downward, and the front quantitative injection cylinder 33 with an electric control mechanism is connected to the front quantitative injection three-way valve pipe 31 downward.

[0018] Specifically, the anhydrous acetonitrile bottle A1 with a filter gas permeation needle head at the upper end is connected to the anhydrous acetonitrile three-way valve pipe B1 and its metering pump, and then connected to the top of the heated catalytic reactor 6 downward; the trifluoromannose acetonitrile solution bottle A2 with a filter gas permeation needle head at the upper end is connected to the trifluoromannose acetonitrile solution three-way valve pipe B2 and its metering pump, and then connected to the top of the heated catalytic reactor 6 downward. More specifically, the lateral output end of the anhydrous acetonitrile three-way valve pipe A1 is connected to the lateral output end of the trifluoromannose acetonitrile solution three-way valve pipe A2 through the standby three-way valve pipe C. More specifically, the anhydrous acetonitrile bottle A1 and the trifluoromannose acetonitrile solution bottle A2, their three-way valve pipes and metering pumps and pipelines are higher than the heated catalytic reactor 6.

[0019] Specifically, the pure water input pipe 13 is connected to the pure water input three-way valve pipe 7 downward, the N a OH solution bottle 80 with a deep filter gas permeation needle head is connected to the liquid outlet pipe connected to the N a OH solution input three-way valve pipe 8 downward, and the rear quantitative injection cylinder 34 with an electric control mechanism is connected to the rear quantitative injection three-way valve pipe 32 downward.

[0020] Specifically, the bottom end of the front purification column 93 is connected to the front purification three-way valve pipe 91 downward, the bottom end of the rear purification column 94 is connected to the rear purification three-way valve pipe 92 downward, and the top end of the front purification column 93 and the top end of the rear purification column 94 are connected through the top interconnection pipe; the rear waste liquid collection bottle 54 with a filter gas permeation needle head at the upper end is connected to the rear waste liquid collection three-way valve pipe 52 downward. More specifically, the rear waste liquid collection three-way valve pipe 52 is connected to the product output pipe 14 laterally.

[0021] Specific is target water input pipe 11 and nitrogen input pipe 12 pass through head end input three-way valve pipe 1 in turn to downstream transverse down inclined type intercommunication K2 input three-way valve pipe 2, front quantitative injection three-way valve pipe 31, top interconnection's QMA column input output three-way valve pipe 41, 42, and the feeding pipe is inserted into the target waste liquid collection three-way valve pipe 51 in the bottom of heating catalytic reactor 6;From the inner bottom of heating catalytic reactor 6, the discharge pipe is in turn to downstream transverse down inclined type intercommunication pure water input three-way valve pipe 7, N a OH solution input three-way valve pipe 8, rear quantitative injection three-way valve pipe 32, front and rear purification column 93, 94 top intercommunication's front and rear purification three-way valve pipe 91, 92, and the rear waste liquid collection three-way valve pipe 52 of outward output finished product.

[0022] Embodiment two, as Figure 2 shown, the utility model 18F high quality efficient quick synthesis device with the difference of the above embodiment one is in the upper end cap is equipped with filter gas permeation needle head's target waste liquid collection bottle 53 upper end intercommunication pipe upward intercommunication target waste liquid collection three-way valve pipe 51, and the upper end cap is equipped with filter gas permeation needle head's rear waste liquid collection bottle 54 upper end intercommunication pipe upward intercommunication rear waste liquid collection three-way valve pipe 52.

[0023] In general, the new 18F high quality efficient quick synthesis device has the advantages of being able to be directly set through simple and direct pipeline, good intuition and convenient visual operation, significantly reducing the material residue of the pipeline, and realizing high quality efficient quick synthesis.

Claims

1. An apparatus for rapid synthesis of high-yield 18F, characterized in that The target water input pipe and the nitrogen input pipe are connected to the K2 input three-way valve pipe, the front quantitative injection three-way valve pipe, the QMA column input and output three-way valve pipe interconnected at the top, the target waste liquid collection three-way valve pipe with the feeding pipe extending into the bottom of the heating catalytic reactor in sequence through the head end input three-way valve pipe; the valve pump pipes for quantitatively extracting acetonitrile and trifluoroacetylmannose acetonitrile solution are connected to the top of the heating catalytic reactor respectively; the discharge pipe from the bottom of the heating catalytic reactor is connected to the pure water input three-way valve pipe, the N a OH solution input three-way valve pipe, the rear quantitative injection three-way valve pipe, the front and rear purification three-way valve pipes interconnected at the top of the front and rear purification columns, and the rear waste liquid collection three-way valve pipe for outputting the finished product.

2. The device for rapid synthesis of 18F with high radiochemical yield according to claim 1, characterized in that The target water input pipe is connected to the head input three-way valve pipe horizontally, the nitrogen gas input pipe is connected to the head input three-way valve pipe downward, the bottle of potassium carbonate containing amino polyether acetonitrile solution with deep top and bottom filtering gas permeable needle head is connected to the K2 output three-way valve pipe downward through the liquid outlet pipe, and the front quantitative injection cylinder with an electric control mechanism is connected to the front quantitative injection three-way valve pipe downward.

3. The 18F high-yield rapid synthesis apparatus of claim 1, wherein The QMA column input three-way valve pipe is connected to the top interconnection pipe upward, the QMA column is connected to the QMA column output three-way valve pipe downward, and the top of the QMA column is connected to the top interconnection pipe; the upper end cap of the target waste liquid collection bottle with a filtering gas permeable needle head is connected to the target waste liquid collection three-way valve pipe downward or upward, and the discharge pipe of the target waste liquid collection three-way valve pipe is connected to the bottom of the heated catalytic reactor downward.

4. The 18F high-yield rapid synthesis apparatus of claim 1, wherein The upper end cap of the anhydrous acetonitrile bottle with a filtering gas permeable needle head is connected to the anhydrous acetonitrile three-way valve pipe and its metering pump, and then connected to the top of the heated catalytic reactor downward; the upper end cap of the trifluoromannose acetonitrile solution bottle with a filtering gas permeable needle head is connected to the trifluoromannose acetonitrile solution three-way valve pipe and its metering pump, and then connected to the top of the heated catalytic reactor downward.

5. The 18F high-yield rapid synthesis apparatus according to claim 4, characterized by The lateral output end of the anhydrous acetonitrile three-way valve pipe is connected to the lateral output end of the trifluoromannose acetonitrile solution three-way valve pipe through a standby three-way valve pipe.

6. The 18F high-yield rapid synthesis apparatus of claim 4, wherein The anhydrous acetonitrile bottle and the trifluoromannose acetonitrile solution bottle, their three-way valve pipes and metering pumps and pipelines are higher than the heated catalytic reactor.

7. The 18F high-yield rapid synthesis apparatus of claim 1, wherein The pure water input pipe is connected downward to the pure water input three-way valve pipe, and the N a OH solution bottle lower end port sealing communication liquid outlet pipe is connected downward to the N a OH solution input three-way valve pipe, and the rear quantitative injection cylinder with an electric control mechanism is connected downward to the rear quantitative injection and extraction three-way valve pipe.

8. The 18F high-yield rapid synthesis apparatus of claim 1, wherein The front purification column bottom end is connected to the front purification three-way valve pipe downward, the rear purification column bottom end is connected to the rear purification three-way valve pipe downward, and the top end of the front purification column and the top end of the rear purification column are connected through the top interconnection pipe; the upper end cap of the rear waste liquid collection bottle with a filtering gas permeable needle head is connected to the rear waste liquid collection three-way valve pipe downward or upward.

9. The 18F high-yield rapid synthesis apparatus according to claim 8, characterized by The rear waste liquid collection three-way valve pipe is connected to the product output pipe horizontally.

10. The 18F high-yield rapid synthesis apparatus of claim 1, wherein The target water input pipe and the nitrogen gas input pipe are connected to the K2 input tee joint valve pipe, the front quantitative injection tee joint valve pipe, the QMA column input and output tee joint valve pipe interconnected at the top, and the target waste liquid collection tee joint valve pipe with the feeding pipe extending into the bottom of the heating catalytic reactor in sequence through the head end input tee joint valve pipe. a OH solution input tee joint valve pipe, the rear quantitative injection tee joint valve pipe, the front and rear purification tee joint valve pipe interconnected at the top of the front and rear purification columns, and the rear waste liquid collection tee joint valve pipe outputting the finished product outward.

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