Chromatographic column sample constant temperature device

Abstract

The utility model relates to the technical field of medicine production research, in particular to a chromatographic column sample constant temperature device which comprises a constant temperature box body, a plurality of separation cavities are formed in the back of the constant temperature box body, an independent transmission structure is arranged in each separation cavity, and the constant temperature box body is provided with a clamping plate through the independent transmission structures. Thermostats are arranged on the two sides of the inner wall of the constant-temperature box body, a heat conduction box is arranged at the middle end of the interior of the constant-temperature box body, and a heating pipe is arranged in the heat conduction box. According to the utility model, through the combination of a plurality of separation cavities and independent transmission structures, independent clamping and position adjustment of different chromatographic column samples can be realized, and cross interference is avoided. Cooperative work of the thermostat and the temperature conducting box ensures that temperature distribution in the box body is uniform and stable, the constant-temperature requirement of a high-precision experiment is met, the temperature conducting box adopts a double-breathable-screen-plate interlayer design, heat of a heating pipe can permeate bidirectionally, and rapid temperature response is achieved in cooperation with a PID algorithm of the thermostat.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of medicine production research, especially a chromatographic column sample constant temperature device. BACKGROUND

[0002] The chromatographic column is composed of a column tube, a pressure cap, a sleeve (sealing ring), a screen plate (filter sheet), a joint and a screw, and can be divided into packed columns and open-tube columns. Most of them are made of metal or glass. They have straight tube shape, coil shape and U-shaped tube shape. Liquid chromatography usually uses packed columns. The separation effect of the chromatographic column depends on the selected stationary phase, the preparation of the chromatographic column and the operating conditions. The liquid chromatography column thermostat is a core module component of the high-performance liquid chromatograph, responsible for providing an ideal constant temperature environment for the liquid chromatography column adsorption-desorption distribution process.

[0003] The existing chromatographic column thermostat, such as the one disclosed in CN222299564U, uses a spring to push the clamping plates closer to each other to clamp the chromatographic column body, effectively preventing the chromatographic column from falling off and being damaged due to loose buckles. However, the spring may experience elastic fatigue after long-term use, resulting in a decrease in clamping force and affecting the stability of the chromatographic column, increasing the maintenance difficulty of the equipment. Moreover, the above-mentioned thermostat can only accommodate a single chromatographic column, which cannot meet the high-throughput experimental requirements, resulting in low test efficiency, increased experimental time and cost. UTILITY MODEL CONTENT

[0004] The utility model aims at solving the problem of existing spring elastic fatigue after long-term use, resulting in a decrease in clamping force and affecting the stability of the chromatographic column, increasing the maintenance difficulty of the equipment. Moreover, the above-mentioned thermostat can only accommodate a single chromatographic column, which cannot meet the high-throughput experimental requirements, resulting in low test efficiency, increased experimental time and cost. A chromatographic column sample constant temperature device is proposed.

[0005] To achieve the above-mentioned purpose, the utility model adopts the following technical scheme:

[0006] A chromatographic column sample constant temperature device, comprising a thermostat body, a plurality of partition cavities are formed in the back of the thermostat body, an independent transmission structure is arranged in each partition cavity, the thermostat body is provided with a clamping plate through the independent transmission structure, a thermostat is arranged on both sides of the inner wall of the thermostat body, a temperature guide box is arranged in the middle of the inside of the thermostat body, and a heating pipe is arranged in the temperature guide box.

[0007] Preferably, the independent transmission structure comprises a motor, a gear one, a gear two, a transmission rod, a bevel gear one, a bevel gear two, a bidirectional screw rod and a connecting plate, the motor is arranged in the separated cavity, the gear one is fixedly arranged at the output end of the motor, the transmission rod is rotatably arranged in the separated cavity, the gear two is fixedly arranged at the middle end of the transmission rod, the bevel gear one is fixedly arranged at the two ends of the transmission rod, the bevel gear two is fixedly arranged on the bidirectional screw rod, the bidirectional screw rod is rotatably arranged in the separated cavity, and the connecting plate is threadedly connected with the bidirectional screw rod.

[0008] Preferably, a pair of sliding openings are arranged in each separated cavity.

[0009] Preferably, the transmission rod is rotatably arranged on the partition plate, and the motor is fixedly arranged on the partition plate.

[0010] Preferably, the connecting plate is fixedly connected with the clamping plate and slidably arranged in the sliding opening, and the clamping plate is arranged in an arc shape at one end of the thermostat body.

[0011] Preferably, the temperature guide box comprises a protection plate and a breathable mesh plate, the breathable mesh plate is arranged on the two sides of the heating pipe, and the protection plate is arranged at the opening end of the thermostat body and protects the heating pipe in the middle.

[0012] Compared with the prior art, the utility model has the advantages that:

[0013] 1. In use, the combination of multiple separated cavities and independent transmission structures can realize independent clamping and position adjustment of different chromatographic column samples, and cross interference is avoided. The cooperative work of the thermostat and the temperature guide box ensures that the temperature distribution in the box body is uniform and stable, meets the constant temperature demand of high-precision experiments, the temperature guide box adopts a double-breathable mesh plate sandwich design, the heating pipe heat can be bidirectionally permeated, and the PID algorithm of the thermostat is matched, so that temperature rapid response is realized.

[0014] 2. In use, the arc-shaped clamping plate cooperates with the bidirectional screw rod transmission (motor→gear set→bevel gear→screw rod), can automatically adapt to chromatographic columns of different diameters, the clamping force is uniform and anti-skid, and compared with the traditional single-layer structure, the number of chromatographic columns that can be tested at the same time is improved. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 It is a three-dimensional structure schematic view of a chromatographic column sample constant temperature device;

[0016] Figure 2 It is a three-dimensional structure schematic view of an independent transmission structure of a chromatographic column sample constant temperature device;

[0017] Figure 3The utility model provides a kind of section view of chromatographic column sample constant temperature device Figure 1 .

[0018] Figure 4 The utility model provides a kind of section view of chromatographic column sample constant temperature device Figure 2 .

[0019] In the drawing: 1, constant temperature box body;2, separate cavity;3, independent transmission structure;4, clamping plate;5, thermostat;6, temperature guide box;7, heating pipe;8, motor;9, gear one;10, gear two;11, transmission rod;12, bevel gear one;13, bevel gear two;14, two-way screw;15, connecting plate;16, sliding port;17, baffle;61, protection plate;62, breathable mesh plate. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the utility model.

[0021] Referring to Figures 1-4 A chromatographic column sample constant temperature device, comprising constant temperature box body 1, the back of constant temperature box body 1 is provided with a plurality of separate cavities 2, each separate cavity 2 is provided with independent transmission structure 3, independent transmission structure 3 includes motor 8, gear one 9, gear two 10, transmission rod 11, bevel gear one 12, bevel gear two 13, two-way screw 14 and connecting plate 15, motor 8 is arranged in separate cavity 2, gear one 9 is fixedly arranged on the output end of motor 8, transmission rod 11 is rotatably arranged in separate cavity 2, gear two 10 is fixedly arranged on the middle end of transmission rod 11, bevel gear one 12 is fixedly arranged on the first end and the last end of transmission rod 11, bevel gear two 13 is fixedly arranged on two-way screw 14, two-way screw 14 is rotatably arranged in separate cavity 2, and connecting plate 15 is threadedly connected with two-way screw 14.

[0022] Constant temperature box body 1 is provided with clamping plate 4 by independent transmission structure 3, the inner wall of constant temperature box body 1 is provided with thermostat 5, the middle end of the inside of constant temperature box body 1 is provided with temperature guide box 6, and heating pipe 7 is arranged in temperature guide box 6.

[0023] It should be noted that the thermostat 5, heating tube 7 and motor 8 are all prior art in the field to which the present technology belongs, the thermostat 5 is used to control the temperature inside the thermostat box 1; the heating tube 7 is used to heat in the middle of the inside of the thermostat box 1, to ensure that the temperature inside the thermostat box 1 meets the test requirements when a large number of tests are carried out; the specific model and specification need to be selected and determined according to the actual specification of the device, the specific selection calculation method uses the prior art in the field, and therefore is not described in detail, and all can be powered by external equipment and controlled to be turned on and off.

[0024] Further, a pair of sliding openings 16 are vertically distributed in each partition cavity 2, and a pair of partition plates 17 are arranged in the partition cavity 2.

[0025] Among them, the sliding opening 16 enables the connecting plate 15 to slide smoothly, ensuring that the lifting process of the clamping plate 4 is stable and without deviation, and improving the positioning accuracy of the chromatographic column.

[0026] The transmission rod 11 is rotationally arranged on the partition plate 17, and the motor 8 is fixedly arranged on the partition plate 17.

[0027] Further, the connecting plate 15 is fixedly connected with the clamping plate 4 and is slidingly arranged in the sliding opening 16, and the clamping plate 4 is arranged in an arc shape at one end of the thermostat box 1.

[0028] Among them, the arc-shaped clamping surface is adapted to chromatographic columns of different diameters (such as 3mm-10mm), provides stable clamping force, and prevents the sample from loosening or slipping off.

[0029] Further, the temperature guide box 6 includes a protective plate 61 and a breathable mesh plate 62, the breathable mesh plate 62 is arranged on both sides of the heating tube 7, and the protective plate 61 is arranged at the opening end of the thermostat box 1 to protect the heating tube 7 in the middle.

[0030] Among them, the breathable mesh plate 62 promotes uniform heat diffusion, avoids local overheating, improves the thermostat accuracy (within ±0.5℃), the protective plate 61 prevents external airflow from interfering with the thermostat environment, and at the same time avoids the experimental personnel from accidentally touching the high-temperature components, and improves the safety.

[0031] Working principle:

[0032] Firstly, the chromatographic column is placed between the clamping plates 4, and then the motor 8 is driven to rotate the gear one 9, the power is transmitted to the transmission rod 11 through the gear two 10, the bevel gears one 12 and two 13 at both ends of the transmission rod 11 are engaged, the rotary motion is converted into the rotation of the bidirectional lead screw 14, the bidirectional lead screw 14 drives the connecting plate 15 to slide along the sliding opening 16, and at the same time drives the clamping plate 4 to move synchronously, firmly clamping the chromatographic column in the middle, and the transmission structure in each partition cavity 2 operates independently, and the height of different samples can be adjusted individually, avoiding mutual interference.

[0033] Then, the thermostat 5 monitors the temperature in the box in real time, and controls the start and stop of the heating pipe 7 through a PID algorithm to maintain the set temperature, and the heat generated by the heating pipe 7 is diffused bidirectionally through the air-permeable mesh plate 62 of the temperature guide box 6, so that local overheating is avoided.

[0034] The above merely describes a preferred specific implementation of the present application, but the protection scope of the present application is not limited to this, any skilled person in the art, according to the technical scheme and the inventive concept of the present application, makes equivalent replacement or change within the technical range disclosed by the present application, should be covered within the protection scope of the present application.

Claims

1. A chromatographic column sample isothermal device, comprising an isothermal chamber (1), characterized in that, The thermostatic chamber (1) has multiple partitioned cavities (2) on its back. Each partitioned cavity (2) is equipped with an independent transmission structure (3). The thermostatic chamber (1) is equipped with a clamping plate (4) through the independent transmission structure (3). The thermostat (5) is provided on both sides of the inner wall of the thermostatic chamber (1). A temperature conducting box (6) is provided in the middle of the interior of the thermostatic chamber (1). A heating tube (7) is provided in the temperature conducting box (6).

2. The chromatographic column sample isothermal device according to claim 1, characterized in that, The independent transmission structure (3) includes a motor (8), a first gear (9), a second gear (10), a transmission rod (11), a first bevel gear (12), a second bevel gear (13), a double-acting screw (14), and a connecting plate (15). The motor (8) is located in the partition cavity (2). The first gear (9) is fixedly located at the output end of the motor (8). The transmission rod (11) is rotatably located in the partition cavity (2). The second gear (10) is fixedly located at the middle end of the transmission rod (11). The first bevel gear (12) is fixedly located at both ends of the transmission rod (11). The second bevel gear (13) is fixedly located on the double-acting screw (14). The double-acting screw (14) is rotatably located in the partition cavity (2). The connecting plate (15) is threadedly connected to the double-acting screw (14).

3. The chromatographic column sample isothermal device according to claim 2, characterized in that, Each of the partition cavities (2) is provided with a pair of sliding openings (16), and a pair of partitions (17) are provided in each partition cavity (2).

4. The chromatographic column sample isothermal device according to claim 2, characterized in that, The transmission rod (11) is rotatably mounted on the partition plate (17), and the motor (8) is fixedly mounted on the partition plate (17).

5. The chromatographic column sample isothermal device according to claim 2, characterized in that, The connecting plate (15) is fixedly connected to the clamping plate (4) and slidably disposed in the sliding opening (16). The clamping plate (4) is located at one end of the constant temperature chamber (1) and is arranged in an arc shape.

6. The chromatographic column sample isothermal device according to claim 1, characterized in that, The temperature conducting box (6) includes a protective plate (61) and a breathable mesh plate (62). The breathable mesh plate (62) is disposed on both sides of the heating tube (7), and the protective plate (61) is disposed at the opening end of the constant temperature box body (1) to protect the heating tube (7) in the middle.

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