Fluidized bed equipment for preparing cyclic dipeptide by fluidized dry heat method

Abstract

The utility model discloses fluidized bed equipment for preparing cyclic dipeptide by a fluidized dry heat method, and belongs to the technical field of food processing. Boiling bed equipment for preparing cyclic dipeptide through a fluidized dry heat method comprises a first support and a second support, and further comprises a top cylinder which is fixedly installed on the first support, an air inlet shell is arranged below the top cylinder, a hopper is installed on the second support, the bottom of the hopper is detachably connected to the air inlet shell, and the top cylinder is fixedly installed on the first support. A screen is mounted on the hopper; by starting the fan and the heating box, hot air can circularly flow in the equipment, and temperature conditions of different areas in the equipment can be fed back in real time through the temperature probe, so that workers can dynamically adjust the temperature, stable temperature control of the equipment is guaranteed, raw materials are heated more uniformly, products are not prone to caking, and the production efficiency is improved. Therefore, the production quality of products is improved.

Description

Technical Field

[0001] This utility model relates to the field of food processing technology, and in particular to a fluidized bed device for preparing cyclic dipeptides by fluidized bed dry heat method. Background Technology

[0002] Cyclic dipeptides are compounds consisting of two amino acid molecules linked end-to-end by a peptide bond. Cyclic dipeptides can cross the blood-brain barrier via passive diffusion. Cyclic dipeptides such as cyclic glycylproline have been widely proven to have neuroprotective and analgesic activities, and are highly promising for the treatment or improvement of neurological diseases such as Parkinson's disease and Alzheimer's disease.

[0003] The initial chemical synthesis method for cyclic dipeptides was based on ester condensation reactions in the aqueous phase. With the development of solid-phase synthesis methods for deprotecting groups on resins, the synthesis efficiency of oligopeptides and cyclic dipeptides has been greatly improved. This method has also become the main synthesis method for high-purity cyclic dipeptides. However, collagen oligopeptides have been reported to generate cyclic dipeptide-like substances under hydrothermal conditions, but the yield of cyclic dipeptides is extremely low due to the unfavorable dehydration condensation reaction in the aqueous phase, making industrial application impossible. In contrast, the synthesis reaction of cyclic dipeptides induced by amino acid hydrolysis during high-temperature thermal degradation of long-chain peptides, such as tripeptides, is not limited by solvents. Therefore, the dry thermal processing method for preparing collagen-derived cyclic dipeptides has great application potential.

[0004] Currently, fluidized bed is the preferred equipment for the production of cyclic dipeptides, enabling long-term processing of solid powder materials. During the processing, feeding and collecting of materials are carried out. Temperature is an important factor affecting the quality of processed materials. However, current fluidized bed equipment, with its dry heat preparation process, cannot meet the production conditions of the dry heat preparation of cyclic dipeptides well, such as continuous production, stable temperature control, and uneven heating of raw materials. This leads to the product being prone to agglomeration, thus affecting the production quality of the product. Utility Model Content

[0005] The purpose of this invention is to solve the problems of continuous production, stable temperature control, and uneven heating of raw materials in the existing dry heat preparation process of cyclic dipeptides, and to propose a fluidized bed equipment for the preparation of cyclic dipeptides by fluidized dry heat method.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A fluidized bed apparatus for preparing cyclic dipeptides using a fluidized bed dry heat method includes a first support and a second support, and further includes: a top cylinder fixedly mounted on the first support, wherein an air inlet shell is provided below the top cylinder; a hopper is mounted on the second support, the bottom of the hopper is detachably connected to the air inlet shell, a screen is mounted on the hopper, and the top of the hopper is connected to the top cylinder via a conveying component; and a heating section disposed on the air inlet shell, wherein the heating section is used to circulate hot air within the top cylinder, the hopper, and the air inlet shell.

[0008] For connecting the top cylinder and the hopper, preferably, the conveying component includes a middle cylinder, the top of the hopper is detachably connected to the bottom of the middle cylinder, wherein the top of the middle cylinder is fixedly connected to the bottom of the top cylinder, and the middle cylinder is connected to an inlet pipe and a outlet pipe, both of which are equipped with valves.

[0009] To circulate hot air within the top cylinder, hopper, and middle cylinder, the heating unit preferably includes a heating box fixedly installed on the air inlet shell, the heating box being interconnected with the air inlet shell, and an air outlet pipe connected to the top cylinder. A pressure component is provided between the air outlet pipe and the heating box, and temperature probes are installed on the air inlet shell, hopper, and air outlet pipe.

[0010] To further facilitate the delivery of hot air, the pressure component includes a fan, the outlet of which is connected to the heating chamber via an air supply duct, and the inlet of which is connected to the outlet pipe via a return air duct.

[0011] To facilitate the tipping and unloading of the hopper, preferably, both sides of the second bracket are rotatably connected to a rotating shaft, and the hopper is fixedly connected to the rotating shaft.

[0012] To facilitate pushing the hopper, preferably, the second bracket is equipped with multiple casters, and the multiple casters are arranged in a rectangular pattern at the bottom of the second bracket.

[0013] Compared with the prior art, this utility model provides a fluidized bed apparatus for the preparation of cyclic dipeptides by fluidized dry heat method, which has the following beneficial effects:

[0014] 1. This fluidized bed equipment for preparing cyclic dipeptides using the fluidized dry heat method can circulate hot air within the equipment by starting the fan and heating chamber. Temperature probes can also provide real-time feedback on the temperature of different areas within the equipment, allowing workers to dynamically adjust the temperature and ensure stable temperature control. This results in more uniform heating of the raw materials, making the product less prone to clumping and thus improving the production quality.

[0015] 2. This fluidized bed equipment for preparing cyclic dipeptides using the fluidized dry heat method can control the air pressure inside the fluidized bed equipment by adjusting the pressure of the blower, so as to realize material collection and replenishment, thereby achieving the purpose of continuous production and improving production efficiency.

[0016] This invention solves the problems of continuous production, stable temperature control, and uneven heating of raw materials in the existing dry heat preparation process of cyclic dipeptides. Attached Figure Description

[0017] Figure 1 This is a front view schematic diagram of a fluidized bed device for preparing cyclic dipeptides using a fluidized dry heat method, as proposed in this utility model.

[0018] Figure 2 This is a side view of a fluidized bed apparatus for preparing cyclic dipeptides using a fluidized dry heat method, as proposed in this utility model.

[0019] Figure 3 This is a top view schematic diagram of a fluidized bed apparatus for preparing cyclic dipeptides using a fluidized dry heat method, as proposed in this utility model.

[0020] In the diagram: 1. First support; 2. Second support; 3. Air inlet shell; 4. Screen; 5. Casters; 6. Hopper; 7. Middle cylinder; 8. Feed pipe; 9. Top cylinder; 10. Air outlet pipe; 11. Air conveying duct; 12. Air return duct; 13. Fan; 14. Heating box. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0022] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0023] Example:

[0024] Reference Figures 1-3This utility model provides a fluidized bed device for preparing cyclic dipeptides using a fluidized bed dry heat method, including a first support 1 and a second support 2, and further including: a top cylinder 9, fixedly installed on the first support 1, the top cylinder 9 having 10 to 15 cylindrical filter cloths for filtering materials, wherein an air inlet shell 3 is provided below the top cylinder 9, a hopper 6 is installed on the second support 2, and rotating shafts are rotatably connected to both sides of the second support 2, the hopper 6 being fixedly connected to the rotating shafts for tipping and unloading, the bottom of the hopper 6 being detachably connected to the air inlet shell 3, a screen 4 with a mesh size of 300 mesh is installed on the hopper 6, and the top of the hopper 6 being connected to the top cylinder 9 via a conveyor; a heating part is provided on the air inlet shell 3, wherein the heating part is used to circulate hot air in the top cylinder 9, the hopper 6, and the air inlet shell 3.

[0025] Specifically, during use, the heating element allows hot air to circulate within the equipment, and temperature probes provide real-time feedback on the temperature of different areas within the equipment. This enables workers to dynamically adjust the temperature, ensuring stable temperature control and resulting in more uniform heating of raw materials. This also prevents product clumping and improves overall product quality.

[0026] The conveying components in this fluidized bed equipment include a middle cylinder 7, and the top of the hopper 6 is detachably connected to the bottom of the middle cylinder 7. The top of the middle cylinder 7 is fixedly connected to the bottom of the top cylinder 9. The middle cylinder 7 is connected to a feed pipe 8 and a take-up pipe. Valves are installed on both the feed pipe 8 and the take-up pipe. Both the hopper 6 and the middle cylinder 7 are equipped with glass windows so that workers can check the boiling state of the raw materials inside the equipment.

[0027] Specifically, the middle cylinder 7 can be used to connect the top cylinder 9 and the hopper 6, so that the top cylinder 9 and the air inlet shell 3 can be interconnected.

[0028] The heating unit includes a heating box 14 fixedly installed on the air inlet shell 3. The heating box 14 is connected to the air inlet shell 3. An air outlet pipe 10 is connected to the top cylinder 9. A pressure component is provided between the air outlet pipe 10 and the heating box 14. Temperature probes are installed on the air inlet shell 3, the hopper 6 and the air outlet pipe 10.

[0029] Specifically, during use, air can be conveyed through the negative pressure component, and the conveyed air is heated by the heating box 14 to achieve hot air circulation in the air inlet shell 3, hopper 6, middle cylinder 7 and top cylinder 9. With the setting of temperature probes, the temperature of different areas in the equipment can be fed back in real time so that workers can make dynamic adjustments to the temperature.

[0030] The pressure component includes a blower 13. The outlet of the blower 13 is connected to the heating box 14 through the air supply channel 11, and the inlet of the blower 13 is connected to the outlet pipe 10 through the return air channel 12.

[0031] Specifically, the combined use of the fan 13, the air conveying duct 11, and the air return duct 12 enables the circulation and delivery of hot air, as well as the replenishment and discharge of materials during equipment operation.

[0032] The second bracket 2 is equipped with multiple casters 5, and the multiple casters 5 are arranged in a rectangular shape at the bottom of the second bracket 2. The number of casters 5 is preferably 4.

[0033] Specifically, the installation of casters 5 improves the mobility of the second support 2, thereby facilitating the pushing and transfer of the hopper 6.

[0034] Working principle: In the process of using this fluidized bed equipment for preparing cyclic dipeptides by fluidized dry heat method, collagen oligopeptide raw materials are first added to the middle cylinder 7 through the feed pipe 8 and fall onto the screen 4 in the hopper 6. Then, the blower 13 and the heating box 14 are turned on and the wind speed and frequency are adjusted to make the hot air circulate in the hopper 6, middle cylinder 7, top cylinder 9, return air channel 12, air conveying channel 11, heating box 14 and air inlet shell 3. The screen 4 is used to support and block the material, allowing the airflow to pass through separately. At the same time, the temperature probe can also provide real-time feedback on the temperature of different areas in the equipment, so that the operator can dynamically adjust the temperature to ensure stable temperature control of the equipment, thereby making the raw materials more evenly heated.

[0035] Furthermore, during use, by adjusting the pressure of the blower 13 to normal pressure, a bag can be placed on the material receiving pipe of the middle cylinder 7, and the valve can be opened to collect the material. When the pressure of the blower 13 is adjusted to negative pressure, by fixing the material bag on the feed pipe 8 and opening the valve, the powder material in the material bag can be sucked into the fluidized bed equipment. By controlling the air pressure in the fluidized bed equipment, material collection and replenishment can be achieved, thereby achieving the purpose of continuous production and improving production efficiency.

[0036] On the other hand, after processing is completed, the equipment can be shut down, and the hopper 6, the middle cylinder 7, and the air inlet shell 3 can be released. Then, the second support 2 can be pushed to move the hopper 6, and the powder product in the hopper 6 can be poured out and collected.

[0037] The above are merely preferred embodiments of this utility model, but the scope of protection of this utility model is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in this utility model, based on the technical solution and inventive concept of this utility model, should be included within the scope of protection of this utility model.

Claims

1. A fluidized bed apparatus for the fluidized dry thermal production of cyclic dipeptides, comprising a first support (1) and a second support (2), characterized in that, Also include: The top cylinder (9) is fixedly installed on the first support (1), Wherein, the lower part of the top cylinder (9) is provided with an air inlet shell (3), the second support (2) is provided with a hopper (6), the bottom of the hopper (6) is detachably connected with the air inlet shell (3), the hopper (6) is provided with a screen (4), and the top of the hopper (6) is connected with the top cylinder (9) through a conveying member; The heating part is arranged on the air inlet shell (3), Wherein, the heating part is used for circulating hot air in the top cylinder (9), the hopper (6) and the air inlet shell (3).

2. A fluidized bed apparatus for the production of cyclic dipeptides by fluidized dry heat process according to claim 1, characterized in that, The conveying member includes a middle cylinder (7), the top of the hopper (6) is detachably connected with the bottom of the middle cylinder (7), Wherein, the top of the middle cylinder (7) is fixedly connected with the bottom of the top cylinder (9), the middle cylinder (7) is communicated with a feeding pipe (8) and a material taking pipe, and the feeding pipe (8) and the material taking pipe are provided with valves.

3. A fluidized bed apparatus for the preparation of cyclic dipeptides by fluidized dry heat process according to claim 1, characterized in that, The heating part includes a heating box (14) fixedly installed on the air inlet shell (3), the heating box (14) is communicated with the air inlet shell (3), and the top cylinder (9) is communicated with an air outlet pipe (10), Wherein, the air outlet pipe (10) and the heating box (14) are provided with a pressure member, and the air inlet shell (3), the hopper (6) and the air outlet pipe (10) are provided with temperature probes.

4. A fluidized bed apparatus for the production of cyclic dipeptides by fluidized dry heat process according to claim 3, characterized in that, The pressure member includes a fan (13), the air outlet end of the fan (13) is communicated with the heating box (14) through a gas conveying channel (11), and the air inlet end of the fan (13) is communicated with the air outlet pipe (10) through a gas return channel (12).

5. A fluidized bed apparatus for the preparation of cyclic dipeptides by fluidized dry heat process according to claim 1, characterized in that, Both sides of the second support (2) are rotatably connected with rotating shafts, and the hopper (6) is fixedly connected with the rotating shafts.

6. A fluidized bed apparatus for the preparation of cyclic dipeptides by fluidized dry heat process according to claim 1, characterized in that, A plurality of universal wheels (5) are arranged on the bottom of the second support (2) in a rectangular shape.

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