Pore plate filling device

Abstract

The utility model provides a pore plate filling device, and belongs to the technical field of biological preparation production, the device comprises: a base on which a placing table is arranged for placing a pore plate parallel to the base, the placing table is movably arranged along the length direction of the base; the mounting table is arranged on the base, located at one end of the placing table, used for placing the liquid storage disc parallel to the base and movably arranged in the height direction of the base; the mounting plate is erected above the mounting table and parallel to the base, the mounting plate is movably arranged in the height direction of the base, and a stirring assembly used for stirring the mixed liquid in the liquid storage disc is arranged on the mounting plate; and the mounting frame is erected above the placement table and is movably arranged in the length direction of the base, and a pipetting assembly is arranged in the mounting frame and is used for sucking the mixed liquid in the liquid storage disc and filling the mixed liquid into the pore plate. The filling device has high automation degree, and can effectively solve the problem of poor filling uniformity.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of biological agent production, and particularly relates to a hole plate filling device. BACKGROUND

[0002] The existing hole plate filling technology mainly includes weighing method or wet column filling. The weighing method is to add a certain amount of filler into the filler hole of the hole plate. The weighing method is time-consuming and laborious, and the weighing error is uncontrollable, and the uniformity is poor. The wet column filling is to mix the filler and the solvent, use a pipette to suck and transfer the mixed liquid to the filler hole, and then remove the solvent to realize filling. Compared with the weighing method, the wet column filling reduces the weighing process and the error caused by weighing. However, after the filler and the solvent are mixed, there is a stratification phenomenon, which leads to a large error in the content of the filler in the mixed liquid sucked in front and back, and further leads to the problem of poor uniformity of the filler. In addition, the general wet column filling is filled by manually using a pipette, which is labor-intensive and has low automation. CONTENT OF THE UTILITY MODEL

[0003] In order to solve the above problems of the prior art, the hole plate filling device has high automation degree and can effectively solve the problem of poor uniformity of the filler.

[0004] In order to achieve the above purpose, the utility model adopts the following technology:

[0005] A hole plate filling device comprises:

[0006] A base is provided with a placing table for placing a hole plate parallel to the base, and the placing table is movably arranged along the length direction of the base;

[0007] An installation table is arranged on the base and located at one end of the placing table, and is used for placing a liquid storage tray parallel to the base, and the installation table is movably arranged along the height direction of the base;

[0008] An installation plate is arranged above the installation table and parallel to the base, and is movably arranged along the height direction of the base, and a stirring assembly for stirring the mixed liquid in the liquid storage tray is arranged on the installation plate;

[0009] An installation frame is arranged above the placing table and movably arranged along the length direction of the base, and a pipetting assembly is arranged in the installation frame and used for sucking the mixed liquid in the liquid storage tray and filling it into the hole plate.

[0010] Further, two vertical columns are connected to the two sides of the installation frame and located at the two sides of the placing table, and two groups of first linear mechanisms are arranged on the base, and the movable ends of the two groups of first linear mechanisms are located in the length direction of the base and connected to the bottom ends of the corresponding vertical columns; a pair of guide rods is vertically arranged at one end of the base, and one end of the installation plate is slidably arranged on the guide rods.

[0011] Furthermore, both sides of the mounting plate are hinged with connecting rods, with their hinge axes facing the width direction of the base. The other end of the connecting rod is hinged to the bottom of the column, with its hinge axis facing the width direction of the base. The two connecting rods are always set parallel to each other, and the hinge axis between the connecting rod and the column is always located below the hinge axis between the connecting rod and the mounting plate.

[0012] Furthermore, the mixing assembly includes a turntable arranged parallel to the bottom of the mounting plate, a motor on the top of the mounting plate with its drive end vertically passing through the mounting plate and connected to the middle of the turntable, and multiple stirring rods vertically arranged at the bottom of the turntable.

[0013] The beneficial effects of this utility model are as follows:

[0014] 1. By setting up the stirring component, the stratification of the mixture in the pipetting tray during the filling process can be effectively avoided, which would lead to a large difference in the content of filler in the mixture absorbed by the subsequent pipetting components, resulting in poor uniformity of the filler amount in each orifice plate.

[0015] 2. Under the hinged action of the connecting rod, column and mounting plate, and in conjunction with the first linear mechanism, the movement of the mounting frame can be converted into the lifting and lowering of the mounting plate, and the liquid transfer component and the stirring component can cooperate with each other without interfering with each other, so as to achieve the purpose of continuous and uniform mixing of the liquid in the storage pan during filling, improve the automation level of the filling device, and thus improve the filling efficiency of the orifice plate. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the main structure of the device according to an embodiment of this application.

[0017] Figure 2 This is a cross-sectional view of the installation frame in an embodiment of this application.

[0018] Figure 3 This is a side view of the device according to an embodiment of this application.

[0019] Figure 4 This is a rear view of the device according to an embodiment of this application.

[0020] Reference numerals: 1-base, 11-placement platform, 12-placement slot, 13-mounting slot, 2-mounting platform, 3-mounting plate, 31-stirring assembly, 32-turntable, 33-motor, 34-guide rod, 35-stirring rod, 4-mounting frame, 41-pipetting assembly, 42-column, 43-first linear mechanism, 44-slider, 45-fitting hole, 46-piston, 47-push-pull rod, 48-pressure plate, 49-second linear mechanism, 5-connecting rod, 6-mounting ring, 7-third linear mechanism. Detailed Implementation

[0021] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the embodiments of the utility model will be described in detail below with reference to the drawings, but the embodiments described by the utility model are part of the embodiments of the utility model, not all the embodiments.

[0022] The embodiments of the present application provide a kind of orifice plate filling device, as shown in Figures 1-4 The device includes base 1, mounting table 2, mounting plate 3, mounting frame 4.

[0023] Among them, base 1 is equipped with placing table 11, placing table 11 top is opened downward and is equipped with placing groove 12 along the length direction of base 1, placing groove 12 upper end both sides are equipped with installation groove 13 along the length direction of base 1, installation groove 13 is used to carry the both sides of orifice plate and make orifice plate be in the state of parallel to base 1, placing groove 12 is used to accommodate the filling hole of orifice plate, placing table 11 is arranged along the length direction of base 1 and moves, correspondingly, linear mechanism for driving placing table 11 to move can be set on base 1, specifically can adopt linear cylinder, linear motor, rack and so on.Form. Mounting table 2 is arranged on base 1 and is located at one end of placing table 11, is used to place liquid storage tray parallel to base 1, mounting table 2 is arranged along the height direction of base 1 and moves, correspondingly, linear mechanism for driving placing table 11 to move can be set on base 1, specifically can adopt linear cylinder, rack and so on.Form. Mounting plate 3 is erected above mounting table 2 and is arranged parallel to base 1, mounting plate 3 is arranged along the height direction of base 1 and moves, and mounting plate 3 is equipped with stirring assembly 31 for stirring liquid in liquid storage tray. Mounting frame 4 is erected above placing table 11 and is arranged along the length direction of base 1 and moves, and mounting frame 4 is equipped with pipette assembly 41 in, is used to suck liquid in liquid storage tray and fills to orifice plate.

[0024] In application, the operator places the two sides of the hole plate in the corresponding installation groove 12, then fills the solvent and the filler into the liquid storage tray, and places the liquid storage tray on the installation table 2. The installation plate 3 is lowered, and the stirring assembly 31 stirs and mixes the solvent and the filler in the liquid storage tray. After mixing, the installation plate 3 rises in the height direction of the base 1 and leaves a space, so that the installation frame 4 can move the liquid transfer assembly 41 in the length direction of the base 1 to the upper side of the liquid storage tray. The installation table 2 rises in the height direction of the base 1 to the height at which the liquid transfer assembly 41 can suck the mixed liquid in the liquid storage tray. The liquid transfer assembly 41 sucks part of the mixed liquid, and the installation frame 4 moves in the length direction of the base 1 to move the liquid transfer assembly 41 to the upper side of the filler hole at one end of the hole plate and discharge the mixed liquid for filling. The placement table 11 starts to move in the length direction of the base 1, so that the liquid transfer assembly 41 fills the filler holes on the hole plate in turn in the length direction of the hole plate. After the installation frame 4 moves out of the upper side of the liquid storage tray, the installation plate 3 is lowered. During the filling process of the liquid transfer assembly 31, the stirring assembly 31 continuously stirs the remaining mixed liquid in the liquid storage tray, which can effectively avoid the stratification of the mixed liquid in the liquid transfer tray during the filling process, so that the content of the filler in the mixed liquid sucked by the liquid transfer assembly 31 is greatly different before and after, and thus the uniformity of the filler amount of each hole plate is poor, effectively ensuring the quality of the biological preparation product.

[0025] Specifically, as shown in Figures 1-3 The installation frame 4 is connected with a vertical column 42 perpendicular to the base 1 on both sides, and is located on both sides of the placement table 11. The base 1 is provided with two groups of first linear mechanisms 43, the movable ends of which are directed to the length direction of the base 1 and are connected to the bottom ends of the corresponding vertical columns 42. The first linear mechanism 43 can be in the form of a linear cylinder, a hydraulic cylinder, etc. A pair of guide rods 34 is vertically arranged at one end of the base 1, and one end of the installation plate 3 is slidably arranged on the guide rod 34. Figure 1 and Figure 3 The installation plate 3 is hinged with a connecting rod 5 on both sides, the hinging axis of which is directed to the width direction of the base 1. The other end of the connecting rod 5 is hinged to the bottom end of the vertical column 42, and the hinging axis thereof is directed to the width direction of the base 1. The two connecting rods 5 are always arranged in parallel to each other, and the hinging axes of the connecting rod 5 and the vertical column 42 are always below the hinging axes of the connecting rod 5 and the installation plate 3.

[0026] In application, as shown in Figures 1-4As shown, when the first linear mechanism 43 drives the column 42 to move the mounting frame 4 along the length direction of the base 1 to the upper side of the liquid storage tray, the column 42 gives the other end of the connecting rod 5 a pushing force. Due to the hinged connection of the connecting rod 5 with the mounting plate 3 and the column 42, the column 42 will make the connecting rod 5 rotate around the corresponding hinged axis, and push the mounting plate 3 upward along the guide rod 34, so that the mounting plate 3 drives the stirring assembly 31 to move away from the liquid storage tray to leave a space for the pipetting assembly 41 to take liquid. After the liquid is taken, the first linear mechanism 43 drives the column 42 to move away from the liquid storage tray, and the column 42 pulls the connecting rod 5, so that the two ends of the connecting rod 5 rotate around the corresponding hinged axis, and the connecting rod 5 pulls the mounting plate 3 downward along the guide rod 34. When the pipetting assembly 41 moves to one end of the hole plate, the mounting plate 3 moves to the height of the stirring assembly 31 that can stir the mixed liquid. During the filling process of the pipetting assembly 41, the stirring assembly 31 continuously stirs the mixed liquid in the liquid storage tray.

[0027] Through the hinged connection of the connecting rod 5 with the column 42 and the mounting plate 3, and the cooperation of the driving of the first linear mechanism 43, the movement of the mounting frame 4 along the length direction of the base 1 is converted into the lifting of the mounting plate 3 along the guide rod 34, and the pipetting assembly 31 and the stirring assembly 41 are matched with each other without interfering with each other, so that the mixed liquid in the liquid storage tray is continuously mixed during the filling process. This not only effectively avoids the stratification of the mixed liquid, but also effectively improves the automation degree of the filling device, which is conducive to improving the filling efficiency of the hole plate.

[0028] During the movement of the column 42, the guide rod 34 is always subjected to a horizontal decomposed force. In order to ensure the stability of the operation of the guide rod 34 and the mounting plate 3, a reinforcing rib can be arranged at the connection between the guide rod 34 and the base 1. At the same time, in order to avoid the stroke interference of the mounting plate 3, lubrication is needed between the mounting plate 3 and the guide rod 34 to reduce the friction between them as much as possible.

[0029] Specifically, as shown in Figure 1 and Figure 3 , the stirring assembly 31 includes a rotating disc 32 arranged in parallel below the mounting plate 3. The top of the mounting plate 3 is provided with a motor 33, the driving end of which is vertically arranged through the mounting plate 3 and connected to the middle part of the rotating disc 32. A plurality of stirring rods 35 are vertically arranged at the bottom of the rotating disc 32.

[0030] The hole plate can be divided into various types according to the number of filling holes, as shown in Figure 1 and Figure 2 , this embodiment takes the hole plate with six filling holes in each column as an example. The pipetting assembly 41 includes a slider 44 arranged in the mounting frame 4 and arranged to move along the width direction of the base 1. Three matching holes 45 are vertically arranged on the slider 44. The matching holes 45 are arrayed along the width direction of the base 1. A piston 46 is slidably arranged in each matching hole 45. Each matching hole 45 is coaxially provided with a mounting ring 6 at the bottom for mounting a suction head.

[0031] Specifically, as shown in Figures 1-3 The top of the piston 46 is connected with a push-pull rod 47 arranged perpendicularly to the base 1, one end of the push-pull rod 47 is connected perpendicularly with a pressing plate 48, the sliding block 44 is provided with a second linear mechanism 49, the movable end of which is arranged perpendicularly to the base 1 and connected to the bottom of the pressing plate 48; at the same time, guide blocks can be arranged on both sides of the sliding block 44, guide grooves adapted to the guide blocks are arranged on both sides inside the mounting frame 4, and a third linear mechanism 7 is arranged at one end of the mounting frame 4, the movable end of which is directed towards the width direction of the base 1 and connected to the sliding block 44.

[0032] In application, the suction heads are installed on the mounting ring 6 at the bottom of the three matching holes 45, the end of the suction head is immersed below the liquid level in the liquid storage tray, the second linear mechanism 49 pushes the pressing plate 48 to rise, driving the piston 46 to suck the mixed liquid into the suction head, completing the liquid taking; in filling, the mounting frame 4 is moved to one end of the hole plate, the third linear mechanism 7 moves the sliding block 44, so that the three suction heads are above the first three filler holes in the row of filler holes, the second linear mechanism 49 pulls the pressing plate 48 to descend, driving the piston 46 to discharge the mixed liquid in the suction head into the filler holes; the third linear mechanism 7 further moves the sliding block 44 so that the suction heads are above the last three filler holes to continue the filling; the placement table 11 drives the hole plate to move, and the above operation is repeated to fill the filler holes thereafter. Through the above arrangement, the manual filling mode using a pipette in turn is changed, the labor intensity is reduced, and the filling efficiency and the biological preparation production efficiency are improved.

[0033] The above only describes the preferred embodiments of the present application and is not used to limit the present application. Obviously, those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application.

Claims

1. An orifice plate packing device, characterized by, The utility model relates to a liquid transfer device for microplate, which comprises: a base (1) provided with a placing table (11) for placing a microplate parallel to the base (1), the placing table (11) being movably arranged along the length direction of the base (1); a mounting table (2) arranged on the base (1) and located at one end of the placing table (11) for placing a liquid storage tray parallel to the base (1), the mounting table (2) being movably arranged along the height direction of the base (1); a mounting plate (3) arranged above the mounting table (2) and parallel to the base (1), the mounting plate (3) being movably arranged along the height direction of the base (1), and the mounting plate (3) being provided with a stirring assembly (31) for stirring a mixed solution in the liquid storage tray; a mounting frame (4) arranged above the placing table (11) and movably arranged along the length direction of the base (1), the mounting frame (4) being provided with a pipetting assembly (41) for sucking the mixed solution in the liquid storage tray and filling it into the microplate.

2. A well plate filling device according to claim 1, wherein, The mounting frame (4) is connected with vertical columns (42) arranged perpendicular to the base (1) and located at both sides of the placing table (11), and the base (1) is provided with two groups of first linear mechanisms (43) with movable ends facing the length direction of the base (1) and connected with the bottom ends of the corresponding vertical columns (42).

3. A well plate filling device according to claim 2, wherein, A pair of guide rods (34) are vertically arranged at one end of the base (1), one end of the mounting plate (3) is slidably arranged on the guide rods (34), and linkages (5) are hingedly arranged at both sides of the mounting plate (3) with hinging axes facing the width direction of the base (1), the other ends of the linkages (5) are hingedly arranged at the bottom ends of the vertical columns (42) with hinging axes facing the width direction of the base (1), the two linkages (5) are always arranged in parallel to each other, and the hinging axes of the linkages (5) and the vertical columns (42) are always located below the hinging axes of the linkages (5) and the mounting plate (3).

4. A well plate filling device according to claim 1, wherein, The stirring assembly (31) comprises a rotating disc (32) arranged parallel to the mounting plate (3), the mounting plate (3) is provided with a motor (33) at the top with a driving end vertically penetrating the mounting plate (3) and connected with the middle part of the rotating disc (32), and the bottom of the rotating disc (32) is vertically provided with a plurality of stirring rods (35).

5. A well plate filling device according to claim 1, wherein, The pipetting assembly (41) comprises a sliding block (44) arranged in the mounting frame (4) and movably arranged along the width direction of the base (1), a plurality of matching holes (45) are vertically arranged on the sliding block (44) and parallel to the base (1), the matching holes (45) are slidably arranged with pistons (46), and the bottom of each matching hole (45) is coaxially provided with a mounting ring (6) for mounting a suction head.

6. A well plate filling device according to claim 5, wherein, The top of the piston (46) is connected with a push-pull rod (47) arranged perpendicular to the base (1), one end of the push-pull rod (47) is vertically connected with a pressing plate (48), and the sliding block (44) is provided with a second linear mechanism (49) with a movable end vertically arranged on the base (1) and connected with the bottom of the pressing plate (48).

7. A well plate filling device according to claim 6, wherein, One end of the mounting frame (4) is provided with a third linear mechanism (7) with a movable end facing the width direction of the base (1) and connected with the sliding block (44).

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