Column oven for liquid chromatograph

Abstract

The utility model belongs to the technical field of material analysis instruments, and particularly relates to a column oven for a liquid chromatograph, which comprises a shell, a heating device and a refrigerating device, the heating device and the refrigerating device are arranged in the shell, a heat conduction part is arranged on a first side of the shell, the heating device is in surface contact with the heat conduction part, and the refrigerating device is arranged on a second side of the shell. A trapezoidal mounting part is arranged on the second surface of the heat conduction part, a plurality of mounting grooves with different lengths are transversely formed in the mounting part, the cross section of each mounting groove is in an arc shape, the mounting grooves penetrate through the mounting part, and fixing clamps are arranged at the two ends of each mounting groove respectively; aiming at the heating requirements of a liquid chromatograph on chromatographic columns with different sizes in the use process, the utility model comprehensively provides a surface contact type hierarchical fixed-point heating column oven.

Description

Technical Field

[0001] This utility model belongs to the field of material analysis instrument technology, specifically relating to a column oven for liquid chromatographs. Background Technology

[0002] Liquid chromatography is an analytical instrument widely used in chemical analysis, biomedicine, environmental monitoring and other fields. It separates and detects samples in a mobile phase to achieve qualitative and quantitative analysis of the components in complex mixtures.

[0003] In the operation of a liquid chromatograph, the temperature of the chromatographic column has a direct impact on the experimental analysis results. More stable temperatures lead to more accurate analytical results, thus placing increasingly stringent requirements on column temperature control. To address this, various solutions have been proposed to improve the heating effect of the chromatographic column.

[0004] For example, Chinese utility model patent CN118330111A discloses a column oven structure for a liquid chromatograph, which includes a chassis and a closed door. The chassis contains a closed cavity formed by the closed door. The end plate of the closed cavity is a column mounting plate. Multiple mounting slots for fixing the column are vertically arranged on the outer wall of the column mounting plate. A semiconductor cooling chip and multiple surface-mount resistance heating elements are arranged on the inner wall of the column mounting plate. A heat sink fixed to an insulation partition is installed on the heat dissipation end of the semiconductor cooling chip. In this design, the semiconductor cooling chip and surface-mount resistance heating elements transfer heat to the column mounting plate through contact. The column mounting plate also transfers heat to the column through contact heat conduction. This achieves both heating and cooling. Compared to heat transfer through air, the contact heat transfer method provides a wider temperature range and better applicability for the column oven.

[0005] However, the above solution has at least the following shortcomings:

[0006] 1. Significant heat loss;

[0007] 2. It is only applicable to chromatographic columns of fixed length and / or fixed diameter.

[0008] 3. The structure is complex and not easy to replace. Utility Model Content

[0009] The purpose of this invention is to provide a column oven for liquid chromatographs to meet the surface contact heating requirements of chromatographic columns of different sizes and improve the heating efficiency of the column oven.

[0010] To solve the aforementioned technical problems, the present invention specifically adopts the following technical solution:

[0011] A column oven for a liquid chromatograph includes an outer shell, and a heating device and a cooling device disposed inside the outer shell. A heat-conducting part is provided on a first side of the outer shell, and the heating device is in surface contact with the heat-conducting part. A trapezoidal mounting member is provided on a second surface of the heat-conducting part. Multiple mounting grooves of different lengths are provided laterally on the mounting member. The cross-sectional shape of the mounting groove is arc-shaped. The mounting groove penetrates the mounting member, and a fixing clip is provided at each end of the mounting groove.

[0012] When the chromatographic column is installed and fixed on the fixing clamp, the middle part of the chromatographic column is located inside the mounting groove and is wrapped, while the two ends of the chromatographic column are located outside the mounting groove and suspended in the air.

[0013] The fixing clamp includes a connecting part connected to the mounting component, and an upper clamping piece and a lower clamping piece symmetrically arranged on both sides of the connecting part. The connecting part, the upper clamping piece, and the lower clamping piece enclose a clamping space. The upper clamping piece and the lower clamping piece can deform under the action of external force.

[0014] The upper clip and the lower clip extend to both sides from the end away from the connecting part to form a guide space with gradually increasing spacing;

[0015] When the chromatographic column enters the clamping space along the guide space, the upper clamp and the lower clamp deform outwards, making the clamping space larger. When the chromatographic column is fully inside the clamping space, the upper clamp and the lower clamp reset to clamp the chromatographic column.

[0016] As an improvement, the length of the plurality of mounting slots increases sequentially from top to bottom.

[0017] As an improvement, the mounting component is in the shape of an equilateral trapezoid, and the line connecting the center points of the plurality of mounting slots is parallel to the height direction of the chromatograph.

[0018] As an improvement, the heating device includes multiple heating tubes disposed inside the heat-conducting part or disposed on the first surface of the heat-conducting part and in contact with the surface of the heat-conducting part; the multiple heating tubes correspond one-to-one with the multiple mounting slots.

[0019] As an improvement, four heating tubes are provided, and correspondingly, four mounting slots are provided.

[0020] As an improvement, the refrigeration device includes a cold end, a refrigeration element, an elastic element, and a pull rod motor connected in sequence. The output end of the pull rod motor is connected to the refrigeration element through the elastic element. The refrigeration element is disposed in close contact with the cold end. The cold end corresponds to but does not contact the heat-conducting part.

[0021] When the output end of the pull rod motor extends, the output end of the pull rod motor drives the cooling chip and the cold end to move closer to the heat-conducting part, so that the cold end is in close contact with the heat-conducting part and the elastic element is compressed. The heat generated by the cooling chip is conducted to the heat-conducting part through the cold end, and then to the mounting part and the chromatographic column.

[0022] When the output end of the pull rod motor retracts, the elastic element resets, causing the cooling element and the cold end to reset, thereby preventing the cold end from contacting the heat-conducting part.

[0023] As an improvement, the column temperature chamber also includes a water guiding assembly arranged along the height direction of the column temperature chamber. The water guiding assembly includes a water guiding column and a flexible water guiding pipe. A water guiding cavity is provided at the first end of the water guiding column. The bottom of the water guiding cavity is opened and extends downward to form a water guiding channel that penetrates the water guiding column. The first end of the water guiding pipe is detachably connected to the second end of the water guiding column, so that the water guiding pipe communicates with the water guiding channel.

[0024] As an improvement, the detection box is provided with a water guide groove that communicates with the water guide cavity; so that the waste liquid generated in the detection box can be guided into the water guide cavity through the water guide groove, and then flow out through the water guide channel and the water guide pipe.

[0025] As an improvement, the infusion set, the column temperature chamber, and the testing box are each provided with at least two limiting protrusions, and the two limiting protrusions cooperate to form a limiting groove for lateral limiting of the water guide tube.

[0026] As an improvement, at least two of the limiting protrusions are staggered along the height direction of the liquid chromatograph and are located on both sides of the water guide tube, so that grooves are formed on both sides of the water guide tube.

[0027] The principle and beneficial technical effects of this utility model are as follows:

[0028] In response to the heating requirements of chromatographic columns of different sizes during the use of liquid chromatographs, this application provides a comprehensive surface-contact, layered, fixed-point heating column oven.

[0029] First, the mounting components in this solution are equipped with mounting slots of different lengths, which can be used to install chromatographic columns of different lengths. The multiple mounting slots are arranged in a trapezoidal shape (in a hierarchical arrangement). Regardless of which mounting slot the chromatographic column is installed in, it can be ensured that at least one side of the mounting slot has sufficient operating space, thus facilitating user operation.

[0030] Furthermore, the fixing clips are located at both ends of the mounting slot, which makes them easy to replace. In addition, during use, the user can pinch the part with the bolt (i.e., the larger diameter part) and push the chromatographic column into the fixing clip to fix it, so that the chromatographic column can automatically align with the mounting slot without repeated adjustments.

[0031] Furthermore, the heating device in this application uses heat-conducting pipes of different lengths. The heat from the heat-conducting pipes can be "directionally" conducted to the chromatographic column through the heat-conducting part to achieve heating, instead of being conducted indiscriminately to various parts of the heat-conducting panel as in the prior art, thereby achieving the purpose of saving heat source. Attached Figure Description

[0032] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. The elements or parts in the drawings are not necessarily drawn to scale. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without any creative effort.

[0033] Figure 1 This is a schematic diagram of the overall structure of the chromatograph in an embodiment of the present invention;

[0034] Figure 2 This is a schematic diagram of the structure of the detection box in an exemplary embodiment of the present invention;

[0035] Figure 3 This is a schematic diagram of the detection box in another exemplary embodiment of the present invention;

[0036] Figure 4 This is a schematic diagram of the magnetic door structure in an embodiment of the present invention;

[0037] Figure 5 This is a schematic diagram of the detection box from another angle in an embodiment of this utility model;

[0038] Figure 6 This is a schematic diagram showing the four sides of the testing box in an embodiment of this utility model;

[0039] Figure 7 This is a schematic diagram of the internal structure of the detection box in an embodiment of this utility model;

[0040] Figure 8 This is a schematic diagram of the internal structure of the testing box after the partition has been removed in an embodiment of this utility model;

[0041] Figure 9This is a partial schematic diagram of the interior of the detection box in an embodiment of this utility model;

[0042] Figure 10 This is another partial schematic diagram of the interior of the detection box in an embodiment of this utility model;

[0043] Figure 11 This is an exploded view of the internal structure of the detection box in an embodiment of this utility model;

[0044] Figure 12 This is a schematic diagram of the installation structure of the water guide pipe in an embodiment of this utility model;

[0045] Figure 13 This is a partial installation structure diagram of the water guide pipe in an embodiment of this utility model;

[0046] Figure 14 This is a schematic diagram showing the installation relationship between the water guide pipe and the water guide column in an embodiment of this utility model;

[0047] Figure 15 This is a partial structural diagram of the column temperature chamber in an embodiment of this utility model;

[0048] Figure 16 This is a schematic diagram of the partitioned structure of the heat dissipation space in an embodiment of the present utility model;

[0049] Figure 17 This is a schematic diagram of the internal structure of the drainage channel in an embodiment of this utility model;

[0050] Figure 18 This is a schematic diagram of the internal structure of another exemplary drainage channel in an embodiment of the present utility model;

[0051] Figure 19 This is an exploded view of the drainage system in an embodiment of this utility model;

[0052] Figure 20 This is a partial side view of the column temperature chamber in an embodiment of this utility model;

[0053] Figure 21 This is a partial schematic diagram showing the fixing clamp structure in the column temperature chamber in an embodiment of this utility model;

[0054] Figure 22 This is a cross-sectional view of the column temperature chamber in an embodiment of this utility model.

[0055] In the diagram, the markings are as follows: 1. Tray; 2. Infusion set; 3. Column oven; 300. Outer shell; 301. Heat-conducting part; 302. Mounting component; 303. Chromatographic column; 304. Fixing clamp; 341. Upper clamp; 342. Lower clamp; 343. Guiding space; 344. Clamping space; 345. Connecting part; 305. Heating tube; 306. Temperature sensor; 307. Cold end; 308. Elastic element; 309. Pull rod motor; 310. Heat sink; 311. Cooling fan; 312. Cooling element; 4. Detection chamber; 401. First side; 402. Second side; 403. Third side; 404. Fourth side; 41. Shell; 411. Air inlet; 412. Exhaust port; 413. First magnetic element; 42. Detection element; 43. Detection... 431. Measurement space; 432. Sample testing area; 433. Installation area; 434. Limiting step; 435. Limiting protrusion; 436. Groove; 44. Locking block; 45. Magnetic door; 451. Second magnetic element; 46. Light source; 5. Partition; 51. Rolled edge; 52. Air inlet; 53. Air outlet; 54. Mounting plate; 6. Suction device; 7. Exhaust device; 8. Water guide column; 81. Buckle; 82. Water guide cavity; 83. Water guide channel; 84. Transition section; 85. Connecting section; 9. Water guide pipe; 10. Water guide groove; 11. Waste liquid outlet; 12. Insulation cotton; 13. Cooling area; 14. Drainage channel; 141. Gathering section; 142. Acceleration section; 143. Buffer section; 15. Heat dissipation area; 16. Inspection window. Detailed Implementation

[0056] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0057] In this document, suffixes such as "module," "component," or "unit" used to denote elements are used solely for the purpose of illustrative purposes and have no specific meaning in themselves. Therefore, "module," "component," or "unit" can be used interchangeably. In this document, terms such as "upper," "lower," "inner," "outer," "front," "rear," "one end," and "the other end," indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are used only for the convenience of describing this utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0058] In this document, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," and "connected," etc., should be interpreted broadly. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; it can also refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances. In this document, "multiple" means two or more, that is, it includes two, three, four, five, etc.

[0059] Example 1

[0060] In the prior art, the heat dissipation method of chromatographs is mostly to install an exhaust device on the side wall of the detection chamber to extract the hot air distributed inside the detection chamber, thereby achieving the purpose of heat dissipation. For example, the ion chromatograph disclosed in Chinese Utility Model Patent Application No. 202120699737.2; in this case, the lamp source (usually referring to deuterium lamp and tungsten lamp, i.e., heat source) is exposed in the entire cavity of the detection chamber. The large amount of heat generated by the lamp source will be rapidly distributed throughout the entire cavity. In the case of low ambient temperature conditions such as cold storage, even if the heat is distributed inside the cavity, the heat inside the cavity exchanges heat with the cold air in the environment. With the help of the exhaust device installed on the side wall of the detection chamber, the cooling of the cavity can be basically achieved. However, this method has at least the following drawbacks: for example, the heat generated by the lamp source is distributed indiscriminately throughout the entire cavity of the detection chamber, and the detection elements located in the cavity are likely to have inaccurate measurement results after being heated; for another example, if some components in the detection chamber (such as the water pipe located in the detection cavity) are exposed to a high-temperature environment for a long time, their aging will inevitably be accelerated.

[0061] Furthermore, in situations where the ambient temperature is high (such as in a typical laboratory, especially during summer power rationing when the air conditioning cannot be set too low, and the indoor temperature is around 20-25°C), if a large amount of heat is stored inside the chamber, and the heat exchange rate between the chamber and the ambient air is slow, the exhaust device located on the side wall of the testing chamber will have difficulty achieving rapid cooling of the chamber.

[0062] This application provides a point-source heat dissipation solution that confines the large amount of heat generated by the light source to a limited area and quickly removes the heat by setting a guiding path, i.e., a "DC" convection air duct.

[0063] Specifically, this embodiment is basically as shown in the appendix. Figure 1-17 As shown:

[0064] See Figure 1 This utility model provides a liquid chromatograph, which includes a tray 1, an infusion set 2, a column oven 3 and a detection chamber 4 arranged from top to bottom.

[0065] In some embodiments, see Figure 15 The column oven includes a heat-conducting space for mounting heating and cooling devices, and an installation space for mounting the chromatographic column. A heat-conducting part 301 is provided between the heat-conducting space and the installation space, separating them. A mounting component 302 is provided on the side of the heat-conducting part 301 near the installation space. The mounting component 302 has multiple slots of varying lengths, allowing the chromatographic column 303 to be secured in these slots. It should be noted that the mounting component is also made of a heat-conducting material. This means that the heat or cold generated by the heating or cooling device within the heat-conducting space can be directly conducted to the chromatographic column through the heat-conducting part and the mounting component in a surface-contact manner. Compared to the traditional method of heating by introducing hot air, the chromatographic column in this solution is heated through surface contact, resulting in better heating performance. Furthermore, the slots in this application have multiple different lengths, enabling compatibility with chromatographs of different lengths and broadening its applicability.

[0066] See Figure 2 and Figure 3 The detection box includes a housing 41, and a light source and detection element disposed inside the housing 41. A detection space 43 is provided on the first side of the housing, and the detection space 43 is located outside the housing 41.

[0067] See Figures 7-11The housing 41 is detachably provided with a partition 5. The partition 5, together with the bottom wall of the housing 41 and the side wall of the first side of the housing, forms a closed heat dissipation space surrounding the light source 46. The heat dissipation space extends from the first side to the third side of the housing. In other words, the heat dissipation space is a straight channel, and the hot air in the heat dissipation space can be directly discharged from its first end to its second end, resulting in high heat dissipation efficiency.

[0068] See Figure 16 The heat dissipation space is divided into a cooling zone 13, a drainage channel 14, and a heat dissipation zone 15 from its first end to its second end. At least one side wall of the cooling zone 13 is provided with an air inlet 52, and an air intake device 6 is provided at the air inlet 52. The lamp source 46 is located in the cooling zone 13 and corresponds to the air intake device 6. The heat dissipation zone 15 is provided with an air outlet 53 corresponding to the third side of the housing 41, and an exhaust device 7 is provided at the air outlet 53. Accordingly, see... Figure 5 The housing is provided with at least one air inlet 411 corresponding to the suction device and an exhaust 412 corresponding to the exhaust device. That is, the air inlet is located on the side wall of the housing, while the air outlet is located on the rear side of the housing, which will not affect the user's operation; that is, the air inlet and the air outlet are located at the two ends of the heat dissipation space, which runs through the entire interior of the housing.

[0069] In some embodiments, see Figure 11 The partition is an n-shaped partition with openings at both ends. An installation plate 54 is provided at the opening at the second end of the partition. The exhaust device is provided on the installation plate 54. When the partition 5 and the installation plate 54 are installed in the housing 41, the partition 5, the installation plate 54, and the bottom wall and the first side wall of the housing 41 enclose a heat dissipation space.

[0070] In some embodiments, both the suction device and the exhaust device are fans (preferably silent fans).

[0071] This application aligns the lamp source (i.e., the heat source) with the cooling zone. Cold air drawn in by the suction device is directly blown onto the lamp source, enabling rapid and direct cooling. The hot air generated by the cold air exchanging heat with the lamp source then enters the airflow channel for buffering and is extracted by the exhaust device located at the rear of the testing box. This design ensures a clear airflow path, efficiently carrying heat out of the channel and preventing heat accumulation. Furthermore, due to the design of the acceleration section of the channel and its straight, hollow structure, the hot air does not form complex eddies or backflow phenomena within the channel, thus ensuring the continuity and effectiveness of heat dissipation.

[0072] In some embodiments, see Figure 17 The inner diameter of the drainage channel gradually decreases and then increases from its first end to its second end, dividing the channel into a gathering section 141, an acceleration section 142, and a buffer section 143. The inner diameter of the acceleration section 142 is smaller than that of the gathering section 141 and the buffer section 143. The first end of the drainage channel is closer to the suction device, and the second end is closer to the exhaust device. In other words, the inner diameters at both ends of the drainage channel are larger than the inner diameter of the middle section, forming an acceleration section in the middle. Of course, the inner diameter here could also be width or length; in any case, the cross-sectional area of ​​the acceleration section is smaller than that of the gathering section and the buffer section.

[0073] In some embodiments, the ratio of the inner diameter of the acceleration section to the inner diameter of both ends of the drainage channel is 0.4-0.6 (preferably 0.5), that is, the two ends of the drainage channel gradually contract inward, so that the cross-sectional area of ​​the middle section (acceleration section) is reduced to 40%-60% (preferably 50%) of that of the two ends.

[0074] In some embodiments, the inner diameters of the two ends of the drainage channel, namely the first end of the gathering section and the first end of the buffer section, are the same as the inner diameters of the second end of the cooling zone and the first end of the heat dissipation zone, respectively, so that the drainage channel smoothly transitions with the cooling zone and the heat dissipation zone, respectively.

[0075] In some embodiments, the acceleration section is divided into multiple segments, with alternating use of a shrinking segment 1421 and a recovery segment 1422. The inner diameter of the shrinking segment 1421 is smaller than the inner diameter of the recovery segment 1422. This ensures that hot air entering the acceleration section (a longer channel) avoids high-pressure loss due to the channel's length, thereby ensuring a continuous negative pressure is formed in the accumulation section. In some specific embodiments,

[0076] After the cold air enters the cooling zone at the first end of the heat dissipation space and fully exchanges heat with the lamp source, the acceleration in the acceleration section and the negative pressure formed in the gathering section quickly draw the hot air to the gathering section to prevent the hot air after heat exchange from mixing with the newly entered cold air in the cooling zone, thus reducing the heat dissipation effect. This ensures that there is a large temperature difference between the air around the lamp source and the lamp source. Then, the hot air gathered in the gathering section immediately enters the acceleration section for rapid discharge and enters the buffer section for temporary storage. On the one hand, this can reduce the escape or conduction of hot air from the acceleration section to the outside. On the other hand, it can facilitate the exhaust device located at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in inner diameter between the acceleration section and the buffer section, it can also effectively prevent the hot air at the second end of the heat dissipation space from flowing back to the first end. In other words, this application provides a "rapidly diverting anti-backflow heat dissipation structure".

[0077] In this document, the first side 401 (i.e., the front side, the side for user operation), the second side 402, the third side 403 (i.e., the rear side), and the fourth side 404 of the housing can be found in [reference needed]. Figure 6 Specifically, the side with the detection space is designated as the first side 401, the side with the air inlet is designated as the second side 402, the side with the air outlet is designated as the third side 403, and the side closer to the detection element is designated as the fourth side 404; that is, the first side 401 and the third side 403 are arranged opposite to each other, and the second side 402 and the fourth side 404 are arranged opposite to each other.

[0078] In some embodiments, see Figure 9 The two sides of the partition 5 that contact the bottom wall of the housing extend towards both sides of the heat dissipation space to form rolled edges 51 parallel to the bottom wall. At least two locking blocks 44 are provided on the bottom wall. When the two rolled edges 51 are fixed by the at least two locking blocks 44, the rolled edges 51 adhere to the bottom wall. By setting the rolled edges to engage with the locking blocks on the bottom wall, quick assembly and disassembly are achieved, and the adherence of the rolled edges to the bottom wall further improves the sealing of the heat dissipation space.

[0079] In other embodiments, see Figure 11 The two sides of the partition 5 that contact the bottom wall of the housing extend toward both sides of the heat dissipation space to form rolled edges parallel to the bottom wall. At least one through hole is provided on the rolled edge. Correspondingly, at least one threaded hole corresponding to the through hole is provided on the bottom wall. When a bolt is passed through the through hole and screwed into the threaded hole, the bolt fixes the partition to the bottom wall, and the rolled edge is attached to the bottom wall, that is, at this time the rolled edge is parallel to the bottom wall.

[0080] In some embodiments, see Figure 2 The air inlet is located on one of the side walls of the first end of the partition, and correspondingly, the air inlet 411 is located on the second side of the housing 41.

[0081] In other embodiments, see Figure 5 The air inlet is provided in two places, which are located on the top of the partition and on one of its side walls, respectively; correspondingly, the air inlet 411 is also provided in two places, which are located on the top and the second side of the housing, respectively.

[0082] In some embodiments, the detection space is formed by an inward recess of the outer surface of the first side of the housing, and the detection space is provided with a sample detection area corresponding to the opening and an installation area for installing a water guide pipe.

[0083] In some embodiments, the sample detection area is provided with an active window, which is closed during the detection process; the user can open the active window to inspect or replace the light source located inside the housing.

[0084] In some embodiments, the partition is disposed near the second side of the housing, and the detection element is disposed near the fourth side of the housing, thereby forming an isolation space between the detection element and the heat dissipation space.

[0085] In some specific embodiments, the detection box is divided into left and right parts. The lamp source and the sample detection area are both located in the left half, and the partition is also located in the left half. The detection element (e.g., sensor, data acquisition and processing unit, signal amplifier, etc.) and the water pipe are located in the right half, preferably at the far right end of the detection box, that is, the end away from the lamp source, so as to separate the lamp source from other components and minimize or avoid the heat generated by the lamp source from being conducted to the detection element and the water pipe and other components, which could lead to inaccurate measurement results or component aging.

[0086] In some embodiments, see Figure 10 and Figure 11 The partition (preferably the top) is provided with heat insulation cotton 12.

[0087] In some embodiments, see Figure 14 The chromatograph also includes a water guiding assembly, which includes a water guiding pipe 9 and a water guiding column. The water guiding column is disposed in the installation area, and the water guiding pipe 9 is detachably connected to the water guiding column.

[0088] In some embodiments, see Figure 12 and Figure 13 The installation area is provided with a limiting step 433, and the water guide column 8 is provided with a buckle 81. When the buckle 81 is fastened to the limiting step 433, the water guide column 8 is fixed to the housing 41. The external water guide pipe is detachably installed, which allows for quick assembly and disassembly of the water guide pipe.

[0089] In some embodiments, see Figure 12 The installation area is provided with multiple limiting protrusions 434, which cooperate to form a limiting groove for fixing the water guide column 8. By fixing the tube body of the water guide column through the limiting groove, the water guide column can be prevented from swinging in the detection space, thereby preventing leakage.

[0090] In some embodiments, see Figure 3The bottom of the detection space is provided with a water guide trough 10, the height of which gradually decreases from the first end to the second end, forming an inclined drainage slope. The second end of the water guide trough 10 is provided with a waste liquid outlet 11. By setting the inclined drainage slope, it can be ensured that the waste liquid generated during the detection process can be discharged quickly.

[0091] In some embodiments, the infusion set and the column temperature chamber are each provided with a water guide column and a water guide pipe. The specific structure and installation method can be referred to the water guide pipe and water guide column in the test box, and will not be repeated here; wherein, the water guide pipes on the infusion set, the column temperature chamber and the test box are connected in sequence.

[0092] In some embodiments, both the infusion set and the column temperature chamber are provided with a water guide channel at the bottom. The height of the water guide channel gradually decreases from its first end to its second end, so that the water guide channel forms an inclined drainage slope. The second end of the water guide channel is provided with a waste liquid outlet.

[0093] In some embodiments, the waste liquid outlet is connected to the water inlet of the water guide pipe, that is, the waste liquid outlet of each of the infusion set, the column temperature box and the detection box is connected to the water guide pipe provided thereon, and the three water guide pipes are also connected in sequence.

[0094] In some embodiments, see Figures 2-4 The infusion set, the column temperature chamber, and the detection box are all equipped with magnetic doors 45;

[0095] Specifically, the infusion set and the column temperature chamber are respectively provided with installation spaces on the first side. Multiple first magnetic elements 413 are provided in the installation spaces. The infusion set and the column temperature chamber also include a magnetic door 45. Multiple second magnetic elements 451 corresponding to the first magnetic elements 413 are provided on the magnetic door 45. When the magnetic door 45 is installed on the infusion set and / or the column temperature chamber through the second magnetic elements 451 and the first magnetic elements 413, the magnetic door 45 and the installation space enclose a sealed space, and the water pipes of the infusion set and the column temperature chamber are located in the sealed space.

[0096] The detection space is provided with a plurality of first magnetic elements 413; the detection box also includes a magnetic door 45, on which a plurality of second magnetic elements 451 corresponding to the first magnetic elements 413 are provided; when the magnetic door 45 is installed on the housing via the second magnetic elements 451 and the first magnetic elements 413, the housing and the magnetic door 45 enclose the detection space to form a sealed detection space. That is, the magnetic door 45 seals the opening of the detection space, making the detection space a sealed space.

[0097] In some embodiments, both the first magnetic element 413 and the second magnetic element 451 are magnets.

[0098] In summary, this application provides a comprehensive heat dissipation solution that confines heat to a limited area and rapidly removes heat through a "direct current" convection airflow duct. Specifically, this solution sets up a "direct current" partitioned heat dissipation channel, simultaneously introducing cool air into the heat dissipation space and extracting hot air from it using both suction and exhaust devices. This allows the air inside the heat dissipation space to be rapidly drawn from one end to the other, achieving rapid and concentrated heat dissipation of the lamp source. On the one hand, it concentrates the large amount of heat generated by the lamp source within the heat dissipation space, preventing heat from diffusing to the detection element or the area where the water pipe is located and causing adverse effects. On the other hand, the flow channel can buffer the heat, meaning that the heat generated by the lamp source can be quickly dispersed into the flow channel, thus preventing the lamp source temperature from becoming too high. Furthermore, the "direct current" airflow design ensures a clear airflow path, efficiently carrying heat out of the channel and preventing heat accumulation within the channel.

[0099] Example 2

[0100] This embodiment is basically as follows: Figure 15 , Figures 19-22 As shown:

[0101] See Figure 15 This embodiment provides a column oven for a liquid chromatograph, including a housing 300 and a heating device and a cooling device disposed inside the housing 300. A heat-conducting part 301 is provided on a first side of the housing 300, and the heating device is in surface contact with the heat-conducting part 301. A trapezoidal mounting member 302 is provided on the second surface of the heat-conducting part 301. Multiple mounting grooves of different lengths are provided laterally on the mounting member 302. The cross-sectional shape of the mounting groove is arc-shaped. The mounting groove penetrates the mounting member, and fixing clips are respectively provided at both ends of the mounting groove. When the chromatographic column 303 is installed and fixed on the fixing clips, the middle part of the chromatographic column 303 is located inside the mounting groove and is wrapped, while the two ends of the chromatographic column 303 are located outside the mounting groove and suspended.

[0102] By setting up mounting slots of different lengths, chromatographic columns of different lengths can be installed accordingly. The multiple mounting slots are arranged in a trapezoidal shape (hierarchical arrangement). Regardless of which mounting slot the chromatographic column is installed in, it can be ensured that at least one side of the mounting slot has sufficient operating space. For example, the end of the second mounting slot from the top, that is, the upper sides of the two fixing clips of the mounting slot are unobstructed, thus facilitating user operation.

[0103] Furthermore, the fixing clips are located at both ends of the mounting slot, which makes them easy to replace. In addition, during operation, the user can pinch the part with the bolt (i.e., the larger diameter part) and push the chromatographic column into the fixing clip to fix it, so that the chromatographic column can automatically align with the mounting slot without repeated adjustments.

[0104] In some embodiments, a heat-conducting space is provided inside the housing, and the column oven further includes a heating device and a cooling device disposed within the heat-conducting space. One side of the housing is provided with an installation space for mounting a chromatographic column, and the installation space corresponds to the heating unit.

[0105] In some embodiments, see Figure 22 The heating device includes multiple heating tubes 305 disposed inside the heat-conducting part 301 or closely attached to the heat-conducting part 301. The number of heating tubes 305 is the same as the number of mounting slots (preferably 4 tubes / slot), and the multiple heating tubes 305 correspond one-to-one with the multiple mounting slots. This makes the heat conduction between the heat-conducting tubes and the chromatographic column 303 more uniform and direct. In other words, the heat from the heat-conducting tubes can be first "directionally" conducted to the chromatographic column 303 through the heat-conducting part 301 to achieve heating, instead of being conducted indiscriminately to various parts of the heat-conducting panel as in the prior art, thereby achieving the purpose of saving heat source.

[0106] In some embodiments, the refrigeration device and the heat-conducting part 301 are installed in an intermittent contact manner. When the cold end 307 of the refrigeration device is in contact with the heat-conducting part 301, the chromatographic column 303 can be cooled by the heat-conducting part 301. When the refrigeration device leaves the first surface of the heat-conducting part 301, the refrigeration device no longer cools the chromatographic column 303.

[0107] In some specific embodiments, the refrigeration device includes a cold end 307, a refrigeration element 312, an elastic element 308, and a pull rod motor 309 connected in sequence. The output end of the pull rod motor 309 is connected to the refrigeration element 312 through the elastic element 308. The refrigeration element 312 is disposed in close contact with the cold end 307. The cold end 307 corresponds to but does not contact the heat-conducting part 301.

[0108] When the output end of the pull rod motor 309 extends, the output end of the pull rod motor 309 drives the cooling chip 312 and the cold end 307 to move closer to the heat-conducting part 301, so that the cold end 307 is in close contact with the heat-conducting part 301, and the elastic member 308 is compressed. The heat generated by the cooling chip 312 is conducted to the heat-conducting part 301 through the cold end 307, and then to the mounting part and the chromatographic column 303.

[0109] When the output end of the pull rod motor 309 retracts, the elastic element 308 resets, causing the cooling chip 312 and the cold end 307 to reset, thereby making the cold end 307 no longer in contact with the heat-conducting part 301.

[0110] Thus, during the heating process, the cooling device is kept in a closed state, and the heat generated by the heating tube 305 will not be conducted to the cooling device, causing heat loss. Only when cooling is needed will the cooling end 307 be brought into contact with the heat-conducting part 301 to achieve cooling. In other words, the cooling device and the heating device in this application are set up independently, work independently, and do not interfere with each other.

[0111] In some embodiments, the cooling device further includes heat sinks 310 disposed on both sides of the cooling chip 312, and correspondingly, a cooling fan 311 corresponding to the heat sink 310 is disposed on the housing.

[0112] In some embodiments, the heat-conducting part 301 is provided with a temperature sensor 306.

[0113] In some embodiments, the length of the plurality of mounting slots increases sequentially from top to bottom.

[0114] In some embodiments, the mounting member is in the shape of an equilateral trapezoid, and the line connecting the center points of the plurality of mounting slots is parallel to the height direction of the chromatograph.

[0115] In some embodiments, see Figure 21 The fixing clamp includes a connecting part connected to the mounting member, and an upper clamping piece 341 and a lower clamping piece 342 symmetrically arranged on both sides of the connecting part. The connecting part, the upper clamping piece 341 and the lower clamping piece 342 enclose a clamping space 344. The upper clamping piece 341 and the lower clamping piece 342 can deform under the action of external force, while the connecting part cannot deform.

[0116] In some embodiments, the upper clip 341 and the lower clip 342 extend outward from the end away from the connecting portion to form a guide space 343 with gradually increasing height;

[0117] When the chromatographic column enters the clamping space 344 along the guide space 343, the upper clamping piece 341 and the lower clamping piece 342 respectively change outward, making the clamping space 344 larger. When the chromatographic column is fully entered into the clamping space 344, the upper clamping piece 341 and the lower clamping piece 342 reset to clamp the chromatographic column.

[0118] The connecting part includes a base arranged in a vertical direction. The base gradually contracts inward, so that the height of the connecting part gradually decreases from the first end to the second end. The upper clamping piece and the lower clamping piece are connected to the second end of the connecting part. The clamping space is circular or elliptical with openings on both sides, and the diameter of the clamping space is greater than the height of the second end of the connecting part. The guiding space is funnel-shaped with the opening facing outward (in the direction of the clamping space).

[0119] This application sets up a guiding space with a guiding function, so that when the user pushes the chromatographic column into the clamping space, he only needs to roughly align the chromatographic column with the clamping space, and the chromatographic column can automatically enter the clamping space and be clamped under the guidance of the guiding space.

[0120] In some embodiments, see Figure 19 The column temperature chamber also includes a water guiding component arranged along the height direction of the column temperature chamber. The water guiding component includes a water guiding column 8 and a flexible water guiding pipe 9. The first end of the water guiding column 8 is provided with a water guiding cavity. The bottom of the water guiding cavity is opened and extends downward to form a water guiding channel that penetrates the water guiding column. The first end of the water guiding pipe is detachably connected to the second end of the water guiding column, so that the water guiding pipe is connected to the water guiding channel.

[0121] In some embodiments, the detection box is provided with a water guide groove communicating with the water guide cavity; so that the waste liquid generated in the detection box can be guided to the water guide cavity through the water guide groove, and flow out through the water guide channel and the water guide pipe.

[0122] The external water pipe can be installed in a detachable manner, allowing for quick assembly and disassembly of the water pipe.

[0123] In summary, this application provides a surface-contact, layered, fixed-point heating column oven that can meet the installation and heating requirements of chromatographic columns of different lengths, is simple and convenient to use, and has high heating efficiency.

[0124] Example 3

[0125] This embodiment is basically as follows: Figures 12-14 and Figure 19 As shown:

[0126] This embodiment provides a liquid discharge system for a liquid chromatograph. The chromatograph includes a tray, a liquid infuser, a column oven, and a detection chamber arranged from top to bottom. The specific structure of the chromatograph can be referred to the chromatograph structure in Embodiment 1.

[0127] The drainage system includes three water-conducting components connected sequentially along the height of the chromatograph. The three water-conducting components are respectively disposed on the infusion set, the column oven, and the detection chamber; the three water-conducting components adopt the same structure.

[0128] Specifically, the water guiding assembly includes a water guiding column 8 and a flexible water guiding pipe 9 (e.g., a rubber hose). The first end of the water guiding column 8 is provided with a water guiding cavity 82. The bottom of the water guiding cavity 82 is opened and extends downward to form a water guiding channel 83 that penetrates the water guiding column 8. The first end of the water guiding pipe 9 is detachably connected to the second end of the water guiding column 8, so that the water guiding pipe 9 communicates with the water guiding channel 83. The second end of the water guiding column 8 refers to the end that is outside the water guiding cavity 82.

[0129] The three water-guiding columns 8 are respectively fixed (including detachable fixing) to the infusion set, the column temperature chamber, and the detection box. The second end of the water-guiding tube 9 on the infusion set is connected to the water-guiding cavity 82 on the column temperature chamber, and the second end of the water-guiding tube 9 on the column temperature chamber is connected to the water-guiding cavity 82 on the detection box. That is to say, the water-guiding tube 9 and the water-guiding column 8 of the same water-guiding assembly are detachably connected and internally interconnected to form a waste liquid channel, while adjacent water-guiding assemblies are interconnected with each other, ultimately making the water-guiding assemblies on the infusion set, the column temperature chamber, and the detection box sequentially connected to form a complete drainage system.

[0130] In some embodiments, the infusion set, the column temperature chamber, and the detection box are respectively provided with water guide channels communicating with the water guide cavity 82; so that the waste liquid generated in the infusion set, the column temperature chamber, and the detection box can be guided into the water guide cavity 82 through the water guide channels, and flow out through the water guide channel 83 and the water guide pipe 9.

[0131] In some embodiments, the diameter of the water guiding cavity 82 is larger than the diameter of the pipe. When the second end of the pipe is connected to the water guiding cavity 82, there is still a certain space between the water guiding cavity 82 and the pipe, which facilitates the waste liquid in the water guiding tank to enter the water guiding cavity 82.

[0132] In some embodiments, the height of the water guide channel gradually decreases from the first end to the second end to form an inclined slope, and the second end of the water guide channel is connected to the water guide cavity 82.

[0133] In some embodiments, the infusion set, the column temperature chamber, and the detection box are respectively provided with a groove 436 for accommodating the water guiding cavity 82, and a limiting step 433 is provided at the bottom of the groove 436; the water guiding cavity 82 is located in the groove 436, the bottom of the water guiding cavity 82 abuts against the limiting step 433, and the second end of the water guiding column 8 extends out of the groove 436 and is located below the groove 436.

[0134] In some embodiments, a buckle 81 is provided at the bottom of the water guide column 8, and the buckle 81 and the bottom of the water guide channel form a groove, with the limiting step 433 located within the groove. That is, the water guide column 8 can be fixed in the water guide channel by snapping, in which case the groove can limit the water guide column 8 vertically, while the water guide channel can limit the water guide column 8 horizontally.

[0135] In some embodiments, the infusion set, the column temperature chamber, and the detection box are each provided with at least two limiting protrusions 434, which cooperate to form a limiting groove for laterally limiting the water guide tube 9. When the water guide tube 9 is installed into the limiting groove, the two limiting protrusions 434 are located on both sides of the water guide tube 9 to prevent lateral displacement of the water guide tube 9.

[0136] In some embodiments, the bottom of the water guiding cavity 82 extends downward to form a transition section 84 and a connecting section 85 in sequence; the diameter of the transition section 84 is larger than the diameter of the connecting section 85, and the water guiding pipe 9 is sleeved on the connecting section 85. By providing the transition section 84, the stability of the water guiding column 8 can be increased.

[0137] In some embodiments, limiting holes are respectively provided on the infusion set, the column temperature chamber, and the detection box. The limiting holes are located below the groove 436, and the second end of the water guide column 8 extends out of the limiting hole and is located below the limiting hole. By providing limiting holes, "double limiting" is achieved for the water guide column 8 at different heights, which can further prevent the water guide column 8 from swinging laterally.

[0138] In some embodiments, at least two of the limiting protrusions 434 are staggered along the height direction of the liquid chromatograph and are respectively located on both sides of the water guide tube 9, so that grooves 435 are formed on both sides of the water guide tube 9. For example, two limiting protrusions 434 are respectively provided on both sides of the water guide tube 9, a first groove 435 is formed between the limiting protrusions 434 on one side, and a second groove 435 is formed between the limiting protrusions 434 on the opposite side. The heights of the first groove 435 and the second groove 435 are different, that is, the limiting protrusions 434 on both sides are staggered, and the two grooves 435 are also staggered, which makes it convenient for the user to pinch at least one side of the water guide tube 9 from the slot and remove the water guide tube 9 from the limiting groove.

[0139] In some embodiments, the second end of the connecting segment 85 extends downward and its outer diameter gradually decreases to form a guide slope. This facilitates the insertion of the water guide pipe 9 along the guide slope into the second end of the water guide column 8.

[0140] In summary, this application provides an external split-type drainage pipe design with multiple limiting structures. Specifically, the water guide pipe is connected to the water guide column by a single-sided fixing method, and the two are restricted by multiple limiting structures. This ensures the stability of the drainage system while facilitating quick assembly and disassembly of the water guide pipe.

[0141] First, the water guide column in this drainage system is fixed on the chromatograph. One end of the water guide tube is sleeved on one end of the water guide column, and the other end is connected to the water guide cavity but not fixed. That is, the water guide tube is installed in a single-sided fixed manner. On the one hand, it is convenient to replace the water guide tube. On the other hand, the water guide column is fixed on the chromatographic column, so the water guide tube can be automatically aligned through the water guide column after the water guide tube is replaced.

[0142] Furthermore, this application sets multiple limiting structures on the chromatograph. For example, the limiting steps and limiting holes can be used to achieve lateral limiting of the water column; the limiting groove can be used to achieve lateral limiting of the water tube, which can ensure that the water column and the water tube always maintain a corresponding state, thereby ensuring the stability of the drainage system.

[0143] Furthermore, by setting an inclined drainage slope, it can be ensured that the waste liquid generated during the testing process can flow into the open water guide cavity and be quickly discharged.

[0144] Example 4

[0145] In the prior art, the heat dissipation method of chromatographs is mostly to install an exhaust device on the side wall of the detection chamber to extract the hot air distributed inside the detection chamber, thereby achieving the purpose of heat dissipation. For example, the ion chromatograph disclosed in Chinese Utility Model Patent Application No. 202120699737.2; in this case, the lamp source (usually referring to deuterium lamp and tungsten lamp, i.e., heat source) is exposed in the entire cavity of the detection chamber. The large amount of heat generated by the lamp source will be rapidly distributed throughout the entire cavity. In the case of low ambient temperature conditions such as cold storage, even if the heat is distributed inside the cavity, the heat inside the cavity exchanges heat with the cold air in the environment. With the help of the exhaust device installed on the side wall of the detection chamber, the cooling of the cavity can be basically achieved. However, this method has at least the following drawbacks: for example, the heat generated by the lamp source is distributed indiscriminately throughout the entire cavity of the detection chamber, and the detection elements located in the cavity are likely to have inaccurate measurement results after being heated; for another example, if some components in the detection chamber (such as the water pipe located in the detection cavity) are exposed to a high-temperature environment for a long time, their aging will inevitably be accelerated.

[0146] Furthermore, in situations where the ambient temperature is high (such as in a typical laboratory, especially during summer power rationing when the air conditioning cannot be set too low, and the indoor temperature is around 20-25°C), if a large amount of heat is stored inside the chamber, and the heat exchange rate between the chamber and the ambient air is slow, the exhaust device located on the side wall of the testing chamber will have difficulty achieving rapid cooling of the chamber.

[0147] Based on the above background, this embodiment provides a detection chamber for a liquid chromatograph, see [link to relevant documentation]. Figure 1 and Figure 10 The detection box includes a housing 41, and a light source 46 and a detection element 42 disposed inside the housing 41;

[0148] It also includes a partition 12 that is detachably disposed inside the housing 41. The partition 12, together with the bottom wall of the housing 41 and the side wall of the first side of the housing 41, forms a closed heat dissipation space surrounding the light source 46. The heat dissipation space extends from the first side to the third side of the housing. In other words, the heat dissipation space is a straight channel, and the hot air in the heat dissipation space can be directly discharged from its first end to its second end, resulting in high heat dissipation efficiency.

[0149] See Figure 16 The heat dissipation space is divided into a cooling zone 13, a drainage channel 14, and a heat dissipation zone 15 from its first end to its second end. At least one side wall of the cooling zone 13 is provided with an air inlet 52, and an air intake device 6 is provided at the air inlet 52. The lamp source 46 is located in the cooling zone 13 and corresponds to the air intake device 6. The heat dissipation zone 15 is provided with an air outlet 53 corresponding to the third side of the housing 41, and an exhaust device 7 is provided at the air outlet 53. Accordingly, see... Figure 5 The housing is provided with at least one air inlet 411 corresponding to the suction device and an exhaust 412 corresponding to the exhaust device. That is, the air inlet is located on the side wall of the housing, while the air outlet is located on the rear side of the housing, which will not affect the user's operation; that is, the air inlet and the air outlet are located at the two ends of the heat dissipation space, which runs through the entire interior of the housing.

[0150] In some embodiments, there are two air inlets, which are located at the top and the second side of the partition, respectively.

[0151] In some embodiments, see Figure 11The partition is an n-shaped partition with openings at both ends. An installation plate 54 is provided at the opening at the second end of the partition. The exhaust device is provided on the installation plate 54. When the partition 5 and the installation plate 54 are installed in the housing 41, the partition 5, the installation plate 54, and the bottom wall and the first side wall of the housing 41 enclose a heat dissipation space.

[0152] In some embodiments, both the suction device and the exhaust device are fans (preferably silent fans).

[0153] This application aligns the lamp source (i.e., the heat source) with the cooling zone. Cold air drawn in by the suction device is directly blown onto the lamp source, enabling rapid and direct cooling. The hot air generated by the cold air exchanging heat with the lamp source then enters the airflow channel for buffering and is extracted by the exhaust device located at the rear of the testing box. This design ensures a clear airflow path, efficiently carrying heat out of the channel and preventing heat accumulation. Furthermore, due to the design of the acceleration section of the channel and its straight, hollow structure, the hot air does not form complex eddies or backflow phenomena within the channel, thus ensuring the continuity and effectiveness of heat dissipation.

[0154] In some embodiments, see Figure 17 The inner diameter of the drainage channel gradually decreases and then increases from its first end to its second end, dividing the channel into a gathering section 141, an acceleration section 142, and a buffer section 143. The inner diameter of the acceleration section 142 is smaller than that of the gathering section 141 and the buffer section 143. The first end of the drainage channel is closer to the suction device, and the second end is closer to the exhaust device. In other words, the inner diameters at both ends of the drainage channel are larger than the inner diameter of the middle section, forming an acceleration section in the middle. Of course, the inner diameter here could also be width or length; in any case, the cross-sectional area of ​​the acceleration section is smaller than that of the gathering section and the buffer section.

[0155] In other words, in some embodiments, the inner diameter of the gathering section gradually decreases from the first end to the second end, while the inner diameter of the buffer section gradually increases from the first end to the second end, making the drainage channel resemble an X shape. That is, the diameter of the middle portion of the drainage channel is small, and both ends extend to the sides with gradually increasing inner diameters. The drainage channel resembles an X shape, but is not completely X-shaped; its middle portion is not closed. The gathering section and the buffer section can be inclined planes or curved surfaces. Of course, the inner diameter here can also be width or length. In short, the cross-sectional area of ​​the channel in the acceleration section is smaller than the cross-sectional area of ​​the channels in the gathering section and the buffer section. The first end of the drainage channel is closer to the suction device, and the second end of the drainage channel is closer to the exhaust device.

[0156] In some embodiments, the ratio of the inner diameter of the acceleration section to the inner diameter of both ends of the drainage channel is 0.4-0.6 (preferably 0.5), that is, the two ends of the drainage channel gradually contract inward, so that the cross-sectional area of ​​the middle section (acceleration section) is reduced to 40%-60% (preferably 50%) of that of the two ends.

[0157] In some embodiments, the inner diameters of the two ends of the drainage channel, namely the first end of the gathering section and the first end of the buffer section, are the same as the inner diameters of the second end of the cooling zone and the first end of the heat dissipation zone, respectively, so that the drainage channel smoothly transitions with the cooling zone and the heat dissipation zone, respectively.

[0158] In some embodiments, the acceleration section is divided into multiple segments, and the shrinking section 1421 and the recovery section 1422 are used alternately. The inner diameter of the shrinking section 1421 is smaller than the inner diameter of the recovery section 1422, so that when hot air enters the acceleration section (a longer channel), it can avoid high pressure loss caused by the excessive length of the channel, thereby ensuring that a continuous negative pressure can be formed in the accumulation section.

[0159] In some specific embodiments, after the cold air enters the cooling zone at the first end of the heat dissipation space and fully exchanges heat with the lamp source, the acceleration in the acceleration section and the negative pressure formed in the gathering section quickly draw the hot air to the gathering section to prevent the hot air after heat exchange from mixing with the newly entered cold air in the cooling zone, thus reducing the heat dissipation effect. This ensures that there is a large temperature difference between the air around the lamp source and the lamp source. Then, the hot air gathered in the gathering section immediately enters the acceleration section and quickly enters the buffer section for discharge. On the one hand, this can reduce the escape or conduction of hot air from the acceleration section to the outside. On the other hand, it can facilitate the exhaust device located at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in inner diameter between the acceleration section and the buffer section, it can also effectively prevent the hot air at the second end of the heat dissipation space from flowing back to the first end. In other words, this application provides a "rapidly diverting anti-backflow heat dissipation structure".

[0160] In some embodiments, the partition is disposed near the second side of the housing, and the detection element is disposed near the fourth side of the housing, thereby forming an isolation space between the detection element and the heat dissipation space.

[0161] In some specific embodiments, the detection box is divided into left and right parts. The lamp source and the sample detection area are both located in the left half, and the partition is also located in the left half. The detection element (e.g., sensor, data acquisition and processing unit, signal amplifier, etc.) and the water pipe are located in the right half, preferably at the far right end of the detection box, that is, the end away from the lamp source, so as to separate the lamp source from other components and minimize or avoid the heat generated by the lamp source from being conducted to the detection element and the water pipe and other components, which could lead to inaccurate measurement results or component aging.

[0162] In some embodiments, see Figure 9 The two sides of the partition 5 that contact the bottom wall of the housing extend towards both sides of the heat dissipation space to form rolled edges 51 parallel to the bottom wall. At least two locking blocks 44 are provided on the bottom wall. When the two rolled edges 51 are fixed by the at least two locking blocks 44, the rolled edges 51 adhere to the bottom wall. By setting the rolled edges to engage with the locking blocks on the bottom wall, quick assembly and disassembly are achieved, and the adherence of the rolled edges to the bottom wall further improves the sealing of the heat dissipation space.

[0163] In other embodiments, see Figure 11 The two sides of the partition 5 that contact the bottom wall of the housing extend toward both sides of the heat dissipation space to form rolled edges parallel to the bottom wall. At least one through hole is provided on the rolled edge. Correspondingly, at least one threaded hole corresponding to the through hole is provided on the bottom wall. When a bolt is passed through the through hole and screwed into the threaded hole, the bolt fixes the partition to the bottom wall, and the rolled edge is attached to the bottom wall, that is, at this time the rolled edge is parallel to the bottom wall.

[0164] In some embodiments, the first end of the partition is provided with an opening corresponding to the first side of the housing;

[0165] The outer side of the housing is provided with a detection space, which is located on the first side of the housing. The detection space includes a sample detection area and an installation area. The sample detection area is provided with an inspection window corresponding to the opening, and the installation area is detachably provided with a water guide pipe.

[0166] In some embodiments, the housing is provided with a plurality of first magnetic elements; the detection box further includes a magnetic door, on which a plurality of second magnetic elements corresponding to the first magnetic elements are provided;

[0167] When the magnetic door is installed on the housing via the second magnetic element and the first magnetic element, the housing and the magnetic door enclose and form a sealed detection space. By using a magnetic door, the airtightness of the detection space can be significantly improved compared to a traditional hinged door.

[0168] In summary, this application provides a point-source heat dissipation solution that confines the large amount of heat generated by the light source to a limited area and quickly removes the heat by setting a guiding path, i.e., a "DC" convection air duct.

[0169] Specifically, this solution sets up a heat dissipation space extending from the first to the third side of the housing. Combined with suction and exhaust devices located on both sides of this space, cool air is simultaneously introduced into the heat dissipation space, and hot air is extracted from it. This allows the air inside the heat dissipation space to be rapidly drawn from the first end to the second end for discharge, achieving rapid and concentrated heat dissipation of the lamp source. On the one hand, it concentrates the large amount of heat generated by the lamp source within the heat dissipation space, preventing heat from diffusing outside the space and adversely affecting the detection elements inside the housing or the area where the water pipes on the housing are located. On the other hand, the flow channel buffers the heat, meaning the heat generated by the lamp source can be quickly dispersed into the flow channel, preventing the lamp source from overheating. Furthermore, the "direct current" airflow design ensures a clear airflow path, efficiently carrying heat out of the channel and preventing heat accumulation within the channel.

[0170] Furthermore, given the relatively long drainage channel (i.e., extending through the entire housing), this application divides the drainage channel into multiple functional zones with different inner diameters. During the operation of the chromatograph, after the cold air enters the cooling zone at the first end of the heat dissipation space and undergoes sufficient heat exchange with the lamp source, the acceleration effect of the acceleration section causes the aggregation section to form a negative pressure, thereby quickly drawing the hot air to the aggregation section to prevent the hot air after heat exchange from mixing with the newly entered cold air in the cooling zone, thus reducing the heat dissipation effect. This ensures that the air around the lamp source has a large temperature difference with the lamp source. The hot air that has accumulated in the aggregation section then enters the acceleration section and is quickly discharged to the buffer section, and then discharged under the action of the exhaust device. On the one hand, this can reduce the escape or conduction of hot air from the acceleration section into the cavity (i.e., other areas outside the heat dissipation space inside the housing). On the other hand, it can facilitate the exhaust device located at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in inner diameter between the acceleration section and the buffer section, it can also effectively prevent the hot air at the second end of the heat dissipation space from flowing back to the first end. In other words, this application also provides a "rapid drainage anti-backflow heat dissipation structure".

[0171] It should be noted that, in this document, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element.

[0172] The embodiments of the present invention have been described above with reference to the accompanying drawings. However, the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of the present invention without departing from the spirit and scope of the claims. All of these forms are within the protection scope of the present invention.

Claims

1. A column oven for a liquid chromatograph, characterized in that, The device includes an outer shell and a heating and cooling device disposed inside the outer shell. A heat-conducting part is provided on a first side of the outer shell. The heating device is in surface contact with the heat-conducting part. A trapezoidal mounting member is provided on a second surface of the heat-conducting part. Multiple mounting grooves of different lengths are provided laterally on the mounting member. The cross-sectional shape of the mounting groove is arc-shaped. The mounting groove penetrates the mounting member. Fixing clips are provided at both ends of the mounting groove. When the chromatographic column is installed and fixed on the fixing clamp, the middle part of the chromatographic column is located inside the mounting groove and is wrapped, while the two ends of the chromatographic column are located outside the mounting groove and suspended in the air. The fixing clamp includes a connecting part connected to the mounting component, and an upper clamping piece and a lower clamping piece symmetrically arranged on both sides of the connecting part. The connecting part, the upper clamping piece, and the lower clamping piece enclose a clamping space. The upper clamping piece and the lower clamping piece can deform under the action of external force. The upper clip and the lower clip extend to both sides from the end away from the connecting part to form a guide space with gradually increasing spacing; When the chromatographic column enters the clamping space along the guide space, the upper clamp and the lower clamp deform outwards, making the clamping space larger. When the chromatographic column is fully inside the clamping space, the upper clamp and the lower clamp reset to clamp the chromatographic column.

2. The column oven for a liquid chromatograph according to claim 1, characterized in that, The length of the multiple mounting slots increases sequentially from top to bottom.

3. A column oven for a liquid chromatograph according to claim 1, characterized in that, The mounting component is in the shape of an equilateral trapezoid, and the line connecting the center points of the plurality of mounting slots is parallel to the height direction of the chromatograph.

4. A column oven for a liquid chromatograph according to claim 1, characterized in that, The heating device includes multiple heating tubes disposed inside the heat-conducting part or disposed on the first surface of the heat-conducting part and in contact with the surface of the heat-conducting part; the multiple heating tubes correspond one-to-one with the multiple mounting slots.

5. A column oven for a liquid chromatograph according to claim 4, characterized in that, There are four heating tubes, and correspondingly, there are four mounting slots.

6. A column oven for a liquid chromatograph according to claim 1, characterized in that, The refrigeration device includes a cold end, a refrigeration plate, an elastic element, and a pull rod motor connected in sequence. The output end of the pull rod motor is connected to the refrigeration plate through the elastic element. The refrigeration plate is disposed in close contact with the cold end. The cold end corresponds to but does not contact the heat-conducting part. When the output end of the pull rod motor extends, the output end of the pull rod motor drives the cooling chip and the cold end to move closer to the heat-conducting part, so that the cold end is in close contact with the heat-conducting part and the elastic element is compressed. The heat generated by the cooling chip is conducted to the heat-conducting part through the cold end, and then to the mounting part and the chromatographic column. When the output end of the pull rod motor retracts, the elastic element resets, causing the cooling element and the cold end to reset, thereby preventing the cold end from contacting the heat-conducting part.

7. A column oven for a liquid chromatograph according to claim 1, characterized in that, The column temperature chamber also includes a water guiding component arranged along the height direction of the column temperature chamber. The water guiding component includes a water guiding column and a flexible water guiding pipe. A water guiding cavity is provided at the first end of the water guiding column. The bottom of the water guiding cavity is opened and extends downward to form a water guiding channel that penetrates the water guiding column. The first end of the water guiding pipe is detachably connected to the second end of the water guiding column, so that the water guiding pipe is connected to the water guiding channel.

8. A column oven for a liquid chromatograph according to claim 7, characterized in that, The column temperature chamber is provided with a water guide groove that communicates with the water guide cavity; so that the waste liquid generated in the column temperature chamber can be guided to the water guide cavity through the water guide groove, and then flow out through the water guide channel and the water guide pipe.

9. A column oven for a liquid chromatograph according to claim 7 or 8, characterized in that, The column temperature chamber is provided with at least two limiting protrusions, which cooperate to form a limiting groove for laterally limiting the water guide pipe.

10. A column oven for a liquid chromatograph according to claim 9, characterized in that, At least two of the limiting protrusions are staggered along the height direction of the liquid chromatograph and are located on both sides of the water guide tube, so that grooves are formed on both sides of the water guide tube.

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