Crystallization device for dexamethasone production

Abstract

The utility model relates to the field of dexamethasone production, in particular to a crystallization device for dexamethasone production, which comprises a treatment box, the device further comprises an L-shaped plate, a filter plate, a through groove, a baffle, a rotating shaft, a crystallization plate, a temperature control plate, a drainage groove, a sliding assembly, a mounting bracket, a water pump, a spray head, a guide pipe and a suction head; the treatment box is arranged, the liquid medicine is added into the treatment box, the water pump conveys the liquid medicine to the position of the spray head through the suction head and the guide pipe during operation, the liquid medicine falls on the surface of the crystallization plate in a dripping mode, and the temperature control plate can adjust the temperature of the crystallization plate so that the crystallization plate can be kept at the crystallization temperature. Due to the arrangement of the drainage groove, the flowing uniformity of the liquid medicine can be improved, part of the liquid medicine can be crystallized and left on the surface of the temperature control plate in the flowing process, the uncrystallized liquid medicine flows back to the bottom of the treatment box again after being filtered by the filter plate, and then is circulated through the water pump, so that circulating crystallization of the dexamethasone liquid medicine is realized, and the crystallization quality is improved.

Description

Technical Field

[0001] This utility model relates to the field of dexamethasone production, and more particularly to a crystallization apparatus for dexamethasone production. Background Technology

[0002] Dexamethasone is a commonly used glucocorticoid drug. The crystallization equipment in its production process is mainly used to purify and separate the target product. Common crystallization equipment promotes the precipitation of dexamethasone crystals from the solution by controlling the temperature, stirring speed and solvent ratio.

[0003] Existing dexamethasone crystallization devices typically employ a stirring method to simultaneously crystallize the drug solution within the entire tank. This method is inefficient, and the crystals tend to mix with the drug solution again during the stirring process, leading to drug waste and increased costs.

[0004] Therefore, in view of the problem that the existing dexamethasone crystallization device crystallizes all the drug solution inside the stirring tank at the same time, and the crystals will continuously re-merge with the drug solution in the process, resulting in low efficiency, there is an urgent need to design a new crystallization device for dexamethasone production. Utility Model Content

[0005] To overcome the problem that existing dexamethasone crystallization devices crystallize all the drug solution inside the stirring tank simultaneously, resulting in low efficiency due to the crystals constantly re-merging with the drug solution.

[0006] The technical solution of this utility model is as follows: a crystallization device for dexamethasone production, including a processing box; it also includes an L-shaped plate, a filter plate, a through groove, a baffle, a rotating shaft, a crystallization plate, a temperature control plate, a diversion groove, a sliding assembly, a mounting bracket, a water pump, a nozzle, a conduit, and a suction head. An L-shaped plate is installed on the bottom left side of the inner surface of the processing box. A filter plate is embedded on the upper surface of the L-shaped plate. A through groove is opened on the right side surface of the L-shaped plate. A baffle is set on the top surface of the L-shaped plate to the right of the filter plate. A rotating shaft is rotatably connected to the left side of the front and rear sides of the inner surface of the processing box. A crystallization plate is installed on the outer surface of the rotating shaft. A temperature control plate is set on the left side surface of the crystallization plate. A diversion groove is opened on the right side surface of the crystallization plate. A sliding assembly is set on the upper front and rear sides of the outer surface of the processing box. The moving end of the sliding assembly is connected to the mounting bracket. A water pump is set in the middle of the top surface of the mounting bracket. A nozzle is installed on the bottom surface of the mounting bracket. One end of the conduit is connected to the top of the water pump, and the other end of the conduit is connected to the suction head.

[0007] Preferably, a treatment tank is set up, and the inside of the treatment tank is filled with drug solution. When the water pump is operating, the drug solution is transported to the nozzle position through the suction head and the conduit, and falls onto the surface of the crystallization plate by dripping. The temperature control plate can adjust the temperature of the crystallization plate to maintain it at the crystallization temperature. The setting of the diversion channel can improve the uniformity of drug solution flow. During the flow, some drug solution will crystallize and remain on the surface of the temperature control plate. The drug solution that is not crystallized will be filtered by the filter plate and flow back to the bottom of the treatment tank. Then it will be circulated by the water pump, thereby realizing the cyclic crystallization of dexamethasone drug solution, improving the crystallization quality. This solves the problem that the existing dexamethasone crystallization device usually uses a stirring method to crystallize the drug solution in the entire tank at the same time. The crystallization efficiency is low, and the crystals are easy to mix with the drug solution again during the stirring process, which easily leads to waste of drug solution and increased cost.

[0008] Preferably, the sliding assembly includes an electric guide rail and an electric slider; electric guide rails are installed on the upper part of both the front and rear surfaces of the processing box, and electric sliders are slidably connected to the outer surface of the electric guide rails. The side surface of the electric slider away from the corresponding electric guide rail is connected to the mounting bracket.

[0009] Preferably, the inner surface of the processing box is rotatably connected to the front and rear sides of the crystallization plate, and the outer surface of the screw is threaded to a movable seat. The lower left side surface of the movable seat is rotatably connected to two symmetrical scrapers, which are in contact with the crystallization plate.

[0010] Preferably, a limiting rod is connected through the front and rear surfaces of the movable seat, and the front and rear ends of the limiting rod are connected to the front and rear sides of the inner surface of the processing box, respectively. A first drive motor is installed on the front surface of the processing box corresponding to the position of the lead screw, and the output end of the first drive motor is connected to the front end of the lead screw through the front side wall of the processing box.

[0011] Preferably, a second drive motor is installed on the left side of the front surface of the processing box. The output end of the second drive motor is connected to a drive gear, and the front end of the rotating shaft passes through the front side wall of the processing box and is connected to a driven gear. The drive gear and the driven gear mesh with each other.

[0012] Preferably, a discharge port is provided on the left side surface of the processing box corresponding to the position of the filter plate, and a movable plate is rotatably connected to the top of the inner surface of the discharge port, and a lever is installed on the left side surface of the movable plate.

[0013] Preferably, the bottom surface of the processing box is provided with support feet at the corners, and the bottom surface of the support feet is fitted with pads.

[0014] The beneficial effects of this utility model are:

[0015] 1. By setting up a treatment tank, the inside of which is filled with drug solution, the water pump is started and the drug solution is transported to the nozzle position through the cooperation of the suction head and the conduit. The drug solution will drip onto the surface of the crystallization plate. The temperature control plate is used to adjust the temperature of the crystallization plate to maintain it at the crystallization temperature. The setting of the diversion channel can improve the uniformity of the drug solution flow. During the flow, some of the drug solution will crystallize and remain on the surface of the temperature control plate. The drug solution that is not crystallized will be filtered by the filter plate and flow back to the bottom of the treatment tank for circulation. This realizes the cyclic crystallization of dexamethasone drug solution, improves the crystallization quality, and solves the problem that the existing dexamethasone crystallization device usually uses a stirring method to crystallize the drug solution in the entire tank at the same time. The crystallization efficiency is low, and the crystals are easy to mix with the drug solution again during the stirring process, which easily leads to waste of drug solution and increased costs. Attached Figure Description

[0016] Figure 1 The diagram shown is a three-dimensional structural schematic of the crystallization apparatus for dexamethasone production according to this utility model.

[0017] Figure 2 The diagram shown is a three-dimensional structural schematic of the mounting bracket for the crystallization device used in the production of dexamethasone according to this utility model.

[0018] Figure 3 The diagram shown is a three-dimensional structural schematic of the lead screw of the crystallization device for dexamethasone production according to this utility model.

[0019] Figure 4 The diagram shown is a three-dimensional structural schematic of the crystallization plate of the crystallization device for dexamethasone production according to this utility model.

[0020] Figure 5 The diagram shown is a three-dimensional structural schematic of the L-shaped plate of the crystallization device for dexamethasone production according to this utility model.

[0021] Figure 6 The diagram shown is a three-dimensional structural schematic of the movable plate of the crystallization device for dexamethasone production according to this utility model.

[0022] Explanation of reference numerals in the attached drawings: 1. Processing box; 2. L-shaped plate; 3. Filter plate; 4. Through groove; 5. Baffle; 6. Rotating shaft; 7. Crystallizing plate; 8. Temperature control plate; 9. Drainage groove; 101. Electric guide rail; 102. Electric slider; 11. Mounting bracket; 12. Water pump; 13. Nozzle; 14. Guide tube; 15. Suction head; 16. Lead screw; 17. Moving seat; 18. Scraper; 19. Limiting rod; 20. First drive motor; 21. Second drive motor; 22. Drive gear; 23. Driven gear; 24. Discharge port; 25. Movable plate; 26. Pulley; 27. Support leg; 28. Gasket. Detailed Implementation

[0023] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0024] Please see Figures 1-6 This utility model provides an embodiment of a crystallization device for dexamethasone production, including a processing box 1; it also includes an L-shaped plate 2, a filter plate 3, a through groove 4, a baffle 5, a rotating shaft 6, a crystallization plate 7, a temperature control plate 8, a diversion groove 9, a sliding assembly, a mounting bracket 11, a water pump 12, a nozzle 13, a conduit 14, and a suction head 15. An L-shaped plate 2 is installed on the bottom left side of the inner surface of the processing box 1. A filter plate 3 is embedded on the upper surface of the L-shaped plate 2. A through groove 4 is formed on the right side surface of the L-shaped plate 2. A baffle 5 is provided on the top surface of the L-shaped plate 2 to the right of the filter plate 3. A rotating shaft 6 is rotatably connected to the left side of the front and rear sides of the inner surface of the processing box 1. A crystallization plate 7 is installed on the outer surface of the rotating shaft 6. A temperature control plate 8 is provided on the left side surface of the crystallization plate 7. A diversion groove 9 is formed on the right side surface of the crystallization plate 7. A sliding assembly is provided on the upper front and rear sides of the outer surface of the processing box 1. The moving end of the sliding assembly is connected to... A mounting bracket 11 is provided, with a water pump 12 positioned at the center of the top surface of the mounting bracket 11 and a nozzle 13 mounted on the bottom surface of the mounting bracket 11. One end of a conduit 14 is connected to the top of the water pump 12, and the other end of the conduit 14 is connected to a suction head 15. A treatment tank 1 is provided, and the inside of the treatment tank 1 contains a drug solution. When the water pump 12 is operating, it transports the drug solution to the nozzle 13 position through the suction head 15 and the conduit 14, and the solution drips onto the surface of the crystallization plate 7. The temperature control plate 8 can adjust the temperature of the crystallization plate 7 to maintain it at the crystallization temperature. The setting of the diversion channel 9 can improve the uniformity of the drug solution flow. During the flow, some of the drug solution will crystallize and remain on the surface of the temperature control plate 8. The drug solution that is not crystallized will be filtered by the filter plate 3 and flow back to the bottom of the treatment tank 1, and then circulated by the water pump 12. This achieves the cyclic crystallization of dexamethasone solution and improves the crystallization quality.

[0025] Please see Figures 1-6In this embodiment, the sliding assembly includes an electric guide rail 101 and an electric slider 102. Electric guide rails 101 are installed on the upper positions of both the front and rear surfaces of the processing box 1. An electric slider 102 is slidably connected to the outer surface of the electric guide rail 101. The side surface of the electric slider 102 away from the corresponding electric guide rail 101 is connected to the mounting bracket 11. By setting the electric guide rail 101 and the electric slider 102, the electric slider 102 can slide on the outer surface of the electric guide rail 101, thereby driving the mounting bracket 11 to move synchronously, thus adapting to the rotation angle of the crystallizing plate 7 and ensuring that the liquid medicine can drip smoothly onto the crystallizing plate 7. Lead screws 16 are rotatably connected to the sides of the crystallizing plate 7 on both the front and rear sides of the inner surface of the processing box 1. A movable seat 17 is threadedly connected to the outer surface of the lead screw 16. The lower left side surface of the movable seat 17 is rotatably connected to... There are two symmetrical scraper rods 18, which are in contact with the crystallizing plate 7. By setting a lead screw 16, when rotating, it can drive the moving seat 17, which is threaded with it, to move back and forth, thereby driving the scraper rod 18 to scrape off the crystals on the surface of the crystallizing plate 7 and drop them onto the upper side of the filter plate 3. Limiting rods 19 are connected through the front and rear surfaces of the moving seat 17. The front and rear ends of the limiting rod 19 are connected to the front and rear sides of the inner surface of the processing box 1, respectively. A first drive motor 20 is installed on the front surface of the processing box 1 at the position corresponding to the lead screw 16. The output end of the first drive motor 20 passes through the front side wall of the processing box 1 and is connected to the front end of the lead screw 16. By setting the first drive motor 20, the lead screw 16 can be driven to rotate. The setting of the limiting rod 19 can provide a limit for the moving seat 17, preventing the lead screw 16 from driving the moving seat 17 to rotate, thereby ensuring transmission efficiency.

[0026] Please see Figures 1-6 In this embodiment, a second drive motor 21 is installed on the left side of the front surface of the processing box 1. The output end of the second drive motor 21 is connected to a drive gear 22. The front end of the rotating shaft 6 passes through the front wall of the processing box 1 and is connected to a driven gear 23. The drive gear 22 and the driven gear 23 mesh. By setting the second drive motor 21, its output end will drive the drive gear 22 to rotate during operation. When the drive gear 22 rotates, it can drive the driven gear 23 meshing with it to rotate, thereby driving the rotating shaft 6 to rotate, thus achieving the angle adjustment of the crystallizing plate 7. The automatic adjustment is achieved by providing a discharge port 24 on the left side surface of the treatment box 1, corresponding to the position of the filter plate 3. A movable plate 25 is rotatably connected to the top of the inner surface of the discharge port 24. A lever 26 is installed on the left side surface of the movable plate 25. By setting the discharge port 24 and the movable plate 25, the operator can open the movable plate 25 to collect the crystals on the upper surface of the filter plate 3. Support feet 27 are provided at the corners of the bottom surface of the treatment box 1. Gaskets 28 are installed on the bottom surface of the support feet 27. By setting the support feet 27 and the gaskets 28, the overall stability of the device during use can be improved.

[0027] During operation, an electric guide rail 101 and an electric slider 102 are configured. The electric slider 102 can slide on the outer surface of the electric guide rail 101, thereby driving the mounting bracket 11 to move synchronously. This is adapted to the rotation angle of the crystallizing plate 7, ensuring that the liquid can drip smoothly onto the crystallizing plate 7. A lead screw 16 is configured, which, when rotated, drives the threaded moving seat 17 to move back and forth, thereby driving the scraper 18 to scrape off the crystals on the surface of the crystallizing plate 7 and drop them onto the filter plate 3. A first drive motor 20 is configured to drive the lead screw 16 to rotate. The setting of the limiting rod 19 can provide... The movable seat 17 provides a limit to prevent the lead screw 16 from driving the movable seat 17 to rotate, thereby ensuring transmission efficiency. By setting a second drive motor 21, its output end will drive the drive gear 22 to rotate during operation. When the drive gear 22 rotates, it can drive the driven gear 23 meshing with it to rotate, thereby driving the rotating shaft 6 to rotate, thereby realizing automatic adjustment of the angle of the crystallizing plate 7. By setting the discharge port 24 and the movable plate 25, the operator can open the movable plate 25 to collect the crystals on the upper surface of the filter plate 3. By setting the support feet 27 and the gaskets 28, the overall stability of the device during use can be improved.

[0028] Through the above steps, by setting up a treatment tank 1, which contains a drug solution, and starting the water pump 12, the drug solution is transported to the nozzle 13 position through the cooperation of the suction head 15 and the conduit 14. The drug solution will drip onto the surface of the crystallization plate 7. The temperature control plate 8 is used to adjust the temperature of the crystallization plate 7 to maintain it at the crystallization temperature. The setting of the diversion channel 9 can improve the uniformity of the drug solution flow. During the flow, some of the drug solution will crystallize and remain on the surface of the temperature control plate 8. The drug solution that is not crystallized will be filtered by the filter plate 3 and flow back to the bottom of the treatment tank 1 for circulation. This achieves the cyclic crystallization of dexamethasone drug solution, improves the crystallization quality, and solves the problem that the existing dexamethasone crystallization device usually uses a stirring method to crystallize the drug solution in the entire tank at the same time, which has low crystallization efficiency. The crystals are easy to mix with the drug solution again during the stirring process, which easily leads to waste of drug solution and increased cost.

Claims

1. Crystallization apparatus for the production of dexamethasone, comprising a treatment tank (1); characterized by the fact that: It also includes L-shaped plate (2), filter plate (3), through slot (4), baffle (5), shaft (6), crystallization plate (7), temperature control plate (8), drainage groove (9), sliding assembly, mounting bracket (11), water pump (12), spray head (13), conduit (14) and suction head (15), the inner surface of the bottom of the processing box (1) is installed with L-shaped plate (2) on the left side, the upper surface of the L-shaped plate (2) is embedded and installed with filter plate (3), the right surface of the L-shaped plate (2) is provided with through slot (4), the top surface of the L-shaped plate (2) is provided with baffle (5) on the right side of the filter plate (3), the inner surface of the processing box (1) is rotatably connected with the shaft (6) on the left side of the front and rear sides, the outer surface of the shaft (6) is installed with crystallization plate (7), the left side surface of the crystallization plate (7) is provided with temperature control plate (8), the right side surface of the crystallization plate (7) is provided with drainage groove (9), the outer surface of the processing box (1) is provided with sliding assembly on the upper side of the front and rear sides, the moving end of the sliding assembly is connected with mounting bracket (11), the top surface of the mounting bracket (11) is provided with water pump (12) on the middle position, the bottom surface of the mounting bracket (11) is installed with spray head (13), one end of the conduit (14) is connected with the water pump (12) on the top end, the other end of the conduit (14) is connected with suction head (15).

2. The crystallization apparatus for dexamethasone production according to claim 1, characterized by: The sliding assembly comprises electric guide rail (101) and electric sliding block (102); the front and rear surfaces of the processing box (1) are installed with electric guide rail (101) on the upper side, the outer surface of the electric guide rail (101) is slidably connected with electric sliding block (102), and the side surface of the electric sliding block (102) away from the corresponding electric guide rail (101) is connected with the mounting bracket (11).

3. The crystallization apparatus for dexamethasone production according to claim 1, characterized by: The inner surface of the processing box (1) is rotatably connected with lead screw (16) on the side of the front and rear sides of the crystallization plate (7), the outer surface of the lead screw (16) is threadedly connected with moving seat (17), the lower left side surface of the moving seat (17) is rotatably connected with two symmetrical scraping rods (18), and the scraping rods (18) are in close contact with the crystallization plate (7).

4. The crystallization apparatus for dexamethasone production according to claim 3, characterized by: The front and rear surfaces of the moving seat (17) are connected with limiting rod (19), the front and rear ends of the limiting rod (19) are connected with the inner surface of the front and rear sides of the processing box (1), respectively, the first driving motor (20) is installed on the front side surface of the processing box (1) corresponding to the position of the lead screw (16), and the output end of the first driving motor (20) penetrates the front side wall of the processing box (1) and is connected with the front end of the lead screw (16).

5. The crystallization apparatus for dexamethasone production according to claim 1, characterized by: The left side surface of the processing box (1) is installed with second driving motor (21) on the left side, the output end of the second driving motor (21) is connected with driving gear (22), the front end of the shaft (6) penetrates the front side wall of the processing box (1) and is connected with driven gear (23), and the driving gear (22) is engaged with the driven gear (23).

6. The crystallization apparatus for dexamethasone production according to claim 1, characterized by: The left side surface of the processing box (1) is provided with discharge port (24) corresponding to the position of the filter plate (3), the inner surface of the discharge port (24) is rotatably connected with movable plate (25), and the left side surface of the movable plate (25) is installed with push block (26).

7. The crystallization apparatus for dexamethasone production according to claim 1, characterized by: The bottom surface corner position of the processing box (1) is provided with a supporting leg (27), and the bottom surface of the supporting leg (27) is provided with a gasket (28).

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