Embolism microsphere preparation system

Abstract

The utility model belongs to the technical field of production and processing of medical supplies, and particularly relates to an embolism microsphere preparation system, which comprises a micro-fluidic chip, an embolism microsphere preparation device, an embolism microsphere preparation device, an embolism microsphere preparation device, an embolism microsphere preparation device and an embolism microsphere preparation device, the first feeding unit is communicated with the first inlet and is used for providing the first material for the runner; the second feeding unit is communicated with the second inlet and is used for providing the second material for the runner; and the temperature control device is used for adjusting the temperature of at least the first material and the second material in the micro-fluidic chip. According to the utility model, the flow state of the material is accurately controlled through the microfluidic chip technology, the stability of the material in the microfluidic chip and the controllability of the microsphere curing process are ensured through the temperature control device, and the uniformity and controllability of the microsphere size are realized, so that the embolism treatment effect and safety are improved.

Description

Technical Field

[0001] This utility model belongs to the field of medical product manufacturing and processing technology, specifically relating to an embolization microsphere preparation system. Background Technology

[0002] Embolizing microspheres are used to treat tumors by embolizing blood vessels at the site of infection, cutting off the nutrient supply to tumor cells and causing them to die from lack of nutrition, thus achieving a therapeutic effect. However, conventional embolizing microspheres are made of non-degradable materials. These microspheres tend to accumulate in the body after embolization, producing toxicity and hindering repeated treatments. To address this, some processes use biodegradable materials (such as gelatin) to prepare embolizing microspheres. For example, gelatin is mixed with a medium and stirred to emulsify it into microspheres, which are then sieved to obtain microspheres with a specific particle size range. However, this method suffers from problems such as uneven particle size, uncontrollable size, and low yield. Microspheres that are too large are difficult to effectively embolize peripheral blood vessels, while microspheres that are too small can cause necrosis at the wrong site, leading to serious complications and hindering the achievement of good embolization therapeutic effects. Utility Model Content

[0003] In view of the shortcomings of the prior art described above, the purpose of this utility model is to provide an embolization microsphere preparation system that can improve the controllability and uniformity of the embolization microsphere particle size.

[0004] To achieve the above and other related objectives, this utility model provides an embolic microsphere preparation system, comprising:

[0005] A microfluidic sheet, the microfluidic sheet including a flow channel, the flow channel having a first inlet, a second inlet and a discharge port, the flow channel being configured to allow a first material flowing in through the first inlet to be squeezed and divided into microspheres by a second material flowing in through the second inlet, and to allow the first material and the second material to be discharged from the discharge port;

[0006] The first feeding unit is connected to the first inlet and is used to supply the first material to the flow channel;

[0007] The second feeding unit is connected to the second inlet and is used to supply the second material to the flow channel;

[0008] A temperature control device for regulating the temperature of at least the first material and the second material in the microfluidic sheet.

[0009] In an optional embodiment of the present invention, the first feeding unit includes a first container, the first container having a first discharge port, the first discharge port being connected to the first inlet via a pipeline; the second feeding unit includes a second container, the second container having a second discharge port, the second discharge port being connected to the second inlet via a pipeline.

[0010] In an optional embodiment of this utility model, the temperature control device includes a housing, a heating unit, a temperature detection unit, and a temperature controller. The heating unit is used to heat the internal space of the housing, and the temperature detection unit is used to detect the temperature inside the housing. The heating unit and the temperature detection unit are electrically connected to the temperature controller. At least the microfluidic sheet is housed within the housing.

[0011] In an optional embodiment of this utility model, the temperature control device includes a housing, a heating unit, a temperature detection unit, and a temperature controller. The heating unit is used to heat the internal space of the housing, and the temperature detection unit is used to detect the internal temperature of the housing. The heating unit and the temperature detection unit are electrically connected to the temperature controller. The microfluidic sheet, the first container, the second container, and the pipeline between the first container, the second container, and the microfluidic sheet are housed within the housing.

[0012] In an optional embodiment of the present invention, a fluid driving device is further included, the fluid driving device being configured to drive the first material contained in the first container and / or the second material contained in the second container to flow toward the microfluidic sheet.

[0013] In an optional embodiment of the present invention, the fluid drive device includes an air pump, which is connected to the first container and / or the second container via an air pipe.

[0014] In an optional embodiment of the present invention, a flow regulating device is further included, which is used to regulate the feeding rate of the first feeding unit and / or the second feeding unit.

[0015] In an optional embodiment of this utility model, a flow regulating device is further included. The flow regulating device includes a flow meter and a pressure controller. The flow meter is disposed on the pipeline between the first container and the microfluidic chip and / or on the pipeline between the second container and the microfluidic chip. The flow meter is electrically connected to the pressure controller, which is used to control the air supply pressure of the air pump.

[0016] In an optional embodiment of the present invention, the flow channel includes a first flow channel and a second flow channel, the first flow channel and the second flow channel intersect and communicate with each other; the first inlet is located at one end of the first flow channel, and the discharge port is located at the other end of the first flow channel; the second inlet is communicated with the second flow channel, and the second flow channel is configured to allow the second material flowing in through the second inlet to converge from both sides of the first flow channel to the first flow channel.

[0017] In an optional embodiment of this utility model, the second flow channel is annular and symmetrically arranged about a first straight line. The first straight line is a straight line passing through the center point of the second inlet and the intersection point between the first flow channel and the second flow channel.

[0018] In an optional embodiment of this utility model, a collection device is also included, and the discharge port is connected to the collection device via a pipeline.

[0019] The technical advantages of this invention are as follows: This invention precisely controls the flow state of materials through microfluidic sheet technology, and ensures the stability of materials in the microfluidic sheet and the controllability of the microsphere solidification process through a temperature control device, thereby achieving uniformity and controllability of microsphere size, thus improving the efficacy and safety of embolization treatment. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the embolization microsphere preparation system provided in an embodiment of the present invention;

[0021] Figure 2 This is a schematic diagram of the embolization microsphere preparation system provided in an embodiment of this utility model;

[0022] Figure 3 This is a schematic diagram of the structure of the microfluidic sheet provided in an embodiment of this utility model;

[0023] Figure 4 yes Figure 3 A magnified schematic diagram of part I. Detailed Implementation

[0024] The following specific examples illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. This utility model can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of this utility model. It should be noted that, unless otherwise specified, the following embodiments and features described therein can be combined with each other.

[0025] It should be noted that the illustrations provided in the following embodiments are only schematic representations of the basic concept of the present invention. Therefore, the illustrations only show the components related to the present invention and are not drawn according to the number, shape and size of the components in actual implementation. In actual implementation, the form, quantity and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex.

[0026] The principle of fabricating microspheres using microfluidic sheet 10 is as follows: Figure 3 , 4 As shown in the diagram, the arrows indicate the flow direction of the materials. The first liquid material flows upstream of the first channel 14, and the second liquid material flows along the second channel 15. The first and second materials are immiscible. When the first material reaches the intersection of the first and second channels 14, it is sheared and compressed by the second materials on both sides, breaking into intermittent droplets. The mixture of the second material and the droplets is discharged downstream of the first channel 14. These droplets can solidify through cooling or solvent evaporation, forming solid microspheres. It should be noted that the upstream and downstream of the first channel 14 are distinguished by the intersection of the first and second channels 15; the inlet side of the intersection is upstream, and the outlet side is downstream. In this process, the particle size of the microspheres, i.e., the diameter of the droplets, depends on parameters such as the flow area of ​​the channels, the flow rates of the first and second materials, and the viscosity of the first material. Therefore, the particle size of the microspheres can be precisely controlled by adjusting these parameters.

[0027] Please see Figure 1 , 2As shown, based on the above principles, an embodiment of this utility model provides an embolic microsphere preparation system, which includes a microfluidic sheet 10, a first feeding unit, a second feeding unit, and a temperature control device. The microfluidic sheet 10 includes a flow channel, which has a first inlet 11, a second inlet 12, and a discharge port 13. The flow channel is configured to allow a first material flowing into the first inlet 11 to be squeezed and divided into microspheres by a second material flowing into the second inlet 12, and to discharge the first material and the second material from the discharge port 13. The first feeding unit is connected to the first inlet 11 and is used to supply the first material to the flow channel. The second feeding unit is connected to the second inlet 12 and is used to supply the second material to the flow channel. The temperature control device is used to regulate the temperature of at least the first material and the second material in the microfluidic sheet 10. Specifically, the first material is used to form the embolic microsphere product of this utility model, and the second material serves as a medium for shearing and dividing the first material. In a specific embodiment, the first material can be a biodegradable material, such as a gelatin solution, and the second material can be, for example, a paraffin solution. The use of biodegradable materials to prepare microspheres avoids the toxicity problems caused by the accumulation of traditional non-biodegradable materials in vivo, and is also beneficial for repeated clinical treatments. It should be noted that the choice of the first and second materials is not unique. For example, in some other embodiments, the first material can also be chitosan, polylactic acid, or other natural or synthetic polymers, and the second material can also be mineral oil, vegetable oil, etc.

[0028] It should be understood that due to the sol-gel conversion characteristics, rheological properties, and temperature sensitivity of microsphere materials, precise control of the material flow state and temperature is required to ensure the uniformity and controllability of the microsphere particle size. To this end, this invention uses a microfluidic sheet 10 to precisely control the material flow state and a temperature control device to ensure the stability of the material in the microfluidic sheet 10 and the controllability of the microsphere solidification process, thereby achieving uniformity and controllability of the microsphere size and improving the efficacy and safety of embolization treatment.

[0029] Please see Figure 1 , 2As shown, in an optional embodiment of this utility model, the first feeding unit includes a first container 20, which has a first outlet, and the first outlet is connected to the first inlet 11 via a pipeline; the second feeding unit includes a second container 30, which has a second outlet, and the second outlet is connected to the second inlet 12 via a pipeline. This further embodiment, by setting up the first container 20 and the second container 30, and connecting them respectively to the first inlet 11 and the second inlet 12 of the microfluidic sheet 10 via pipelines, enables continuous and stable feeding of the first and second materials, avoiding the generation and accumulation of bubbles due to material interruption during the feeding process, and preventing bubbles from interfering with the microsphere formation process. This ensures the uniformity of microsphere particle size and the stability of the preparation process, further improving the quality and preparation efficiency of the embolized microspheres.

[0030] Please see Figure 1 , 2 As shown, in an optional embodiment of this utility model, the temperature control device includes a housing 40, a heating unit 42, a temperature detection unit 43, and a temperature controller 41. The heating unit 42 is used to heat the internal space of the housing 40, and the temperature detection unit 43 is used to detect the internal temperature of the housing 40. The heating unit 42 and the temperature detection unit 43 are electrically connected to the temperature controller 41; at least the microfluidic chip 10 is housed within the housing 40. This further embodiment, by housing the microfluidic chip 10 within the housing 40 and configuring the heating unit 42, temperature detection unit 43, and temperature controller 41, enables uniform heating and precise temperature control of the internal space of the housing 40. The chamber 40 ensures a uniform temperature distribution around the microfluidic sheet 10, avoiding the impact of local overheating or overcooling on the microsphere formation process. The temperature detection unit 43 monitors the internal temperature of the chamber 40 in real time and feeds the data back to the temperature controller 41. Through closed-loop control, the temperature is precisely adjusted, thereby ensuring the temperature stability of the first and second materials in the microfluidic sheet 10, further improving the uniformity of microsphere particle size and the repeatability of the preparation process.

[0031] In a further embodiment, in order to make it easier to adjust the temperature, the temperature controller 41 can also be connected to a control device and a visual interactive device. The control device can be a device with control signal input function, such as a button, knob or touch screen, and the visual interactive device can be a device with information display function, such as a display screen or signal light.

[0032] In a specific embodiment, in order to facilitate observation of the system operation, the housing 40 can be made of a transparent material, such as glass, acrylic (polymethyl methacrylate), etc.

[0033] Please see Figure 1 ,2 As shown, in a further specific embodiment, the first container 20, the second container 30, and the pipeline connecting the first container 20, the second container 30, and the microfluidic sheet 10 are also housed within the housing 40. This further embodiment, by housing the first container 20, the second container 30, and the connecting pipelines within the housing 40, ensures that the entire chain from material storage to the microfluidic sheet 10 is in the same temperature environment. This avoids viscosity changes or viscosity inhomogeneities caused by temperature fluctuations or localized cooling during material transport, significantly improving the temperature uniformity and stability of the material throughout the preparation process. This further guarantees the uniformity of microsphere particle size and the controllability of the preparation process, improving the quality and preparation efficiency of the embolized microspheres. Furthermore, some types of first or second materials have excessively high viscosity at room temperature, or are even solid. Therefore, placing the first container 20 and the second container 30 within the housing 40 also ensures the flowability of these materials, guaranteeing a smooth supply.

[0034] It should be noted that in some embodiments, when the material has sufficient fluidity at room temperature and the temperature uniformity requirement of the material in the pipeline is not high, the first container 20 and the second container 30 can also be placed outside the box 40.

[0035] The specific form of the temperature control device is not unique. For example, in some other embodiments, the temperature control device may also be a heating base, heating jacket, or other structure that can directly heat the microfluidic plate 10, the first container 20, and the second container 30.

[0036] Please see Figure 1 , 2 As shown, in an optional embodiment of this utility model, a fluid driving device is further included. This fluid driving device is configured to drive the first material contained in the first container 20 and / or the second material contained in the second container 30 to flow towards the microfluidic sheet 10. This further embodiment, by introducing a fluid driving device, can precisely control the flow rate and pressure of the first and second materials towards the microfluidic sheet 10, ensuring stable and continuous material delivery in the flow channel and avoiding inconsistent or failed microsphere formation due to uneven or interrupted feeding. Simultaneously, the fluid driving device can adjust the material flow rate as needed to further optimize the particle size and distribution of the microspheres, thereby improving the preparation accuracy and consistency of the embolized microspheres and enhancing the controllability and reliability of the overall system.

[0037] Please see Figure 1 , 2As shown, in an optional embodiment of this utility model, the fluid driving device includes an air pump 50, which is connected to the first container 20 and / or the second container 30 via an air pipe. This further embodiment positions the fluid driving device upstream of the first container 20 and the second container 30, avoiding direct contact between the driving element and the material, thereby preventing contamination of the material by the driving element. Furthermore, this gas-driven method allows for control of the material flow rate by controlling the air pressure, resulting in smoother material flow control.

[0038] Please see Figure 1 , 2 As shown, in a specific embodiment, a single air pump 50 can be used to simultaneously drive the first material and the second material to save equipment costs. For example, a tee can be connected to the air outlet pipe of the air pump 50 to divide the outlet pipe into two branch pipes, and the two branch pipes can be connected to the first container 20 and the second container 30 respectively. In some other embodiments, two air pumps 50 can also be used to drive the flow of the first material and the second material respectively.

[0039] Please see Figure 1 , 2 As shown, in an optional embodiment of this utility model, a flow regulating device is further included. This flow regulating device is used to regulate the feeding rate of the first feeding unit and / or the second feeding unit. Specifically, the flow regulating device includes a flow meter and a pressure controller 60. The flow meter is installed on the pipeline between the first container 20 and the microfluidic plate 10 and / or on the pipeline between the second container 30 and the microfluidic plate 10. The flow meter is electrically connected to the pressure controller 60, which is used to control the air supply pressure of the air pump 50. Specifically, two flow meters can be provided: a first flow meter 61 is installed on the pipeline between the first container 20 and the microfluidic plate 10, and a second flow meter 62 is installed on the pipeline between the second container 30 and the microfluidic plate 10. The first flow meter 61 and the second flow meter 62 are respectively electrically connected to the pressure controller 60. This embodiment achieves negative feedback control of the material flow rate through the flow meter and the pressure controller 60, improving the flow rate control accuracy of the first and second materials, thereby further improving the uniformity of the microsphere particle size. In a specific embodiment, the pressure controller 60 controls the air pressure by controlling the output power of the air pump 50, or by setting a pressure regulating valve on the air pipe. The pressure controller 60 controls the air pressure by controlling the stroke of the pressure regulating valve.

[0040] Similarly, to facilitate pressure adjustment, the pressure controller 60 can also be connected to a control device and a visual interactive device. The control device can be a device with control signal input function, such as a button, knob or touch screen, and the visual interactive device can be a device with information display function, such as a display screen or indicator light.

[0041] Please see Figure 3 , 4 As shown, in an optional embodiment of this utility model, the flow channel includes a first flow channel 14 and a second flow channel 15, the first flow channel 14 and the second flow channel 15 intersecting and communicating with each other; the first inlet 11 is located at one end of the first flow channel 14, and the discharge port 13 is located at the other end of the first flow channel 14; the second inlet 12 is communicating with the second flow channel 15, and the second flow channel 15 is configured to allow the second material flowing into the second inlet 12 to converge from both sides of the first flow channel 14 towards the first flow channel 14. Specifically, as... Figure 4 As shown in the figure, the dark shading represents the first material, and the light shading represents the second material. When the first material flows to the intersection of the first channel 14 and the second channel 15, the second material applies shear force and compression to the first material from both sides. Since the two materials are immiscible, under the action of interfacial tension, the first material will naturally break down to form uniform droplets. This embodiment can achieve efficient and uniform generation of microspheres. In practical applications, the particle size and distribution of microspheres can be precisely controlled by adjusting the channel size and material flow rate, significantly improving the uniformity, controllability, and production efficiency of microsphere preparation.

[0042] Please see Figure 3 As shown, in an optional embodiment of this utility model, the second flow channel 15 is annular and symmetrically arranged about a first straight line. The first straight line is a straight line passing through the center point of the second inlet 12 and the intersection point between the first flow channel 14 and the second flow channel 15. This further embodiment, by designing the second flow channel 15 as annular and symmetrically arranged about the first straight line, ensures that the second material, after flowing in from the second inlet 12, can be evenly distributed to both sides of the second flow channel 15, making the flow path length and flow resistance of the second material on both sides completely consistent. This symmetrical design avoids the difference in the flow velocity of the second material caused by uneven flow resistance, thereby ensuring that the shear force and extrusion effect applied by the second material to the first material from both sides are uniform and consistent, further improving the uniformity and stability of droplet generation and enhancing the precise control capability of microsphere particle size.

[0043] It should be noted that the specific forms of the first flow channel 14 and the second flow channel 15 are not unique. For example, in some other embodiments, the second flow channel 15 can also be an open-loop structure. In this case, a second inlet 12 can be provided at each end of the second flow channel 15. As long as the pressure of the second material entering the two second inlets 12 is consistent, it can still be ensured that the shear force and extrusion effect applied by the second material to the first material from both sides are uniform. It should be understood that, based on the above embodiments, the first flow channel 14 and the second flow channel 15 can also be configured in other shapes, as long as there is an intersection between them and the shear force and extrusion effect applied by the second material to the first material from both sides are uniform.

[0044] Please see Figure 1 , 2 As shown, in an optional embodiment of this utility model, a collection device 70 is further included, and the discharge port 13 is connected to the collection device 70 via a pipeline. This further embodiment, by setting up the collection device 70 and connecting the discharge port 13 to the collection device 70 via a pipeline, can efficiently and orderly collect the mixture of microspheres and the second material discharged from the microfluidic sheet 10, avoiding contamination or damage to the microspheres after discharge due to exposure to the external environment. Simultaneously, the design of the collection device 70 facilitates subsequent separation, cleaning, and solidification of the microspheres, improving the continuity and overall efficiency of microsphere preparation, and further enhancing the practicality and operability of the system. In a specific embodiment, the collection device 70 can be located outside the housing 40 to facilitate the cooling and solidification of the microspheres.

[0045] In summary, this invention precisely controls the flow state of materials through microfluidic sheet 10 technology and ensures the stability of materials within the microfluidic sheet 10 and the controllability of the microsphere solidification process through a temperature control device, achieving uniformity and controllability of microsphere size, thereby improving the efficacy and safety of embolization treatment. This invention achieves continuous and stable feeding of the first and second materials, avoiding the generation and accumulation of bubbles due to material interruption during feeding, and preventing bubbles from interfering with the microsphere formation process, thus ensuring the uniformity of microsphere particle size and the stability of the preparation process, further improving the quality and preparation efficiency of embolization microspheres. This invention ensures that the entire chain from material storage to the microfluidic sheet 10 is in the same temperature environment, avoiding material transport problems caused by temperature fluctuations or localized cooling. This invention significantly improves the temperature uniformity and stability of the material throughout the entire preparation process, thus further ensuring the uniformity of microsphere particle size and the controllability of the preparation process, and improving the quality and preparation efficiency of the embolized microspheres. The fluid drive device is positioned upstream of the first container 20 and the second container 30, avoiding direct contact between the drive element and the material, thereby preventing contamination of the material by the drive element. Furthermore, this gas-driven method can control the material flow rate by controlling the gas pressure, making the material flow rate control smoother. This invention achieves negative feedback control of the material flow rate through a flow meter and pressure controller 60, improving the flow rate control accuracy of the first and second materials, thereby further improving the uniformity of the microsphere particle size.

[0046] The above embodiments are merely illustrative of the principles and effects of this utility model and are not intended to limit the scope of this utility model. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this utility model. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this utility model should still be covered by the claims of this utility model.

[0047] Throughout this description, numerous specific details, such as examples of components and / or methods, are provided to provide a complete understanding of embodiments of the present invention. However, those skilled in the art will recognize that embodiments of the present invention may be practiced without one or more of these specific details or by other devices, systems, components, methods, parts, materials, components, etc. In other instances, well-known structures, materials, or operations have not been specifically shown or described in detail to avoid obscuring aspects of embodiments of the present invention.

Claims

1. A system for preparing embolizing microspheres, characterized by comprising: The application relates to a microfluidic chip and a temperature control device. The microfluidic chip comprises a flow channel provided with a first inlet, a second inlet and a discharge outlet, and is configured to extrude and divide a first material flowing into the first inlet into microspheres by a second material flowing into the second inlet, and discharge the first material and the second material from the discharge outlet. A first feeding unit is in communication with the first inlet and used for providing the first material to the flow channel. A second feeding unit is in communication with the second inlet and used for providing the second material to the flow channel. The temperature control device is used for adjusting the temperature of at least the first material and the second material in the microfluidic chip.

2. The embolizing microsphere preparation system according to claim 1, wherein The first feeding unit comprises a first container provided with a first discharge outlet in communication with the first inlet through a pipeline.

3. The embolizing microsphere preparation system according to claim 1, wherein The temperature control device comprises a box, a heating unit, a temperature detection unit and a temperature controller.

4. The embolizing microsphere preparation system according to claim 2, wherein The heating unit is used for heating the internal space of the box.

5. The embolizing microsphere preparation system according to claim 2, wherein The temperature detection unit is used for detecting the temperature inside the box.

6. The embolizing microsphere preparation system according to claim 5, wherein The heating unit and the temperature detection unit are electrically connected with the temperature controller.

7. The embolizing microsphere preparation system according to claim 1, wherein At least the microfluidic chip is accommodated in the box.

8. The embolizing microsphere preparation system according to claim 6, wherein The temperature control device comprises a box, a heating unit, a temperature detection unit and a temperature controller. The heating unit is used for heating the internal space of the box. The temperature detection unit is used for detecting the temperature inside the box. The heating unit and the temperature detection unit are electrically connected with the temperature controller. The microfluidic chip, the first container, the second container and the pipelines between the first container, the second container and the microfluidic chip are accommodated in the box. The fluid driving device is configured to drive the first material accommodated in the first container and / or the second material accommodated in the second container to flow to the microfluidic chip. The fluid driving device comprises an air pump in communication with the first container and / or the second container through an air pipe. The flow rate adjusting device is used for adjusting the feeding rate of the first feeding unit and / or the second feeding unit. The flow rate adjusting device comprises a flow meter and a pressure controller. The flow meter is arranged on the pipeline between the first container and the microfluidic chip and / or the pipeline between the second container and the microfluidic chip. The flow meter is electrically connected with the pressure controller. The pressure controller is used for controlling the air supply pressure of the air pump.

9. The embolizing microsphere preparation system according to claim 1, wherein The flow channel comprises a first flow channel and a second flow channel, the first flow channel and the second flow channel are mutually crossed and communicated; the first inlet is located at one end of the first flow channel, and the discharge port is located at the other end of the first flow channel; the second inlet is communicated with the second flow channel, and the second flow channel is configured to enable the second material flowing into the second inlet to converge to the first flow channel from both sides of the first flow channel.

10. The embolizing microsphere preparation system according to claim 9, wherein The second flow channel is annular, and the second flow channel is symmetrically arranged about a first straight line, the first straight line is a straight line passing through a center point of the second inlet and an intersection between the first flow channel and the second flow channel.

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