Tumor electric field treatment device and electrode plate

Abstract

The utility model provides a tumor electric field treatment device and an electrode slice, the electrode slice comprises an electrode array, the electrode array comprises a plurality of electrode units and a plurality of connecting parts connecting two adjacent electrode units, the plurality of electrode units are arranged in multiple rows and multiple columns, and the plurality of connecting parts comprise a plurality of first connecting parts for connecting two adjacent electrode units in the same row and a plurality of second connecting parts for connecting two adjacent electrode units in the same column. Only two second connecting parts are arranged between every two adjacent rows of electrode units, all the electrode units connected through the second connecting parts and the corresponding connecting parts between the electrode units form two trunks, and the other electrode units and the corresponding connecting parts form a plurality of branches transversely extending from the corresponding trunks. And the electrode unit at the tail end of each branch is only connected with one first connecting part. According to the tumor electric field treatment device and the electrode plate thereof provided by the invention, most of the electrode units have good degree of freedom, so that the attaching property of the electrode plate can be improved, and wrinkles are not easy to generate when the electrode plate is attached to a curved surface body surface.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a tumor electric field therapy device and electrode pads. Background Technology

[0002] Tumor electric field therapy (TEF) is a tumor treatment method that uses a specialized electric field generator to generate a low-intensity, medium-to-high-frequency, alternating electric field to interfere with the mitotic process of tumor cells. Studies have shown that TGF therapy is highly effective in treating glioblastoma, non-small cell lung cancer, and malignant pleural mesothelioma. The applied electric field can affect the aggregation of microtubules, prevent spindle formation, inhibit mitosis, and induce apoptosis in cancer cells. The TGF device mainly consists of an electric field generator, an adapter, and multiple pairs of electrodes. The electric field generator produces an alternating electrical signal, which is transmitted to the electrode pads via the adapter. The electrode pads are applied in pairs to the skin on opposite sides of the tumor region, and an alternating current signal is applied between each pair of electrodes to non-invasively apply a therapeutic electric field to the tumor region.

[0003] One publicly disclosed electrode pad has twenty electrode units arranged in four rows and six columns, with four electrode units in the first and last rows and six electrode units in each of the middle two rows. The electrode units in the first and last rows, as well as those at the ends of the middle two rows, are located around the outer periphery of the electrode pad. A connecting portion is provided between any two adjacent electrode units on the outer periphery, which increases the overall strength of the electrode pad. However, this structure also makes the electrode pad prone to wrinkling when applied to curved surfaces such as the chest and abdomen, affecting the application effect and thus reducing the therapeutic efficacy. Furthermore, because the connecting portions are relatively thin, their location around the outer periphery may scratch the patient, posing a safety hazard.

[0004] Therefore, it is indeed necessary to provide an improved tumor electric field therapy device and electrode pads to overcome the problems existing in the prior art. Utility Model Content

[0005] This application provides an electrode pad with better adhesion and less crease formation, as well as a tumor electric field therapy device.

[0006] This application provides the following technical solution: an electrode sheet, comprising an electrode array, the electrode array comprising a plurality of electrode units and a plurality of connecting portions connecting adjacent electrode units, the plurality of electrode units being arranged in multiple rows and columns, the plurality of connecting portions comprising a plurality of first connecting portions connecting adjacent electrode units in a row and a plurality of second connecting portions connecting adjacent electrode units in a column, wherein only two second connecting portions are provided between adjacent rows of electrode units, wherein all electrode units connected by the second connecting portions and their corresponding connecting portions form two main trunks, and other electrode units and their corresponding connecting portions form a plurality of branches extending laterally from the corresponding main trunks, and the electrode unit located at the end of each branch is connected to only one first connecting portion.

[0007] According to one embodiment of the present invention, the two adjacent electrode units located in the middle two columns of each row are disconnected.

[0008] According to one embodiment of the present invention, a plurality of the electrode units are distributed in an axially symmetrical and centrally symmetrical manner.

[0009] According to one embodiment of the present invention, the electrode array includes twenty electrode units arranged in four rows and six columns, wherein the second and third rows each have six electrode units, and the first and fourth rows each have four electrode units.

[0010] According to one embodiment of the present invention, the electrode array is provided with a wiring portion, which is located between two adjacent parallel second connection portions.

[0011] According to one embodiment of the present invention, the second connecting portion is respectively disposed between two adjacent electrode units in the second column (excluding two adjacent electrode units in the second and third rows), between two adjacent electrode units in the fifth column (excluding two adjacent electrode units in the second and third rows), between two adjacent electrode units in the third column and in the second and third rows, and between two adjacent electrode units in the fourth column and in the second and third rows.

[0012] According to one embodiment of the present invention, the second connecting portion is respectively disposed between two adjacent electrode units in the third column (excluding the two adjacent electrode units in the second and third rows), between two adjacent electrode units in the fourth column (excluding the two adjacent electrode units in the second and third rows), between two adjacent electrode units in the second column and in the second and third rows, and between two adjacent electrode units in the fifth column and in the second and third rows.

[0013] According to one embodiment of the present invention, the electrode array is provided with a plurality of temperature sensors. Except for the four electrode units located in the second row, second column, second row, fifth column, third row, second column, and third row, fifth column, the other sixteen electrode units are each provided with a temperature sensor.

[0014] According to one embodiment of the present invention, the electrode array is provided with a plurality of diodes, and the diodes are connected in series with the corresponding temperature sensors.

[0015] This application also provides the following technical solution: a tumor electric field therapy device, which includes an electric field generator and several of the aforementioned electrode plates.

[0016] The tumor electric field therapy device and its electrode pads provided in this application have most of their electrode units having good degrees of freedom, which can improve the adhesion of the electrode pads and make them less prone to wrinkling when applied to curved surfaces.

[0017] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Attached Figure Description

[0018] Figure 1 This is a frame diagram of a tumor electric field therapy device according to one embodiment of this application;

[0019] Figure 2 This is a plan view of the electrode sheet according to the first embodiment of the tumor electric field therapy device of this application;

[0020] Figure 3 for Figure 2 The diagram shown is a plan view of the electrode sheet after the adhesive has been removed.

[0021] Figure 4 for Figure 2 Partial exploded three-dimensional view of the electrode sheet shown;

[0022] Figure 5 for Figure 4 A plan view of the electrode array of the electrode sheet shown;

[0023] Figure 6 for Figure 5 An exploded three-dimensional view of the electrode array shown.

[0024] Figure 7 This is a plan view of the electrode array of the electrode sheet according to the second embodiment of the tumor electric field therapy device of this application.

[0025] Explanation of reference numerals in the attached figures:

[0026] Tumor electric field therapy device 100, electric field generator 10, adapter 20, electrode sheet 30, electrode array 31, 31', main trunk L1, L1', L2, L2', branch L3, L3', electrode unit 310, 310', connecting part 311, 311', second connecting part 3112, 3112', first connecting part 3111, 3111', wiring part 312, 312', flexible circuit board 313, main body 314, dielectric element 315, perforation 3151, insulating plate 316, temperature sensor 317, backing 32, support member 33, through hole 331, adhesive member 34. Detailed Implementation

[0027] Exemplary embodiments will now be described in detail, examples of which are illustrated in the accompanying drawings. When the following description relates to the drawings, unless otherwise indicated, the same numbers in different drawings denote the same or similar elements. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with this application. Rather, they are merely examples of apparatuses, systems, devices, and methods consistent with some aspects of this application.

[0028] refer to Figure 1 As shown, the tumor electric field therapy device 100 includes an electric field generator 10, an adapter 20, and several pairs of electrode pads 30. The adapter 20 electrically connects the electric field generator 10 to each electrode pad 30. The electric field generator 10 generates an alternating current signal required for treatment. The adapter 20 receives the alternating current signal output from the electric field generator 10 and transmits it to the electrode pads 30. The pairs of electrode pads 30 are applied to the patient's body surface corresponding to the tumor area, applying the alternating current signal to the patient's tumor area to interfere with or prevent the mitosis of the patient's tumor cells, thereby achieving the purpose of treating the tumor.

[0029] First Embodiment

[0030] refer to Figures 2 to 4As shown, the electrode sheet 30 includes an electrode array 31, a backing 32, several support members 33, and several adhesive members 34. The electrode array 31 is adhered to the backing 32 and electrically connected to the adapter 20 via wires (not shown). The electrode array 31 has twenty electrode units 310 arranged in four rows and six columns. Each support member 33 corresponds to two or three electrode units 310 in the same row. The support member 33 has several through holes 331 and is adhered to the backing 32 such that each through hole 331 surrounds its corresponding electrode unit 310. The inner diameter of the through holes 331 is slightly larger than the outer diameter of the electrode unit 310 to facilitate installation. The support member 33 supports and protects the electrode units 310. Similarly, each adhesive member 34 corresponds to two or three electrode units 310 in the same row, covering each row of electrode units 310 and the corresponding support member 33. In other embodiments, the adhesive members 34 can also be laid separately for each electrode unit 310. Electrode pads 30 are applied to the patient's skin with the exposed side of the adhesive patch 34 facing the patient. Here, the side of the electrode pad 30 facing the patient is defined as the front, and the opposite side as the back. The backing 32 is a mesh non-woven fabric with a biocompatible adhesive (not shown) coated on the front side to ensure a tight fit to the patient's skin. The support 33 is made of foam material. The adhesive patch 34 is double-sided adhesive, preferably a conductive gel, to keep the skin surface moist and prevent itching.

[0031] refer to Figure 5 As shown, the twenty electrode units 310 of the electrode array 31 are arranged both axially symmetrically and centrally symmetrically. These twenty electrode units 310 are arranged in four rows and six columns. Specifically, the first and fourth rows each have four electrode units 310, and the two middle rows (i.e., the second and third rows) each have six electrode units 310. The six electrode units 310 in each of the two middle rows are arranged in six columns, located in columns one through six respectively; the four electrode units 310 in each of the first and fourth rows are arranged in four columns, located in columns two through five respectively.

[0032] The electrode array 31 also includes a plurality of connecting portions 311 and a wiring portion 312 connecting two adjacent electrode units 310. The wiring portion 312 is positioned between two adjacent parallel connecting portions 311 in a "T" shape and is used to connect external wires (not shown) for electrical connection with the adapter 20. The connecting portions 311 connect the electrode array 31 into a whole and also serve as wiring to ensure that each electrode unit 310 can receive AC signals. The plurality of connecting portions 311 include a first connecting portion 3111 connecting two adjacent electrode units 310 in the same row and a second connecting portion 3112 connecting two adjacent electrode units 310 in the same column. The wiring portion 312 connects two parallel second connecting portions 3112 located in the third and fourth columns (i.e., the middle two columns) and between the second and third rows. The two adjacent electrode units 310 in the third and fourth columns of each row are disconnected and do not have a first connecting part 3111. However, the two adjacent electrode units 310 in other adjacent columns of each row are provided with a first connecting part 3111. That is, the electrode array 31 is divided into left and right parts, which are connected only by the wiring part 312. Therefore, the positions of the left and right parts are relatively independent, and the application position is more flexible.

[0033] Two second connecting portions 3112 are provided between each two adjacent rows, with one portion in each of the left and right parts of the electrode array 31. Specifically, in the left half of the electrode array 31, a second connecting portion 3112 is provided between two adjacent electrode units 310 located in the first and second rows and in the second column; a second connecting portion 3112 is provided between two adjacent electrode units 310 located in the second and third rows and in the third column; and a second connecting portion 3112 is provided between two adjacent electrode units 310 located in the third and fourth rows and in the second column. In the right half of the electrode array, a second connecting portion 3112 is provided between two adjacent electrode units 310 located in the first and second rows and in the fifth column; a second connecting portion 3112 is provided between two adjacent electrode units 310 located in the second and third rows and in the fourth column; and a second connecting portion 3112 is provided between two adjacent electrode units 310 located in the third and fourth rows and in the fifth column. Apart from the twelve electrode units 310 mentioned above, all other adjacent electrode units 310 along the column are disconnected, without a second connecting part 3112, thus having a high degree of freedom.

[0034] This can be understood as the twelve electrode units 310 connected by the second connecting part 3112 and their corresponding connecting parts 311 forming two main trunks L1 and L2. Figure 5As shown by the dashed line. Other electrode units 310 and their corresponding first connecting portions 3111 form eight branches L3, which are formed by the lateral extension of the main trunks L1 and L2. Specifically, the branches L3 can be formed by the lateral extension of the main trunks L1 and L2. For example, two electrode units 310 located in the first column of the second row and the second column of the second row, and their corresponding first connecting portions 3111 together constitute one branch L3; two electrode units 310 located in the first column of the third row and the second column of the third row, and their corresponding first connecting portions 3111 together constitute another branch L3; two electrode units 310 located in the fifth column of the second row and the sixth column of the second row, and their corresponding first connecting portions 3111 together constitute yet another branch L3; two electrode units 310 located in the fifth column of the third row and the sixth column of the third row, and their corresponding first connecting portions 3111 together constitute yet another branch L3. In this case, each electrode unit 310 located on the outer side of the second and third rows is located at the end of its corresponding branch L3. Branch L3 can also be formed by extending laterally inward from the main branches L1 and L2. For example, two electrode units 310 located in the second and third columns of the first row, and their corresponding first connecting parts 3111 together constitute one branch L3; two electrode units 310 located in the second and third columns of the fourth row, and their corresponding first connecting parts 3111 together constitute another branch L3; two electrode units 310 located in the fourth and fifth columns of the first row, and their corresponding first connecting parts 3111 together constitute yet another branch L3; two electrode units 310 located in the fourth and fifth columns of the fourth row, and their corresponding first connecting parts 3111 together constitute yet another branch L3. In this case, each electrode unit 310 located on the relatively inner side of the first and fourth rows is located at the end of the corresponding branch L3. Here, the direction away from the vertical axis of symmetry of the electrode array 31 is defined as the outer side, and the direction closer to the vertical axis of symmetry of the electrode array 31 is defined as the inner side. The eight electrode units 310 located at the ends of each branch L3 are connected to only one adjacent electrode unit 310 in the same row via a connecting part 311. The four electrode units 310 located on the main branches L1 and L2, specifically in the second row, second column, third row, second column, fifth column, and third row, are connected to three adjacent electrode units 310 via corresponding connecting parts 311. The other eight electrode units 310 located on the main branches L1 and L2 are connected to two adjacent electrode units 310. Specifically, the electrode units 310 located at the ends of each branch L3 are connected to an adjacent electrode unit 310 only via a first connecting part 3111. Therefore, the eight electrode units 310 located at the ends of each branch L3 of the electrode array 31 have a high degree of freedom and a large range of motion, allowing for better adhesion to the patient's body surface and avoiding wrinkles.In addition, the eight electrode units 310 located on the main trunks L1 and L2 and connected to only two adjacent electrode units 310 through the connecting part 311 also have a certain degree of freedom and a certain range of motion, which can also improve the adhesion of the electrode sheet 30.

[0035] refer to Figure 6 The diagram shows the hierarchical structure of the electrode array 31. The electrode array 31 includes a flexible circuit board 313, which comprises several main body portions 314 corresponding to each electrode unit 310, several connecting portions 311, and several wiring portions 312. The connecting portions 311 connect two adjacent main body portions 314. The electrode array 31 also includes several dielectric elements 315, several insulating plates 316, several temperature sensors 317, and several diodes (not shown). A conductive pad (not shown) is provided on the front side of each main body portion 314. The dielectric elements 315 are disposed on the front side of each main body portion 314 in a one-to-one correspondence and are soldered to the conductive pad (not shown). A through hole 3151 is provided at the center of each dielectric element 315. The temperature sensors 317 are located on the front side of each main body portion 314 and are selectively disposed within some of the through holes 3151 of the dielectric elements 315. The insulating plates 316 are disposed on the back side of each main body portion 314 in a one-to-one correspondence. The main body 314, dielectric element 315, and insulating plate 316 are arranged in a centrally overlapping manner to form electrode unit 310. In this embodiment, there are sixteen temperature sensors 317. Except for the four electrode units 310 located in the second row, second column, third row, second column, second row, fifth column, and third row, the other sixteen electrode units 310 are each provided with a temperature sensor 317 mounted on the main body 314 and housed in the opening 3151 of the dielectric element 315, and a diode (not shown). The diode (not shown) is connected in series with the corresponding temperature sensor 317. In other embodiments, the temperature sensors 317 may have different numbers and different arrangements, which are not limited here.

[0036] In this embodiment, the dielectric element 315 is a ceramic sheet, but it can also be in other forms, such as a polymer dielectric layer with high dielectric constant and low dielectric loss made of a thin film material with non-fixed crystal orientation, high flexibility and high toughness. This polymer dielectric layer can be formed on the main body 314 by vapor deposition, sputtering or ion plating vapor deposition, printing, spraying or casting. In addition, the insulating plate 316 is not necessary and can be selectively provided according to requirements.

[0037] Second Embodiment

[0038] The difference between the electrode array 31' of the electrode sheet in the second embodiment and the electrode array 31 of the electrode sheet 30 in the first embodiment lies only in the different arrangement of the connecting part 311' and the wiring part 312'. The specific implementation method is described below.

[0039] refer to Figure 7 As shown, in the left half of the electrode array 31', a second connection portion 3112' is provided between two adjacent electrode units 310' located in the first and second rows and in the third column; a second connection portion 3112' is provided between two adjacent electrode units 310' located in the second and third rows and in the second column; a second connection portion 3112' is provided between two adjacent electrode units 310' located in the third and fourth rows and in the third column. In the right half of the electrode array 31', a second connection portion 3112' is provided between two adjacent electrode units 310' located in the first and second rows and in the fourth column; a second connection portion 3112' is provided between two adjacent electrode units 310' located in the second and third rows and in the fifth column; a second connection portion 3112' is provided between two adjacent electrode units 310' located in the third and fourth rows and in the fourth column. Similar to the first embodiment, except for the twelve electrode units 310' mentioned above, the other two adjacent electrode units 310 along the column are disconnected, and no second connecting part 3112' is provided, which allows for a high degree of freedom.

[0040] It can be understood that, in the second embodiment, the twelve electrode units 310' connected by the second connecting portion 3112' and the corresponding connecting portions 311' between them form two main trunks L1' and L2'. Figure 7 As shown by the dashed lines. Other electrode units 310' and their corresponding first connecting portions 3111' form eight branches L3', which are formed by the lateral extension of the main trunks L1' and L2'. Specifically, all eight branches L3' are formed by the lateral outward extension of the main trunks L1' and L2'. The eight electrode units 310' located at the ends of each branch L3' are connected only to one adjacent electrode unit 310' in the same row via connecting portions 311'; the four electrode units 310' located on the main trunks L1' and L2', specifically in the second row, second column, third row, second column, and third row, fifth column, are connected to three adjacent electrode units 310' via connecting portions 311'; the other eight electrode units 310' located on the main trunks L1' and L2' are connected to two adjacent electrode units 310'. Specifically, the electrode unit 310' located at the ends of each branch L3' is connected to an adjacent electrode unit 310' only via a first connecting portion 3111'. Therefore, the eight electrode units 310' located on the main trunks L1' and L2' and connected only to two adjacent electrode units 310' through the connecting part 311' also have a certain degree of freedom and a certain range of motion, which can also improve the adhesion of the electrode sheet.

[0041] Furthermore, in the second embodiment, such as Figure 7As shown, the wiring portion 312' is disposed between two adjacent parallel second connecting portions 3112', connecting the two parallel second connecting portions 3112' located in the third column and the fourth column respectively and located between the third row and the fourth row. In other embodiments, the wiring portion 312' may also be configured to connect the two parallel second connecting portions 3112' located in the third column and the fourth column respectively and located between the first row and the second row.

[0042] Except for the differences mentioned above, the electrode sheet in the second embodiment is arranged in the same way as the first embodiment, and will not be described again here.

[0043] The tumor electric field therapy device and its electrode pads provided in this application have most of their electrode units having good degrees of freedom, which improves the adhesion of the electrode pads and makes them less prone to wrinkling when applied to curved surfaces. Therefore, when the tumor electric field therapy device is used, the electrode pads can better apply the received alternating current signal to the tumor area corresponding to the curved surface, avoiding a sharp increase in heat generation and a decrease in alternating electric field strength at the corresponding location due to poor electrode pad adhesion, thus preventing any impact on the treatment effect.

[0044] The above are merely preferred embodiments of this application and are not intended to limit this application. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of protection of this application.

Claims

1. An electrode sheet comprising an electrode array, the electrode array comprising a plurality of electrode units, a plurality of connecting portions connecting adjacent two of the electrode units, the plurality of electrode units being arranged in a plurality of rows and a plurality of columns, characterized in that: The connecting parts include first connecting parts connecting adjacent electrode units in the same row and second connecting parts connecting adjacent electrode units in the same column. Only two second connecting parts are arranged between adjacent rows of electrode units. The electrode units connected by the second connecting parts and the corresponding connecting parts therebetween form two main branches. Other electrode units and the corresponding connecting parts form branches extending transversely from the main branches. The electrode units at the ends of the branches are connected to only one first connecting part.

2. The electrode pad of claim 1, wherein: The electrode units in the middle two columns in each row are disconnected.

3. The electrode pad of claim 2, wherein: The electrode units are arranged in axial symmetry and central symmetry.

4. The electrode pad of claim 3, wherein: The electrode array includes twenty electrode units arranged in four rows and six columns. The second and third rows each include six electrode units, and the first and fourth rows each include four electrode units.

5. The electrode pad of claim 4, wherein: The electrode array is provided with a wiring part arranged between adjacent parallel second connecting parts.

6. The electrode pad of claim 5, wherein: The second connecting parts are arranged between adjacent electrode units in the third column and the second and third rows, between adjacent electrode units in the fourth column and the second and third rows, between adjacent electrode units in the second column and the second and third rows, and between adjacent electrode units in the fifth column and the second and third rows.

7. The electrode pad of claim 5, wherein: The second connecting parts are arranged between adjacent electrode units in the third column and the second and third rows, between adjacent electrode units in the fourth column and the second and third rows, between adjacent electrode units in the second column and the second and third rows, and between adjacent electrode units in the fifth column and the second and third rows.

8. The electrode patch of claim 4, wherein: The electrode array is provided with temperature sensors. Except for the four electrode units in the second column of the second row, the fifth column of the second row, the second column of the third row, and the fifth column of the third row, one temperature sensor is arranged on each of the other sixteen electrode units.

9. The electrode pad of claim 8, wherein: The electrode array is provided with diodes connected in series with the corresponding temperature sensors.

10. A tumor electric field treatment device, comprising an electric field generator and a plurality of electrode sheets according to any one of claims 1 to 9.

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